Term	Overlap	P.value	Adjusted.P.value	Old.P.value	Old.Adjusted.P.value	Odds.Ratio	Combined.Score	Genes
Endocytosis	100/252	3.06918909624908e-15	9.66794565318461e-13	0	0	2.9410263886864	98.2813464416403	VPS29;WIPF1;WIPF2;WASHC2C;CBLB;WASHC2A;KIF5B;VPS35;VPS36;AP2M1;SH3GL1;SH3GLB1;USP8;IST1;RNF41;RUFY1;ACAP2;BIN1;HGS;RAB35;CHMP4A;VPS28;RAB5B;RAB5C;AGAP2;VPS26A;VPS26B;ACTR3B;PRKCZ;SNX3;RAB11FIP1;GRK5;GRK4;GRK6;RAB11FIP4;SNX6;SMAD2;RAB4A;SMURF2;VTA1;IQSEC3;HSPA6;SNF8;STAM;ARPC5;IGF2R;EHD1;ARPC2;ARPC3;CHMP2B;MDM2;RAB5A;ARF1;CLTC;AP2A1;ARRB1;WASL;RAB22A;EEA1;PSD4;CHMP1A;CCR5;RAB8A;ACTR3;ACTR2;PDCD6IP;ARAP3;VPS37A;VPS37B;RHOA;DNM1;EPN1;TGFBR1;DNM2;EPN2;TRAF6;CHMP6;ARF5;ARF6;RAB7A;SRC;VPS4B;CBL;CDC42;CYTH3;CYTH2;CYTH4;MVB12B;EPS15;GIT2;AP2B1;RAB11B;ITCH;CAPZA1;CAPZA2;IL2RB;VPS45;HSPA1B;SPG21;HSPA1A
Salmonella infection	96/249	8.93310577442587e-14	1.40696415947207e-11	0	0	2.8016536996647	84.1796838604795	CYFIP2;ARF1;HSP90AB1;FHOD1;PIK3CD;WASL;FBXO22;ACTB;PIK3CG;ACTR1A;CASP7;ACTR1B;KIF5B;CASP3;CASP1;AKT1;KPNA4;RAC1;KPNA3;MAP3K7;KPNA1;DYNC2H1;ACTR3;VPS18;MAP2K4;ACTR2;MAP2K2;ANXA2;RIPK2;VPS33A;RHOH;IRAK4;DYNLL1;RHOA;TIRAP;RHOB;DNM2;TNFRSF1A;DYNC1LI1;TRAF6;ELMO2;EXOC5;GAPDH;BIRC2;ARF6;RAB7A;ARL8B;DCTN6;RAB5B;RALA;RAB5C;DCTN2;DCTN1;ROCK2;DCTN4;SNX33;ACTR3B;MYL12A;RELA;MYL12B;STX10;HSP90B1;DYNC2LI1;CDC42;CYTH3;CYTH2;KLC2;CYTH4;RRAS;MYO6;MAPK1;SNX9;RIPK1;FADD;MAP2K7;RILP;VPS16;MAP2K6;DYNC1H1;ARPC5;TUBB4B;TUBB4A;MAPK12;MAPK11;SNX18;ARPC2;ARPC3;VPS41;BCL2;CTNNB1;BAX;PKN1;DYNLRB1;ACTR10;RAB5A;MYD88
Yersinia infection	55/137	3.03201677392137e-09	3.18361761261744e-07	0	0	2.97434186380167	58.338853856439	ITGB1;WIPF1;WIPF2;PIK3CD;WASL;ACTB;CRKL;RPS6KA3;TBK1;RPS6KA1;CASP1;RAC2;AKT1;RAC1;MAP3K7;ACTR3;VAV3;MAP2K4;ACTR2;MAP2K2;ARHGEF12;IRAK4;RHOA;LCK;TRAF6;ELMO2;LCP2;ARHGEF7;SKAP2;ARF6;ROCK1;ROCK2;SRC;PIK3R3;PIK3R1;ACTR3B;RELA;CDC42;MAPK1;PTK2B;MAP2K7;WASF2;MAP2K6;GIT2;LIMK1;NFATC3;ARPC5;BAIAP2;MAPK12;MAPK11;ARPC2;ARPC3;GNAQ;PKN1;MYD88
Shigellosis	83/246	8.41538734657177e-09	6.62711753542527e-07	0	0	2.2641047630163	42.0969616905646	ITGB1;ARF1;CALCOCO2;UBE2D3;ILK;PIK3CD;WASL;ACTB;CRKL;HK1;RPS6KA5;TBK1;CAPNS1;CASP1;AKT1;RAC1;CAPN1;MAP3K7;CAST;ACTR3;ACTR2;GABARAPL1;FNBP1;RIPK2;PRKCE;WIPI1;ACTN4;ATG12;RHOA;RBX1;TNFRSF1A;RRAGA;PLCB3;TRAF6;TRAF5;UBE2V2;HCLS1;ELMO2;VDAC1;RBCK1;TLN1;SQSTM1;PPID;ARF6;BECN1;ROCK1;ROCK2;SRC;PIK3R3;U2AF1;PIK3R1;FOXO3;ACTR3B;MYL12A;RELA;MYL12B;U2AF1L4;CDC42;CYTH3;CYTH2;SHARPIN;CYTH4;UBB;CCL5;UBC;PLCG2;MAPK1;RIPK1;WASF1;WASF2;ATG5;BNIP3;ARPC5;MAPK12;MAPK11;ARPC2;TNIP1;ARPC3;BCL2;MDM2;BAX;MYD88;BCL2L1
Protein processing in endoplasmic reticulum	59/171	4.89235293320631e-07	3.08218234791998e-05	0	0	2.33424795555034	33.9176085254967	HSP90AB1;UBXN2A;PRKCSH;UBE2D3;NGLY1;MAN1A2;UFD1;FBXO6;MAN1A1;CAPN1;UBXN4;SEC63;PDIA3;FBXO2;RAD23A;PDIA6;RAD23B;DDOST;RBX1;DNAJC3;SELENOS;DAD1;DNAJB11;CANX;PLAA;PREB;MAN1B1;ATF6;VCP;SAR1A;RPN1;DERL1;UBE2J2;RNF5;HSP90B1;UBE2J1;DNAJB2;ERLEC1;GANAB;HSPH1;BAG1;MAN1C1;MAP2K7;BCAP31;HSPA5;EIF2AK1;HSPA6;SYVN1;UBE2G1;SVIP;DNAJC10;DNAJA2;BCL2;BAX;STUB1;CALR;SEC24C;HSPA1B;HSPA1A
Pathogenic Escherichia coli infection	65/197	8.21126806744527e-07	4.31091573540877e-05	0	0	2.18287816435965	30.5877729943788	CYFIP2;ITGB1;ARF1;WIPF1;WIPF2;FASLG;WASL;ACTB;CASP9;CASP7;CASP3;CASP1;RAC1;MAP3K7;NCK1;ACTR3;ACTR2;ARHGEF12;IRAK4;RHOA;TIRAP;TNFRSF1A;NCL;TRAF6;CLDN7;HCLS1;MYH9;GAPDH;ARF6;ROCK1;ROCK2;SRC;ACTR3B;RELA;CDC42;CYTH3;SLC9A3R1;CYTH2;CYTH4;MYO6;ABL1;MAPK1;RIPK1;FYN;FADD;WASF1;PAK2;WASF2;PTPN11;ARPC5;TUBB4B;BAIAP2;TUBB4A;MAPK12;MYO1D;MAPK11;MYO1E;MYO1C;LPAR5;ARPC2;ARPC3;BAX;PTPN6;SEC24C;MYD88
Natural killer cell mediated cytotoxicity	47/131	1.99591613648816e-06	8.98162261419673e-05	0	0	2.47546897546898	32.4890633320582	PRF1;PIK3R3;PIK3CD;FASLG;KIR2DL1;PIK3R1;KIR2DL3;ICAM1;PPP3CA;PPP3R1;KLRK1;CASP3;KLRC4-KLRK1;SH3BP2;PLCG2;RAC2;MAPK1;PTK2B;FYN;KLRC1;RAC1;IFNAR2;VAV3;MAP2K2;FCER1G;KLRC2;KLRC3;SH2D1B;PRKCA;KIR3DL1;PTPN11;KIR3DL2;KIR3DL3;NCR1;NCR2;NCR3;TYROBP;LCK;GRB2;KLRD1;LCP2;PTPN6;CD247;SOS1;HCST;SOS2;CD244
Human cytomegalovirus infection	70/225	3.51685767903078e-06	0.000129540965353283	0	0	2.00186104218362	25.1392562047985	CDKN1A;CCL4L2;PIK3CD;FASLG;CRKL;CASP9;AKAP13;PPP3CA;TBK1;GNGT2;CASP3;CREB3L2;RAC2;AKT1;ITGAV;RAC1;CCR5;PRKACB;JAK1;PDIA3;MAP2K2;ARHGEF12;PRKCA;RHOA;TNFRSF1A;CREB3;PLCB3;ADCY9;TRAF5;SOS1;SOS2;CCL3L1;ROCK1;PTGER1;ROCK2;SRC;PTGER2;GNAI3;PIK3R3;ADCY3;PIK3R1;RELA;GNAI2;PPP3R1;GNG2;GNG5;CCL5;CCL4;EIF4EBP1;MAPK1;PTK2B;RIPK1;FADD;MAP2K6;NFATC3;MAPK12;MAPK11;CDK6;CDK4;RHEB;GNAQ;GNB2;GNAS;MDM2;CTNNB1;BAX;GRB2;CALR;GNB5;CALM2
Herpes simplex virus 1 infection	133/498	3.70117043866522e-06	0.000129540965353283	0	0	1.62225558266091	20.2893258146092	ZNF331;ZNF571;PPP1CB;TBK1;ZNF81;ZFP30;ZNF606;ZNF84;AKT1;ZNF569;ZNF568;ZNF567;ZNF600;ZNF721;ZNF324;ZNF566;MAP3K7;ZNF564;ZNF17;IFNAR2;ZNF441;PDIA3;DAXX;ZNF680;ZNF160;ZNF10;ZNF12;ZNF14;ZNF91;ZNF718;ZNF558;SRSF5;ZNF555;ZNF554;SRSF8;ZNF432;SRSF9;ZNF431;ZNF552;ZNF430;ZNF550;ZNF791;PIK3R3;PIK3R1;ZNF25;ZNF549;EIF4EBP1;ZNF669;ZNF701;ZNF700;FADD;ZNF544;ZNF665;ZNF786;ZNF420;ZNF540;ZNF141;ZNF383;ZNF140;ZNF382;TNFSF14;EIF2AK1;ZNF34;BST2;ZNF816;RHEB;BCL2;ZNF416;CALR;ZNF136;ZNF256;MYD88;ZNF773;BCL2L1;ZNF254;ZNF250;ZNF490;ZNF43;PIK3CD;ZNF44;FASLG;CASP9;ZNF808;ZNF528;CASP3;ZNF768;ZNF766;EIF2B1;ZNF124;JAK1;APAF1;ZNF480;IRAK4;ZFP90;TNFRSF1A;TRAF6;TRAF5;ZNF235;ZNF234;BIRC2;ZNF630;ZNF595;ZNF230;ZNF350;ZNF195;SRC;ZNF3;RELA;CCL5;ZNF627;ZNF746;ZNF624;ZNF227;ZNF623;ZNF226;ZNF468;ZNF224;ZNF585A;ZNF100;ZNF583;ZNF461;ZNF184;PTPN11;PPP1CA;ZNF33A;ZNF619;ZNF737;ZNF614;BAX;ZNF699;ZNF853;ZNF354A;ZFP28
Neurotrophin signaling pathway	43/119	4.32551013894864e-06	0.000136253569376882	0	0	2.50169362593831	30.8983691242285	ZNF274;PRDM4;IRS1;MAGED1;PSEN2;PIK3R3;PIK3CD;FASLG;PIK3R1;PSEN1;FOXO3;RELA;CRKL;RAP1B;CDC42;RPS6KA3;RPS6KA5;RAP1A;ARHGDIA;RPS6KA1;ABL1;PLCG2;AKT1;MAPK1;RAC1;MAP2K7;SH2B3;MAP2K2;RIPK2;MATK;PTPN11;IRAK4;RHOA;MAPK12;MAPK11;TRAF6;CAMK4;BCL2;BAX;GRB2;SOS1;CALM2;SOS2
