Term	Overlap	P.value	Adjusted.P.value	Old.P.value	Old.Adjusted.P.value	Odds.Ratio	Combined.Score	Genes
Oxidative phosphorylation	86/133	1.38635289825486e-39	4.38087515848537e-37	0	0	10.9209609170355	977.143609418754	NDUFA13;COX7B;NDUFA11;NDUFA12;COX4I1;NDUFA10;COX6A1;COX7C;UQCRFS1;ATP6V1E1;COX8A;ATP6V1G1;ATP6V0B;ATP6V0E1;ATP6AP1;NDUFC2;SDHC;NDUFC1;SDHD;SDHA;SDHB;COX6B1;COX7A2L;NDUFS8;NDUFS7;NDUFS6;NDUFS5;NDUFS4;UQCRC1;ATP6V1B2;NDUFS3;NDUFS2;UQCRC2;ATP6V0D1;ATP6V0C;ATP6V1A;NDUFB9;NDUFB10;UQCRB;NDUFB6;NDUFB11;NDUFB5;NDUFB4;COX17;NDUFB3;ATP5MC2;NDUFB2;ATP5MC3;NDUFB1;COX7A2;UQCR11;UQCR10;COX5B;COX5A;UQCRH;ATP5F1A;ATP5F1B;COX11;CYC1;NDUFV2;ATP6V0E2;ATP5MG;ATP6V1D;ATP5MF;COX10;ATP5ME;ATP6V0A1;ATP6V1F;NDUFA9;ATP5PF;NDUFA8;NDUFA7;ATP5PD;NDUFA6;NDUFA5;ATP5PB;NDUFA4;NDUFA3;NDUFA2;NDUFA1;ATP5F1C;COX6C;ATP5F1D;ATP5F1E;UQCRQ;NDUFAB1
Parkinson disease	120/249	1.55547555439493e-36	2.0767660684173e-34	0	0	5.59196242085015	461.06447064113	NDUFA13;NDUFA11;NDUFA12;NDUFA10;UBE2L6;PARK7;COX6A1;UBE2L3;TXN2;PSMD8;PSMD9;PSMD6;PSMD7;PSMD4;PSMD2;KIF5B;PSMD1;MAP3K5;SDHC;SDHD;SDHA;SDHB;COX6B1;COX7A2L;UQCRC1;VDAC2;VDAC1;UQCRC2;PSMD11;NDUFB10;UQCRB;NDUFB11;ATP5MC2;ATP5MC3;ITPR2;COX7A2;TXN;UBE2J2;UQCRH;UBC;CYC1;NDUFV2;SEM1;UQCRQ;CALM3;UBA1;CALM2;BCL2L1;COX7B;COX4I1;COX7C;UQCRFS1;COX8A;NDUFC2;NDUFC1;PSMA5;PSMA6;PSMA3;PSMA4;NDUFS8;PSMA1;ADORA2A;NDUFS7;PSMA2;NDUFS6;NDUFS5;NDUFS4;NDUFS3;NDUFS2;MAPT;SLC25A5;SLC25A6;NDUFB9;CAMK2D;NDUFB6;NDUFB5;NDUFB4;NDUFB3;NDUFB2;NDUFB1;UQCR11;UQCR10;COX5B;COX5A;PSMA7;GNAI2;PSMB6;PSMB7;ATP5F1A;PSMB4;ATP5F1B;PSMB5;PSMB2;PSMB3;PSMB1;NDUFA9;ATP5PF;NDUFA8;NDUFA7;ATP5PD;NDUFA6;NDUFA5;ATP5PB;NDUFA4;NDUFA3;ADRM1;NDUFA2;NDUFA1;UBE2G1;ATP5F1C;COX6C;ATP5F1D;ATP5F1E;PSMC5;PSMC3;PSMC4;PSMC1;NDUFAB1;PSMC2;BAX
Huntington disease	136/306	1.97161335609237e-36	2.0767660684173e-34	0	0	4.82484826847554	396.671094444901	NDUFA13;NDUFA11;NDUFA12;NDUFA10;COX6A1;PSMD8;PSMD9;PSMD6;PSMD7;CREB3L3;PSMD4;PSMD2;KIF5B;PSMD1;AP2M1;MAP3K5;SDHC;SDHD;SDHA;ATG13;SDHB;COX6B1;COX7A2L;UQCRC1;VDAC2;VDAC1;UQCRC2;PSMD11;NDUFB10;UQCRB;NDUFB11;ATP5MC2;ATP5MC3;COX7A2;UQCRH;CYC1;NDUFV2;SEM1;UQCRQ;COX7B;COX4I1;CLTB;CLTA;COX7C;BBC3;ACTR1B;RB1CC1;UQCRFS1;IFT57;COX8A;GPX7;NDUFC2;NDUFC1;TRAF2;WIPI2;PSMA5;PSMA6;PSMA3;PSMA4;CREB1;NDUFS8;PSMA1;NDUFS7;PSMA2;NDUFS6;NDUFS5;NDUFS4;NDUFS3;NDUFS2;PPARG;PIK3C3;SLC25A5;PLCB2;SLC25A6;BECN1;DCTN5;NDUFB9;DCTN2;NDUFB6;DNAH8;HDAC1;NDUFB5;NDUFB4;DCTN3;NDUFB3;NDUFB2;NDUFB1;UQCR11;UQCR10;COX5B;COX5A;PSMA7;PSMB6;PSMB7;ATP5F1A;PSMB4;ATP5F1B;PSMB5;PSMB2;PSMB3;PSMB1;AP2S1;POLR2E;POLR2F;POLR2G;POLR2H;POLR2I;POLR2J;POLR2K;NDUFA9;ATP5PF;NDUFA8;NDUFA7;ATP5PD;NDUFA6;NDUFA5;ATP5PB;NDUFA4;NDUFA3;ADRM1;NDUFA2;NDUFA1;ATP5F1C;COX6C;SOD2;ATP5F1D;ATP5F1E;SOD1;PSMC5;REST;PSMC3;PSMC4;PSMC1;NDUFAB1;PSMC2;BAX
Amyotrophic lateral sclerosis	144/364	9.85831562437754e-32	7.78806934325825e-30	0	0	3.94719265696709	281.807481628379	NDUFA13;NDUFA11;NDUFA12;NDUFA10;COX6A1;ACTB;ACTG1;PSMD8;PSMD9;PSMD6;PSMD7;TBK1;PSMD4;PSMD2;KIF5B;PSMD1;MAP3K5;MAP2K3;GABARAPL2;ANXA11;SDHC;SDHD;SDHA;ATG13;SDHB;COX6B1;COX7A2L;UQCRC1;SRSF3;VDAC1;UQCRC2;PFN1;SQSTM1;OPTN;VCP;SEH1L;PSMD11;NDUFB10;UQCRB;NDUFB11;ATP5MC2;ATP5MC3;COX7A2;GABARAP;UQCRH;TPR;CYC1;NDUFV2;SEM1;UQCRQ;CHMP2B;BCL2;RAB5A;BCL2L1;COX7B;COX4I1;COX7C;ACTR1B;RB1CC1;NUP62;CASP1;ANXA7;UQCRFS1;RAC1;COX8A;GPX7;NDUFC2;NDUFC1;TRAF2;WIPI2;TNFRSF1B;PSMA5;PSMA6;PSMA3;PSMA4;NDUFS8;PSMA1;NDUFS7;PSMA2;NDUFS6;NDUFS5;NUP50;CAT;NDUFS4;NDUFS3;NDUFS2;PIK3C3;NUP58;BECN1;DCTN5;NDUFB9;DCTN2;NDUFB6;DNAH8;NDUFB5;NDUFB4;DCTN3;NDUFB3;DERL1;NDUFB2;NDUFB1;UQCR11;UQCR10;COX5B;COX5A;TANK;PSMA7;PSMB6;PSMB7;ATP5F1A;PSMB4;ATP5F1B;PSMB5;PSMB2;PSMB3;PSMB1;HNRNPA1;UBQLN2;NDUFA9;ATP5PF;NDUFA8;HNRNPA3;NDUFA7;ATP5PD;NDUFA6;NDUFA5;ATP5PB;NDUFA4;NDUFA3;ADRM1;NDUFA2;NDUFA1;ATP5F1C;COX6C;ATP5F1D;ATP5F1E;SOD1;PSMC5;PSMC3;PSMC4;PSMC1;NDUFAB1;PSMC2;BAX
Prion disease	118/273	2.24837447276154e-30	1.42097266678529e-28	0	0	4.56612159425099	311.716999516579	ATF2;NDUFA13;NDUFA11;NDUFA12;NCF4;NDUFA10;COX6A1;PSMD8;PSMD9;PSMD6;PSMD7;CREB3L3;PSMD4;PSMD2;KIF5B;PSMD1;SDHC;SDHD;SDHA;SDHB;COX6B1;COX7A2L;CSNK2B;UQCRC1;VDAC2;VDAC1;UQCRC2;PSMD11;NDUFB10;UQCRB;NDUFB11;ATP5MC2;ATP5MC3;ITPR2;COX7A2;UQCRH;CYC1;NDUFV2;HSPA8;CAV1;SEM1;UQCRQ;RYR1;GSK3B;COX7B;COX4I1;PIK3CB;COX7C;RAC2;UQCRFS1;RAC1;COX8A;NDUFC2;NDUFC1;PSMA5;PSMA6;PSMA3;PSMA4;CREB1;NDUFS8;PSMA1;NDUFS7;PSMA2;NDUFS6;NDUFS5;NDUFS4;NDUFS3;NDUFS2;SLC25A5;SLC25A6;NDUFB9;ATF6B;NDUFB6;NDUFB5;NDUFB4;NDUFB3;NDUFB2;NDUFB1;UQCR11;UQCR10;COX5B;COX5A;PSMA7;PSMB6;PSMB7;ATP5F1A;PSMB4;ATP5F1B;PSMB5;PSMB2;PSMB3;PSMB1;MAPK3;NDUFA9;ATP5PF;NDUFA8;NDUFA7;ATP5PD;NDUFA6;NDUFA5;ATP5PB;NDUFA4;NDUFA3;ADRM1;NDUFA2;NDUFA1;ATP5F1C;COX6C;ATP5F1D;ATP5F1E;SOD1;PSMC5;PSMC3;PSMC4;PSMC1;NDUFAB1;PSMC2;BAX
Pathways of neurodegeneration	164/475	6.67156440455116e-28	3.51369058639695e-26	0	0	3.18566609810031	199.341553180547	NDUFA13;CSF1;NDUFA11;NDUFA12;NDUFA10;UBE2L6;PARK7;COX6A1;UBE2L3;PSMD8;PSMD9;PSMD6;PSMD7;TBK1;FRAT2;PSMD4;PSMD2;KIF5B;PSMD1;CAPN1;MAP3K5;MAP2K3;GABARAPL2;PRKCB;TPTEP2-CSNK1E;SDHC;SDHD;SDHA;ATG13;SDHB;COX6B1;COX7A2L;CSNK2B;UQCRC1;VDAC2;VDAC1;UQCRC2;SQSTM1;OPTN;VCP;PSMD11;UQCRB;NDUFB10;NDUFB11;ATP5MC2;ITPR2;ATP5MC3;COX7A2;PSEN1;UBE2J2;GABARAP;UQCRH;ATXN1;UBC;CYC1;NDUFV2;WNT10A;NFKB1;SEM1;CDK5;UQCRQ;CHMP2B;BCL2;CALM3;UBA1;RAB5A;CALM2;BCL2L1;RYR1;GSK3B;COX7B;COX4I1;COX7C;ACTR1B;RB1CC1;UQCRFS1;RAC1;IFT57;COX8A;GPX7;NDUFC2;NDUFC1;TRAF2;WIPI2;TNFRSF1B;PSMA5;PSMA6;PSMA3;PSMA4;NDUFS8;PSMA1;NDUFS7;PSMA2;NDUFS6;NDUFS5;CAT;NDUFS4;NDUFS3;NDUFS2;PIK3C3;MAPT;SLC25A5;PLCB2;SLC25A6;BECN1;NDUFB9;DCTN5;CAMK2D;NDUFB6;DCTN2;NDUFB5;DNAH8;NDUFB4;NDUFB3;DCTN3;NDUFB2;DERL1;NDUFB1;UQCR11;UQCR10;COX5B;TANK;HSD17B10;COX5A;PSMA7;PSMB6;PSMB7;PSMB4;ATP5F1A;PSMB5;ATP5F1B;PSMB2;PSMB3;PSMB1;BAK1;MAPK3;NDUFA9;NDUFA8;ATP5PF;NDUFA7;NDUFA6;ATP5PD;NDUFA5;CSNK1A1;NDUFA4;ATP5PB;NDUFA3;ADRM1;NDUFA2;NDUFA1;UBE2G1;ATP5F1C;COX6C;ATP5F1D;ATP5F1E;SOD1;PSMC5;PSMC3;PSMC4;PSMC1;PSMC2;NDUFAB1;FAS;BAX
Diabetic cardiomyopathy	93/203	1.69421600400639e-26	7.64817510380026e-25	0	0	5.03972957422325	299.057514221847	GSK3B;COX7B;NDUFA13;NDUFA11;NDUFA12;COX4I1;NCF4;NDUFA10;PTEN;PIK3CB;COX6A1;COX7C;PPP1CC;AKT2;MPC2;RAC2;UQCRFS1;RAC1;PDK2;COX8A;PARP1;PRKCB;NDUFC2;SDHC;NDUFC1;SDHD;SDHA;SDHB;COX6B1;COX7A2L;NDUFS8;NDUFS7;TBC1D4;NDUFS6;NDUFS5;NDUFS4;UQCRC1;NDUFS3;VDAC2;NDUFS2;VDAC1;UQCRC2;SLC25A5;PLCB2;GAPDH;SLC25A6;NDUFB9;CAMK2D;NDUFB10;UQCRB;NDUFB6;NDUFB11;NDUFB5;NDUFB4;NDUFB3;ATP5MC2;NDUFB2;ATP5MC3;NDUFB1;UQCR11;COX7A2;UQCR10;PDHB;COX5B;COX5A;UQCRH;ATP5F1A;ATP5F1B;CYC1;NDUFV2;SMAD2;NDUFA9;ATP5PF;NDUFA8;NDUFA7;ATP5PD;SMAD3;NDUFA6;NDUFA5;ATP5PB;NDUFA4;NDUFA3;GSR;NDUFA2;NDUFA1;ATP5F1C;COX6C;ATP5F1D;ATP5F1E;NFKB1;PPP1CA;UQCRQ;NDUFAB1
Alzheimer disease	136/369	1.95654062276434e-26	7.72833545991914e-25	0	0	3.50714720217948	207.609206750195	NDUFA13;CSF1;NDUFA11;NDUFA12;NDUFA10;COX6A1;PSMD8;PSMD9;PSMD6;FRAT2;PSMD7;PSMD4;AKT2;PSMD2;KIF5B;PSMD1;CAPN1;MAP3K5;TPTEP2-CSNK1E;ADAM10;SDHC;SDHD;SDHA;ATG13;SDHB;COX6B1;COX7A2L;ADAM17;CSNK2B;UQCRC1;VDAC2;VDAC1;UQCRC2;PSMD11;NDUFB10;UQCRB;NDUFB11;ATP5MC2;ATP5MC3;ITPR2;COX7A2;PSEN1;UQCRH;APH1A;CYC1;NDUFV2;WNT10A;NFKB1;SEM1;CDK5;UQCRQ;CALM3;CALM2;GSK3B;COX7B;COX4I1;IDE;PIK3CB;COX7C;IKBKB;RB1CC1;UQCRFS1;COX8A;MME;NDUFC2;NDUFC1;TRAF2;WIPI2;PSMA5;PSMA6;PSMA3;PSMA4;NDUFS8;PSMA1;NDUFS7;PSMA2;NDUFS6;NDUFS5;NDUFS4;NDUFS3;NDUFS2;PIK3C3;MAPT;SLC25A5;PLCB2;GAPDH;SLC25A6;BECN1;NDUFB9;NDUFB6;NDUFB5;NDUFB4;NDUFB3;NDUFB2;NDUFB1;UQCR11;UQCR10;COX5B;COX5A;HSD17B10;PSMA7;PSMB6;PSMB7;ATP5F1A;PSMB4;ATP5F1B;PSMB5;PSMB2;PSMB3;PSMB1;MAPK3;NDUFA9;ATP5PF;NDUFA8;NDUFA7;ATP5PD;NDUFA6;NDUFA5;ATP5PB;CSNK1A1;NDUFA4;NDUFA3;ADRM1;NDUFA2;NDUFA1;ATP5F1C;COX6C;ATP5F1D;ATP5F1E;PSMC5;PSMC3;PSMC4;PSMC1;NDUFAB1;PSMC2;FAS
Thermogenesis	99/232	3.68372338539956e-25	1.29339621087362e-23	0	0	4.44046161916419	249.823493647182	ATF2;NDUFA13;SMARCB1;NDUFA11;NDUFA12;NDUFA10;COX6A1;ACTB;ACTG1;CREB3L3;RPS6KA2;RPS6KA1;MAP3K5;MAP2K3;SMARCC1;SMARCC2;ACSL4;SDHC;SDHD;SDHA;SDHB;COX6B1;COX7A2L;UQCRC1;UQCRC2;COX16;NDUFB10;UQCRB;NDUFB11;COX17;ATP5MC2;ATP5MC3;COX7A2;UQCRH;COX11;COX14;CYC1;NDUFV2;ATP5MG;ATP5MF;COX10;ATP5ME;COA3;UQCRQ;NDUFAF3;GRB2;FGFR1;COX7B;COX4I1;COX7C;UQCRFS1;COA6;COA5;COX8A;NDUFC2;SIRT6;NDUFC1;CREB1;NDUFS8;NDUFS7;NDUFS6;NDUFS5;NDUFS4;NDUFS3;NDUFS2;PPARG;NDUFB9;NDUFB6;NDUFB5;NDUFB4;NDUFB3;NDUFB2;NDUFB1;UQCR11;UQCR10;COX5B;COX5A;ATP5F1A;ATP5F1B;NDUFA9;SMARCE1;ATP5PF;NDUFA8;NDUFA7;ATP5PD;NDUFA6;NDUFA5;ATP5PB;NDUFA4;NDUFA3;NDUFA2;NDUFA1;ATP5F1C;COX6C;ATP5F1D;ATP5F1E;NDUFAB1;RPS6KB2;PNPLA2
Non-alcoholic fatty liver disease	74/155	1.0468600015126e-22	3.30807760477982e-21	0	0	5.41893809049473	274.258292072182	GSK3B;NDUFA13;COX7B;NDUFA11;NDUFA12;COX4I1;NDUFA10;PIK3CB;COX6A1;COX7C;IKBKB;AKT2;MLX;UQCRFS1;RAC1;IL6R;MAP3K5;COX8A;NDUFC2;SDHC;NDUFC1;TRAF2;SDHD;SDHA;SDHB;COX6B1;COX7A2L;NDUFS8;NDUFS7;NDUFS6;NDUFS5;NDUFS4;UQCRC1;NDUFS3;NDUFS2;PPARG;UQCRC2;CEBPA;NDUFB9;NDUFB10;UQCRB;NDUFB6;NDUFB11;NDUFB5;NDUFB4;NDUFB3;NDUFB2;NDUFB1;COX7A2;UQCR11;UQCR10;COX5B;COX5A;UQCRH;CDC42;SOCS3;BCL2L11;CYC1;NDUFV2;NDUFA9;NDUFA8;NDUFA7;NDUFA6;NDUFA5;NDUFA4;NDUFA3;NDUFA2;NDUFA1;COX6C;NFKB1;UQCRQ;NDUFAB1;BAX;FAS
Proteasome	36/46	7.5096734077775e-22	2.15732436077972e-20	0	0	21.1619441571872	1029.33135538111	PSMD11;POMP;PSMA7;PSMB10;PSMB6;PSMD8;PSMB7;PSMD9;PSMB4;PSMD6;PSMB5;PSMD7;PSMB2;PSMD4;PSMB3;PSMD2;PSMB1;PSMD1;PSMF1;ADRM1;PSMB8;PSMB9;PSMA5;SEM1;PSMA6;PSMA3;PSMC5;PSMA4;PSMA1;PSMC3;PSMA2;PSMC4;PSMC1;PSMC2;PSME1;PSME2
Endocytosis	84/252	6.35007141410446e-14	1.67218547238084e-12	0	0	2.96091833158079	89.9755727263273	ARF3;ARF4;ARF1;TFRC;WIPF1;SH3KBP1;WIPF2;ARPC1B;ARPC5L;CLTB;CLTA;CAPZB;KIF5B;CHMP1A;AP2M1;WASHC3;SH3GLB1;ACTR3;ACTR2;IST1;HLA-B;HLA-C;HLA-A;HLA-F;RHOA;HLA-E;ARFGAP2;RABEP1;HGS;RAB35;CHMP4B;CHMP3;CHMP4A;STAMBP;VPS25;CHMP7;VPS28;ARF5;ARF6;RAB7A;CHMP5;RAB5B;RAB5C;TSG101;ASAP1;IL2RG;SNX3;CDC42;ACTR3C;SNX1;RAB11FIP1;SNX2;GRK6;AP2S1;PIP5K1B;LDLR;SNX5;CYTH1;SNX6;SMAD2;ARFGEF1;HSPA8;RAB4A;SMAD3;CAV1;WWP1;ARPC4;SNF8;STAM;RAB11B;RAB10;EHD4;ARPC2;ARPC3;CAPZA1;IL2RA;CAPZA2;CHMP2B;IL2RB;CHMP2A;SMAP2;RAB5A;FGFR2;SPG21
Epstein-Barr virus infection	71/202	2.9694868693545e-13	7.21813731320016e-12	0	0	3.20198377396483	92.3619169259249	CDKN1B;TRADD;PIK3CB;RBPJ;CD3E;ITGAL;CD3D;PSMD8;IKBKB;PSMD6;PSMD7;TBK1;PSMD4;AKT2;PSMD2;PSMD1;RAC1;POLK;B2M;IKBKE;JAK3;JAK1;IFNAR2;MAP2K3;ENTPD1;HLA-B;HLA-C;TAP1;TRAF2;HLA-A;HLA-F;HLA-E;DDB2;OAS1;OAS2;TRAF3;IRF7;CD44;PSMD11;HDAC1;RELB;BCL2L11;E2F3;HES1;CD58;BAK1;GADD45A;STAT1;STAT2;STAT3;ADRM1;ISG15;NFKB1;GADD45G;NFKB2;SEM1;PSMC5;SNW1;PSMC3;PSMC4;PSMC1;PSMC2;BCL2;FAS;BAX;TAB2;CALR;CD247;NFKBIE;MAP3K14;NFKBIB
Th17 cell differentiation	46/107	1.38391454810631e-12	3.12369283715425e-11	0	0	4.43486002347591	121.098753476135	IL21;IL22;IL23R;RORC;RORA;AHR;GATA3;CD3E;IL2RG;HIF1A;CD3D;IL27RA;IKBKB;IL21R;IL12RB1;IL6R;JAK3;JAK1;MAPK3;SMAD2;STAT5A;STAT5B;SMAD3;IL1R1;STAT1;IFNGR2;STAT3;NFATC2;NFATC1;FOXP3;NFKB1;RUNX1;IL4;CD4;IRF4;LCK;IL2RA;IL2RB;PRKCQ;IL17F;CD247;IL6ST;NFKBIE;LAT;NFKBIB;IL17A
Spliceosome	55/150	2.08250067860502e-11	4.3871347629279e-10	0	0	3.408597830454	83.8340089399336	TCERG1;HNRNPU;PQBP1;SART1;SNRPD2;SNRPD1;MAGOH;DHX15;TXNL4A;BCAS2;RBM17;BUD31;THOC3;PRPF40A;SYF2;SNRPG;SRSF3;SRSF4;SNRPC;SLU7;SRSF8;SNRPB;SRSF9;SF3B4;SF3B5;SF3B2;SF3B6;SNU13;U2AF1L4;ZMAT2;PUF60;U2AF2;PCBP1;SNRPB2;HNRNPA1;SF3B1;SMNDC1;SF3A3;HSPA8;HNRNPA3;SF3A1;PRPF38A;SF3A2;CCDC12;CWC15;LSM3;LSM8;LSM7;SNRNP40;HNRNPK;LSM6;SNW1;PHF5A;PRPF31;HNRNPC
Shigellosis	75/246	1.73044964729853e-10	3.41763805341459e-09	0	0	2.58866943739502	58.1867386960219	ITGB1;GSK3B;ARF1;ARPC1B;UBE2D2;TRADD;UBE2D3;ARPC5L;PIK3CB;ACTB;ACTG1;HK1;IKBKB;TBK1;AKT2;CASP4;CASP1;RAC1;CAPN1;SKP1;ACTR3;GABARAPL2;ACTR2;IL1R1;ACTN1;TRAF2;WIPI2;RHOA;RBX1;CTTN;RRAGB;ELMO1;UBE2V2;HCLS1;PRKCQ;VDAC1;PIK3C3;RBCK1;UBE2V1;PFN1;PLCB2;SQSTM1;CD44;ARF6;BECN1;ROCK1;PXN;ITPR2;BCL10;GABARAP;FOXO1;MALT1;U2AF1L4;CDC42;ACTR3C;UBC;TIFA;WASF2;CYTH1;MAPK3;CBX3;ARPC4;NFKB1;DIAPH1;ARPC2;TNIP1;ARPC3;RPS6KB2;BCL2;UBE2N;TAB3;BAX;TAB2;BCL2L1;NFKBIB
Yersinia infection	50/137	2.0317234347287e-10	3.776615325731e-09	0	0	3.37939793525475	75.4179105600604	ITGB1;GSK3B;WIPF1;WIPF2;ARPC1B;ARPC5L;PIK3CB;ACTB;ACTG1;IKBKB;TBK1;AKT2;RPS6KA2;RPS6KA1;CASP1;RAC2;RAC1;MAP2K3;ACTR3;IL10;VAV3;ACTR2;ITGA4;RHOG;TRAF2;TICAM1;RHOA;LCK;ELMO1;LCP2;ARF6;ROCK1;PXN;WAS;CDC42;ACTR3C;PIP5K1B;WASF2;MAPK3;FYB1;NFATC2;ARPC4;NFATC1;NFKB1;CD4;ARPC2;ARPC3;TAB2;PKN1;LAT
Spinocerebellar ataxia	51/143	3.49240237473112e-10	6.13110639119464e-09	0	0	3.25981876525355	70.9834046575899	RYR1;KCNC3;RORA;PIK3CB;RBPJ;PSMD8;PSMD9;PSMD6;PSMD7;PSMD4;AKT2;PSMD2;RB1CC1;PSMD1;MAP3K5;PRKCB;TRAF2;WIPI2;ATG13;PSMA5;PSMA6;PSMA3;PSMA4;PSMA1;PSMA2;VDAC2;VDAC1;PIK3C3;SLC25A5;PLCB2;SLC25A6;BECN1;PSMD11;ITPR2;PSMA7;PSMB6;PSMB7;PSMB4;ATXN1;PSMB5;PSMB2;PSMB3;PSMB1;ADRM1;SEM1;PSMC5;PSMC3;PSMC4;PSMC1;PSMC2;ATXN10
T cell receptor signaling pathway	39/104	8.00694911989252e-09	1.33168206415055e-07	0	0	3.51925465838509	65.6093098628437	GSK3B;ITK;BCL10;PIK3CB;CD3E;RASGRP1;CD3D;MALT1;IKBKB;CDC42;AKT2;NCK2;CTLA4;ICOS;PAK3;PAK2;NCK1;MAPK3;IL10;VAV3;NFATC2;NFATC1;NFKB1;RHOA;IL4;CD4;PTPRC;CD40LG;LCK;CD28;PRKCQ;GRB2;LCP2;CD247;PDCD1;NFKBIE;MAP3K14;LAT;NFKBIB
Human T-cell leukemia virus 1 infection	64/219	2.28103359649667e-08	3.60403308246474e-07	0	0	2.42999225267507	42.7582702124159	ATF2;TRRAP;ITGB2;PTEN;PIK3CB;CD3E;ITGAL;ELK1;CD3D;ETS1;IKBKB;POLB;CREB3L3;PTTG1;AKT2;CDC26;TSPO;B2M;JAK3;JAK1;IL1R1;IL1R2;HLA-B;HLA-C;HLA-A;HLA-F;HLA-E;KAT2B;CREB1;LCK;LTA;VDAC2;VDAC1;SLC25A5;MAD1L1;SLC25A6;ATF6B;IL2RG;ANAPC10;ANAPC11;RELB;E2F3;MAPK3;STAT5A;SMAD2;STAT5B;RANBP1;FDPS;MAP3K1;RANBP3;SMAD3;CDKN2A;NFATC2;NFATC1;NFKB1;NFKB2;CD4;IL2RA;IL2RB;BAX;CALR;MAP3K14;RAN;BCL2L1
Measles	46/139	3.6448902961367e-08	5.48469206466285e-07	0	0	2.90341177477005	49.7277626563559	GSK3B;CDKN1B;TRADD;ADAR;PIK3CB;CD3E;IL2RG;RCHY1;CD3D;BBC3;IFIH1;IKBKB;TBK1;AKT2;RACK1;BAK1;IKBKE;JAK3;SLAMF1;JAK1;IFNAR2;STAT5A;HSPA8;STAT5B;STAT1;EIF2AK1;STAT2;MX1;STAT3;NFKB1;OAS1;OAS2;TRAF3;IL2RA;CSNK2B;IL2RB;BCL2;CD28;IRF7;BAX;EIF3H;FAS;RAB9A;TAB2;BCL2L1;NFKBIB
Viral carcinogenesis	59/203	9.82415721349896e-08	1.41110621793894e-06	0	0	2.40864846343912	38.8655574781176	YWHAE;ATF2;CDKN1B;YWHAB;TRADD;PIK3CB;RBPJ;POLB;CREB3L3;YWHAQ;CCR8;RAC1;CCR4;JAK3;JAK1;YWHAH;ACTN1;HLA-B;HLA-C;TRAF2;HLA-A;TRAF1;HLA-F;YWHAZ;RHOA;HLA-E;DDB1;KAT2B;CREB1;PKM;TRAF3;IRF7;ATP6V0D1;IL6ST;MAD1L1;GTF2A2;HDAC3;ATF6B;HDAC1;PXN;HDAC9;GTF2E2;HDAC7;CDC42;PMAIP1;BAK1;MAPK3;STAT5A;STAT5B;RANBP1;CDKN2A;STAT3;NFKB1;NFKB2;HNRNPK;SNW1;PSMC1;BAX;GRB2
Salmonella infection	68/249	1.54275421386936e-07	2.11961013731616e-06	0	0	2.2106688183266	34.673293401453	ARF1;ARPC1B;TRADD;ARPC5L;BRK1;PIK3CB;ACTB;ACTG1;TXN2;IKBKB;ACTR1B;AKT2;KIF5B;CASP4;CASP1;RAC1;SKP1;MAP2K3;ACTR3;ACTR2;RHOG;RHOH;TRAF2;DYNLL1;RHOA;EXOC4;ELMO1;PIK3C3;PFN1;GAPDH;ARF6;RAB7A;ARL8B;BIRC3;DCTN5;RAB5B;RALA;RAB5C;DCTN2;DCTN3;LEF1;LY96;TXN;STX10;CDC42;ACTR3C;NCKAP1L;SNX9;FLNB;BAK1;PAK3;CYTH1;MAPK3;ARPC4;TNFRSF10A;NFKB1;PTPRC;ARPC2;ARPC3;ABI1;BCL2;RAB9A;TAB3;BAX;TAB2;PKN1;DYNLRB1;RAB5A
Ubiquitin mediated proteolysis	44/140	3.76715219894544e-07	4.9600837286115e-06	0	0	2.68805449936629	39.7611008901668	UBE2D2;CUL3;UBE2D3;KEAP1;UBE2L6;RNF7;UBE2Z;UBE2J2;RCHY1;ANAPC10;UBE2L3;ANAPC11;HERC4;SOCS3;CDC26;UBC;UBR5;ELOB;ELOC;VHL;SKP1;UBE2F;UBE2H;UBE2I;MAP3K1;UBE2B;UBE2E1;WWP1;UBE2G1;WWP2;UBE2A;RBX1;DDB2;DDB1;UBE2R2;UBA3;UBE2N;UBA2;UBA1;TRIP12;SAE1;UBE2K;TRIM32;BIRC3
Human immunodeficiency virus 1 infection	59/212	5.02027092860998e-07	6.34269699479013e-06	0	0	2.26575735691543	32.8639307792005	TRADD;PIK3CB;CD3E;CD3D;IKBKB;TBK1;AKT2;CFL2;CFL1;AP1S2;RAC2;AP1S1;ELOB;ELOC;RAC1;B2M;SKP1;MAP2K3;PRKCB;HLA-B;HLA-C;TAP1;TRAF2;HLA-A;HLA-F;TNFRSF1B;HLA-E;RBX1;DDB1;PXN;ITPR2;RNF7;SAMHD1;GNAI2;GNG10;GNG5;GNG4;GNG8;BAK1;PAK3;PAK2;AP1M1;MAPK3;NFATC2;NFATC1;NFKB1;BST2;CD4;GNB2;RPS6KB2;BCL2;FAS;BAX;CALM3;TAB2;CALR;CD247;CALM2;BCL2L1
PD-L1 expression and PD-1 checkpoint pathway in cancer	32/89	5.21867474254884e-07	6.34269699479013e-06	0	0	3.28648126339946	47.5417520896337	PTEN;PIK3CB;CD3E;CD3D;HIF1A;RASGRP1;IKBKB;AKT2;JAK1;MAPK3;MAP2K3;STAT1;IFNGR2;STAT3;NFATC2;NFATC1;PTPN11;TICAM1;NFKB1;BATF;EML4;CD4;LCK;CSNK2B;RPS6KB2;CD28;PRKCQ;CD247;PDCD1;NFKBIE;LAT;NFKBIB
NOD-like receptor signaling pathway	52/181	8.14904722634887e-07	9.53740342046756e-06	0	0	2.36606881356388	33.1727452866361	YWHAE;ANTXR2;TXN2;IKBKB;TBK1;NAMPT;CASP4;CASP1;IKBKE;CTSB;JAK1;IFNAR2;GABARAPL2;GBP5;TRAF2;TICAM1;RHOA;AIM2;OAS1;OAS2;TRAF3;CARD17;IRF7;VDAC2;VDAC1;CARD16;RBCK1;PLCB2;BIRC3;ITPR2;TXN;TANK;GABARAP;IFI16;NLRP1;GBP2;GBP1;GBP4;MAPK3;STAT1;CARD8;STAT2;NEK7;CARD6;ERBIN;NFKB1;BCL2;TAB3;TAB2;PKN1;BCL2L1;NFKBIB
Retrograde endocannabinoid signaling	44/148	2.0477531952116e-06	2.31103574888166e-05	0	0	2.48011114360924	32.4863989174168	NDUFB9;NDUFA13;NDUFA11;NDUFB10;NDUFB6;NDUFA12;NDUFB11;NDUFB5;NDUFB4;NDUFA10;NDUFB3;NDUFB2;ITPR2;NDUFB1;GNAI2;GNG10;GNG5;GNG4;GNG8;NDUFV2;MAPK3;NDUFA9;NDUFA8;NDUFA7;NDUFA6;NDUFA5;PRKCB;NDUFA4;NDUFA3;NDUFA2;NDUFA1;NDUFC2;NDUFC1;NDUFS8;NDUFS7;NDUFS6;GNB2;NDUFS5;NDUFS4;NDUFAB1;NAPEPLD;NDUFS3;NDUFS2;PLCB2
Vibrio cholerae infection	21/50	2.66583942504669e-06	2.90484571832674e-05	0	0	4.23009791400596	54.2932710609863	ATP6V1A;ARF1;ATP6V0B;ATP6V1G1;ATP6V0E1;ATP6AP1;KDELR1;ACTB;ACTG1;SEC61G;ATP6V1B2;KDELR2;SEC61B;ATP6V1E1;ATP6V0D1;ATP6V0E2;ATP6V0C;ATP6V1D;ATP6V0A1;ATP6V1F;TJP2
Protein processing in endoplasmic reticulum	48/171	4.31771955705931e-06	4.54799793343581e-05	0	0	2.28824219706372	28.2661597131209	VCP;TRAM1;UBXN1;ATF6B;SAR1B;PRKCSH;UBE2D2;UBE2D3;RPN1;DERL1;DERL2;UBE2J2;RNF5;HERPUD1;DNAJB1;LMAN1;OS9;MAN1A2;SEC61G;LMAN2;SSR1;UFD1;CAPN1;SEC61B;BAK1;UBXN4;UBXN6;MAP3K5;SKP1;UBQLN2;BCAP31;HSPA8;EIF2AK1;SSR2;SSR3;DNAJB12;TRAF2;UBE2G1;PDIA6;RAD23B;DDOST;RBX1;NSFL1C;DAD1;DNAJA2;BCL2;BAX;CALR
Pancreatic cancer	27/76	5.13563936337118e-06	5.2350388349203e-05	0	0	3.22167052387965	39.2377118227461	RALA;RALB;PIK3CB;IKBKB;CDC42;AKT2;RAC2;E2F3;POLK;RAC1;BAK1;RALGDS;JAK1;MAPK3;SMAD2;SMAD3;CDKN2A;GADD45A;STAT1;STAT3;NFKB1;DDB2;GADD45G;RPS6KB2;BAX;ARHGEF6;BCL2L1
Pathogenic Escherichia coli infection	53/197	5.57402158418518e-06	5.50434631438287e-05	0	0	2.15919970334412	26.1206890105195	ITGB1;ARF1;WIPF1;WIPF2;ARPC1B;TRADD;ARPC5L;BRK1;ACTB;ACTG1;IKBKB;CASP4;CASP1;NCK2;RAC1;NCK1;ACTR3;ACTR2;IL1R1;TRAF2;RHOA;CTTN;HCLS1;TMBIM6;EZR;GAPDH;ARF6;ROCK1;LPAR2;CDC42;GNA13;ACTR3C;NCKAP1L;BAK1;PAK3;PAK2;WASF2;CYTH1;MAPK3;MYO5A;ARPC4;TNFRSF10A;PTPN11;NFKB1;ARPC2;ARPC3;MYO5C;ABI1;FAS;TAB3;BAX;TAB2;NFKBIB
Inflammatory bowel disease	24/65	7.92267045371435e-06	7.58655716173859e-05	0	0	3.42056215618799	40.1771781923729	IL21;IL10;SMAD2;IL22;SMAD3;STAT1;IL23R;IFNGR2;IL13;STAT3;RORC;RORA;NFATC1;GATA3;IL2RG;FOXP3;NFKB1;IL4;MAF;IL21R;IL17F;IL12RB1;IL18R1;IL17A
NF-kappa B signaling pathway	33/104	8.22971677860873e-06	7.64879559423635e-05	0	0	2.71959026888604	31.8403073303536	TRADD;LY96;BCL10;MALT1;RELB;IKBKB;UBE2I;PARP1;IL1R1;PRKCB;GADD45A;TRAF2;TRAF1;CFLAR;TICAM1;NFKB1;GADD45G;NFKB2;CYLD;CD40LG;LCK;TRAF3;CSNK2B;BCL2;LTA;TAB3;PRKCQ;TAB2;LTB;MAP3K14;LAT;BCL2L1;BIRC3
Lysosome	38/128	1.02597618951997e-05	9.10336380036542e-05	0	0	2.47201717067188	28.3967556923813	IDUA;CLTB;CLTA;CTSS;SGSH;CLN5;LAPTM4A;LAMP1;GM2A;LAMP3;LAMP2;PSAP;AP1S2;AP1S1;ACP5;CTSH;ACP2;AP3S2;CTSC;AP1M1;ATP6V0A1;CTSB;CTSA;ARSA;CD164;ATP6V0B;ATP6AP1;SLC11A2;FUCA2;LAPTM5;GNPTG;NPC1;GLB1;MAN2B1;TPP1;ATP6V0D1;ATP6V0C;LGMN
RNA transport	50/186	1.03709207852264e-05	9.10336380036542e-05	0	0	2.15558079830477	24.7385332631865	POP5;POP4;SUMO1;SUMO3;MAGOH;NUP62;SUMO2;EIF2B1;EIF1AY;PABPC4;THOC3;TRNT1;RANGAP1;RPP25L;THOC7;DDX19B;CLNS1A;NUP50;STRAP;GEMIN8;EIF4E2;EIF1B;KPNB1;NUP58;SEH1L;FXR1;TGS1;TPR;SAP18;EIF4E;EIF4B;EIF2B4;EIF2B2;UBE2I;PYM1;EIF2S2;EIF1;EIF2S3;EIF3I;EIF3J;EIF3G;TACC3;EIF3H;RNPS1;EIF3E;EIF3F;EIF3D;EIF4G2;EIF3A;RAN