Vasopressin-regulated water reabsorption	21/44	9.83702534303554e-06	0.00028169663482329	0	0	4.02615295767676	46.4189555713238	DCTN6;DYNC2H1;DYNC1H1;RAB5B;RAB5C;DCTN2;DCTN1;DCTN4;ADCY3;DYNLL1;RAB11B;DYNC2LI1;CREB3;DYNC1LI1;ADCY9;ARHGDIA;CREB3L2;GNAS;STX4;PRKACB;RAB5A
Sphingolipid signaling pathway	42/119	1.09189345424108e-05	0.000286622031738283	0	0	2.41097452166154	27.5454132317346	ASAH1;ROCK1;SGMS1;ROCK2;GNAI3;PIK3R3;PIK3CD;PIK3R1;PRKCZ;RELA;GNAI2;PPP2CA;SMPD2;SPTLC1;SPTLC2;PPP2R5E;SMPD1;RAC2;AKT1;MAPK1;FYN;S1PR3;RAC1;CTSD;CERS4;ABCC1;MAP2K2;FCER1G;PRKCE;SPHK1;PPP2R5B;PRKCA;RHOA;MAPK12;TNFRSF1A;MAPK11;PLCB3;PPP2R2B;GNAQ;BCL2;BAX;DEGS1
Platelet activation	43/124	1.42821096795257e-05	0.000346066503773122	0	0	2.34654425355271	26.1792277117874	ITGB1;ROCK1;ROCK2;SRC;SNAP23;GNAI3;PIK3R3;PIK3CD;ADCY3;PIK3R1;PRKCZ;ACTB;MYL12A;PIK3R6;PIK3CG;MYL12B;GNAI2;PPP1CB;RAP1B;RAP1A;P2RY1;PLCG2;AKT1;MAPK1;FYN;PRKACB;LYN;VASP;ARHGEF12;FCER1G;PPP1R12A;RHOA;MAPK12;PPP1CA;APBB1IP;VAMP8;MAPK11;PLCB3;ADCY9;GNAQ;GNAS;LCP2;TLN1
Renal cell carcinoma	28/69	1.70747506691406e-05	0.000384181890055663	0	0	3.01381804692572	33.0854225362794	CDKN1A;EPAS1;CUL2;SLC2A1;PIK3CD;PIK3R3;PIK3R1;CRKL;CDC42;RAP1B;RAP1A;AKT1;EP300;MAPK1;PAK6;ELOB;RAC1;VHL;PAK2;EGLN1;MAP2K2;TGFB1;ARNT;PTPN11;RBX1;GRB2;SOS1;SOS2
Leukocyte transendothelial migration	40/114	2.04825957450794e-05	0.000430134510646668	0	0	2.38839384343472	25.7849447369862	ITGB1;NCF1;ROCK1;ROCK2;TXK;GNAI3;PIK3R3;PIK3CD;PIK3R1;ACTB;MYL12A;ICAM1;MYL12B;GNAI2;RAP1B;CDC42;RAP1A;RASSF5;PLCG2;RAC2;CTNNA1;PTK2B;RAC1;CD99;JAM3;VASP;VAV3;MSN;RHOH;CYBA;PRKCA;PTPN11;ACTN4;RHOA;MAPK12;MAPK11;CLDN7;PECAM1;CTNNB1;SIPA1
Ubiquitin mediated proteolysis	46/140	3.51833367984267e-05	0.000663026215623288	0	0	2.16312830995076	22.1827466480268	MGRN1;UBE2D3;CUL2;KEAP1;XIAP;CBLB;UBE3A;RNF7;UBE2J2;CBL;ANAPC11;RHOBTB2;UBE2J1;CDC23;SOCS1;UBB;UBE2Q2;CDC26;UBC;ELOB;VHL;UBE2F;PIAS3;UBE2I;FBXW8;SMURF2;FBXW7;FANCL;FBXO2;UBE2E3;SIAH1;UBE2E1;SYVN1;UBE4A;UBE2G1;UBE2A;RBX1;DDB1;ITCH;TRAF6;MDM2;UBA3;UBA2;STUB1;BIRC2;UBE2M
Colorectal cancer	32/86	3.57823671923679e-05	0.000663026215623288	0	0	2.61591444625702	26.7818768194961	CDKN1A;RALA;RALB;PIK3CD;PIK3R3;PIK3R1;AREG;BBC3;CASP9;BCL2L11;CASP3;RAC2;AKT1;MAPK1;RAC1;RALGDS;APPL1;SMAD2;MAP2K2;TGFB1;GADD45B;AXIN1;RHOA;TGFBR1;APC;MSH3;BCL2;BAX;CTNNB1;GRB2;SOS1;SOS2
Longevity regulating pathway	36/102	4.50650062467868e-05	0.000788637609318769	0	0	2.40867026278022	24.1045376926128	HDAC2;PRKAA1;IRS1;EHMT2;PRKAG1;EHMT1;PIK3R3;PIK3CD;PRKAG2;ADCY3;IRS2;PIK3R1;ADIPOR1;FOXO3;ADIPOR2;RELA;CAMKK2;ATG101;CREB3L2;EIF4EBP1;AKT1;EIF4EBP2;PRKACB;EIF4E;ATG5;APPL1;HSPA6;PRKAB1;CREB3;ADCY9;RHEB;CAMK4;CAT;BAX;HSPA1B;HSPA1A
Human immunodeficiency virus 1 infection	63/212	5.03409941785677e-05	0.000834600692960465	0	0	1.87132386092826	18.5199136741534	PIK3CD;CD3G;FASLG;CD3E;CRKL;CASP9;PPP3CA;TBK1;GNGT2;CASP3;CFL1;RAC2;AKT1;AP1S1;ELOB;AP1S3;RAC1;CCR5;MAP3K7;PDIA3;MAP2K2;PRKCA;IRAK4;RBX1;TNFRSF1A;DDB1;TRAF6;TRAF5;GNAI3;PIK3R3;PIK3R1;RNF7;RELA;GNAI2;PPP3R1;GNG2;GNG5;PLCG2;PAK6;MAPK1;PTK2B;RIPK1;FADD;MAP2K7;PAK2;MAP2K6;APOBEC3C;APOBEC3G;LIMK1;NFATC3;MAPK12;BST2;MAPK11;GNAQ;GNB2;BCL2;BAX;CALR;GNB5;CD247;CALM2;MYD88;BCL2L1
Bacterial invasion of epithelial cells	29/77	6.32489311820955e-05	0.000996170666118004	0	0	2.6658177125781	25.7742781549944	ITGB1;SRC;CLTC;ILK;PIK3CD;PIK3R3;WASL;PIK3R1;CBL;ACTR3B;ACTB;CRKL;CDC42;CTNNA1;RAC1;WASF1;WASF2;ACTR3;ACTR2;ARPC5;DNM1;RHOA;DNM2;MAD2L2;ARPC2;ARPC3;ELMO2;HCLS1;CTNNB1
Fc gamma R-mediated phagocytosis	34/97	8.48004906313374e-05	0.00127200735947006	0	0	2.38232550909374	22.334800100377	NCF1;INPPL1;PIK3R3;PIK3CD;PIK3R1;ACTR3B;CRKL;CDC42;INPP5D;CFL1;PLCG2;RAC2;AKT1;MAPK1;RAC1;WASF1;WASF2;LYN;VASP;ACTR3;VAV3;ACTR2;PRKCE;SPHK1;LIMK1;PRKCA;ARPC5;DNM2;ARPC2;BIN1;ARPC3;PLPP2;PLPP1;ARF6
Autophagy	44/137	9.41531210400238e-05	0.00128981606545551	0	0	2.0903155412421	19.37845449425	BECN1;PRKAA1;IRS1;WDR41;PIK3R3;PIK3CD;IRS2;PIK3R1;CAMKK2;PPP2CA;TBK1;LAMP1;RRAS;ATG101;AKT1;MAPK1;MAP3K7;PRKACB;ATG7;CTSD;RAB8A;ATG5;SH3GLB1;ATG3;GABARAPL1;MAP2K2;DAPK2;BNIP3;DAPK3;RRAS2;WIPI1;ATG12;RAB33B;VAMP8;RRAGA;RHEB;TRAF6;BCL2;ULK2;ATG4A;SQSTM1;BCL2L1;ATG4D;RAB7A
Pentose phosphate pathway	15/30	9.41770460491328e-05	0.00128981606545551	0	0	4.40460081190798	40.8321210092133	PRPS2;GPI;G6PD;PGD;DERA;RPIA;PGM2;ALDOC;IDNK;PGLS;ALDOA;FBP1;PGM1;PFKP;RBKS
Lysosome	41/128	0.000170929036315608	0.00224344360164236	0	0	2.0811928459319	18.0528121844286	CD63;ASAH1;CLTC;CTSZ;CTSW;TCIRG1;LIPA;LITAF;AP4M1;LAPTM4B;AP3M1;CTSO;GNPTAB;LAMP1;SMPD1;ATP6V0A2;AP1S1;ATP6V1H;ACP5;IDS;AP1S3;ARSG;AP3S1;GUSB;CTSD;CTSC;CTSA;ABCA2;CD164;MANBA;FUCA1;FUCA2;AP3D1;AP4B1;IGF2R;SUMF1;GALC;GNPTG;DNASE2;ATP6V0D1;ATP6V0C
Insulin signaling pathway	43/137	0.000200075602938835	0.00252095259702933	0	0	2.02040046649531	17.2073775004199	PYGB;PRKAA1;IRS1;PDE3B;INPPL1;PRKAG1;PIK3R3;PIK3CD;PRKAG2;CBLB;IRS2;PIK3R1;CBL;PRKCZ;CRKL;HK1;PPP1CB;SOCS1;PRKAR2B;PRKAR2A;PHKG2;EIF4EBP1;FLOT1;AKT1;FLOT2;MAPK1;PRKACB;EIF4E;PTPN1;MAP2K2;PRKAB1;PPP1CA;PPP1R3B;PRKAR1A;RHEB;PPP1R3D;TRIP10;GRB2;SOS1;CALM2;FBP1;SOS2;RHOQ
Adherens junction	26/71	0.000251689312105202	0.0030493128197361	0	0	2.54777415852334	21.1142073051459	SRC;PTPRJ;WASL;IQGAP1;ACTB;CDC42;RAC2;CTNNA1;EP300;MAPK1;FYN;RAC1;WASF1;ACP1;MAP3K7;WASF2;PTPN1;YES1;ACTN4;BAIAP2;RHOA;TGFBR1;FER;CTNNB1;PTPN6;NECTIN3
Fc epsilon RI signaling pathway	25/68	0.000306086264567489	0.00357100641995404	0	0	2.5633460603957	20.7416827067353	PIK3CD;PIK3R3;PIK3R1;INPP5D;RAC2;PLCG2;AKT1;MAPK1;FYN;RAC1;MAP2K7;MAP2K6;VAV3;LYN;MAP2K4;FCER1G;MAP2K2;PRKCA;MAPK12;MAPK11;ALOX5AP;LCP2;GRB2;SOS1;SOS2
T cell receptor signaling pathway	34/104	0.000387154179241217	0.00435548451646369	0	0	2.14316803979481	16.8382016521724	PIK3R3;PIK3CD;CBLB;CD3G;PIK3R1;CD3E;RELA;CDC42;PPP3CA;PPP3R1;AKT1;MAPK1;PAK6;MAP3K8;FYN;MAP2K7;MAP3K7;PAK2;NCK1;VAV3;MAP2K2;NFATC3;RHOA;MAPK12;MAPK11;TEC;CDK4;LCK;GRB2;LCP2;PTPN6;CD247;SOS1;SOS2