Kaposi sarcoma-associated herpesvirus infection	51/193	1.42448062635362e-05	0.000121658345385877	0	0	2.10577289098416	23.4985685726752	GSK3B;TRADD;PIK3CB;IKBKB;TBK1;AKT2;CCR8;RAC1;CCR4;IKBKE;JAK1;IFNAR2;ATG3;GABARAPL2;HLA-B;HLA-C;TRAF2;HLA-A;HLA-F;TICAM1;HLA-E;CREB1;TRAF3;IRF7;PIK3C3;IL6ST;BECN1;LEF1;ITPR2;HIF1A;GABARAP;PIK3R5;GNG10;GNG5;GNG4;UBC;GNG8;E2F3;BAK1;MAPK3;STAT1;STAT2;STAT3;NFATC2;NFATC1;NFKB1;GNB2;FAS;BAX;CALM3;CALM2
Phagosome	42/152	2.52041245709257e-05	0.000209592193800329	0	0	2.23591144606689	23.6749548384033	ATP6V1A;ITGB1;STX12;RAB5B;RAB5C;TFRC;NCF4;ITGB2;CORO1A;ACTB;CTSS;ACTG1;LAMP1;CLEC7A;SEC61G;LAMP2;RAC1;SEC61B;ATP6V1E1;ATP6V0E2;ATP6V1D;ATP6V0A1;ATP6V1F;ATP6V1G1;ATP6V0B;ATP6V0E1;ATP6AP1;HLA-B;HLA-C;TAP1;HLA-A;HLA-F;HLA-E;PIKFYVE;HGS;ATP6V1B2;PIK3C3;CALR;ATP6V0D1;RAB5A;ATP6V0C;RAB7A
Protein export	12/23	2.7249462262871e-05	0.000220790514745314	0	0	6.35972027972028	66.8436922670199	SRP19;OXA1L;SPCS2;SPCS1;SEC61G;SRPRA;SRP68;SEC61B;SRP14;SEC11A;SRP9;SEC11C
Th1 and Th2 cell differentiation	29/92	3.26098379503065e-05	0.000257617719807421	0	0	2.69098927971005	27.8003318322077	GATA3;CD3E;RBPJ;IL2RG;CD3D;IKBKB;IL12RB1;JAK3;JAK1;MAPK3;STAT5A;STAT5B;STAT1;IFNGR2;IL13;NFATC2;NFATC1;NFKB1;IL4;CD4;MAF;LCK;IL2RA;IL2RB;PRKCQ;CD247;NFKBIE;LAT;NFKBIB
RNA degradation	26/79	3.58241466740549e-05	0.000276108057292716	0	0	2.86655043005386	29.3445568563847	BTG3;BTG1;PARN;ENO1;TOB2;TOB1;HSPD1;NUDT16;DCPS;EXOSC1;CNOT6L;DIS3;PABPC4;LSM3;LSM8;LSM7;PFKL;CNOT7;LSM6;XRN1;C1D;XRN2;CNOT9;DCP2;PFKP;DCP1B
Pathways in cancer	111/531	5.60871628905713e-05	0.000421989130319537	0	0	1.55644272571024	15.2354008635677	IL23R;KEAP1;ELK1;ETS1;FRAT2;AKT2;RASSF5;PIM2;IL6R;SKP1;IFNAR2;PRKCB;RBX1;RUNX1;EML4;IL6ST;MAX;PDGFA;LPAR2;MGST2;CSF2RB;HIF1A;RASGRP1;FOXO1;RASGRP4;GNG10;BCL2L11;TPR;PMAIP1;RALGDS;STAT5A;SMAD2;STAT5B;WNT10A;SMAD3;GADD45A;NFKB1;NFKB2;GADD45G;IL4;IL7;GNB2;BCL2;CALM3;GRB2;CALM2;FGFR2;BCL2L1;FGFR1;ITGB1;GSK3B;CDKN1B;PTEN;PIK3CB;BBC3;IKBKB;SUFU;RAC2;ELOB;ELOC;RAC1;POLK;JAK3;JAK1;NCOA1;GSTO1;IFNGR2;NCOA3;IL13;NCOA4;TRAF2;TRAF1;RHOA;DDB2;TRAF4;TRAF3;PPARG;PLCB2;BIRC3;CEBPA;CAMK2D;RALA;RALB;ROCK1;HDAC1;LEF1;IL2RG;GNAI2;CDC42;GNA13;GNG5;GNG4;GNG8;E2F3;HES1;BAK1;VHL;IL12RB1;MAPK3;NTRK1;CDKN2A;STAT1;STAT2;STAT3;HEYL;IL2RA;IL2RB;RPS6KB2;CCDC6;FAS;BAX
Bacterial invasion of epithelial cells	25/77	6.4750932333929e-05	0.000475844060872595	0	0	2.80850459636517	27.0879213964912	ITGB1;ARPC1B;PXN;ARPC5L;CLTB;CLTA;PIK3CB;ACTB;ACTG1;CDC42;ACTR3C;RAC1;WASF2;ACTR3;ACTR2;CAV1;RHOG;ARPC4;RHOA;ARHGAP10;CTTN;ARPC2;ARPC3;ELMO1;HCLS1
Human cytomegalovirus infection	55/225	7.17689823014762e-05	0.000515431781983329	0	0	1.89638527166592	18.0954185875249	ATF2;GSK3B;TRADD;PIK3CB;ELK1;IKBKB;AKAP13;TBK1;CREB3L3;AKT2;RAC2;RAC1;B2M;IL6R;JAK1;IL1R1;PRKCB;HLA-B;HLA-C;TAP1;TRAF2;HLA-A;HLA-F;RHOA;HLA-E;CREB1;PLCB2;ATF6B;ROCK1;PXN;ITPR2;GNAI2;GNA13;GNG10;GNG5;GNG4;GNG8;E2F3;BAK1;MAPK3;CDKN2A;IL10RB;IL10RA;STAT3;NFATC2;NFATC1;NFKB1;GNB2;RPS6KB2;FAS;BAX;CALM3;GRB2;CALR;CALM2
Apoptosis	38/142	0.000125610258886447	0.000882063151291496	0	0	2.13748109427654	19.1995533504659	BECN1;TRADD;ITPR2;CSF2RB;PIK3CB;ACTB;CTSS;ACTG1;BBC3;LMNB1;IKBKB;BCL2L11;AKT2;PMAIP1;CTSH;CAPN1;BAK1;SPTAN1;CTSC;MAP3K5;CTSB;MAPK3;NTRK1;PARP1;GADD45A;TNFRSF10A;TRAF2;TRAF1;CFLAR;PTPN13;NFKB1;GADD45G;BCL2;BAX;FAS;MAP3K14;BCL2L1;BIRC3
HIF-1 signaling pathway	31/109	0.000155594331766415	0.00106886540952581	0	0	2.32293486508903	20.3680930856749	CAMK2D;CDKN1B;TFRC;ENO1;PIK3CB;PDHB;HIF1A;HK1;LDHB;LDHA;AKT2;MKNK2;ELOB;ELOC;VHL;IL6R;EIF4E;MAPK3;PRKCB;IFNGR2;STAT3;NFKB1;RBX1;PFKL;RPS6KB2;BCL2;ALDOC;ALDOA;EIF4E2;GAPDH;PFKP
Primary immunodeficiency	15/38	0.000165280075794258	0.00111124476491459	0	0	3.80323185429872	33.1180451214102	TNFRSF13B;TAP1;RFXANK;CD3E;IL2RG;CD3D;CD79A;CD4;CD40LG;PTPRC;LCK;RFX5;ICOS;JAK3;ADA
Mitophagy	22/68	0.000184514213445553	0.00121471857184989	0	0	2.79196062346185	24.0046745440054	BNIP3L;GABARAPL2;BECN1;FIS1;USP15;ATG9A;TFE3;HIF1A;GABARAP;BCL2L13;TBK1;FUNDC1;CSNK2B;UBC;NBR1;TAX1BP1;TBC1D17;SQSTM1;OPTN;TBC1D15;RAB7A;BCL2L1
Fc gamma R-mediated phagocytosis	28/97	0.000241500658978953	0.00155743282117039	0	0	2.37061393675799	19.7439861613871	ARPC1B;ARPC5L;WAS;ASAP1;PIK3CB;PLA2G6;CDC42;ACTR3C;AKT2;CFL2;CFL1;RAC2;PIP5K1B;RAC1;WASF2;MAPK3;ACTR3;VAV3;ACTR2;PRKCB;ARPC4;GAB2;PTPRC;ARPC2;ARPC3;RPS6KB2;LAT;ARF6
Hepatitis B	41/162	0.0002590074233553	0.00163692691560549	0	0	1.98227820647459	16.370949512081	ATF2;ATF6B;YWHAB;PIK3CB;ELK1;IFIH1;IKBKB;TBK1;CREB3L3;YWHAQ;AKT2;E2F3;IKBKE;JAK3;JAK1;MAPK3;MAP2K3;STAT5A;STAT5B;SMAD3;MAP3K1;ATP6AP1;PRKCB;STAT1;STAT2;STAT3;NFATC2;NFATC1;TICAM1;YWHAZ;NFKB1;DDB2;DDB1;CREB1;TRAF3;BCL2;IRF7;BAX;FAS;GRB2;TAB2
Autophagy	36/137	0.000275017213974741	0.00170402822776506	0	0	2.08406114654899	17.0865439095093	BECN1;MTMR14;PTEN;PIK3CB;HIF1A;TANK;GABARAP;PPP2CA;TBK1;LAMP1;AKT2;RB1CC1;LAMP2;SNAP29;CTSB;MAPK3;SH3GLB1;IGBP1;ATG3;GABARAPL2;ATG9A;WIPI2;CFLAR;ATG13;VAMP8;VMP1;RRAGB;DDIT4;RPS6KB2;BCL2;ATG4B;PRKCQ;PIK3C3;SQSTM1;BCL2L1;RAB7A
Epithelial cell signaling in Helicobacter pylori infection	22/70	0.000294122514511501	0.00178735989587759	0	0	2.67531446540881	21.7543574616756	ATP6V1A;ATP6V0B;ATP6V1G1;ATP6V0E1;ATP6AP1;ADAM10;PTPN11;NFKB1;IKBKB;CDC42;ADAM17;ATP6V1B2;CSK;RAC1;ATP6V1E1;ATP6V0D1;ATP6V0E2;ATP6V0C;ATP6V1D;MAP3K14;ATP6V0A1;ATP6V1F
Necroptosis	40/159	0.000349137464445589	0.00206887124271058	0	0	1.9659862564287	15.6493387410147	CAMK2D;TRADD;FTH1;CHMP1A;CASP1;CAPN1;JAK3;JAK1;IFNAR2;STAT5A;STAT5B;PARP1;STAT1;IFNGR2;STAT2;STAT3;TNFRSF10A;TRAF2;CFLAR;TICAM1;CYLD;GLUD1;CHMP2B;BCL2;CHMP2A;CHMP4B;VDAC2;CHMP3;BAX;FAS;CHMP4A;VDAC1;RBCK1;SLC25A5;PPIA;SQSTM1;CHMP7;BIRC3;CHMP5;SLC25A6
Tuberculosis	44/180	0.000359822105581976	0.00206887124271058	0	0	1.89297696264818	15.0111195301223	RAB5B;CAMK2D;RAB5C;TRADD;ITGB2;BCL10;LSP1;CORO1A;CTSS;MALT1;HSPD1;LAMP1;CLEC7A;AKT2;LAMP2;ATP6V0A1;JAK1;MAPK3;IL10;PLK3;CD74;ATP6V0B;ATP6AP1;KSR1;VDR;IL10RB;STAT1;IFNGR2;IL10RA;NFYC;RFXANK;NFKB1;RHOA;CREB1;RFX5;BCL2;BAX;CALM3;PIK3C3;ATP6V0D1;CALM2;RAB5A;ATP6V0C;RAB7A
C-type lectin receptor signaling pathway	29/104	0.000360088349205956	0.00206887124271058	0	0	2.25883539660706	17.9106698533175	ITPR2;BCL10;LSP1;PIK3CB;MALT1;RELB;IKBKB;CLEC7A;AKT2;CASP1;IKBKE;MAPK3;IL10;PLK3;KSR1;STAT1;STAT2;NFATC2;NFATC1;PTPN11;NFKB1;RHOA;NFKB2;CYLD;IRF1;BCL3;CALM3;CALM2;MAP3K14
Chronic myeloid leukemia	23/76	0.000399979272532293	0.00222433258560818	0	0	2.53318397845146	19.8198792709921	STAT5A;STAT5B;CDKN1B;SMAD3;HDAC1;CDKN2A;GADD45A;PTPN11;PIK3CB;GAB2;NFKB1;DDB2;RUNX1;GADD45G;IKBKB;AKT2;BAX;E2F3;GRB2;POLK;BAK1;MAPK3;BCL2L1
Regulation of actin cytoskeleton	51/218	0.00040122454866983	0.00222433258560818	0	0	1.78789199148481	13.9830841629177	ITGB1;ARPC1B;ITGB2;ARPC5L;BRK1;PIK3CB;ITGAL;ACTB;ACTG1;PPP1CC;CFL2;CFL1;RAC2;ITGB8;RAC1;VAV3;ACTR3;ACTR2;PPP1R12A;ITGA4;ACTN1;RHOA;TIAM1;SPATA13;EZR;PFN1;ARHGEF6;ROCK1;PXN;LPAR2;PDGFA;IQGAP2;CDC42;GNA13;ACTR3C;NCKAP1L;PIP5K1B;PAK3;PAK2;WASF2;MAPK3;RDX;ARPC4;PPP1CA;DIAPH1;PIKFYVE;ABI2;ARPC2;ARPC3;FGFR2;FGFR1
Colorectal cancer	25/86	0.000451917973584419	0.00246217378711511	0	0	2.39286840208971	18.4298960480445	GSK3B;RALA;RALB;LEF1;PIK3CB;BBC3;BCL2L11;AKT2;RAC2;PMAIP1;POLK;RAC1;BAK1;RALGDS;MAPK3;SMAD2;SMAD3;GADD45A;RHOA;DDB2;GADD45G;RPS6KB2;BCL2;BAX;GRB2
Hepatitis C	39/157	0.000538097196353428	0.00288201210250311	0	0	1.93252798540197	14.5470490465743	YWHAE;GSK3B;YWHAB;TRADD;PPP2R2A;PIK3CB;IKBKB;PPP2CA;SOCS3;TBK1;YWHAQ;PPP2R1A;AKT2;E2F3;BAK1;IKBKE;LDLR;JAK1;YWHAH;MAPK3;IFNAR2;STAT1;EIF2AK1;STAT2;MX1;STAT3;TRAF2;CFLAR;TICAM1;YWHAZ;NFKB1;OAS1;OAS2;TRAF3;IRF7;BAX;FAS;GRB2;EIF3E
Osteoclast differentiation	33/127	0.000599736961004592	0.00313412591513166	0	0	2.05137814313346	15.2192142348961	CSF1;NCF4;SIRPG;PIK3CB;SIRPB1;RELB;IKBKB;SOCS3;AKT2;ACP5;RAC1;JAK1;MAPK3;IFNAR2;IL1R1;STAT1;IFNGR2;STAT2;NFATC2;NFATC1;TRAF2;GAB2;NFKB1;NFKB2;CYLD;CREB1;LCK;GRB2;TAB2;LCP2;PPARG;SQSTM1;MAP3K14
TNF signaling pathway	30/112	0.000605232150835157	0.00313412591513166	0	0	2.13710387877873	15.835722725576	ATF2;CSF1;ATF6B;TRADD;PIK3CB;IKBKB;SOCS3;CREB3L3;AKT2;MAP3K5;MAPK3;MAP2K3;CCL20;LIF;TRAF2;TRAF1;CFLAR;TNFRSF1B;NFKB1;CREB1;TRAF3;IRF1;BCL3;LTA;TAB3;FAS;TAB2;MAP3K14;IL18R1;BIRC3
Ribosome	39/158	0.000614923439044819	0.00313412591513166	0	0	1.91617516571846	14.1682236779624	RPL4;MRPS15;MRPS16;MRPS14;MRPS11;MRPL19;MRPS12;MRPL16;RPS27L;MRPL14;RPS4Y1;MRPL34;MRPL13;RPL6;MRPL32;RPL7;MRPL4;MRPL20;MRPL3;RPS17;RPL36AL;MRPL9;RPL15;RPS11;RPS8;RPL23;RPL22;MRPL27;MRPL28;MRPS21;MRPS7;MRPS6;MRPL21;MRPS18C;RPS26;RPL24;RPL28;RSL24D1;RPS24
Human papillomavirus infection	70/331	0.000882816993661917	0.00442034166161246	0	0	1.57177660443119	11.053350215353	ITGB1;GSK3B;CDKN1B;TRADD;PTEN;PPP2R2A;PIK3CB;RBPJ;IKBKB;LFNG;TBK1;CREB3L3;PPP2R1A;AKT2;ITGB8;ATP6V1E1;IKBKE;JAK1;IFNAR2;ATP6V1G1;ATP6V0B;ATP6V0E1;ATP6AP1;ITGA4;HLA-B;HLA-C;HLA-A;HLA-F;TICAM1;HLA-E;CREB1;PKM;TRAF3;MFNG;IRF1;ATP6V1B2;COL6A3;ATP6V0D1;ATP6V0C;ATP6V1A;HDAC1;PXN;PSEN1;FOXO1;PPP2CA;CDC42;HES1;BAK1;ATP6V0E2;ATP6V1D;ATP6V0A1;ATP6V1F;HES4;MAPK3;BCAP31;WNT10A;CSNK1A1;STAT1;STAT2;MX1;ISG15;NFKB1;HEYL;PSMC1;TADA3;RPS6KB2;FAS;BAX;GRB2;COL9A2
Collecting duct acid secretion	11/27	0.00089525907070632	0.00442034166161246	0	0	4.00540413533835	28.1115180378997	ATP6V1A;ATP6V1G1;ATP6V0E1;ATP6V1B2;ATP6V0E2;ATP6V1E1;ATP6V0D1;ATP6V1D;ATP6V0C;ATP6V0A1;ATP6V1F
Ras signaling pathway	52/232	0.00101609204509992	0.00492250756324629	0	0	1.69057577508184	11.6510954835479	CSF1;PIK3CB;ELK1;ETS1;IKBKB;SYNGAP1;TBK1;AKT2;RASSF5;RAC2;RAC1;KSR1;PRKCB;GAB2;KSR2;RHOA;TIAM1;RASA3;RASA1;ARF6;RAB5B;RALA;RAB5C;RALB;PDGFA;PLA2G6;RASGRP1;RASGRP4;CDC42;GNG10;RAP1A;GNG5;GNG4;GNG8;SHOC2;PAK3;RALGDS;PAK2;MAPK3;NTRK1;NTRK2;PTPN11;NFKB1;GNB2;CALM3;GRB2;CALM2;RAB5A;FGFR2;LAT;BCL2L1;FGFR1
JAK-STAT signaling pathway	39/162	0.00102811866827296	0.00492250756324629	0	0	1.85342288205491	12.7515951757374	IL21;IL22;IL23R;PDGFA;CSF2RB;PIK3CB;IL2RG;IL27RA;SOCS3;AKT2;IL21R;IL12RB1;IL6R;JAK3;JAK1;IFNAR2;STAT5A;IL10;STAT5B;IL10RB;STAT1;IFNGR2;IL10RA;STAT2;IL13;STAT3;LIF;PTPN11;STAM;IL4;IL7;IL2RA;IL2RB;BCL2;GRB2;IL6ST;PTPN2;BCL2L1;CRLF2
Glycolysis / Gluconeogenesis	20/67	0.00112689797202051	0.0053149217784848	0	0	2.48229381687686	16.8505218012883	GPI;PGAM1;AKR1A1;ENO1;PDHB;ADH5;HK1;ALDH3A2;MINPP1;LDHB;LDHA;PFKL;PKM;ALDOC;GALM;ALDOA;GAPDH;PFKP;ALDH9A1;PCK2
Cardiac muscle contraction	24/87	0.00131271119862109	0.00610024615829801	0	0	2.22320304709594	14.7524210059399	COX8A;COX7B;TPM4;UQCRB;COX4I1;ATP1B3;COX7A2;UQCR11;UQCR10;COX6A1;ATP1B1;COX5B;COX6C;COX7C;COX5A;UQCRH;COX6B1;COX7A2L;SLC9A7;UQCRQ;UQCRC1;UQCRFS1;UQCRC2;CYC1
Thyroid cancer	13/37	0.00160704234929872	0.00735978815041155	0	0	3.15644949840401	20.3065754386214	NTRK1;GADD45A;LEF1;NCOA4;DDB2;GADD45G;TPR;CCDC6;BAX;PPARG;BAK1;POLK;MAPK3
Neurotrophin signaling pathway	30/119	0.0017387452840655	0.00784919299663853	0	0	1.96820537795248	12.507141218105	YWHAE;BEX3;GSK3B;CAMK2D;PSEN1;PIK3CB;IKBKB;CDC42;RAP1A;AKT2;RPS6KA2;ARHGDIB;RPS6KA1;RAC1;MAP3K5;MAPK3;NTRK1;NTRK2;MAP3K1;IRAK3;PTPN11;NFKB1;RHOA;BCL2;BAX;CALM3;GRB2;NFKBIE;CALM2;NFKBIB
Citrate cycle (TCA cycle)	11/30	0.00245847968590584	0.0107899941770312	0	0	3.37237831420657	20.2619643076742	CS;MDH1;MDH2;OGDH;SDHC;SUCLG1;PDHB;SDHD;SDHA;SDHB;PCK2
Pentose phosphate pathway	11/30	0.00245847968590584	0.0107899941770312	0	0	3.37237831420657	20.2619643076742	RPIA;GPI;PRPS1;PFKL;GLYCTK;TALDO1;ALDOC;PGLS;ALDOA;TKT;PFKP
Chemokine signaling pathway	43/192	0.00267361458723408	0.0115734549255612	0	0	1.68666948048033	9.99237638901073	GSK3B;ITK;ROCK1;PXN;CXCR5;WAS;PIK3CB;CXCR6;CXCL13;PIK3R5;GNAI2;IKBKB;CDC42;GNG10;RAP1A;GNG5;GNG4;AKT2;GRK6;RAC2;CCR8;GNG8;CCR7;CCR6;RAC1;CCR4;JAK3;MAPK3;VAV3;STAT5B;PRKCB;CCL20;STAT1;STAT2;STAT3;NFKB1;RHOA;TIAM1;GNB2;ELMO1;GRB2;PLCB2;NFKBIB
Lipid and atherosclerosis	47/215	0.00291649049858936	0.0122021487082666	0	0	1.63549390344373	9.54699003003138	GSK3B;CAMK2D;NCF4;LY96;PIK3CB;TANK;HSPD1;IKBKB;CDC42;TBK1;RAP1A;AKT2;CASP1;RAC1;IKBKE;LDLR;MAP3K5;MAPK3;VAV3;MAP2K3;HSPA8;HSPA4;STAT3;NFATC2;NFATC1;TNFRSF10A;TRAF2;TICAM1;POU2F2;SOD2;RHOA;NFKB1;MIB1;SELP;CD40LG;TRAF3;BCL2;IRF7;FAS;BAX;CALM3;PPARG;TAB2;CALM2;PLCB2;ABCG1;BCL2L1
Non-small cell lung cancer	20/72	0.00292499243040756	0.0122021487082666	0	0	2.2429524537855	13.0864239685911	STAT5A;STAT5B;PRKCB;CDKN2A;GADD45A;STAT3;PIK3CB;DDB2;GADD45G;EML4;AKT2;KIF5B;RASSF5;BAX;E2F3;GRB2;POLK;BAK1;JAK3;MAPK3
Phosphatidylinositol signaling system	25/97	0.00293469399312742	0.0122021487082666	0	0	2.02597966269841	11.8137955493504	INPP1;DGKA;MTMR14;PTEN;ITPR2;PIK3CB;MTMR6;PIP4P2;PIP4P1;INPP5F;PIP5K1B;IP6K1;CDIPT;IP6K2;PRKCB;DGKZ;PIKFYVE;SYNJ1;CALM3;PIK3C3;PI4KB;CALM2;PLCB2;PI4K2A;DGKH
Influenza A	39/172	0.00326631352966387	0.0134046113684907	0	0	1.71305593175485	9.80569196603386	TRADD;ADAR;PIK3CB;ACTB;ACTG1;IFIH1;IKBKB;SOCS3;DNAJB1;TBK1;PABPN1;AKT2;CASP1;BAK1;KPNA2;IKBKE;JAK1;MAPK3;IFNAR2;FDPS;PRKCB;STAT1;IFNGR2;STAT2;MX1;TNFRSF10A;TICAM1;NFKB1;RAB11B;OAS1;OAS2;TRAF3;IRF7;BAX;FAS;VDAC1;SLC25A5;NFKBIB;SLC25A6
Cellular senescence	36/156	0.00337608658457586	0.0136774789836663	0	0	1.75211995863495	9.97138136237036	TRAF3IP2;PTEN;ITPR2;PIK3CB;ETS1;FOXO1;ZFP36L1;PPP1CC;RBBP4;AKT2;RASSF5;E2F3;CAPN1;MAPK3;MAP2K3;SMAD2;SMAD3;GADD45A;CDKN2A;HLA-B;HLA-C;NFATC2;NFATC1;HLA-A;HLA-F;NFKB1;HLA-E;GADD45G;PPP1CA;VDAC2;VDAC1;CALM3;SLC25A5;SQSTM1;CALM2;SLC25A6
Antigen processing and presentation	21/78	0.00351198898701134	0.01388860778105	0	0	2.14861742834452	12.1430676846388	CD74;HSPA8;HSPA4;NFYC;HLA-B;HLA-C;TAP1;RFXANK;HLA-A;HLA-F;CTSS;HLA-E;CD4;CREB1;RFX5;PSME1;PSME2;CALR;B2M;CTSB;LGMN
Sphingolipid signaling pathway	29/119	0.00351610323570887	0.01388860778105	0	0	1.88070074889195	10.6267151561459	ROCK1;SGMS1;TRADD;PTEN;PPP2R2A;PIK3CB;GNAI2;GNA13;PPP2CA;PPP2R1A;AKT2;RAC2;RAC1;S1PR2;S1PR4;MAP3K5;MAPK3;ABCC1;CERS5;PRKCB;TRAF2;GAB2;SGPP2;NFKB1;RHOA;SGPP1;BCL2;BAX;PLCB2
Central carbon metabolism in cancer	19/70	0.0048508299557858	0.0189242255065224	0	0	2.17196844467739	11.5735629214411	NTRK1;TIGAR;PGAM1;PTEN;SIRT6;PIK3CB;PDHB;HIF1A;HK1;LDHB;LDHA;PFKL;PKM;SCO2;AKT2;FGFR2;PFKP;MAPK3;FGFR1
SNARE interactions in vesicular transport	11/33	0.00572073951168095	0.0220457766547705	0	0	2.911995898838	15.0365485797612	VAMP8;STX8;SNAP23;STX6;STX5;USE1;SNAP29;VAMP5;STX11;BET1L;VTI1B
mRNA surveillance pathway	24/98	0.00700327918493382	0.0266630870173384	0	0	1.89150221282044	9.38445516675806	HBS1L;CPSF7;CPSF6;RNGTT;PABPC4;CPSF2;SSU72;PYM1;PPP2R2A;MSI2;GSPT1;WDR33;PPP1CA;PPP2CA;PPP1CC;NUDT21;DDX19B;FIP1L1;PABPN1;PPP2R1A;MAGOH;CSTF1;SAP18;RNPS1
Rheumatoid arthritis	23/93	0.00722402889724388	0.0271761087086794	0	0	1.91606530051966	9.44685811246437	ATP6V1A;ATP6V0B;ATP6V1G1;ATP6V0E1;CSF1;ATP6AP1;CCL20;CD80;ITGB2;ITGAL;ATP6V1B2;CD28;ACP5;CTLA4;LTB;ATP6V1E1;ATP6V0D1;ATP6V0E2;ATP6V0C;ATP6V1D;ATP6V0A1;ATP6V1F;IL17A
p53 signaling pathway	19/73	0.00788059358161041	0.0292972655504575	0	0	2.05094179168888	9.9334331318916	CD82;CDKN2A;GADD45A;PTEN;SHISA5;TNFRSF10A;RCHY1;BBC3;DDB2;GADD45G;SESN3;ZMAT3;CCNG2;CCNG1;BCL2;PMAIP1;BAX;FAS;BCL2L1
Renal cell carcinoma	18/69	0.00931166158575209	0.034214942570903	0	0	2.05694939846442	9.61929862395129	TFE3;PRCC;PTPN11;PIK3CB;ETS1;HIF1A;RBX1;CDC42;RAP1A;AKT2;ELOB;GRB2;ELOC;RAC1;VHL;PAK3;PAK2;MAPK3
Glioma	19/75	0.0106398711143154	0.0382234757760269	0	0	1.977461323803	8.98389729983129	CAMK2D;PRKCB;CDKN2A;GADD45A;PTEN;PDGFA;PIK3CB;DDB2;GADD45G;AKT2;BAX;E2F3;CALM3;GRB2;POLK;BAK1;CAMK1;CALM2;MAPK3
RNA polymerase	10/31	0.0106445122414252	0.0382234757760269	0	0	2.772544617437	12.5948683830063	POLR3GL;POLR3E;POLR2E;POLR1D;POLR2F;POLR2G;POLR2H;POLR2I;POLR2J;POLR2K
Viral myocarditis	16/60	0.0110886157521205	0.0393708154794392	0	0	2.11870156546637	9.53804762661539	CD80;CAV1;ITGB2;HLA-B;HLA-C;HLA-A;ITGAL;HLA-F;ACTB;ACTG1;HLA-E;CD40LG;RAC2;CD28;RAC1;EIF4G2
B cell receptor signaling pathway	20/81	0.0119264659862726	0.0418751472406905	0	0	1.91101344858012	8.46386961239115	VAV3;GSK3B;PRKCB;DAPP1;NFATC2;NFATC1;PIK3CB;BCL10;MALT1;NFKB1;IKBKB;CD79B;CD79A;AKT2;RAC2;GRB2;RAC1;NFKBIE;MAPK3;NFKBIB
Ferroptosis	12/41	0.0123996148342717	0.04300835491613	0	0	2.40976127320955	10.579068551276	MAP1LC3B;MAP1LC3A;TFRC;GPX4;FTH1;PCBP1;PCBP2;NCOA4;SLC11A2;VDAC2;ACSL4;SAT1
Tight junction	36/169	0.0125851264271394	0.04300835491613	0	0	1.5796471530429	6.91133478526481	ITGB1;ROCK1;ARPC1B;ARPC5L;WAS;PPP2R2A;MYL6B;ACTB;ACTG1;CDC42;PPP2CA;ACTR3C;RAP1A;PPP2R1A;RAC1;MAP3K5;RAB8B;ACTR3;ACTR2;MAP3K1;HSPA4;ACTN1;RDX;ARHGEF18;ARPC4;RHOA;RUNX1;TIAM1;MYL6;ARPC2;CTTN;ARPC3;HCLS1;NF2;EZR;TJP2
Small cell lung cancer	22/92	0.0126575221746838	0.04300835491613	0	0	1.83212938005391	8.00549592588046	ITGB1;CDKN1B;MAX;GADD45A;PTEN;TRAF2;PIK3CB;TRAF1;NFKB1;DDB2;GADD45G;IKBKB;TRAF4;TRAF3;AKT2;BCL2;BAX;E2F3;POLK;BAK1;BIRC3;BCL2L1
Pyruvate metabolism	13/47	0.0154189811594507	0.0518340217700683	0	0	2.22677436227569	9.29044998436829	MDH1;MDH2;AKR1A1;ACYP2;PDHB;ACAT2;ADH5;ALDH3A2;LDHB;LDHA;PKM;PCK2;ALDH9A1
Cytokine-cytokine receptor interaction	57/295	0.0169167290210068	0.0562703828488225	0	0	1.39913778011204	5.70771578439624	IL21;IL22;TNFRSF13B;CSF1;IL26;IL23R;CXCL13;IL27RA;CCR8;TNFRSF8;CCR7;CCR6;CCR4;IL6R;TNFRSF4;IL10;IFNAR2;IL1R1;IL1R2;IFNGR2;TNFRSF18;IL13;IL16;TNFRSF1B;LTA;TNFRSF25;LTB;IL6ST;EBI3;CXCR5;CSF2RB;CXCR6;IL2RG;IL21R;TNFRSF14;IL12RB1;IL32;CCL20;CD70;IL10RB;IL10RA;TNFRSF9;LIF;TNFRSF10A;IL4;CD4;CD40LG;IL7;IL2RA;IL2RB;CD27;FAS;TNFSF8;IL17F;IL18R1;CRLF2;IL17A
Cytosolic DNA-sensing pathway	16/63	0.0177112041194172	0.0577973461636003	0	0	1.98311566280857	7.99901172650457	POLR3GL;ADAR;NFKB1;IKBKB;TBK1;AIM2;POLR3E;CASP1;IRF7;POLR1D;POLR2E;POLR2F;POLR2H;IKBKE;POLR2K;NFKBIB
Allograft rejection	11/38	0.017741590436295	0.0577973461636003	0	0	2.37204121414648	9.56369931525342	IL10;IL4;CD40LG;CD80;HLA-B;CD28;HLA-C;FAS;HLA-A;HLA-F;HLA-E
Type I diabetes mellitus	12/43	0.0182129036883809	0.0587273220972282	0	0	2.25402812241522	9.02879126767871	PTPRN2;CD80;ICA1;HLA-B;CD28;LTA;HLA-C;FAS;HLA-A;HLA-F;HSPD1;HLA-E
Vasopressin-regulated water reabsorption	12/44	0.0217878409603054	0.0695450277116819	0	0	2.18346153846154	8.35480425912277	NSF;DCTN5;RAB5B;RAB5C;CREB1;DCTN2;CREB3L3;ARHGDIB;DYNLL1;AQP3;RAB5A;RAB11B
RIG-I-like receptor signaling pathway	17/70	0.0227368704363253	0.0714086987407196	0	0	1.86850607392091	7.06999241379238	OTUD5;MAP3K1;TRADD;TRAF2;ISG15;TANK;NFKB1;IFIH1;IKBKB;CYLD;TBK1;TKFC;TRAF3;IRF7;PIN1;IKBKE;NFKBIB
Proteoglycans in cancer	41/205	0.0228236663696604	0.0714086987407196	0	0	1.45882251381215	5.51428678525177	ITGB1;CAMK2D;SDC4;ROCK1;PXN;ITPR2;PIK3CB;ELK1;HIF1A;ACTB;ACTG1;CDC42;PPP1CC;AKT2;FLNB;RAC1;EIF4B;MAPK3;VAV3;SMAD2;WNT10A;PPP1R12A;PRKCB;CAV1;RDX;STAT3;PTPN11;NUDT16L1;ANK1;RHOA;PPP1CA;TIAM1;CTTN;RPS6KB2;HCLS1;FAS;GRB2;HPSE;EZR;CD44;FGFR1
Cell adhesion molecules	31/148	0.0242962446681615	0.0747390768391798	0	0	1.54506738195658	5.7436852160603	ITGB1;SELPLG;SDC4;CD80;ITGB2;ICAM2;ICAM3;ITGAL;GLG1;VSIR;CTLA4;ITGB8;CD58;ICOS;TIGIT;CADM1;ITGA4;HLA-B;HLA-C;HLA-A;HLA-F;HLA-E;SELP;CD2;CD4;PTPRC;CD40LG;SELL;CD6;CD28;PDCD1
FoxO signaling pathway	28/131	0.0243611547925175	0.0747390768391798	0	0	1.58490389717883	5.8875462102634	CDKN1B;SETD7;PTEN;PIK3CB;FOXO1;GABARAP;IKBKB;BCL2L11;AKT2;S1PR4;PCK2;MAPK3;IL10;GABARAPL2;PLK3;SMAD3;GADD45A;PRMT1;TPTEP2-CSNK1E;STAT3;FBXO32;SOD2;KLF2;GADD45G;BCL6;CCNG2;CAT;GRB2
mTOR signaling pathway	32/154	0.0248972802870541	0.0756494285645105	0	0	1.52961823876301	5.64887511856067	ATP6V1A;GSK3B;SEH1L;CAB39;PTEN;PIK3CB;IKBKB;AKT2;RPS6KA2;RPS6KA1;ATP6V1E1;ATP6V1D;EIF4E;EIF4B;ATP6V1F;MAPK3;ATP6V1G1;WNT10A;PRKCB;RHOA;CLIP1;RRAGB;DDIT4;RPS6KB2;ATP6V1B2;GRB2;LAMTOR2;LAMTOR1;EIF4E2;LAMTOR4;LAMTOR3;LAMTOR5