Regulation of actin cytoskeleton	61/218	0.000404435422493372	0.00439300545122111	0	0	1.71779546966013	13.4211677526481	CYFIP2;ITGB1;PIK3CD;WASL;ITGAE;ACTB;CRKL;PPP1CB;FGF9;TMSB4X;CFL1;RAC2;PIP4K2A;ITGAV;ITGB7;PIP4K2C;RAC1;VAV3;PDGFRB;ACTR3;ACTR2;MAP2K2;ARHGEF12;PPP1R12A;ITGA3;ITGA1;RRAS2;ACTN4;RHOA;MYH9;ARHGEF7;SOS1;SOS2;ROCK1;ROCK2;SRC;PIK3R3;IQGAP1;PIK3R1;ACTR3B;MYL12A;MYL12B;CDC42;RRAS;PDGFD;PAK6;MAPK1;WASF1;PAK2;WASF2;LIMK1;MSN;ARPC5;BAIAP2;SSH3;PPP1CA;SSH1;LPAR5;ARPC2;APC;ARPC3
Phospholipase D signaling pathway	44/148	0.000631652037678852	0.00663234639562795	0	0	1.86795501279953	13.7615456597118	DGKE;ARF1;RALA;DGKD;RALB;PIK3R3;PIK3CD;ADCY3;PIK3R1;AGPAT2;PIK3R6;PIK3CG;CYTH3;CYTH2;CYTH4;RRAS;PDGFD;PLCG2;AKT1;MAPK1;PTK2B;FYN;RALGDS;PDGFRB;MAP2K2;FCER1G;SPHK1;RRAS2;PRKCA;PTPN11;DNM1;RHOA;DNM2;PLCB3;ADCY9;LPAR5;RHEB;GNAS;GRB2;SOS1;PLPP2;SOS2;PLPP1;ARF6
Chemokine signaling pathway	54/192	0.00073680813862605	0.00748692140861954	0	0	1.72876034630387	12.4698647880119	NCF1;CCL4L2;PIK3CD;ARRB1;PIK3CG;CRKL;PREX1;GNGT2;CCR9;RAC2;AKT1;RAC1;CCR5;PRKACB;VAV3;RHOA;FGR;PLCB3;ADCY9;XCL2;XCL1;SOS1;SOS2;CCL3L1;ROCK1;ROCK2;SRC;GNAI3;PIK3R3;ADCY3;PIK3R1;FOXO3;PRKCZ;PIK3R6;RELA;GNAI2;RAP1B;CDC42;RAP1A;GNG2;GRK5;GNG5;GRK4;CCL5;GRK6;CCL4;PLCG2;MAPK1;PTK2B;LYN;GNAQ;GNB2;GRB2;GNB5
Thermogenesis	63/232	0.000776003042828196	0.00763877995284006	0	0	1.64782109961499	11.8006304151784	SMARCB1;PRKAG1;PRKAG2;ACTB;RPS6KA3;CREB3L2;RPS6KA1;UQCRFS1;PRKACB;COA5;SMARCC2;ACSL1;ACSL5;SIRT6;ACSL3;SDHD;PRKAB1;CREB3;COX7A2L;ADCY9;NDUFS8;NDUFS7;UQCRC1;NDUFS3;SOS1;SOS2;MGLL;SMARCD1;PRKAA1;SMARCD2;SMARCD3;NDUFB10;NDUFB6;ADCY3;COX5A;UQCRH;ATP5MC1;ATP5F1B;COX14;CYC1;NDUFV3;SLC25A20;NDUFV1;COA4;SMARCE1;COA3;COA1;NDUFA6;NDUFA3;BMP8B;ATP5F1C;SMARCA2;ATP5F1D;MAPK12;MAPK11;NDUFAF8;RHEB;NDUFAF4;GNAS;NDUFAF3;GRB2;PNPLA2;COX20
Insulin resistance	34/108	0.000832327087385014	0.00794494037958422	0	0	2.02682116283857	14.3727666323905	PYGB;SLC27A1;PRKAA1;IRS1;PRKAG1;SLC2A1;PIK3R3;PIK3CD;PRKAG2;IRS2;PIK3R1;PRKCZ;RELA;PPP1CB;PTPA;RPS6KA3;CREB3L2;RPS6KA1;AKT1;PPARGC1B;MLXIP;PTPN1;PRKCE;NR1H2;PTPN11;PRKAB1;TNFRSF1A;PPP1CA;CREB3;PPP1R3B;PPP1R3D;TRIB3;SLC27A3;PPARA
HIF-1 signaling pathway	34/109	0.000997293175374075	0.00923962794831863	0	0	1.99967355821545	13.8186756825851	CDKN1A;PFKFB3;CUL2;SLC2A1;PIK3R3;PIK3CD;ENO1;PIK3R1;PDHB;ENO2;RELA;HK1;EIF4EBP1;PGK1;PLCG2;AKT1;EP300;HMOX1;MAPK1;ELOB;TIMP1;VHL;EIF4E;EGLN1;MAP2K2;PDHA1;ARNT;PRKCA;RBX1;BCL2;ALDOC;ALDOA;GAPDH;PFKP
Fluid shear stress and atherosclerosis	41/139	0.00112320445552282	0.0101088400997054	0	0	1.84633526345943	12.539514368968	PRKAA1;BMPR2;HSP90AB1;NCF1;SRC;MGST3;GSTP1;KEAP1;MGST2;PIK3R3;PIK3CD;PIK3R1;PRKCZ;ACTB;RELA;ICAM1;HSP90B1;SUMO1;GPC1;RAC2;AKT1;HMOX1;ITGAV;RAC1;MAP2K7;MAP3K7;MAP2K6;GSTM4;MAP2K4;GSTM1;CYBA;RHOA;MAPK12;TNFRSF1A;MAPK11;BCL2;PECAM1;CTNNB1;SQSTM1;CALM2;BMPR1A
Osteoclast differentiation	38/127	0.0012509521217218	0.0109458310650658	0	0	1.88379109446525	12.5909777099969	CSF1;NCF1;SIRPG;PIK3R3;PIK3CD;PIK3R1;SIRPB1;RELA;PPP3CA;PPP3R1;SOCS1;PLCG2;AKT1;ACP5;MAPK1;FYN;RAC1;MAP2K7;MAP3K7;MAP2K6;JAK1;IFNAR2;TGFB1;CYBA;LILRB1;TGFBR1;MAPK12;FOSL2;TNFRSF1A;MAPK11;TYROBP;TEC;LCK;TRAF6;CAMK4;GRB2;LCP2;SQSTM1
Lipid and atherosclerosis	58/215	0.00144732554857607	0.0119050851455074	0	0	1.63197201079942	10.669894817381	HSP90AB1;NCF1;PIK3CD;FASLG;ICAM1;CASP9;PPP3CA;CASP7;TBK1;CASP3;CASP1;AKT1;RAC1;MAP3K7;VAV3;MAP2K4;APAF1;PRKCA;CYBA;IRAK4;RHOA;TIRAP;TNFRSF1A;PLCB3;TRAF6;ATF6;CCL3L1;ROCK2;SRC;PIK3R3;PIK3R1;RELA;HSP90B1;RAP1B;CDC42;PPP3R1;RXRA;RAP1A;CCL5;MAPK1;MAP2K7;MAP2K6;LYN;HSPA5;HSPA4;HSPA6;NFATC3;MIB2;MAPK12;MIB1;MAPK11;BCL2;BAX;CALM2;HSPA1B;MYD88;HSPA1A;BCL2L1
VEGF signaling pathway	21/59	0.00145769082324621	0.0119050851455074	0	0	2.43463497453311	15.9003617507099	MAP2K2;SRC;SPHK1;SH2D2A;HSPB1;PIK3CD;PIK3R3;PRKCA;PIK3R1;MAPK12;CASP9;CDC42;PPP3CA;MAPK11;PPP3R1;MAPKAPK3;RAC2;PLCG2;AKT1;MAPK1;RAC1
Pathways in cancer	126/531	0.00147644241709907	0.0119050851455074	0	0	1.37890625	8.98787620925265	KEAP1;CRKL;FRAT1;RASSF1;RPS6KA5;CCND2;FGF9;RASSF5;PIM1;AKT1;EP300;PRKACB;IFNAR2;PDGFRB;RALBP1;MAP2K2;IL4R;TPM3;DAPK2;DAPK3;PRKCA;RBX1;ADCY9;MSH3;NOTCH1;EPAS1;MGST3;CUL2;MGST2;PIK3R3;PIK3R1;HSP90B1;BCL2L11;PLCG2;ABL1;DVL2;HMOX1;DVL3;FADD;RALGDS;GSTM4;JAG2;STAT5A;SMAD2;GSTM1;TGFB1;GADD45B;ZBTB16;CDK6;LPAR5;CDK4;GNAQ;GNB2;BCL2;MDM2;GNAS;GRB2;GNB5;CALM2;BCL2L1;ITGB1;CDKN1A;HSP90AB1;SLC2A1;PIK3CD;FASLG;BBC3;CASP9;CASP7;GNGT2;CASP3;RAC2;ELOB;ITGAV;RAC1;APPL1;JAK1;ARHGEF12;APAF1;ITGA3;IL15;AXIN1;ARNT;KIF7;RHOA;TGFBR1;PLCB3;TRAF6;TRAF5;CKS2;RARA;SOS1;SOS2;BIRC2;HDAC2;RALA;RALB;ROCK1;ROCK2;PTGER1;GSTP1;PTGER2;GNAI3;ADCY3;XIAP;CBL;DLL1;RELA;GNAI2;CDC42;RXRA;GNG2;GNG5;STAT4;CTNNA1;MAPK1;VHL;IL12RB2;EGLN1;CDKN2B;VEGFB;EPOR;APC;IL2RB;CTNNB1;BAX
Huntington disease	78/306	0.00151175684387395	0.0119050851455074	0	0	1.51291154648736	9.82557806454441	HIP1;CLTC;AP2A1;BBC3;CASP9;ACTR1A;ACTR1B;PSMD4;PSMD2;KIF5B;CASP3;CREB3L2;EP300;UQCRFS1;AP2M1;TBP;APAF1;WIPI1;SDHD;PSMA5;CREB3;COX7A2L;PLCB3;NDUFS8;NDUFS7;UQCRC1;NDUFS3;TBPL1;TFAM;ULK2;VDAC2;VDAC1;HAP1;STX1A;DCTN6;BECN1;HDAC2;NDUFB10;PSMD14;DCTN2;NDUFB6;PSMD13;DCTN1;DCTN4;COX5A;PSMA7;UQCRH;ATP5MC1;ATP5F1B;KLC2;ATG101;POLR2B;POLR2C;PSMB1;POLR2D;POLR2E;POLR2G;CYC1;NDUFV3;MAP2K7;POLR2I;NDUFV1;POLR2K;POLR2L;NDUFA6;NDUFA3;ADRM1;AP2B1;ATP5F1C;TUBB4B;ATP5F1D;TUBB4A;REST;PSMC1;GNAQ;BAX;ACTR10;DNAL4
Ferroptosis	16/41	0.00174787803598429	0.0132996504201056	0	0	2.81797509474824	17.8923179951811	PRNP;GPX4;ACSL1;ACSL5;SLC3A2;ACSL3;MAP1LC3B;GCLC;PCBP1;PCBP2;HMOX1;VDAC2;GCLM;ATG7;ATG5;FTL
Non-alcoholic fatty liver disease	44/155	0.00177328672268074	0.0132996504201056	0	0	1.74939915365447	11.0823046466173	PRKAA1;NDUFB10;NDUFB6;IRS1;PRKAG1;PIK3R3;PIK3CD;PRKAG2;IRS2;FASLG;PIK3R1;ADIPOR1;ADIPOR2;COX5A;UQCRH;RELA;CDC42;CASP7;BCL2L11;RXRA;CASP3;AKT1;UQCRFS1;CYC1;NDUFV3;RAC1;NDUFV1;MLXIP;TGFB1;NDUFA6;NDUFA3;SDHD;PRKAB1;MAPK12;TNFRSF1A;MAPK11;COX7A2L;ITCH;NDUFS8;NDUFS7;UQCRC1;NDUFS3;BAX;PPARA
Chronic myeloid leukemia	25/76	0.00196628754703665	0.0144041994724778	0	0	2.16018836299784	13.4614471016778	CDKN1A;HDAC2;PIK3CD;PIK3R3;PIK3R1;CBL;RELA;CRKL;ABL1;AKT1;MAPK1;STAT5A;MAP2K2;TGFB1;GADD45B;PTPN11;TGFBR1;CDK6;CDK4;MDM2;BAX;GRB2;SOS1;SOS2;BCL2L1
Cellular senescence	44/156	0.00203421270408014	0.0145631136769374	0	0	1.73367235601278	10.7446882577726	CDKN1A;PIK3R3;PIK3CD;PIK3R1;FOXO3;KIR2DL4;ZFP36L2;RELA;ZFP36L1;PPP1CB;PPP3CA;PPP3R1;CCND2;RRAS;RASSF5;EIF4EBP1;AKT1;MAPK1;TRPM7;CAPN1;NBN;E2F4;MAP2K6;SMAD2;CDKN2B;MAP2K2;TGFB1;GADD45B;NFATC3;RRAS2;TGFBR1;MAPK12;PPP1CA;MAPK11;CDK6;CDK4;RHEB;MDM2;VDAC2;VDAC1;SQSTM1;CALM2;PPID;RAD9A
Rap1 signaling pathway	56/210	0.0022868008324026	0.0160076058268182	0	0	1.60581181270836	9.76430164412223	ITGB1;CSF1;PIK3CD;ACTB;CRKL;SIPA1L1;FGF9;RASSF5;RAC2;AKT1;RAC1;VAV3;PDGFRB;MAP2K2;ARAP3;PRKCA;RHOA;APBB1IP;PLCB3;ADCY9;PRKD3;PRKD2;EVL;LCP2;TLN1;RAPGEF5;SKAP1;RALA;RALB;SRC;GNAI3;PIK3R3;ADCY3;PIK3R1;PRKCZ;THBS1;GNAI2;RAP1B;CDC42;RAP1A;RRAS;PDGFD;P2RY1;MAPK1;RALGDS;MAP2K6;VASP;VEGFB;MAPK12;MAPK11;LPAR5;GNAQ;GNAS;CTNNB1;CALM2;SIPA1
Chagas disease	31/102	0.00256458269941693	0.0175618163112246	0	0	1.92485327840924	11.4835967099016	CCL3L1;GNAI3;PIK3R3;PIK3CD;CD3G;FASLG;PIK3R1;CD3E;RELA;GNAI2;PPP2CA;CCL5;AKT1;MAPK1;FADD;SMAD2;MAP2K4;TGFB1;IRAK4;TGFBR1;MAPK12;TNFRSF1A;MAPK11;PLCB3;PPP2R2B;GNAQ;TRAF6;GNAS;CALR;CD247;MYD88
Relaxin signaling pathway	37/129	0.00323902381862392	0.0217083511248199	0	0	1.77359462114845	10.1671015203179	SRC;GNAI3;PIK3R3;PIK3CD;ADCY3;ARRB1;PIK3R1;PRKCZ;RELA;GNAI2;GNGT2;GNG2;GNG5;CREB3L2;AKT1;MAPK1;MAP2K7;PRKACB;SMAD2;MAP2K4;MAP2K2;TGFB1;VEGFB;PRKCA;TGFBR1;MAPK12;ACTA2;CREB3;MAPK11;PLCB3;ADCY9;GNB2;GNAS;GRB2;GNB5;SOS1;SOS2
Human T-cell leukemia virus 1 infection	57/219	0.00374375061772686	0.0245683634288325	0	0	1.55342640751893	8.68002998855904	CDKN1A;CRTC3;SLC2A1;PIK3CD;CD3G;CD3E;ETS2;ICAM1;PPP3CA;ZFP36;CDC23;CCND2;KAT5;PTTG1;CDC26;CREB3L2;AKT1;EP300;PRKACB;JAK1;MAP2K4;MAP2K2;TBP;IL15;TGFBR1;TNFRSF1A;CREB3;ADCY9;LCK;CANX;TBPL1;VDAC2;VDAC1;TLN1;PIK3R3;ADCY3;GPS2;XIAP;PIK3R1;RELA;ANAPC11;PPP3R1;MAPK1;BUB3;STAT5A;SMAD2;FDPS;CDKN2B;CDKN2C;TGFB1;NFYB;NFATC3;CDK4;IL2RB;BAX;CALR;BCL2L1
Amyotrophic lateral sclerosis	88/364	0.0041193745959131	0.0264816938308699	0	0	1.40969437975656	7.74211755033733	NXT1;WDR41;ACTB;GLE1;CASP9;PPP3CA;ACTR1A;TBK1;ACTR1B;PSMD4;PSMD2;KIF5B;CASP3;CASP1;ANXA7;UQCRFS1;RAC1;SPG11;RAB8A;DAXX;GABARAPL1;APAF1;ANXA11;WIPI1;SDHD;NRG2;TNFRSF1A;PSMA5;COX7A2L;NDUFS8;ALS2;NDUFS7;CAT;UQCRC1;NDUFS3;ULK2;VDAC1;NUP54;HAP1;ATF6;SQSTM1;DCTN6;BECN1;VCP;NDUFB10;PSMD14;DCTN2;NDUFB6;PSMD13;DCTN1;DCTN4;DERL1;COX5A;PSMA7;UQCRH;ATP5MC1;PPP3R1;ATP5F1B;KLC2;POM121C;ATG101;PSMB1;CYC1;NDUFV3;RAE1;NDUFV1;MAP2K6;RANBP2;NDUFA6;HSPA5;NDUFA3;ADRM1;CHCHD10;ATP5F1C;TUBB4B;ATP5F1D;TUBB4A;MAPK12;FIG4;MAPK11;PSMC1;CHMP2B;BCL2;BAX;ACTR10;DNAL4;RAB5A;BCL2L1
Epstein-Barr virus infection	53/202	0.00422907294062832	0.0266431595259584	0	0	1.56998346464352	8.58117240398134	CDKN1A;PIK3CD;CD3G;CD3E;ICAM1;CASP9;TBK1;CCND2;PSMD4;PSMD2;CASP3;AKT1;RAC1;MAP3K7;JAK1;IFNAR2;PDIA3;MAP2K4;ENTPD1;APAF1;IRAK4;RUNX3;TRAF6;TRAF5;HDAC2;PSMD14;PSMD13;PIK3R3;PIK3R1;RELA;BCL2L11;PLCG2;RIPK1;FADD;CD58;MAP2K7;MAP2K6;LYN;GADD45B;ADRM1;ISG15;MAPK12;MAPK11;SNW1;CDK6;CDK4;PSMC1;BCL2;MDM2;BAX;CALR;CD247;MYD88
Pancreatic cancer	24/76	0.00434780282118151	0.0267609250487826	0	0	2.03322342334822	11.0568411089964	SMAD2;CDKN1A;RALBP1;RALA;RALB;TGFB1;GADD45B;PIK3CD;PIK3R3;PIK3R1;TGFBR1;RELA;CASP9;CDC42;CDK6;CDK4;RAC2;AKT1;MAPK1;BAX;RAC1;RALGDS;JAK1;BCL2L1
Non-small cell lung cancer	23/72	0.0044176765159895	0.0267609250487826	0	0	2.06762314364314	11.2109450389375	STAT5A;CDKN1A;MAP2K2;GADD45B;PIK3CD;PIK3R3;PRKCA;PIK3R1;FOXO3;CASP9;RASSF1;RXRA;CDK6;CDK4;KIF5B;RASSF5;PLCG2;AKT1;MAPK1;BAX;GRB2;SOS1;SOS2
Diabetic cardiomyopathy	53/203	0.00471167089833786	0.0280033270372911	0	0	1.55942028985507	8.35492585787784	NCF1;IRS1;SLC2A1;PIK3CD;ATP2A1;PPP1CB;MPC1;MPC2;RAC2;AKT1;UQCRFS1;RAC1;CTSD;G6PD;PRKCA;CYBA;SDHD;TGFBR1;COX7A2L;PLCB3;NDUFS8;NDUFS7;UQCRC1;NDUFS3;VDAC2;VDAC1;PPARA;GAPDH;NDUFB10;NDUFB6;PIK3R3;PIK3R1;PDHB;PRKCZ;COX5A;RELA;UQCRH;ATP5MC1;PTPA;ATP5F1B;CYC1;NDUFV3;NDUFV1;SMAD2;PDHA1;TGFB1;NDUFA6;NDUFA3;ATP5F1C;ATP5F1D;MAPK12;PPP1CA;MAPK11
ErbB signaling pathway	26/85	0.00495916203158396	0.0289284451842397	0	0	1.94154290656803	10.3028333479044	CDKN1A;SRC;PIK3CD;PIK3R3;CBLB;PIK3R1;CBL;AREG;CRKL;ABL1;EIF4EBP1;PLCG2;AKT1;MAPK1;PAK6;MAP2K7;PAK2;NCK1;STAT5A;MAP2K4;MAP2K2;PRKCA;NRG2;GRB2;SOS1;SOS2
p53 signaling pathway	23/73	0.00533893064539957	0.0305775118781975	0	0	2.02614591809059	10.6022743268166	CDKN1A;APAF1;GADD45B;SIVA1;EI24;SIAH1;SHISA5;PPM1D;THBS1;BBC3;CASP9;CCND2;CDK6;RRM2B;AIFM2;ZMAT3;CDK4;CASP3;PERP;BCL2;MDM2;BAX;BCL2L1
Axon guidance	48/182	0.00562638394727842	0.0316484097034411	0	0	1.58034513396969	8.18664344868306	ITGB1;SEMA7A;BMPR2;ROCK1;ROCK2;SRC;GNAI3;PIK3R3;ILK;PIK3CD;PIK3R1;PRKCZ;MYL12A;MYL12B;GNAI2;CDC42;PPP3CA;PPP3R1;ABLIM1;RGS3;RRAS;DPYSL2;CFL1;ABL1;PLCG2;RAC2;MAPK1;PAK6;FYN;SRGAP3;RAC1;PAK2;PLXNA4;NCK1;ARHGEF12;SEMA4D;RYK;LIMK1;NFATC3;PRKCA;PTPN11;L1CAM;SSH3;RHOA;SSH1;FES;PLXNB1;EPHA1
Tight junction	45/169	0.00595733636767083	0.0329221220318651	0	0	1.60073493816838	8.20077609067895	ITGB1;PATJ;PRKAA1;ROCK1;ROCK2;SRC;PRKAG1;PRKAG2;ARHGAP17;ACTR3B;PRKCZ;ACTB;MYL12A;MYL12B;CDC42;PPP2CA;SLC9A3R1;RAP1A;RAC1;MAP2K7;PRKACB;RAB8A;RAB8B;JAM3;VASP;ACTR3;ACTR2;HSPA4;PRKCE;MSN;ACTN4;ARPC5;PRKAB1;RHOA;RAP2C;ARPC2;DLG3;ARPC3;CDK4;PPP2R2B;CLDN7;HCLS1;MYH9;LLGL1;TJP3
Pathways of neurodegeneration	110/475	0.00627402666996862	0.0340744551903468	0	0	1.33314307458143	6.76081769156884	CSF1;PARK7;FRAT1;TBK1;PSMD4;PSMD2;KIF5B;CAPN1;DAXX;GABARAPL1;MAP2K2;PRKCA;SDHD;COX7A2L;UQCRC1;ULK2;VDAC2;VDAC1;ATF6;SQSTM1;STX1A;PPID;VCP;NDUFB10;PSMD14;PSMD13;PSEN2;PSEN1;UBE2J2;UQCRH;UBE2J1;ATP5MC1;PPP3R1;KLC2;UBB;ATG101;UBC;DVL2;DVL3;FADD;CYC1;NDUFV3;MAP2K7;NDUFV1;MAP2K6;PRNP;HSPA5;GNAQ;CHMP2B;BCL2;RAB5A;CALM2;DNAL4;BCL2L1;HIP1;WDR41;FASLG;ATP2A1;CASP9;PPP3CA;ACTR1A;CASP7;ACTR1B;CASP3;UQCRFS1;RAC1;SPG11;RAB8A;APAF1;AXIN1;WIPI1;TNFRSF1A;PSMA5;PLCB3;NDUFS8;ALS2;NDUFS7;CAT;NDUFS3;HAP1;DCTN6;BECN1;NDUFB6;DCTN2;DCTN1;DCTN4;DERL1;COX5A;PSMA7;RELA;ATP5F1B;PSMB1;MAPK1;NDUFA6;CSNK1A1;NDUFA3;ADRM1;UBE2G1;TUBB4B;ATP5F1C;TUBB4A;ATP5F1D;MAPK12;FIG4;MAPK11;APC;PSMC1;CTNNB1;BAX;ACTR10