Fluid shear stress and atherosclerosis	29/139	0.0300208441764773	0.0895671231037606	0	0	1.53694197824184	5.38830852601049	SDC4;KEAP1;MGST2;PDGFA;PLAT;TXN;PIK3CB;ACTB;ACTG1;TXN2;IKBKB;SUMO1;AKT2;SUMO3;SUMO2;RAC2;RAC1;MAP3K5;IL1R1;GSTO1;IL1R2;CAV1;NFKB1;RHOA;KLF2;BCL2;CALM3;SQSTM1;CALM2
Circadian rhythm	9/31	0.0300446678765779	0.0895671231037606	0	0	2.38091467958271	8.34527279562113	CREB1;TPTEP2-CSNK1E;RORC;CRY1;RORA;NR1D1;ARNTL;SKP1;RBX1
Synaptic vesicle cycle	18/78	0.0316638069971345	0.0935118038420046	0	0	1.74748201438849	6.03332317534796	NSF;ATP6V1A;NAPA;ATP6V0B;ATP6V1G1;ATP6V0E1;CLTB;CLTA;ATP6V1B2;AP2S1;ATP6V1E1;ATP6V0D1;ATP6V0E2;ATP6V0C;ATP6V1D;AP2M1;ATP6V0A1;ATP6V1F
MAPK signaling pathway	55/294	0.0330412828941907	0.0966763462459654	0	0	1.34338369159028	4.58093503331141	ATF2;CSF1;TRADD;HSPB1;ELK1;DUSP16;IKBKB;DUSP10;AKT2;RPS6KA2;RPS6KA1;RAC2;RAC1;MAP3K4;MAP3K5;DUSP4;MAP4K1;MAP2K3;DUSP2;IL1R1;PRKCB;TRAF2;CDC25B;MAPKAPK3;RASA1;MAPT;MAX;PDGFA;RASGRP1;RASGRP4;RELB;CDC42;RAP1A;MKNK2;FLNB;PAK2;MAP4K3;MAPK3;NTRK1;HSPA8;NTRK2;MAP3K1;GADD45A;NFATC1;NFKB1;GADD45G;NFKB2;FAS;GRB2;TAB2;PTPN7;LAMTOR3;MAP3K14;FGFR2;FGFR1
Glutathione metabolism	14/57	0.0334177961194136	0.0968809502177495	0	0	1.89579040329703	6.44315971945785	GSTK1;GGT7;GPX4;GSTO1;ODC1;GSR;GPX7;MGST2;TXNDC12;GGCT;HPGDS;SMS;LAP3;GGT1
Toxoplasmosis	24/112	0.034156388050564	0.0981219874907111	0	0	1.58927066754049	5.36665817251298	MAP2K3;ITGB1;IL10;HSPA8;IL10RB;STAT1;IFNGR2;IL10RA;STAT3;LY96;NFKB1;PIK3R5;GNAI2;IKBKB;CD40LG;AKT2;BCL2;TAB2;LDLR;BCL2L1;NFKBIB;JAK1;BIRC3;MAPK3
Fatty acid elongation	8/27	0.0354683859943879	0.100455074344951	0	0	2.45012668235971	8.18125111762853	HADHB;HADHA;HACD1;ECHS1;ELOVL5;TECR;THEM4;HACD2
Nucleotide excision repair	12/47	0.0356043301475776	0.100455074344951	0	0	1.99595604395604	6.65708827219668	DDB1;POLE4;POLD4;RPA3;ERCC2;RPA1;RPA2;XPC;RAD23B;GTF2H5;DDB2;RBX1
Platelet activation	26/124	0.0362536533920477	0.101381897981302	0	0	1.54617601076844	5.12899844037696	ITGB1;ROCK1;SNAP23;ITPR2;PIK3CB;RASGRP1;ACTB;ACTG1;PIK3R5;GNAI2;GNA13;PPP1CC;RAP1A;AKT2;MAPK3;PTGIR;PPP1R12A;RHOA;PPP1CA;APBB1IP;VAMP8;STIM1;TBXAS1;LCP2;PLCB2;FERMT3
Endometrial cancer	14/58	0.0382994537368328	0.106163398077536	0	0	1.85259540322831	6.04375837937989	GSK3B;GADD45A;LEF1;PTEN;PIK3CB;ELK1;DDB2;GADD45G;AKT2;BAX;GRB2;POLK;BAK1;MAPK3
Autoimmune thyroid disease	13/53	0.0398853969541575	0.10959813423925	0	0	1.89209131326949	6.09583575304747	IL10;CD80;HLA-B;HLA-C;HLA-A;HLA-F;TSHR;HLA-E;IL4;CD40LG;CD28;CTLA4;FAS
Leukocyte transendothelial migration	24/114	0.0411503174248082	0.111670706274162	0	0	1.55377045428539	4.95734136248833	ITGB1;VAV3;ITK;ITGA4;ROCK1;PRKCB;ACTN1;NCF4;PXN;ITGB2;RHOH;PTPN11;PIK3CB;ITGAL;ACTB;RHOA;ACTG1;GNAI2;CDC42;RAP1A;RASSF5;RAC2;RAC1;EZR
Valine, leucine and isoleucine degradation	12/48	0.0413464323863193	0.111670706274162	0	0	1.94039886039886	6.18166280812728	BCKDHA;MCCC2;ALDH3A2;HADHB;HADHA;ECHS1;OXCT1;ABAT;HSD17B10;ACAT2;HIBCH;ALDH9A1
Coronavirus disease	44/232	0.0426725830037765	0.114275730755876	0	0	1.36518081061403	4.30605146874243	RPL4;RPS27L;ADAR;PIK3CB;RPS4Y1;RPL6;RPL7;IFIH1;IKBKB;RPS17;TBK1;RPL36AL;C3AR1;CASP1;RPL15;RPS11;IKBKE;IL6R;JAK1;MAPK3;IFNAR2;PRKCB;STAT1;RPS8;RPL23;STAT2;RPL22;STAT3;MX1;ISG15;NFKB1;RPS26;SELP;ADAM17;OAS1;OAS2;TRAF3;RPL24;TAB2;IL6ST;RPL28;RSL24D1;RPS24;NFKBIB
Notch signaling pathway	14/59	0.0436691322015283	0.11596172920742	0	0	1.81132018094043	5.67144958471605	HDAC1;DTX3;PSEN1;RBPJ;LFNG;APH1A;KAT2B;HEYL;ADAM17;ATXN1;SNW1;MFNG;NUMB;HES1
Choline metabolism in cancer	21/98	0.0453044414632014	0.119301695853097	0	0	1.58866442199776	4.91588408108284	LYPLA1;CHKB;PRKCB;SLC44A2;DGKA;WAS;PDGFA;PIK3CB;GPCPD1;DGKZ;HIF1A;AKT2;RPS6KB2;RAC2;PIP5K1B;GRB2;RAC1;RALGDS;WASF2;DGKH;MAPK3
Sulfur metabolism	4/10	0.0466268990156091	0.121769422222582	0	0	3.8770314808501	11.8853411424606	ETHE1;SQOR;SUOX;PAPSS1
Hepatocellular carcinoma	33/168	0.0472539126382178	0.12239538027604	0	0	1.42491582491582	4.34915632451016	GSK3B;SMARCB1;LEF1;PTEN;KEAP1;MGST2;PIK3CB;ELK1;ACTB;ACTG1;FRAT2;AKT2;E2F3;POLK;BAK1;MAPK3;SMAD2;SMARCE1;SMARCC1;WNT10A;SMARCC2;SMAD3;PRKCB;GADD45A;GSTO1;CDKN2A;CSNK1A1;GADD45G;DDB2;RPS6KB2;BAX;GRB2;BCL2L1
Various types of N-glycan biosynthesis	10/39	0.0510900315698213	0.131255690862305	0	0	2.00676224921362	5.96844380629571	B4GALT3;B4GALT1;MAN1A2;MAN2A1;DAD1;RPN1;ALG3;MGAT1;ALG1;DDOST
Propanoate metabolism	9/34	0.0521971248372257	0.133018479423898	0	0	2.09483606557377	6.18548082417475	BCKDHA;LDHB;HADHA;LDHA;ECHS1;ABAT;SUCLG1;ACAT2;HIBCH
IL-17 signaling pathway	20/94	0.0531453433941158	0.134351428100325	0	0	1.5740903742275	4.61952204382854	GSK3B;TRAF3IP2;CCL20;TRADD;IL13;TRAF2;ELAVL1;NFKB1;IKBKB;IL4;TBK1;TRAF4;TRAF3;TAB3;IL17F;TAB2;MAPK6;IKBKE;MAPK3;IL17A
Viral protein interaction with cytokine and cytokine receptor	21/100	0.05468601253613	0.137149047312834	0	0	1.54826274938793	4.49947963138798	IL10;CSF1;CCL20;IL10RB;IL10RA;CXCR5;TNFRSF10A;CXCL13;TNFRSF1B;IL2RG;IL2RA;IL2RB;LTA;CCR8;TNFRSF14;CCR7;CCR6;IL6ST;IL6R;CCR4;IL18R1
Glycerolipid metabolism	14/61	0.0559502613219581	0.139214823446762	0	0	1.73403891367802	4.99974082852804	AGPAT5;GK;DGKA;GLYCTK;AKR1A1;MBOAT1;DGKZ;AGPAT4;ALDH3A2;PLPP5;TKFC;ALDH9A1;DGKH;PNPLA2
Cell cycle	25/124	0.059073988613166	0.145838909388753	0	0	1.47109834609835	4.161685109575	YWHAE;GSK3B;CDKN1B;YWHAB;HDAC1;SMC3;ANAPC10;ANAPC11;PTTG1;YWHAQ;CDC26;RAD21;E2F3;SKP1;YWHAH;SMAD2;SMAD3;GADD45A;CDKN2A;YWHAZ;CDC25B;RBX1;GADD45G;DBF4;MAD1L1
Inositol phosphate metabolism	16/73	0.0620849585287149	0.152084084457937	0	0	1.63423965596978	4.54196306928962	INPP1;MTMR14;PTEN;PIK3CB;MTMR6;MINPP1;PIKFYVE;INPP5F;SYNJ1;INPP5K;PIK3C3;PIP5K1B;PI4KB;CDIPT;PLCB2;PI4K2A
Natural killer cell mediated cytotoxicity	26/131	0.0646023543984699	0.156474934010762	0	0	1.4425021674764	3.95174106807664	ITGB2;ICAM2;PIK3CB;ITGAL;RAC2;RAC1;MAPK3;IFNAR2;VAV3;PRKCB;IFNGR2;SH2D1A;HLA-B;HLA-C;NFATC2;NFATC1;TNFRSF10A;PTPN11;HLA-A;HLA-E;LCK;FAS;GRB2;LCP2;CD247;LAT
Chagas disease	21/102	0.0653629471184195	0.156474934010762	0	0	1.50985622110451	4.11858540569914	SMAD2;IL10;IFNGR2;PPP2R2A;PIK3CB;CFLAR;TICAM1;CD3E;CD3D;NFKB1;GNAI2;IKBKB;PPP2CA;GNA15;PPP2R1A;AKT2;FAS;CALR;CD247;PLCB2;MAPK3
Longevity regulating pathway	21/102	0.0653629471184195	0.156474934010762	0	0	1.50985622110451	4.11858540569914	ATF2;HSPA8;ATF6B;HDAC1;PIK3CB;SOD2;ATG13;FOXO1;NFKB1;SOD1;CREB1;CREB3L3;SESN3;AKT2;RB1CC1;CAT;RPS6KB2;BAX;PPARG;EIF4E2;EIF4E
Insulin resistance	22/108	0.0665471199171428	0.157323058047875	0	0	1.48986397542782	4.0373004624536	GSK3B;PRKCB;STAT3;PTEN;PTPN11;PIK3CB;FOXO1;NFKB1;PPP1CA;IKBKB;PPP1CC;SOCS3;CREB1;CREB3L3;TBC1D4;AKT2;RPS6KA2;RPS6KA1;RPS6KB2;MLX;PRKCQ;PCK2
Legionellosis	13/57	0.066712942336757	0.157323058047875	0	0	1.71967883347842	4.65578333557626	HBS1L;HSPA8;ARF1;VCP;SAR1B;ITGB2;NFKB1;HSPD1;NFKB2;EEF1G;BCL2L13;HSF1;CASP1
Dopaminergic synapse	26/132	0.0696543756989709	0.162463844984347	0	0	1.42880939572085	3.80664793243531	ATF2;GSK3B;CAMK2D;ATF6B;ITPR2;PPP2R2A;COMT;ARNTL;GNAI2;PPP2CA;PPP1CC;GNG10;CREB3L3;GNG5;PPP2R1A;GNG4;AKT2;KIF5B;GNG8;PRKCB;PPP1CA;CREB1;GNB2;CALM3;CALM2;PLCB2
Prostate cancer	20/97	0.0699211484742757	0.162463844984347	0	0	1.51249504694825	4.02382234532619	GSK3B;CDKN1B;IL1R2;LEF1;PTEN;PDGFA;PLAT;PIK3CB;FOXO1;NFKB1;IKBKB;CREB1;CREB3L3;AKT2;BCL2;GRB2;E2F3;FGFR2;FGFR1;MAPK3
Thyroid hormone signaling pathway	24/121	0.0739173113224819	0.170495404218279	0	0	1.44104812766093	3.75365401571363	NCOA1;GSK3B;HDAC3;PRKCB;HDAC1;STAT1;NCOA3;ATP1B3;SLC16A10;PIK3CB;ATP1B1;MED4;MED27;HIF1A;ACTB;FOXO1;ACTG1;KAT2B;PFKL;TBC1D4;AKT2;PLCB2;PFKP;MAPK3
Oocyte meiosis	25/129	0.0862096853824938	0.195987486193295	0	0	1.399959715765	3.43126311191596	YWHAE;CAMK2D;YWHAB;ITPR2;SMC3;ANAPC10;ANAPC11;PPP2CA;PPP1CC;PTTG1;YWHAQ;PPP2R1A;CDC26;RPS6KA2;RPS6KA1;SKP1;YWHAH;MAPK3;YWHAZ;REC8;RBX1;PPP1CA;CALM3;CALM2;MAD1L1
Purine metabolism	25/129	0.0862096853824938	0.195987486193295	0	0	1.399959715765	3.43126311191596	PRPS1;CANT1;GMPR2;ADK;NUDT2;NTPCR;NUDT5;PAPSS1;NT5C;DGUOK;ATIC;PDE4B;PDE6D;NUDT16;ENTPD1;ADSL;NME3;DCK;APRT;NT5C3A;PKM;HPRT1;PDE7B;ADA;ITPA
Adherens junction	15/71	0.0898337109506536	0.201641452237978	0	0	1.5590165737753	3.75691030351986	SMAD3;ACTN1;LEF1;WAS;PTPRJ;ACTB;RHOA;ACTG1;CDC42;CSNK2B;RAC2;RAC1;WASF2;MAPK3;FGFR1
AGE-RAGE signaling pathway in diabetic complications	20/100	0.0899729264732751	0.201641452237978	0	0	1.45551936921495	3.5052493841948	SMAD2;STAT5A;STAT5B;SMAD3;CDKN1B;PRKCB;STAT1;STAT3;NFATC1;PIK3CB;FOXO1;NFKB1;CDC42;DIAPH1;AKT2;BCL2;BAX;RAC1;PLCB2;MAPK3
Glucagon signaling pathway	21/107	0.0980810913416234	0.218264963830655	0	0	1.4216551823141	3.30102743356786	ATF2;CAMK2D;PRMT1;PGAM1;ITPR2;PPP4R3B;PDHB;FOXO1;LDHB;LDHA;PFKL;PPP4C;CREB1;PKM;CREB3L3;AKT2;CALM3;CALM2;PLCB2;PFKP;PCK2
Apelin signaling pathway	26/137	0.0989991352490105	0.21876731985096	0	0	1.36404628606621	3.15455368254794	RYR1;BECN1;ITPR2;PLAT;GABARAP;PIK3R5;GNAI2;GNA13;GNG10;GNG5;GNG4;AKT2;GNG8;MEF2D;MAPK3;SMAD2;GABARAPL2;SMAD3;KLF2;ACTA2;GNB2;RPS6KB2;CALM3;PIK3C3;CALM2;PLCB2
PI3K-Akt signaling pathway	61/354	0.100276473640766	0.219012323185934	0	0	1.21396564245943	2.79190752782628	ITGB1;YWHAE;ATF2;GSK3B;CDKN1B;CSF1;YWHAB;PTEN;PPP2R2A;PIK3CB;IKBKB;CREB3L3;YWHAQ;PPP2R1A;AKT2;MYB;ITGB8;RAC1;JAK3;IL6R;JAK1;YWHAH;IFNAR2;ITGA4;YWHAZ;CREB1;DDIT4;COL6A3;EIF4E2;ATF6B;LPAR2;PDGFA;IL2RG;PIK3R5;PPP2CA;GNG10;BCL2L11;GNG5;GNG4;THEM4;GNG8;EIF4E;EIF4B;PCK2;MAPK3;NTRK1;NTRK2;NFKB1;IL4;IL7;GNB2;IL2RA;IL2RB;RPS6KB2;BCL2;GRB2;COL9A2;PKN1;FGFR2;BCL2L1;FGFR1
Fructose and mannose metabolism	8/33	0.100496160955571	0.219012323185934	0	0	1.86144076476613	4.2769128507234	TIGAR;PFKL;TKFC;PMM1;ALDOC;ALDOA;PFKP;HK1