Endometrial cancer	19/58	0.00682444414852183	0.0357977599868149	0	0	2.14498885021779	10.6975835984238	CDKN1A;MAP2K2;GADD45B;AXIN1;ILK;PIK3CD;PIK3R3;PIK3R1;FOXO3;CASP9;APC;CTNNA1;AKT1;MAPK1;BAX;CTNNB1;GRB2;SOS1;SOS2
RNA polymerase	12/31	0.00690484192737701	0.0357977599868149	0	0	2.77891321055478	13.8265726738583	POLR2B;POLR3GL;POLR1A;POLR3C;POLR2C;POLR1B;POLR2D;POLR2E;POLR2G;POLR2I;POLR2K;POLR2L
Kaposi sarcoma-associated herpesvirus infection	50/193	0.00693226463236733	0.0357977599868149	0	0	1.54256945240552	7.66899005711323	CDKN1A;PIK3CD;PIK3CG;ICAM1;CASP9;PREX1;PPP3CA;ZFP36;TBK1;GNGT2;CASP3;AKT1;EP300;RAC1;CCR5;JAK1;IFNAR2;ATG3;MAP2K4;GABARAPL1;MAP2K2;TNFRSF1A;BECN1;SRC;PIK3R3;PIK3R1;PIK3R6;RELA;PPP3R1;GNG2;UBB;GNG5;UBC;PLCG2;MAPK1;FADD;MAP2K7;MAP2K6;LYN;NFATC3;MAPK12;MAPK11;CDK6;CLEC2B;CDK4;GNB2;CTNNB1;BAX;GNB5;CALM2
Hepatitis B	43/162	0.00748363674746011	0.0380217028298376	0	0	1.59348309817519	7.80015778263997	CDKN1A;SRC;PIK3R3;PIK3CD;FASLG;PIK3R1;RELA;CASP9;TBK1;CASP3;CREB3L2;STAT4;AKT1;EP300;MAPK1;PTK2B;FADD;MAP2K7;MAP3K7;MAP2K6;JAK1;STAT5A;MAP2K4;MAP2K2;TGFB1;APAF1;NFATC3;PRKCA;IRAK4;YWHAZ;TGFBR1;TIRAP;MAPK12;DDB1;CREB3;MAPK11;TRAF6;BCL2;BAX;GRB2;SOS1;SOS2;MYD88
Focal adhesion	51/201	0.00980692307791351	0.0490346153895676	0	0	1.49975403115605	6.93586253536561	ITGB1;ILK;PIK3CD;ACTB;CRKL;PPP1CB;CCND2;RAC2;AKT1;ITGAV;ITGB7;RAC1;VAV3;PDGFRB;PPP1R12A;ITGA3;ITGA1;PRKCA;ACTN4;RHOA;TLN1;SOS1;SOS2;BIRC2;ROCK1;ROCK2;SRC;PIK3R3;XIAP;PIK3R1;THBS1;MYL12A;MYL12B;RAP1B;CDC42;RAP1A;PDGFD;PAK6;MAPK1;FYN;PAK2;VASP;VEGFB;PARVB;PPP1CA;PARVG;ZYX;BCL2;CTNNB1;COL9A3;GRB2
Choline metabolism in cancer	28/98	0.0100895083123622	0.0496592987249079	0	0	1.76208582292232	8.09900313249924	DGKE;DGKD;SLC44A1;SLC44A2;PIK3R3;PIK3CD;PIK3R1;PDGFD;EIF4EBP1;RAC2;AKT1;MAPK1;RAC1;WASF1;RALGDS;WASF2;PDGFRB;LYPLA1;MAP2K2;CHKA;PRKCA;RHEB;GRB2;CHPT1;SOS1;PLPP2;SOS2;PLPP1
AMPK signaling pathway	33/120	0.010260465460802	0.0497237941561941	0	0	1.67146193017171	7.65438815957626	PRKAA1;PFKFB3;IRS1;PRKAG1;PIK3R3;PIK3CD;PRKAG2;IRS2;PIK3R1;HMGCR;ADIPOR1;FOXO3;ADIPOR2;ELAVL1;CAMKK2;PPP2CA;PPP2R5E;CREB3L2;EIF4EBP1;AKT1;MLYCD;MAP3K7;RAB8A;RAB2A;PPP2R5B;PRKAB1;RAB11B;CREB3;RAB14;RHEB;PPP2R2B;FBP1;PFKP
Base excision repair	12/33	0.0120835269184304	0.0576713784743268	0	0	2.51394576218806	11.1013636750111	SMUG1;POLD4;MBD4;PARP4;NEIL2;MPG;NTHL1;POLE3;APEX2;XRCC1;NEIL1;UNG
Antigen processing and presentation	23/78	0.0126268208957454	0.0593649042113402	0	0	1.84138373153833	8.05040461644207	PDIA3;HSP90AB1;HSPA5;KLRC2;HSPA4;KLRC3;NFYB;KLRC4;HSPA6;KIR3DL1;KIR2DL1;KIR3DL2;KIR3DL3;KIR2DL3;KIR2DL4;PSME3;CANX;RFXAP;KLRD1;KLRC1;CALR;HSPA1B;HSPA1A
Spliceosome	39/150	0.0147459227643437	0.0683083186877684	0	0	1.54849183152098	6.52966279086952	SF3B4;SF3B5;SF3B2;DHX8;RBM8A;EIF4A3;DDX23;HNRNPU;U2AF1;U2AF1L4;ZMAT2;PUF60;PCBP1;SNRPB2;CTNNBL1;SF3A1;SF3A2;HSPA6;CDC5L;PRPF40A;CWC15;WBP11;CDC40;U2SURP;LSM2;XAB2;PRPF6;HNRNPK;SNW1;SNRNP27;PPIH;SRSF5;SLU7;SRSF8;HSPA1B;SNRPB;SRSF9;RBM22;HSPA1A
Glycolysis / Gluconeogenesis	20/67	0.0167530466210415	0.0764812997917113	0	0	1.87314766764689	7.65962889374931	GPI;TPI1;PDHA1;PGAM1;ENO1;PDHB;ENO2;HK1;ALDH3A2;PGK1;PGM2;ALDOC;ALDOA;ACSS1;DLD;FBP1;GAPDH;PGM1;PFKP;ALDH9A1
Tuberculosis	45/180	0.0187832854828681	0.0840113643168052	0	0	1.46930422919509	5.84017263439664	RAB5B;CEBPB;RAB5C;SRC;LSP1;TCIRG1;RELA;CASP9;EEA1;PPP3CA;PPP3R1;LAMP1;CASP3;ATP6V0A2;AKT1;EP300;ATP6V1H;MAPK1;FADD;CTSD;JAK1;HSPA9;TGFB1;ARHGEF12;FCER1G;APAF1;RIPK2;NFYB;SPHK1;IRAK4;RHOA;TIRAP;MAPK12;TNFRSF1A;MAPK11;TRAF6;RFXAP;BCL2;BAX;ATP6V0D1;CALM2;RAB5A;ATP6V0C;MYD88;RAB7A
Ras signaling pathway	56/232	0.0194664027604026	0.0840113643168052	0	0	1.40316962730756	5.52717669736551	CSF1;PIK3CD;FASLG;ETS2;RASSF1;TBK1;GNGT2;FGF9;RASSF5;RAC2;AKT1;RAC1;PRKACB;PDGFRB;RALBP1;MAP2K2;RRAS2;PRKCA;RHOA;RASA2;RAPGEF5;SOS1;SOS2;ARF6;RAB5B;RALA;RAB5C;RALB;PIK3R3;PIK3R1;RELA;RAP1B;CDC42;RAP1A;GNG2;RRAS;GNG5;PDGFD;PLCG2;ABL1;PAK6;MAPK1;SHOC2;RALGDS;PAK2;BRAP;VEGFB;PTPN11;GNB2;REL;NF1;GRB2;GNB5;CALM2;RAB5A;BCL2L1
MAPK signaling pathway	69/294	0.0195211116494024	0.0840113643168052	0	0	1.35308981049162	5.32611160657949	CSF1;HSPB1;ARRB1;FASLG;AREG;CRKL;RPS6KA4;RPS6KA3;PPP3CA;RPS6KA5;DUSP10;FGF9;CASP3;RPS6KA1;RAC2;AKT1;MAP3K8;RAC1;PRKACB;MAP3K7;DUSP4;MAP4K1;PDGFRB;DUSP5;MAP2K4;DAXX;DUSP3;MAP2K2;RRAS2;PRKCA;IRAK4;TGFBR1;TNFRSF1A;CACNB1;PPM1A;PPM1B;MAPKAPK3;TRAF6;RASA2;SOS1;SOS2;RELA;RAP1B;CDC42;PPP3R1;RAP1A;RRAS;PDGFD;MAPK1;MAP2K7;PAK2;MAP2K6;MAP3K2;TGFB1;GADD45B;HSPA6;NFATC3;VEGFB;MAPK12;NR4A1;MAPK11;PPP5C;TAOK1;NF1;GRB2;PTPN7;HSPA1B;MYD88;HSPA1A
B cell receptor signaling pathway	23/81	0.0198835275031371	0.0840113643168052	0	0	1.74581708332164	6.83987329675206	VAV3;LYN;MAP2K2;INPPL1;NFATC3;PIK3CD;PIK3R3;LILRB1;PIK3R1;RELA;PPP3CA;PPP3R1;INPP5D;RAC2;PLCG2;AKT1;MAPK1;GRB2;PTPN6;RAC1;SOS1;PIK3AP1;SOS2
TNF signaling pathway	30/112	0.0200027057897155	0.0840113643168052	0	0	1.61134676564157	6.30340763338183	CEBPB;CSF1;PIK3R3;PIK3CD;PIK3R1;RELA;ICAM1;RPS6KA4;CASP7;RPS6KA5;CASP3;CCL5;CREB3L2;AKT1;MAPK1;MAP3K8;RIPK1;FADD;MAP2K7;MAP3K7;MAP2K6;MAP2K4;IL15;MAPK12;TNFRSF1A;CREB3;MAPK11;ITCH;TRAF5;BIRC2
Toxoplasmosis	30/112	0.0200027057897155	0.0840113643168052	0	0	1.61134676564157	6.30340763338183	ITGB1;GNAI3;XIAP;PIK3R6;PIK3CG;RELA;GNAI2;CASP9;SOCS1;CASP3;AKT1;MAPK1;CCR5;MAP3K7;MAP2K6;JAK1;TGFB1;HSPA6;IRAK4;IRGM;MAPK12;TNFRSF1A;MAPK11;TRAF6;BCL2;MYD88;BIRC2;HSPA1B;BCL2L1;HSPA1A
Inositol phosphate metabolism	21/73	0.0219599444389993	0.091018190766905	0	0	1.77762370456868	6.78791867481856	ISYNA1;MTMR2;TPI1;SACM1L;IPMK;ITPK1;INPPL1;PIK3CD;PIK3CG;MTM1;INPP4A;INPP5B;FIG4;PLCB3;IMPA1;INPP5D;PLCG2;PIP4K2A;INPP5K;PIP4K2C;PLCH2
Hepatocellular carcinoma	42/168	0.0225625347005616	0.0923012783204793	0	0	1.46892039258451	5.56935952903027	SMARCD1;CDKN1A;SMARCD2;SMARCB1;SMARCD3;MGST3;GSTP1;KEAP1;MGST2;PIK3R3;PIK3CD;PIK3R1;ACTB;FRAT1;DVL2;PLCG2;AKT1;DVL3;HMOX1;MAPK1;GSTM4;SMAD2;SMARCE1;MAP2K2;SMARCC2;GSTM1;TGFB1;GADD45B;CSNK1A1;AXIN1;PRKCA;SMARCA2;TGFBR1;CDK6;APC;CDK4;BAX;CTNNB1;GRB2;SOS1;SOS2;BCL2L1
Adipocytokine signaling pathway	20/69	0.0230377171912361	0.0930369348107613	0	0	1.7964714341021	6.77381566088123	PRKAA1;IRS1;ACSL1;PRKAG1;SLC2A1;PRKAG2;ACSL5;IRS2;PTPN11;ACSL3;ADIPOR1;PRKAB1;ADIPOR2;RELA;TNFRSF1A;CAMKK2;POMC;RXRA;AKT1;PPARA
Amino sugar and nucleotide sugar metabolism	15/48	0.023657717358066	0.0943314046555797	0	0	1.99987698363882	7.48767122248043	GPI;CMAS;UAP1;NPL;HK1;UGDH;GALE;CYB5R3;UGP2;GMDS;UAP1L1;PGM2;PGM1;GALK1;GNE
Prion disease	64/273	0.02426026345706	0.0946762597455976	0	0	1.35061035624017	5.0228058096147	NCF1;PIK3CD;CASP9;PPP3CA;PSMD4;PSMD2;KIF5B;CASP3;CREB3L2;RAC2;UQCRFS1;RAC1;PRKACB;APAF1;CYBA;SDHD;PSMA5;CREB3;COX7A2L;NDUFS8;NDUFS7;UQCRC1;NDUFS3;VDAC2;VDAC1;NOTCH1;NDUFB10;PSMD14;NDUFB6;PSMD13;PIK3R3;PIK3R1;COX5A;PSMA7;UQCRH;ATP5MC1;STIP1;PPP3R1;ATP5F1B;KLC2;CCL5;PSMB1;MAPK1;FYN;NCAM1;CYC1;NDUFV3;NDUFV1;PRNP;NDUFA6;HSPA5;NDUFA3;HSPA6;ADRM1;ATP5F1C;TUBB4B;ATP5F1D;TUBB4A;MAPK12;MAPK11;PSMC1;BAX;HSPA1B;HSPA1A
Human papillomavirus infection	76/331	0.0243453239345822	0.0946762597455976	0	0	1.31509598886335	4.8861279992268	ITGB1;PATJ;CDKN1A;PIK3CD;UBE3A;CHD4;FASLG;TCIRG1;TBK1;CCND2;PPP2R5E;CASP3;CREB3L2;AKT1;EP300;ITGAV;ITGB7;PRKACB;JAK1;IFNAR2;PDGFRB;HES6;MAP2K2;TBP;ITGA3;ITGA1;AXIN1;PPP2R5B;TUBG2;TNFRSF1A;CREB3;NFX1;MFNG;TBPL1;ATP6V0D1;SOS1;ATP6V0C;SOS2;LLGL1;HDAC2;NOTCH1;PIK3R3;PIK3R1;PSEN1;PRKCZ;THBS1;RELA;PPP2CA;CDC42;SLC9A3R1;ATP6V0A2;DVL2;EIF4EBP1;ATP6V1H;DVL3;MAPK1;FADD;ATP6V1F;HES4;BCAP31;CSNK1A1;ISG15;CDK6;DLG3;APC;CDK4;RHEB;PPP2R2B;PSMC1;TADA3;GNAS;MDM2;CTNNB1;BAX;COL9A3;GRB2
Apelin signaling pathway	35/137	0.0258098089020319	0.0984116511421164	0	0	1.51148459383753	5.52750017131144	BECN1;HDAC5;PRKAA1;PDE3B;PRKAG1;GNAI3;PRKAG2;ADCY3;PIK3R6;PIK3CG;GNAI2;GNGT2;GNG2;RRAS;GNG5;AKT1;MAPK1;PRKACB;SMAD2;GABARAPL1;MAP2K2;PRKCE;SPHK1;RRAS2;PRKAB1;TGFBR1;ACTA2;PLCB3;ADCY9;GNAQ;GNB2;CAMK4;TFAM;GNB5;CALM2
Glutathione metabolism	17/57	0.0263288378809767	0.0984116511421164	0	0	1.87009206607095	6.80169398129305	GSTM4;G6PD;GSTM1;GPX4;GSTP1;MGST3;IDH1;IDH2;MGST2;TXNDC12;PGD;PRDX6;SRM;GCLC;RRM2B;LAP3;GCLM
Growth hormone synthesis, secretion and action	31/119	0.0266496602672674	0.0984116511421164	0	0	1.55137883318095	5.62371549956957	IRS1;GNAI3;PIK3R3;PIK3CD;ADCY3;IRS2;PIK3R1;CRKL;GNAI2;SOCS1;CREB3L2;PLCG2;AKT1;EP300;MAPK1;PRKACB;MAP2K6;STAT5A;MAP2K4;MAP2K2;PRKCA;MAPK12;CREB3;MAPK11;PLCB3;ADCY9;GNAQ;GNAS;GRB2;SOS1;SOS2
Small cell lung cancer	25/92	0.026759595283864	0.0984116511421164	0	0	1.64270236335284	5.94799884035072	ITGB1;CDKN1A;PIK3CD;PIK3R3;XIAP;PIK3R1;RELA;CASP9;RXRA;CASP3;AKT1;ITGAV;CDKN2B;APAF1;GADD45B;ITGA3;CDK6;CDK4;TRAF6;TRAF5;CKS2;BCL2;BAX;BIRC2;BCL2L1
Apoptosis	36/142	0.0268679428514984	0.0984116511421164	0	0	1.49604050903339	5.41091135614975	BECN1;BCL2A1;CTSZ;PRF1;PIK3R3;PIK3CD;XIAP;CTSW;FASLG;PIK3R1;ACTB;RELA;BBC3;CASP9;CASP7;CTSO;BCL2L11;CASP3;AKT1;MAPK1;RIPK1;CAPN1;FADD;CTSD;CTSC;DAXX;DFFA;MAP2K2;PARP4;GADD45B;APAF1;TNFRSF1A;BCL2;BAX;BIRC2;BCL2L1
Glycosaminoglycan biosynthesis	16/53	0.0273967015909307	0.0991949540361282	0	0	1.90263246462488	6.8444018911343	B4GALT1;CHPF;B3GAT3;CSGALNACT2;EXTL2;B3GNT7;CHST11;CHSY1;CHST12;B3GNT2;CHSY3;CHST14;EXTL3;ST3GAL1;CHST2;ST3GAL2
Measles	35/139	0.0315889857396388	0.113074210318025	0	0	1.48223443223443	5.12104106653745	PIK3R3;PIK3CD;CBLB;CD3G;FASLG;PIK3R1;CD3E;RELA;BBC3;CASP9;CCND2;TBK1;CASP3;AKT1;FADD;MAP3K7;JAK1;IFNAR2;STAT5A;APAF1;EIF2AK1;HSPA6;MSN;IRAK4;CDK6;CDK4;TRAF6;IL2RB;BCL2;BAX;CD46;MYD88;HSPA1B;BCL2L1;HSPA1A
Glucagon signaling pathway	28/107	0.0320378086999663	0.113392244275162	0	0	1.56047552582182	5.36934434831963	PYGB;PRKAA1;PDE3B;PRKAG1;SLC2A1;PRKAG2;PDHB;PPP3CA;PPP3R1;PPP4C;CREB3L2;PHKG2;AKT1;EP300;PRKACB;PDHA1;PGAM1;PRKAB1;CREB3;PLCB3;GNAQ;GNAS;SIK1;SIK2;PPARA;CALM2;FBP1;PFKP
Vibrio cholerae infection	15/50	0.0338349648107268	0.118422376837544	0	0	1.88536632514982	6.38434160787935	ARF1;KDELR1;ADCY3;PRKCA;TCIRG1;ACTB;ADCY9;ATP6V0A2;PLCG2;GNAS;ATP6V1H;ATP6V0D1;PRKACB;ATP6V0C;ATP6V1F
FoxO signaling pathway	33/131	0.0358098174183516	0.123957060294294	0	0	1.48284149123343	4.93716996591886	CDKN1A;PRKAA1;IRS1;AGAP2;PRKAG1;PIK3R3;PIK3CD;PRKAG2;IRS2;FASLG;PIK3R1;FOXO3;CCND2;BCL2L11;AKT1;EP300;MAPK1;GABARAPL1;CDKN2B;MAP2K2;TGFB1;GADD45B;BNIP3;PRKAB1;ATG12;TGFBR1;MAPK12;MAPK11;CAT;MDM2;GRB2;SOS1;SOS2
Mitophagy	19/68	0.0377135387634607	0.126120525172101	0	0	1.70618548150769	5.5924257982456	USP8;BECN1;GABARAPL1;CALCOCO2;SRC;BNIP3;RRAS2;FOXO3;RELA;TBK1;RRAS;UBB;UBC;NBR1;TAX1BP1;SQSTM1;RAB7A;ATG5;BCL2L1
Terpenoid backbone biosynthesis	8/22	0.0377388181097947	0.126120525172101	0	0	2.5123099482905	8.2330056541404	FDPS;IDI1;NUS1;HMGCS1;FNTA;HMGCR;ZMPSTE24;PCYOX1
Regulation of lipolysis in adipocytes	16/55	0.0381008601401862	0.126120525172101	0	0	1.80483944858606	5.89734614564718	IRS1;PDE3B;GNAI3;PIK3CD;ADCY3;PIK3R3;IRS2;ADRB1;PIK3R1;GNAI2;ADCY9;GNAS;AKT1;PRKACB;MGLL;PNPLA2
Toll-like receptor signaling pathway	27/104	0.0381442673221194	0.126120525172101	0	0	1.54359976162854	5.04198307963209	CCL3L1;CCL4L2;PIK3R3;PIK3CD;PIK3R1;RELA;TBK1;CCL5;CCL4;AKT1;MAPK1;MAP3K8;RIPK1;FADD;RAC1;MAP2K7;MAP3K7;MAP2K6;IFNAR2;MAP2K4;MAP2K2;IRAK4;TIRAP;MAPK12;MAPK11;TRAF6;MYD88
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	9/26	0.0387174007031722	0.126120525172101	0	0	2.32778104486864	7.56870127066821	PIGC;DPM2;PIGT;GPAA1;PIGZ;PIGM;MPPE1;PIGX;PIGH
Citrate cycle (TCA cycle)	10/30	0.0388371141006153	0.126120525172101	0	0	2.19864864864865	7.1420439679817	ACLY;PDHA1;MDH2;IDH1;IDH2;DLST;SUCLG2;PDHB;SDHD;DLD