Acute myeloid leukemia	14/67	0.106092878515725	0.229625682266912	0	0	1.53719040272659	3.44859498449808	STAT5A;CEBPA;STAT5B;LEF1;STAT3;PIK3CB;NFKB1;RUNX1;IKBKB;AKT2;RPS6KB2;GRB2;PIM2;MAPK3
N-Glycan biosynthesis	11/50	0.106883661200737	0.229763516594781	0	0	1.64102564102564	3.6693568238508	B4GALT3;ST6GAL1;B4GALT1;MAN1A2;DAD1;MAN2A1;RPN1;ALG3;MGAT1;ALG1;DDOST
Focal adhesion	36/201	0.117022634183995	0.249859137852314	0	0	1.27088464792705	2.72654055654522	ITGB1;GSK3B;ROCK1;PXN;PTEN;PDGFA;PIK3CB;ELK1;ACTB;ACTG1;CDC42;PPP1CC;RAP1A;AKT2;RAC2;ITGB8;PIP5K1B;FLNB;RAC1;PAK3;PAK2;MAPK3;VAV3;PPP1R12A;ITGA4;PRKCB;ACTN1;CAV1;RHOA;PPP1CA;DIAPH1;BCL2;COL6A3;GRB2;COL9A2;BIRC3
Glycerophospholipid metabolism	19/98	0.121810066762647	0.258335443604003	0	0	1.39984903826967	2.94709136948982	AGPAT5;LYPLA2;LYPLA1;PCYT2;CHKB;DGKA;MBOAT1;PLA2G6;GPCPD1;DGKZ;CRLS1;AGPAT4;PGS1;PLPP5;PTDSS1;LPCAT4;PNPLA6;CDIPT;DGKH
Adipocytokine signaling pathway	14/69	0.127392066724525	0.268372620566332	0	0	1.48111840263739	3.05182344918123	TRADD;STAT3;ACSL4;TRAF2;PTPN11;TNFRSF1B;NFKB1;IKBKB;SOCS3;AKT2;PRKCQ;NFKBIE;PCK2;NFKBIB
Hematopoietic cell lineage	19/99	0.131047518304296	0.274245137643428	0	0	1.38226953392735	2.80904163139002	CSF1;TFRC;ITGA4;MME;IL1R1;IL1R2;CD3E;CD3D;IL4;CD2;CD4;IL7;CD5;IL2RA;CD38;CD37;CD59;IL6R;CD44
Rap1 signaling pathway	37/210	0.134450908166051	0.279516361713632	0	0	1.24562487542356	2.49941624392968	ITGB1;RALA;RALB;CSF1;ITGB2;LPAR2;PDGFA;PIK3CB;ITGAL;ACTB;GNAI2;ACTG1;CDC42;RAP1A;AKT2;RASSF5;RAC2;RAC1;RALGDS;MAPK3;VAV3;MAP2K3;FYB1;PRKCB;RHOA;APBB1IP;TIAM1;ADORA2A;CALM3;LCP2;PFN1;CALM2;PLCB2;SKAP1;FGFR2;LAT;FGFR1
Transcriptional misregulation in cancer	34/192	0.139233061557463	0.282927380394281	0	0	1.25311223221722	2.47064365598062	CEBPA;CDKN1B;MAX;HDAC1;PRCC;PDGFA;PLAT;FOXO1;LYL1;POLK;BAK1;NTRK1;SMAD1;BCL11B;GADD45A;IL1R2;TFE3;PBX3;TRAF1;KLF3;NFKB1;RUNX1;GADD45G;DDB2;ETV6;ETV7;MAF;BCL6;IL2RB;BAX;PPARG;CDK14;BCL2L1;BIRC3
Pertussis	15/76	0.139935003333813	0.282927380394281	0	0	1.4308075537752	2.81379355015339	ITGB1;IL10;ITGB2;LY96;TICAM1;RHOA;NFKB1;GNAI2;CFL2;IRF1;CFL1;CASP1;CALM3;CALM2;MAPK3
Parathyroid hormone synthesis, secretion and action	20/106	0.140287501323875	0.282927380394281	0	0	1.35349315559949	2.6583436366354	ATF2;ATF6B;PRKCB;VDR;ITPR2;GATA3;RHOA;PTHLH;GNAI2;GNA13;AKAP13;CREB1;CREB3L3;NACA;BCL2;PDE4B;PLCB2;MEF2D;FGFR1;MAPK3
Glyoxylate and dicarboxylate metabolism	7/30	0.14049846938803	0.282927380394281	0	0	1.76999554830093	3.47372013449574	CS;MDH1;SHMT2;MDH2;GLYCTK;CAT;ACAT2
Peroxisome	16/82	0.140568350385766	0.282927380394281	0	0	1.41064185158673	2.76776596697233	PECR;GSTK1;ACOT8;EPHX2;ECH1;PEX11B;ACSL4;PEX2;SOD2;SOD1;NUDT7;SCP2;PRDX1;CAT;PMVK;MPV17
Endocrine and other factor-regulated calcium reabsorption	11/53	0.145861002426574	0.291722004853147	0	0	1.52354099534551	2.93297052057266	PRKCB;VDR;CLTB;AP2S1;ATP2B4;CLTA;ATP1B3;ATP2B1;ATP1B1;PLCB2;AP2M1
VEGF signaling pathway	12/59	0.148256049979898	0.294647243985206	0	0	1.48530278232406	2.83516738772427	CDC42;MAPKAPK3;PRKCB;AKT2;SH2D2A;PXN;RAC2;HSPB1;NFATC2;PIK3CB;RAC1;MAPK3
Leishmaniasis	15/77	0.15151426302045	0.29924066946539	0	0	1.40764721467841	2.6563365899236	ITGB1;IL10;ITGA4;PRKCB;STAT1;IFNGR2;ITGB2;NCF4;ELK1;NFKB1;IL4;TAB2;JAK1;MAPK3;NFKBIB
One carbon pool by folate	5/20	0.15940845066062	0.311771368106334	0	0	1.9381537062301	3.55900354479759	ATIC;MTHFD1L;SHMT2;MTHFD2;MTHFS
Galactose metabolism	7/31	0.159832157067171	0.311771368106334	0	0	1.69614618885097	3.11010628784467	PFKL;B4GALT1;UGP2;GLB1;GALM;PFKP;HK1
Melanoma	14/72	0.163524321987024	0.317016476980978	0	0	1.4042610921703	2.54282691611016	CDKN2A;GADD45A;PTEN;PDGFA;PIK3CB;DDB2;GADD45G;AKT2;BAX;E2F3;POLK;BAK1;MAPK3;FGFR1
Synthesis and degradation of ketone bodies	3/10	0.17164675138294	0.330733984372006	0	0	2.49138182880514	4.3906037658031	BDH2;OXCT1;ACAT2
Sphingolipid metabolism	10/49	0.173657099130018	0.332579656515671	0	0	1.49133180906327	2.61083376366706	ARSA;UGCG;CERS5;CERK;SGMS1;GLB1;PSAP;KDSR;SGPP2;SGPP1
ErbB signaling pathway	16/85	0.175385333543942	0.333866056625817	0	0	1.34907144168416	2.34842285035081	STAT5A;GSK3B;STAT5B;CAMK2D;CDKN1B;PRKCB;PIK3CB;ELK1;AKT2;RPS6KB2;NCK2;GRB2;PAK3;PAK2;NCK1;MAPK3
Toll-like receptor signaling pathway	19/104	0.183067020742196	0.346402266793616	0	0	1.3005765431601	2.20825276184902	IFNAR2;MAP2K3;STAT1;CD80;LY96;PIK3CB;TICAM1;NFKB1;IKBKB;TBK1;TRAF3;AKT2;TOLLIP;IRF7;TAB2;IRF5;RAC1;IKBKE;MAPK3
cGMP-PKG signaling pathway	29/167	0.189587533786885	0.356605123075332	0	0	1.22307527460479	2.03385730629706	ATF2;ATF6B;ROCK1;ITPR2;PIK3R5;GNAI2;GNA13;PPP1CC;CREB3L3;AKT2;MEF2D;MAPK3;PPP1R12A;ATP2B4;NFATC2;ATP1B3;NFATC1;ATP2B1;ATP1B1;RHOA;PPP1CA;CREB1;VDAC2;VDAC1;CALM3;SLC25A5;CALM2;PLCB2;SLC25A6
Fc epsilon RI signaling pathway	13/68	0.190996952222232	0.357130395871156	0	0	1.37485387389628	2.27606757457552	MAP2K3;VAV3;IL13;PIK3CB;GAB2;IL4;AKT2;RAC2;LCP2;GRB2;RAC1;LAT;MAPK3
Base excision repair	7/33	0.201770830275569	0.375056366865175	0	0	1.5654896298241	2.50575828382894	POLB;POLE4;POLD4;PARP1;MPG;OGG1;TDG
Lysine degradation	12/63	0.206888221249908	0.382319753888719	0	0	1.36848667672197	2.15615562018937	ALDH3A2;NSD3;HADHA;SETD2;ECHS1;NSD1;SETD1B;SETD7;PRDM2;SMYD3;ACAT2;ALDH9A1
Growth hormone synthesis, secretion and action	21/119	0.212546085586902	0.388973935052385	0	0	1.24669312169312	1.93062453100033	MAP2K3;STAT5A;ATF2;STAT5B;GSK3B;MAP3K1;ATF6B;PRKCB;STAT1;STAT3;ITPR2;PIK3CB;SSTR3;GNAI2;SOCS3;CREB1;CREB3L3;AKT2;GRB2;PLCB2;MAPK3
Terpenoid backbone biosynthesis	5/22	0.212950920139439	0.388973935052385	0	0	1.70993499719124	2.64474545108886	FDPS;IDI1;FNTA;PMVK;ACAT2
Butanoate metabolism	6/28	0.220327152443025	0.400134368804575	0	0	1.58565180980739	2.39852317706885	HADHA;ECHS1;BDH2;OXCT1;ABAT;ACAT2
Mismatch repair	5/23	0.241603335265447	0.433787806499326	0	0	1.61484386842504	2.29381790475186	POLD4;RPA3;RPA1;RPA2;SSBP1
Proximal tubule bicarbonate reclamation	5/23	0.241603335265447	0.433787806499326	0	0	1.61484386842504	2.29381790475186	GLUD1;MDH1;ATP1B3;ATP1B1;PCK2
Other types of O-glycan biosynthesis	9/47	0.24610672520286	0.43937697832827	0	0	1.37713006902502	1.93072257837202	LFNG;GALNT7;B4GALT3;ST6GAL1;B4GALT1;MFNG;POMT1;XXYLT1;GALNT10
Mineral absorption	11/60	0.259997205049429	0.461568071885504	0	0	1.30535522479669	1.75842365695507	MT2A;VDR;FTH1;SLC11A2;ATP2B4;MT1X;ATP1B3;ATP2B1;ATP1B1;ATOX1;MT1E
Intestinal immune network for IgA production	9/48	0.266511302381103	0.470489226549881	0	0	1.34174022698613	1.77423492798692	IL10;IL4;CD40LG;TNFRSF13B;ITGA4;CD80;CD28;ICOS;MAP3K14
Graft-versus-host disease	8/42	0.26923439388888	0.472655935938256	0	0	1.36798345148917	1.79503084831614	CD80;HLA-B;CD28;HLA-C;FAS;HLA-A;HLA-F;HLA-E
DNA replication	7/36	0.271289525396527	0.472656509728988	0	0	1.4032952806873	1.83069505653378	POLE4;POLD4;RNASEH2B;RPA3;RPA1;RPA2;SSBP1
beta-Alanine metabolism	6/30	0.272226217628721	0.472656509728988	0	0	1.45334356874787	1.89097711047292	ALDH3A2;HADHA;ECHS1;ABAT;HIBCH;ALDH9A1
Long-term potentiation	12/67	0.273857955066872	0.47289133224662	0	0	1.268662004662	1.64310216442535	PPP1CC;CAMK2D;RAP1A;PRKCB;RPS6KA2;RPS6KA1;ITPR2;CALM3;PLCB2;CALM2;MAPK3;PPP1CA
Fatty acid degradation	8/43	0.291736258926426	0.50102531424321	0	0	1.32882017265766	1.63698035793849	ALDH3A2;HADHB;HADHA;ECHS1;ACSL4;ACAT2;ADH5;ALDH9A1
Glycosaminoglycan degradation	4/19	0.30146774120286	0.514939493081642	0	0	1.54999431753608	1.85858619368291	IDUA;GLB1;HPSE;SGSH
AMPK signaling pathway	20/120	0.305528466424989	0.519069867689766	0	0	1.16304422351731	1.37903587025644	RAB2A;CAB39;PPP2R2A;PIK3CB;EEF2;ELAVL1;FOXO1;RAB11B;PPP2CA;RAB10;PFKL;CREB1;CREB3L3;RAB14;PPP2R1A;AKT2;RPS6KB2;PPARG;PFKP;PCK2
Cysteine and methionine metabolism	9/50	0.308707818548314	0.521666688028167	0	0	1.27613954418233	1.49992340075964	LDHB;LDHA;AHCY;MDH1;MDH2;ADI1;GOT2;SMS;MAT2B
Breast cancer	24/147	0.319565022983446	0.536434663500587	0	0	1.13469476610317	1.29445356089414	NCOA1;GSK3B;WNT10A;GADD45A;CSNK1A1;NCOA3;LEF1;PTEN;PIK3CB;GADD45G;NFKB2;DDB2;HEYL;FRAT2;AKT2;RPS6KB2;BAX;GRB2;E2F3;HES1;POLK;BAK1;FGFR1;MAPK3
Gastric acid secretion	13/76	0.320842251270921	0.536434663500587	0	0	1.19970468807678	1.36383113456733	CAMK2D;PRKCB;ITPR2;ATP1B3;ATP1B1;ACTB;ACTG1;GNAI2;HRH2;CALM3;EZR;PLCB2;CALM2
Oxytocin signaling pathway	25/154	0.325562623681166	0.54146204780657	0	0	1.1269859016952	1.26470407878725	RYR1;CAMK2D;ROCK1;ITPR2;MYL6B;ELK1;ACTB;ACTG1;PIK3R5;GNAI2;PPP1CC;CD38;MAPK3;PPP1R12A;PRKCB;NFATC2;NFATC1;EEF2;RHOA;PPP1CA;MYL6;CALM3;CAMK1;CALM2;PLCB2
Prolactin signaling pathway	12/70	0.328034181600487	0.542716237621748	0	0	1.20282935455349	1.34071866118111	STAT5A;GSK3B;SOCS3;STAT5B;STAT1;AKT2;IRF1;STAT3;GRB2;PIK3CB;NFKB1;MAPK3
Phospholipase D signaling pathway	24/148	0.332166469615266	0.544950767731256	0	0	1.12547755888509	1.2404102256126	AGPAT5;ARF1;RALA;RALB;DGKA;LPAR2;PDGFA;PTPN11;PIK3CB;GAB2;DGKZ;RHOA;PIK3R5;AGPAT4;GNA13;AKT2;PIP5K1B;GRB2;RALGDS;PLCB2;CYTH1;DGKH;ARF6;MAPK3
Riboflavin metabolism	2/8	0.332833854975103	0.544950767731256	0	0	1.93719477569563	2.13113092369541	ACP5;ACP2
Basal transcription factors	8/45	0.337937342107889	0.54763179541586	0	0	1.25684441696733	1.36354394606213	GTF2A2;TAF12;TAF10;TAF9;ERCC2;TAF9B;GTF2E2;GTF2H5
Glycosphingolipid biosynthesis	8/45	0.337937342107889	0.54763179541586	0	0	1.25684441696733	1.36354394606213	B4GALT3;B4GALT1;FUT7;ST8SIA1;GLB1;GCNT2;B3GNT2;ST6GALNAC6
Adrenergic signaling in cardiomyocytes	24/150	0.357742769860244	0.576768955488965	0	0	1.10748205907835	1.13842629368314	ATF2;CAMK2D;TPM4;ATF6B;CREM;ATP2B4;PPP2R2A;ATP1B3;ATP2B1;ATP1B1;PIK3R5;GNAI2;PPP1CA;PPP2CA;PPP1CC;CREB1;CREB3L3;PPP2R1A;AKT2;BCL2;CALM3;CALM2;PLCB2;MAPK3
Insulin signaling pathway	22/137	0.359647355908843	0.576896266330937	0	0	1.11225594749795	1.13742773945084	GSK3B;PIK3CB;ELK1;FOXO1;HK1;PPP1CA;IKBKB;PPP1CC;PPP1R3F;SOCS3;PRKAR1A;AKT2;MKNK2;RPS6KB2;FLOT2;CALM3;GRB2;EIF4E2;CALM2;EIF4E;PCK2;MAPK3
Biosynthesis of unsaturated fatty acids	5/27	0.36330816365929	0.578497252496014	0	0	1.3209258340568	1.33744251785441	HACD1;SCP2;ELOVL5;TECR;HACD2
Aldosterone synthesis and secretion	16/98	0.364306814071857	0.578497252496014	0	0	1.13432586568248	1.14539560500209	ATF2;CAMK2D;ATF6B;PRKCB;ATP2B4;ITPR2;ATP1B3;ATP2B1;ATP1B1;CREB1;CREB3L3;CALM3;CAMK1;CALM2;PLCB2;LDLR
Glycosaminoglycan biosynthesis	9/53	0.374328348298591	0.591438790311773	0	0	1.18892045454545	1.16825931178237	HS3ST3B1;B4GALT3;B4GALT1;CHST7;CHST11;B3GAT3;GLCE;B3GNT2;CHST2
Carbohydrate digestion and absorption	8/47	0.385107320873515	0.605442355204133	0	0	1.19225079006574	1.1376853200184	PRKCB;AKT2;ATP1B3;PIK3CB;SLC37A4;ATP1B1;PLCB2;HK1
Homologous recombination	7/41	0.396962631318555	0.620991047013185	0	0	1.19657699257177	1.10553319495522	SEM1;BABAM2;POLD4;RPA3;RPA1;RPA2;SSBP1
Arachidonic acid metabolism	10/61	0.406258292512279	0.632319145145493	0	0	1.1396263322548	1.02653680460786	HPGDS;PTGES2;EPHX2;PTGES3;TBXAS1;AKR1C3;GPX7;LTA4H;GGT1;PLA2G6
Amino sugar and nucleotide sugar metabolism	8/48	0.408826517843177	0.632319145145493	0	0	1.16237623762376	1.03970413452206	GPI;CYB5R4;UGP2;GNPDA1;PMM1;UXS1;RENBP;HK1
Nicotinate and nicotinamide metabolism	6/35	0.410207040363374	0.632319145145493	0	0	1.20241414604878	1.07146315359202	NT5C;NAPRT;NAMPT;CD38;SIRT6;SIRT7
Thyroid hormone synthesis	12/75	0.422225590646889	0.647685857497169	0	0	1.10704110704111	0.954508037925453	ATF2;CREB1;CREB3L3;ATF6B;PRKCB;GSR;GPX7;ITPR2;ATP1B3;ATP1B1;PLCB2;TSHR
Amoebiasis	16/102	0.429282813688261	0.655330285630389	0	0	1.08131175210783	0.914399754105534	IL10;RAB5B;RAB5C;IL1R1;PRKCB;ACTN1;IL1R2;ITGB2;HSPB1;PIK3CB;NFKB1;GNA15;PRDX1;RAB5A;PLCB2;RAB7A
Amphetamine addiction	11/69	0.434657210108063	0.660344607664172	0	0	1.10221674876847	0.918364329127549	ATF2;PPP1CC;CAMK2D;CREB1;CREB3L3;ATF6B;PRKCB;HDAC1;CALM3;CALM2;PPP1CA
Basal cell carcinoma	10/63	0.44817855858674	0.677628825423014	0	0	1.09649264170282	0.880005035517339	GSK3B;WNT10A;GADD45A;SUFU;LEF1;BAX;POLK;BAK1;DDB2;GADD45G
Arginine and proline metabolism	8/50	0.456101844181493	0.683071956214937	0	0	1.1068949259458	0.868955853908784	ALDH3A2;ODC1;GOT2;SMS;LAP3;SAT1;ALDH9A1;AGMAT
Cholesterol metabolism	8/50	0.456101844181493	0.683071956214937	0	0	1.1068949259458	0.868955853908784	STARD3;LRPAP1;NPC1;VAPA;TSPO;VDAC2;VDAC1;LDLR
Primary bile acid biosynthesis	3/17	0.465353128632703	0.693639569094028	0	0	1.24517966695881	0.95251107557429	ACOT8;SCP2;CYP7B1
Vascular smooth muscle contraction	20/133	0.491571212006387	0.729279356779428	0	0	1.02845389098389	0.730354949739468	PTGIR;PPP1R12A;ROCK1;PRKCB;ITPR2;MYL6B;PLA2G6;ACTG2;RHOA;PPP1CA;ACTA2;GNA13;PPP1CC;MYL6;ADORA2A;PRKCQ;CALM3;CALM2;PLCB2;MAPK3
Taurine and hypotaurine metabolism	2/11	0.495746659587317	0.731227922860311	0	0	1.29123604012871	0.906047739424906	GGT7;GGT1
Cholinergic synapse	17/113	0.497512669034706	0.731227922860311	0	0	1.02896332762557	0.718354548532477	CAMK2D;PRKCB;ITPR2;PIK3CB;PIK3R5;GNAI2;GNG10;CREB1;CREB3L3;GNG5;GNG4;AKT2;GNB2;BCL2;GNG8;PLCB2;MAPK3
Other glycan degradation	3/18	0.50514069788476	0.739002132090667	0	0	1.16209952283572	0.793619005973957	GLB1;FUCA2;MAN2B1
Gastric cancer	22/149	0.524484711773287	0.758971539957924	0	0	1.00644777893329	0.649500002970122	SMAD2;GSK3B;WNT10A;SMAD3;CDKN1B;GADD45A;CSNK1A1;LEF1;PIK3CB;GADD45G;DDB2;FRAT2;AKT2;RPS6KB2;BCL2;BAX;GRB2;E2F3;POLK;BAK1;FGFR2;MAPK3
Ribosome biogenesis in eukaryotes	16/108	0.526385012750944	0.758971539957924	0	0	1.01043418721998	0.648418221952184	POP5;NOP58;POP4;SNU13;REXO2;RPP25L;RRP7A;XRN1;EIF6;NOB1;CSNK2B;XRN2;RIOK2;UTP14A;NOP10;RAN
Long-term depression	9/60	0.528050029672444	0.758971539957924	0	0	1.02531340405014	0.654728481383255	RYR1;GNA13;PPP2CA;PPP2R1A;PRKCB;ITPR2;PLCB2;GNAI2;MAPK3
Hippo signaling pathway	24/163	0.528397907565643	0.758971539957924	0	0	1.00313405300476	0.639904896455886	SMAD2;YWHAE;SMAD1;GSK3B;WNT10A;SMAD3;YWHAB;TPTEP2-CSNK1E;ITGB2;LEF1;PPP2R2A;YWHAZ;ACTB;ACTG1;BBC3;PPP1CA;PPP2CA;PPP1CC;MOB1A;YWHAQ;PPP2R1A;NF2;YWHAH;BIRC3
Relaxin signaling pathway	19/129	0.532553324159214	0.761478961241229	0	0	1.0035111221883	0.632284507793214	SMAD2;ATF2;ATF6B;PIK3CB;NFKB1;GNAI2;ACTA2;GNG10;GNA15;CREB1;CREB3L3;GNG5;GNG4;AKT2;GNB2;GNG8;GRB2;PLCB2;MAPK3
Glycine, serine and threonine metabolism	6/40	0.545461850950982	0.773142262480037	0	0	1.02528749473177	0.621449727505876	DMGDH;ALAS1;SHMT2;GLYCTK;PGAM1;SARDH
D-Glutamine and D-glutamate metabolism	1/5	0.548050211378254	0.773142262480037	0	0	1.45257152588556	0.873559621721722	GLUD1
Neomycin, kanamycin and gentamicin biosynthesis	1/5	0.548050211378254	0.773142262480037	0	0	1.45257152588556	0.873559621721722	HK1
Circadian entrainment	14/97	0.57195013773247	0.803272193437603	0	0	0.979848233165299	0.547444601278287	RYR1;CAMK2D;PRKCB;GNAI2;GNG10;CREB1;GNG5;GNG4;GNB2;GNG8;CALM3;CALM2;PLCB2;MAPK3
Inflammatory mediator regulation of TRP channels	14/98	0.588238394436469	0.814833941259662	0	0	0.968126354202304	0.513710091600402	MAP2K3;NTRK1;CAMK2D;IL1R1;PRKCB;ITPR2;PIK3CB;PLA2G6;PPP1CA;PPP1CC;PRKCQ;CALM3;CALM2;PLCB2
Non-homologous end-joining	2/13	0.589341892205488	0.814833941259662	0	0	1.05634195446802	0.558539542488925	XRCC6;XRCC5
Hedgehog signaling pathway	8/56	0.591330242490485	0.814833941259662	0	0	0.968191646750882	0.508669138975538	EVC2;GSK3B;CSNK1A1;SUFU;CUL3;TPTEP2-CSNK1E;SPOP;BCL2
Pyrimidine metabolism	8/56	0.591330242490485	0.814833941259662	0	0	0.968191646750882	0.508669138975538	NT5C3A;NT5C;ENTPD1;CANT1;NUDT2;NME3;DCK;TYMP
Cocaine addiction	7/49	0.593100849771251	0.814833941259662	0	0	0.968202502844141	0.505780106528555	ATF2;CREB1;CREB3L3;ATF6B;CDK5;NFKB1;GNAI2
Tryptophan metabolism	6/42	0.5956539254145	0.814833941259662	0	0	0.968213351529626	0.501626924913752	ALDH3A2;HADHA;ECHS1;CAT;ACAT2;ALDH9A1
Phenylalanine, tyrosine and tryptophan biosynthesis	1/6	0.61443547225777	0.827520628200042	0	0	1.16198910081744	0.565948376530339	GOT2
Phosphonate and phosphinate metabolism	1/6	0.61443547225777	0.827520628200042	0	0	1.16198910081744	0.565948376530339	PCYT2
Vitamin B6 metabolism	1/6	0.61443547225777	0.827520628200042	0	0	1.16198910081744	0.565948376530339	PDXK
Malaria	7/50	0.615402998819652	0.827520628200042	0	0	0.945630605603619	0.459082801384312	IL10;SELP;CD40LG;GYPC;KLRB1;ITGB2;ITGAL
Porphyrin and chlorophyll metabolism	6/43	0.619608142362705	0.828204130372337	0	0	0.941990096544856	0.450900543043213	ALAD;ALAS1;UROS;CPOX;COX10;BLVRA
GnRH signaling pathway	13/93	0.621153097779252	0.828204130372337	0	0	0.943822674418605	0.449427303863482	MAP2K3;CAMK2D;MAP3K1;PRKCB;ITPR2;ELK1;CDC42;CALM3;GRB2;PLCB2;CALM2;MAP3K4;MAPK3
Estrogen signaling pathway	19/137	0.643403624953168	0.85426699783698	0	0	0.93503502515073	0.412334578673037	NCOA1;ATF2;HSPA8;ATF6B;NCOA3;ITPR2;PIK3CB;KRT10;GNAI2;CREB1;CREB3L3;AKT2;BCL2;CALM3;GRB2;CALM2;PLCB2;FKBP5;MAPK3
Alanine, aspartate and glutamate metabolism	5/37	0.650413191374749	0.855371201328083	0	0	0.907603598226467	0.390403363415841	GLUD1;ADSL;GOT2;ASNS;ABAT
Aldosterone-regulated sodium reabsorption	5/37	0.650413191374749	0.855371201328083	0	0	0.907603598226467	0.390403363415841	PRKCB;ATP1B3;PIK3CB;ATP1B1;MAPK3
Wnt signaling pathway	23/166	0.652355884557177	0.855371201328083	0	0	0.933904804872547	0.398931474699306	GSK3B;WNT10A;CAMK2D;SMAD3;PRKCB;CSNK1A1;TPTEP2-CSNK1E;LEF1;NFATC2;NFATC1;CACYBP;PSEN1;RHOA;RBX1;FRAT2;DAAM1;TBL1XR1;RUVBL1;CSNK2B;RAC2;RAC1;PLCB2;SKP1
cAMP signaling pathway	30/216	0.659266926537714	0.860860945396354	0	0	0.936393799172187	0.390126732080503	CAMK2D;VIPR2;ROCK1;PIK3CB;GNAI2;PPP1CC;RAP1A;CREB3L3;AKT2;RAC2;PDE4B;RAC1;MAPK3;VAV3;PPP1R12A;ATP2B4;NFATC1;ATP1B3;ATP2B1;ATP1B1;RHOA;NFKB1;TSHR;PPP1CA;TIAM1;CREB1;ADORA2A;FXYD1;CALM3;CALM2
Thiamine metabolism	2/15	0.669356173406771	0.867204779540847	0	0	0.893722972087538	0.358775223843662	TPK1;NTPCR
GABAergic synapse	12/89	0.671048528443259	0.867204779540847	0	0	0.905014985014985	0.361022986691559	NSF;GABARAPL2;GNG10;GNG5;PRKCB;GNG4;PLCL1;GNB2;GNG8;ABAT;GABARAP;GNAI2
Neutrophil extracellular trap formation	26/189	0.672358136036416	0.867204779540847	0	0	0.926041058561454	0.367605092315575	HDAC3;SELPLG;HDAC1;NCF4;ITGB2;PIK3CB;ITGAL;HDAC9;ACTB;ACTG1;HDAC7;CLEC7A;AKT2;CASP4;CASP1;RAC2;RAC1;MAPK3;PRKCB;NFKB1;SELP;VDAC2;VDAC1;SLC25A5;PLCB2;SLC25A6
Mannose type O-glycan biosynthesis	3/23	0.677357634968414	0.8701016774391	0	0	0.871319018404908	0.339427448018638	B4GALT3;B4GALT1;POMT1
Type II diabetes mellitus	6/46	0.68635356610579	0.875545642719478	0	0	0.871187308085977	0.327882130042075	IKBKB;SOCS3;PKM;PIK3CB;HK1;MAPK3
Asthma	4/31	0.687137086691236	0.875545642719478	0	0	0.860501824702302	0.322878753337637	IL10;IL4;CD40LG;IL13
Fanconi anemia pathway	7/54	0.697484978577546	0.885161659560259	0	0	0.864948079297074	0.311618565195987	RMI2;RPA3;REV3L;RPA1;RPA2;HES1;POLK
Sulfur relay system	1/8	0.719392184941448	0.90931172176599	0	0	0.829894900739587	0.273324732901256	URM1
Nitrogen metabolism	2/17	0.736247663022331	0.92323119648832	0	0	0.774469051675185	0.237133686206064	GLUD1;CA8
Selenocompound metabolism	2/17	0.736247663022331	0.92323119648832	0	0	0.774469051675185	0.237133686206064	SEPHS2;PAPSS1
TGF-beta signaling pathway	12/94	0.743333944177728	0.928432910514475	0	0	0.849580988117573	0.251994116152996	PPP2CA;SMAD2;SMAD1;TGIF2;SMAD3;ROCK1;PPP2R1A;RPS6KB2;RHOA;SKP1;RBX1;MAPK3
PPAR signaling pathway	9/74	0.777374966576708	0.967127911174172	0	0	0.803814627994956	0.202426617204217	SCP2;GK;FABP5;UBC;DBI;ACSL4;PLIN2;PPARG;PCK2