Viral carcinogenesis	48/203	0.0399845959631262	0.128521915595763	0	0	1.36445799052166	4.39254639497079	GTF2A1;HDAC5;CDKN1A;HDAC2;HDAC10;SRC;PIK3R3;PIK3CD;UBE3A;CHD4;PIK3R1;RELA;GTF2E2;CDC42;CCND2;CASP3;CREB3L2;EP300;MAPK1;RAC1;CCR5;PRKACB;YWHAG;JAK1;LYN;STAT5A;CDKN2B;TBP;MRPS18B;ACTN4;YWHAZ;RHOA;DDB1;CREB3;HNRNPK;SNW1;CDK6;CDK4;PSMC1;DNAJA3;RASA2;TRAF5;REL;MDM2;TBPL1;BAX;GRB2;ATP6V0D1
AGE-RAGE signaling pathway in diabetic complications	26/100	0.0406181397298842	0.129239535504177	0	0	1.54655632831529	4.95445586542604	PIK3R3;PIK3CD;PIK3R1;PRKCZ;RELA;ICAM1;CDC42;CASP3;PIM1;PLCG2;AKT1;MAPK1;RAC1;SMAD2;STAT5A;TGFB1;PRKCE;VEGFB;PRKCA;TGFBR1;MAPK12;MAPK11;PLCB3;CDK4;BCL2;BAX
Peroxisome	22/82	0.0411541973059538	0.129635721513754	0	0	1.61361171366594	5.14811418194342	PEX16;PHYH;ACSL1;PEX11A;IDH1;ECI2;ECH1;PEX11B;IDH2;ACSL5;PEX2;ACSL3;PEX1;PRDX5;SCP2;PEX3;CAT;FAR1;HACL1;MLYCD;ACAA1;PAOX
Nucleotide excision repair	14/47	0.0418364665368655	0.130480068902105	0	0	1.86604683195592	5.92280822663552	RFC2;XPA;RPA1;XPC;RAD23A;RAD23B;RBX1;DDB1;POLD4;ERCC1;POLE3;ERCC5;ERCC6;MNAT1
Sulfur relay system	4/8	0.0438986387140816	0.135569325440546	0	0	4.39449541284404	13.7366300252724	MPST;CTU2;TST;URM1
Central carbon metabolism in cancer	19/70	0.0494381912562537	0.148314573768761	0	0	1.63907437805792	4.92874918899733	PDGFRB;G6PD;MAP2K2;PDHA1;PGAM1;IDH1;IDH2;SLC2A1;PIK3CD;PIK3R3;SIRT6;PDHB;PIK3R1;HK1;SIRT3;AKT1;MAPK1;SLC16A3;PFKP
Epithelial cell signaling in Helicobacter pylori infection	19/70	0.0494381912562537	0.148314573768761	0	0	1.63907437805792	4.92874918899733	LYN;MAP2K4;SRC;PTPN11;TCIRG1;RELA;MAPK12;CDC42;MAPK11;CASP3;CCL5;ATP6V0A2;PLCG2;ATP6V1H;RAC1;ATP6V0D1;ATP6V0C;ATP6V1F;JAM3
Prolactin signaling pathway	19/70	0.0494381912562537	0.148314573768761	0	0	1.63907437805792	4.92874918899733	STAT5A;MAP2K2;CISH;SRC;PIK3CD;PIK3R3;PIK3R1;FOXO3;RELA;MAPK12;MAPK11;CCND2;SOCS1;AKT1;MAPK1;GRB2;SOS1;SOS2;SOCS5
Legionellosis	16/57	0.0515330164968522	0.153140567891589	0	0	1.71658721459981	5.09059531079411	ARF1;VCP;APAF1;SAR1A;RAB1B;BNIP3;HSPA6;RELA;CASP9;CASP7;CASP3;HSF1;CASP1;HSPA1B;MYD88;HSPA1A
Glioma	20/75	0.0527449486782145	0.155277185361099	0	0	1.59990145355999	4.70736968144943	PDGFRB;CDKN1A;MAP2K2;GADD45B;PIK3CD;PIK3R3;PRKCA;PIK3R1;CDK6;CDK4;CAMK4;PLCG2;MDM2;AKT1;MAPK1;BAX;GRB2;SOS1;SOS2;CALM2
PD-L1 expression and PD-1 checkpoint pathway in cancer	23/89	0.0550161859644545	0.160463875729659	0	0	1.53344675395123	4.44719163269103	MAP2K2;NFATC3;PIK3CD;PIK3R3;CD3G;PTPN11;PIK3R1;CD3E;TIRAP;RELA;MAPK12;PPP3CA;MAPK11;PPP3R1;LCK;TRAF6;AKT1;MAPK1;PTPN6;CD247;MYD88;JAK1;MAP2K6
Steroid biosynthesis	7/20	0.0616442641801155	0.178146268043453	0	0	2.36687509088265	6.59500179944457	EBP;CYP51A1;MSMO1;HSD17B7;LIPA;TM7SF2;FDFT1
Bladder cancer	12/41	0.0642304153803756	0.183932553134712	0	0	1.81954831129595	4.9951667143419	CDKN1A;RASSF1;RPS6KA5;MAP2K2;SRC;CDK4;DAPK2;DAPK3;MDM2;MAPK1;THBS1;TYMP
Proteoglycans in cancer	47/205	0.065726670903337	0.186521633644605	0	0	1.3100626518348	3.56631869070595	ITGB1;CD63;CDKN1A;ROCK1;ROCK2;SRC;PIK3R3;PIK3CD;FASLG;IQGAP1;PIK3R1;CBL;THBS1;ACTB;PPP1CB;CDC42;RRAS;GPC1;CASP3;PLCG2;AKT1;MAPK1;ITGAV;RAC1;PRKACB;VAV3;SMAD2;MAP2K2;TGFB1;ARHGEF12;PPP1R12A;RRAS2;MSN;PRKCA;PTPN11;RHOA;MAPK12;PPP1CA;MAPK11;MDM2;PDCD4;HCLS1;CTNNB1;GRB2;PTPN6;SOS1;SOS2
N-Glycan biosynthesis	14/50	0.0669611846059449	0.18832833170422	0	0	1.71022727272727	4.62384256065128	B4GALT1;RPN1;ALG12;DDOST;DPM2;GANAB;MAN1A2;DAD1;MGAT5;MAN1C1;MAN1A1;MGAT1;MAN1B1;MGAT2
Notch signaling pathway	16/59	0.0679536012038505	0.189428180347017	0	0	1.63654449075182	4.40055380980867	PSENEN;JAG2;TLE3;HDAC2;TLE1;NOTCH1;PSEN2;DTX2;PSEN1;DLL1;APH1A;SNW1;MFNG;DVL2;EP300;DVL3
Gap junction	22/88	0.0809562055815522	0.223694778580605	0	0	1.46637744034707	3.68624844475939	PDGFRB;MAP3K2;MAP2K2;SRC;GNAI3;ADCY3;CSNK1D;PRKCA;ADRB1;TUBB4B;TUBB4A;GNAI2;PLCB3;ADCY9;PDGFD;GNAQ;GNAS;MAPK1;GRB2;SOS1;PRKACB;SOS2
Pyrimidine metabolism	15/56	0.0826452049025795	0.2263759960375	0	0	1.60886497904221	4.01121970950327	ENTPD1;NME2;NT5C2;DCK;AK9;TYMP;DCTD;NT5C;NT5C3B;NME6;RRM2B;NME7;TK2;UPP1;DCTPP1
mRNA surveillance pathway	24/98	0.0860277850096896	0.233609933431485	0	0	1.4268158554648	3.50010050631353	NXT1;RBM8A;RNMT;EIF4A3;SSU72;PPP2R5B;CSTF2T;GSPT1;SRRM1;WDR33;PPP1CA;GLE1;PPP1CB;PPP2CA;FIP1L1;CLP1;PPP2R5E;PPP2R2B;PAPOLA;SAP18;RNPS1;ETF1;PABPC1;PELO
Alzheimer disease	79/369	0.0887983019132908	0.239072351305014	0	0	1.20039126677366	2.90661271069134	CSF1;IRS1;PIK3CD;IRS2;ATP2A1;CASP9;PPP3CA;FRAT1;CASP7;PSMD4;PSMD2;KIF5B;CASP3;AKT1;UQCRFS1;CAPN1;PSENEN;MAP2K2;APAF1;AXIN1;WIPI1;SDHD;TNFRSF1A;PSMA5;COX7A2L;PLCB3;NDUFS8;NDUFS7;UQCRC1;NDUFS3;ULK2;VDAC2;VDAC1;ATF6;GAPDH;PPID;BECN1;NDUFB10;PSMD14;NDUFB6;PSMD13;PSEN2;PIK3R3;PIK3R1;PSEN1;COX5A;PSMA7;RELA;RTN4;UQCRH;ATP5MC1;APH1A;PPP3R1;ATP5F1B;KLC2;ATG101;PSMB1;DVL2;DVL3;MAPK1;FADD;CYC1;NAE1;NDUFV3;MAP2K7;NDUFV1;NDUFA6;CSNK1A1;NDUFA3;ADRM1;ATP5F1C;TUBB4B;ATP5F1D;TUBB4A;APC;PSMC1;GNAQ;CTNNB1;CALM2
Various types of N-glycan biosynthesis	11/39	0.0932962739922063	0.248601865632514	0	0	1.72712702274746	4.09670230579497	B4GALT1;MAN1A2;DAD1;RPN1;MAN1C1;MAN1A1;MGAT1;ALG12;MGAT2;MAN1B1;DDOST
NOD-like receptor signaling pathway	41/181	0.0939162603500609	0.248601865632514	0	0	1.28908227232021	3.04913299724373	HSP90AB1;XIAP;RELA;TRPM2;TBK1;SHARPIN;NLRP6;CCL5;CASP1;MAPK1;RIPK1;TRPM7;FADD;MAP3K7;ATG5;JAK1;GBP3;IFNAR2;GABARAPL1;RIPK2;CARD6;CYBA;IRAK4;ATG12;RHOA;MAPK12;P2RX7;MAPK11;PLCB3;TRAF6;TRAF5;BCL2;TXNIP;VDAC2;VDAC1;RBCK1;PKN1;SUGT1;MYD88;BIRC2;BCL2L1
Acute myeloid leukemia	17/67	0.10286779268311	0.267796319794872	0	0	1.49515299214731	3.40044242038658	STAT5A;MAP2K2;BCL2A1;ZBTB16;PIK3CD;PIK3R3;PIK3R1;RELA;PER2;PIM1;RARA;EIF4EBP1;AKT1;MAPK1;GRB2;SOS1;SOS2
Long-term potentiation	17/67	0.10286779268311	0.267796319794872	0	0	1.49515299214731	3.40044242038658	MAP2K2;PRKCA;PPP1CA;PPP1CB;RAP1B;PPP3CA;RPS6KA3;PLCB3;PPP3R1;RAP1A;CAMK4;GNAQ;RPS6KA1;EP300;MAPK1;PRKACB;CALM2