Signaling pathways regulating pluripotency of stem cells	18/143	0.794267194131869	0.981942545717958	0	0	0.835584789311408	0.192464721422555	SMAD2;SMAD1;GSK3B;WNT10A;SMAD3;STAT3;LIF;PIK3CB;REST;AKT2;GRB2;IL6ST;JARID2;JAK3;FGFR2;FGFR1;JAK1;MAPK3
Starch and sucrose metabolism	4/36	0.795497758556321	0.981942545717958	0	0	0.725835322195704	0.16606186649214	GPI;UGP2;PGM2L1;HK1
Chemical carcinogenesis	31/239	0.79934336579679	0.982850208528349	0	0	0.864433334215681	0.193602536032445	ATF2;ATF6B;MGST2;AHR;PIK3CB;GNAI2;HPGDS;CREB3L3;AKT2;RPS6KA2;RPS6KA1;KPNA2;IKBKE;MAPK3;STAT5A;GSTK1;STAT5B;PRKCB;GSTO1;VDR;PTGES3;EPHX2;STAT3;AIP;NFKB1;CREB1;BCL6;RPS6KB2;BCL2;GRB2;KPNB1
Axon guidance	23/182	0.811770635705583	0.986776456178714	0	0	0.8391327056975	0.174990592194931	EPHB6;ITGB1;GSK3B;CAMK2D;ROCK1;NFATC2;PTPN11;PIK3CB;RHOA;GNAI2;EFNB2;CDC42;CDK5;CFL2;RASA1;CFL1;NCK2;RAC2;RAC1;PAK3;PAK2;NCK1;MAPK3
African trypanosomiasis	4/37	0.813083739167427	0.986776456178714	0	0	0.703798985421897	0.145630912698313	IL10;PRKCB;FAS;PLCB2
Steroid biosynthesis	2/20	0.814729409621208	0.986776456178714	0	0	0.645277304561802	0.132216825167039	LBR;FDFT1
Progesterone-mediated oocyte maturation	12/100	0.815027389438748	0.986776456178714	0	0	0.791375291375291	0.161862805350318	STK10;AKT2;CDC26;RPS6KA2;RPS6KA1;PIK3CB;MAD1L1;ANAPC10;CDC25B;ANAPC11;GNAI2;MAPK3
Salivary secretion	11/93	0.822029829373632	0.991455824740717	0	0	0.778516412983679	0.152572553430544	PRKCB;ATP2B4;CD38;ITPR2;ATP1B3;CALM3;ATP2B1;ATP1B1;KCNN4;PLCB2;CALM2
Melanogenesis	12/101	0.825381847996506	0.991506172607015	0	0	0.782437337942956	0.150156887325442	GSK3B;WNT10A;CAMK2D;CREB1;CREB3L3;PRKCB;LEF1;CALM3;CALM2;PLCB2;GNAI2;MAPK3
Insulin secretion	10/86	0.82982504152823	0.991506172607015	0	0	0.76362541132469	0.142446984906788	ATF2;CAMK2D;CREB1;CREB3L3;ATF6B;PRKCB;ATP1B3;ATP1B1;KCNN4;PLCB2
Cushing syndrome	19/155	0.834018547333281	0.991506172607015	0	0	0.810418598556626	0.147090682154611	ATF2;GSK3B;WNT10A;CAMK2D;CDKN1B;ATF6B;CDKN2A;LEF1;AIP;ITPR2;AHR;GNAI2;RAP1A;CREB1;CREB3L3;E2F3;PLCB2;LDLR;MAPK3
Pancreatic secretion	12/102	0.835293798927426	0.991506172607015	0	0	0.773698005698006	0.139243792579134	RAP1A;PRKCB;RAB3D;ATP2B4;ITPR2;CD38;ATP1B3;RAC1;ATP2B1;ATP1B1;PLCB2;RHOA
Ascorbate and aldarate metabolism	3/30	0.837759962297699	0.991506172607015	0	0	0.64515640384761	0.114207948335964	ALDH3A2;AKR1A1;ALDH9A1
Alcoholism	23/186	0.842035584079152	0.992847927496313	0	0	0.818346800510335	0.140700823935136	ATF2;NTRK2;HDAC3;ATF6B;HDAC1;HDAC9;GNAI2;HDAC7;PPP1CA;PPP1CC;GNG10;CREB1;CREB3L3;ADORA2A;GNG5;GNG4;GNB2;PKIA;GNG8;CALM3;GRB2;CALM2;MAPK3
GnRH secretion	7/64	0.848518504228151	0.996662956126147	0	0	0.712783665648763	0.117084258676155	PRKCB;AKT2;ITPR2;PIK3CB;KCNN4;PLCB2;MAPK3
Arginine biosynthesis	2/22	0.854733104779069	0.996662956126147	0	0	0.580681431005111	0.091147251330091	GLUD1;GOT2
Histidine metabolism	2/22	0.854733104779069	0.996662956126147	0	0	0.580681431005111	0.091147251330091	ALDH3A2;ALDH9A1
Cortisol synthesis and secretion	7/65	0.85954631042031	0.998590566517713	0	0	0.700453101094504	0.106013979582356	ATF2;CREB1;CREB3L3;ATF6B;ITPR2;PLCB2;LDLR
Bladder cancer	4/41	0.871391832334498	0.999995406020107	0	0	0.627565171717916	0.0863928421033304	CDKN2A;E2F3;TYMP;MAPK3
Renin-angiotensin system	2/23	0.871625965255904	0.999995406020107	0	0	0.5529974851951	0.0759790264479979	CTSA;MME
Morphine addiction	10/91	0.877268641458719	0.999995406020107	0	0	0.716277147207565	0.0937907728556018	GNG10;GNG5;PRKCB;GNG4;GNB2;GRK6;PDE4B;GNG8;PDE7B;GNAI2
Vitamin digestion and absorption	2/24	0.886691982838033	0.999995406020107	0	0	0.527830261731454	0.0634756079832081	ABCC1;LMBRD1
Pentose and glucuronate interconversions	3/34	0.894165823971799	0.999995406020107	0	0	0.561778481430174	0.0628428080358224	UGP2;AKR1A1;CRYL1
Renin secretion	7/69	0.89726869477445	0.999995406020107	0	0	0.655108444346582	0.0710136987234959	CREB1;ITPR2;CALM3;PLCB2;CALM2;CTSB;GNAI2
Folate biosynthesis	2/26	0.912020548565639	0.999995406020107	0	0	0.483787620670074	0.0445533361961942	GCH1;AKR1C3
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/26	0.912020548565639	0.999995406020107	0	0	0.483787620670074	0.0445533361961942	PIGS;PIGB
ABC transporters	4/45	0.913289089771373	0.999995406020107	0	0	0.566206248492761	0.0513564985125814	ABCC1;ABCB7;TAP1;ABCG1
Mucin type O-glycan biosynthesis	3/36	0.915159246164747	0.999995406020107	0	0	0.527669331350313	0.0467816798107439	GALNT7;ST6GALNAC1;GALNT10
Tyrosine metabolism	3/36	0.915159246164747	0.999995406020107	0	0	0.527669331350313	0.0467816798107439	GOT2;COMT;ADH5
Regulation of lipolysis in adipocytes	5/55	0.921849231733902	0.999995406020107	0	0	0.58025238744884	0.0472172209532589	AKT2;PIK3CB;TSHR;GNAI2;PNPLA2
Phototransduction	2/28	0.931959457631573	0.999995406020107	0	0	0.446520770541213	0.0314645172736211	CALM3;CALM2
Phenylalanine metabolism	1/17	0.932867552014345	0.999995406020107	0	0	0.362887431880109	0.0252177906416642	GOT2
Fatty acid biosynthesis	1/18	0.942734060301723	0.999995406020107	0	0	0.341521077095688	0.02013985673495	ACSL4
Protein digestion and absorption	10/103	0.948518783912425	0.999995406020107	0	0	0.623413455003655	0.0329496989955687	COL5A1;MME;SLC7A8;COL5A3;COL6A3;ATP1B3;SLC16A10;COL9A2;ATP1B1;KCNN4
ECM-receptor interaction	8/88	0.956754257440802	0.999995406020107	0	0	0.579822465005121	0.0256332001844531	ITGB1;ITGA4;SDC4;ITGB8;COL6A3;CD47;COL9A2;CD44
Glutamatergic synapse	11/114	0.957656969245449	0.999995406020107	0	0	0.619023286371268	0.0267824354499294	GNG10;GNG5;PRKCB;GNG4;GNB2;ITPR2;GNG8;DLGAP1;PLCB2;GNAI2;MAPK3
Pantothenate and CoA biosynthesis	1/21	0.964455811012654	0.999995406020107	0	0	0.290241825613079	0.0105042182795436	ALDH3A2
Calcium signaling pathway	26/240	0.967273787538743	0.999995406020107	0	0	0.70322046250606	0.0233987416019822	RYR1;CAMK2D;PDGFA;ITPR2;GNA15;HRH2;CD38;NTRK1;NTRK2;PRKCB;ATP2B4;ATP2B1;P2RX5;STIM1;ADORA2A;ORAI3;VDAC2;VDAC1;CALM3;CAMK1;SLC25A5;CALM2;PLCB2;FGFR2;FGFR1;SLC25A6
Metabolism of xenobiotics by cytochrome P450	6/76	0.975143106118233	0.999995406020107	0	0	0.496943997660477	0.0125085988573836	GSTK1;AKR7A2;HPGDS;GSTO1;MGST2;ADH5
Serotonergic synapse	10/113	0.97694368966622	0.999995406020107	0	0	0.56255618098653	0.0131223343082587	GNG10;GNG5;PRKCB;GNG4;GNB2;ITPR2;GNG8;PLCB2;GNAI2;MAPK3
Arrhythmogenic right ventricular cardiomyopathy	6/77	0.977480242527087	0.999995406020107	0	0	0.489915954272204	0.011158913465626	ITGB1;ITGA4;LEF1;ITGB8;ACTB;ACTG1
Herpes simplex virus 1 infection	58/498	0.97994482667856	0.999995406020107	0	0	0.761102339827592	0.0154191785512	TRADD;PIK3CB;IFIH1;IKBKB;PPP1CC;TBK1;AKT2;ZNF688;EIF2B1;IKBKE;B2M;ZNF564;JAK1;IFNAR2;ZNF561;ZNF282;IFNGR2;HLA-B;TAP1;HLA-C;TRAF2;HLA-A;TICAM1;HLA-F;HLA-E;OAS1;TRAF3;OAS2;IRF7;LTA;SRSF3;SRSF4;SRSF8;SRSF9;BIRC3;SOCS3;TNFRSF14;BAK1;ZNF267;ZNF101;EIF2B4;CD74;EIF2B2;STAT1;EIF2AK1;STAT2;PTPN11;POU2F2;NFKB1;SRPK1;PPP1CA;BST2;BCL2;FAS;BAX;TAB2;CALR;BCL2L1
Gap junction	7/88	0.980818592354507	0.999995406020107	0	0	0.500880630345932	0.00970093466717594	PRKCB;ITPR2;PDGFA;GRB2;PLCB2;GNAI2;MAPK3
alpha-Linolenic acid metabolism	1/25	0.981182712397759	0.999995406020107	0	0	0.241811421435059	0.00459359136378098	PLA2G6
Ether lipid metabolism	3/49	0.981630533174963	0.999995406020107	0	0	0.378256423935272	0.00701298022063466	LPCAT4;PLA2G6;PAFAH1B1
Drug metabolism	9/108	0.983558545446355	0.999995406020107	0	0	0.526701440635867	0.00873171719684275	GSTK1;HPGDS;GSTO1;MGST2;NME3;HPRT1;ADH5;ITPA;TYMP
Maturity onset diabetes of the young	1/26	0.983949155313092	0.999995406020107	0	0	0.232125340599455	0.00375603283226169	HES1
Hypertrophic cardiomyopathy	7/90	0.984172741503796	0.999995406020107	0	0	0.488753649409926	0.00779750095720966	ITGB1;ITGA4;TPM4;ITGB8;ACTB;ACTG1;TTN
Linoleic acid metabolism	1/29	0.990038842457768	0.999995406020107	0	0	0.207218275593616	0.00207448325538135	PLA2G6
Staphylococcus aureus infection	7/95	0.990317286661845	0.999995406020107	0	0	0.460847812596959	0.00448400111434979	IL10;SELP;SELPLG;ITGB2;C3AR1;KRT10;ITGAL
Fat digestion and absorption	2/43	0.990960783979127	0.999995406020107	0	0	0.282910208999875	0.0025689145515727	GOT2;ACAT2
Dilated cardiomyopathy	7/96	0.991239148479152	0.999995406020107	0	0	0.455642903708249	0.00400940849950217	ITGB1;ITGA4;TPM4;ITGB8;ACTB;ACTG1;TTN
Steroid hormone biosynthesis	3/61	0.995960512372916	0.999995406020107	0	0	0.299784923489176	0.00121342996022517	AKR1C3;COMT;CYP7B1
Complement and coagulation cascades	5/85	0.996749972251571	0.999995406020107	0	0	0.362018246930423	0.00117848544217499	ITGB2;C3AR1;PLAT;CD59;F5
Ovarian steroidogenesis	2/51	0.997053230318272	0.999995406020107	0	0	0.236609533080694	0.000698263114802038	AKR1C3;LDLR
MicroRNAs in cancer	28/310	0.998983532449219	0.999995406020107	0	0	0.572773661588272	0.000582501938285181	CDKN1B;ROCK1;HDAC1;PTEN;PDGFA;PIK3CB;IKBKB;BCL2L11;E2F3;BAK1;MAPK3;ABCC1;UBE2I;PRKCB;CDKN2A;RDX;STAT3;RHOA;NFKB1;CDC25B;FOXP1;HNRNPK;DDIT4;CCNG1;BCL2;GRB2;EZR;CD44
Systemic lupus erythematosus	8/135	0.999580058609277	0.999995406020107	0	0	0.364231698760427	0.00015298809138751	IL10;CD40LG;SNRPD1;CD80;ACTN1;CD28;TRIM21;SNRPB
Bile secretion	3/90	0.999914794013594	0.999995406020107	0	0	0.199515784030275	1.70006634713556e-05	ATP1B3;ATP1B1;LDLR
Retinol metabolism	1/68	0.999976821187199	0.999995406020107	0	0	0.0864004229533531	2.00268243955384e-06	ADH5
Olfactory transduction	3/440	0.999994211043365	0.999995406020107	0	0	0.0389016018306636	2.25200337874351e-07	CAMK2D;CALM3;CALM2
Neuroactive ligand-receptor interaction	18/341	0.999994603554546	0.999995406020107	0	0	0.319588645757432	1.72464734808711e-06	NMB;P2RY10;PTGIR;VIPR2;PMCH;LPAR2;NR3C1;SSTR3;TSHR;P2RY8;P2RX5;ADORA2A;HRH2;C3AR1;TSPO;UTS2;S1PR2;S1PR4
Taste transduction	1/86	0.999995406020107	0.999995406020107	0	0	0.068031735855105	3.12537144487952e-07	PLCB2