Galactose metabolism	9/31	0.105504174111794	0.272408318403402	0	0	1.7981872221267	4.04413162518523	GALE;B4GALT1;UGP2;AKR1B1;PGM2;PGM1;PFKP;HK1;GALK1
Sphingolipid metabolism	13/49	0.107740633117179	0.275921133592775	0	0	1.5876386259129	3.53730408306187	CERS4;ASAH1;SGMS1;SPHK1;SMPD3;GALC;SMPD2;SPTLC1;SPTLC2;SMPD1;DEGS1;PLPP2;PLPP1
Lysine degradation	16/63	0.110422388531361	0.28050848699499	0	0	1.49689548318723	3.29832293265977	KMT2E;ECHS1;SETDB1;PHYKPL;EHMT2;SETDB2;EHMT1;DLST;PRDM2;ALDH3A2;TMLHE;SMYD2;KMT5B;SMYD3;DLD;ALDH9A1
Biosynthesis of unsaturated fatty acids	8/27	0.111886426736392	0.281953795375708	0	0	1.8506070687253	4.05333093798284	ELOVL1;SCP2;ACOT2;ELOVL6;HSD17B12;ACAA1;ACOT4;HACD4
Parkinson disease	54/249	0.116432935015088	0.29108233753772	0	0	1.21911294394883	2.62162904027692	PARK7;CASP9;PSMD4;PSMD2;KIF5B;CASP3;UQCRFS1;PRKACB;DAXX;APAF1;SDHD;PSMA5;COX7A2L;NDUFS8;NDUFS7;UQCRC1;NDUFS3;VDAC2;VDAC1;ATF6;NDUFB10;PSMD14;NDUFB6;PSMD13;GNAI3;UBE2J2;COX5A;PSMA7;UQCRH;UBE2J1;GNAI2;ATP5MC1;ATP5F1B;KLC2;UBB;PSMB1;UBC;CYC1;NDUFV3;NDUFV1;NDUFA6;HSPA5;NDUFA3;ADRM1;UBE2G1;ATP5F1C;TUBB4B;ATP5F1D;TUBB4A;PSMC1;GNAS;BAX;CALM2;BCL2L1
Th1 and Th2 cell differentiation	22/92	0.118434396759409	0.293754606135541	0	0	1.38224356987914	2.94887302126005	JAG2;STAT5A;IL4R;NOTCH1;NFATC3;CD3G;CD3E;RUNX3;DLL1;RELA;MAPK12;PPP3CA;MAPK11;PPP3R1;LCK;TBX21;IL2RB;STAT4;MAPK1;CD247;JAK1;IL12RB2
Thyroid hormone signaling pathway	28/121	0.119437427954095	0.293928045355782	0	0	1.32442045872685	2.8143440211888	HDAC2;NOTCH1;SRC;SLC2A1;PIK3R3;PIK3CD;ATP2A1;PIK3R1;ACTB;CASP9;MED14;RXRA;PLCG2;AKT1;EP300;MAPK1;ITGAV;PRKACB;MAP2K2;PRKCA;ATP1B1;MED4;PLCB3;NCOR1;RHEB;MDM2;CTNNB1;PFKP
Prostate cancer	23/97	0.120657103399583	0.294627810626888	0	0	1.36699433363388	2.8909231881234	PDGFRB;CDKN1A;MAP2K2;HSP90AB1;GSTP1;PIK3R3;PIK3CD;PIK3R1;RELA;HSP90B1;CASP9;CREB3;PDGFD;CREB3L2;BCL2;MDM2;AKT1;EP300;MAPK1;CTNNB1;GRB2;SOS1;SOS2
Th17 cell differentiation	25/107	0.124449292253279	0.301550208152176	0	0	1.34096700532813	2.7943833965842	HSP90AB1;CD3G;AHR;CD3E;RELA;PPP3CA;PPP3R1;RXRA;TBX21;IL21R;MAPK1;JAK1;SMAD2;STAT5A;IL4R;TGFB1;NFATC3;TGFBR1;MAPK12;MAPK11;IRF4;LCK;IL2RB;RARA;CD247
GnRH signaling pathway	22/93	0.129228551170536	0.310740409303197	0	0	1.36269133237604	2.78830184065596	MAP3K2;MAP2K4;MAP2K2;SRC;ADCY3;PRKCA;MAPK12;CDC42;MAPK11;PLCB3;ADCY9;GNAQ;GNAS;MAPK1;PTK2B;GRB2;SOS1;MAP2K7;PRKACB;SOS2;CALM2;MAP2K6
Estrogen signaling pathway	31/137	0.131931532262896	0.314836611081912	0	0	1.28650627990584	2.60578268698976	HSP90AB1;SRC;GNAI3;PIK3R3;PIK3CD;ADCY3;PIK3R1;HSP90B1;GNAI2;CREB3L2;AKT1;MAPK1;PRKACB;CTSD;MAP2K2;HSPA6;POMC;CREB3;PLCB3;ADCY9;GNAQ;BCL2;GNAS;RARA;GRB2;FKBP4;SOS1;CALM2;SOS2;HSPA1B;HSPA1A
Hepatitis C	35/157	0.134680951391665	0.31898120066447	0	0	1.26213895394223	2.53039501656904	CDKN1A;PIK3R3;PIK3CD;FASLG;PIK3R1;RELA;CASP9;PPP2CA;TBK1;RXRA;CASP3;AKT1;MAPK1;RIPK1;FADD;YWHAG;JAK1;IFNAR2;MAP2K2;APAF1;EIF2AK1;YWHAZ;TNFRSF1A;CDK6;CDK4;PPP2R2B;PSME3;TRAF6;CLDN7;BAX;CTNNB1;GRB2;PPARA;SOS1;SOS2
Cholinergic synapse	26/113	0.136179256143843	0.320122878248585	0	0	1.31440712868322	2.62064285276302	GNAI3;PIK3R3;PIK3CD;ADCY3;PIK3R1;PIK3R6;PIK3CG;GNAI2;GNGT2;GNG2;GNG5;CREB3L2;AKT1;MAPK1;FYN;PRKACB;PRKCA;CREB3;PLCB3;ADCY9;GNAQ;GNB2;CAMK4;BCL2;KCNQ5;GNB5
TGF-beta signaling pathway	22/94	0.14058800378906	0.328038675507807	0	0	1.34368221258134	2.63619918972627	TGIF1;SMAD2;CDKN2B;BMPR2;TGFB1;ROCK1;SMURF2;BMP8B;ACVR1B;THBS1;SMAD5;RHOA;TGFBR1;RBX1;PPP2CA;ID2;EP300;MAPK1;ID3;E2F4;NBL1;BMPR1A
Fructose and mannose metabolism	9/33	0.143677782755492	0.331240452829256	0	0	1.64813563901648	3.19768327569305	PFKFB3;TPI1;GMDS;AKR1B1;ALDOC;ALDOA;FBP1;PFKP;HK1
C-type lectin receptor signaling pathway	24/104	0.144063308055899	0.331240452829256	0	0	1.31931633206728	2.556178608214	ARHGEF12;FCER1G;SRC;NFATC3;PIK3R3;PIK3CD;RRAS2;CBLB;PTPN11;PIK3R1;LSP1;RHOA;RELA;MAPK12;PPP3CA;MAPK11;PPP3R1;RRAS;PLCG2;MDM2;CASP1;AKT1;MAPK1;CALM2
Glycerolipid metabolism	15/61	0.147038758721981	0.335631949256697	0	0	1.43354709654645	2.7481944524983	DGKE;DGKD;AKR1B1;AGPAT2;ALDH3A2;GPAT4;GPAT3;GPAT2;LPIN1;PLPP2;LPIN2;MGLL;PLPP1;ALDH9A1;PNPLA2
Purine metabolism	29/129	0.149686979711554	0.33921869502978	0	0	1.27549578918772	2.42243304046889	PRPS2;PDE3B;AK2;GMPS;AK3;ADCY3;AK4;NUDT5;NT5C2;AK9;NT5C;DGUOK;ATIC;GUK1;PDE4A;PGM2;ENPP4;PGM1;ENTPD1;NME2;DCK;NT5C3B;ADCY9;NME6;RRM2B;NME7;IMPDH1;HPRT1;ITPA
Oxytocin signaling pathway	34/154	0.152383495984458	0.342862865965031	0	0	1.24632752992383	2.34478444986995	CDKN1A;PRKAA1;ROCK1;ROCK2;SRC;PRKAG1;GNAI3;PRKAG2;ADCY3;ACTB;PIK3R6;PIK3CG;CAMKK2;GNAI2;PPP1CB;TRPM2;PPP3CA;PPP3R1;MAPK1;PRKACB;MAP2K2;PPP1R12A;NFATC3;PRKCA;PRKAB1;RHOA;PPP1CA;CACNB1;PLCB3;ADCY9;GNAQ;CAMK4;GNAS;CALM2
Pertussis	18/76	0.156978979658422	0.350697720513495	0	0	1.3644412896477	2.52645866789898	ITGB1;GNAI3;IRAK4;RHOA;TIRAP;RELA;MAPK12;GNAI2;MAPK11;CASP7;CASP3;TRAF6;CFL1;CASP1;IRF8;MAPK1;CALM2;MYD88
Adrenergic signaling in cardiomyocytes	33/150	0.161820852465525	0.35896879244113	0	0	1.24058074098868	2.2594267852131	CREM;GNAI3;ADCY3;ADRB1;ATP2A1;PIK3R6;PIK3CG;GNAI2;PPP1CB;PPP2CA;RPS6KA5;PPP2R5E;CREB3L2;AKT1;MAPK1;PRKACB;TPM3;TPM1;PPP2R5B;PRKCA;ATP1B1;MAPK12;PPP1CA;CACNB1;CREB3;MAPK11;PLCB3;ADCY9;PPP2R2B;GNAQ;BCL2;GNAS;CALM2
Endocrine and other factor-regulated calcium reabsorption	13/53	0.171119115693851	0.376321497439681	0	0	1.42852312685962	2.52190813120364	CLTC;AP2A1;PRKCA;AP2B1;ATP1B1;DNM1;DNM2;PLCB3;ADCY9;GNAQ;GNAS;PRKACB;AP2M1
Riboflavin metabolism	3/8	0.172032684543854	0.376321497439681	0	0	2.63582411653628	4.63923704511884	ACP5;BLVRB;ACP1
Phosphatidylinositol signaling system	22/97	0.177968165534847	0.385626410613902	0	0	1.28969631236443	2.22621005050175	DGKE;MTMR2;DGKD;SACM1L;IPMK;ITPK1;INPPL1;PIK3R3;PIK3CD;PRKCA;PIK3R1;MTM1;INPP4A;INPP5B;PLCB3;IMPA1;PPIP5K2;INPP5D;PLCG2;PIP4K2A;PIP4K2C;CALM2
Glyoxylate and dicarboxylate metabolism	8/30	0.178734780792475	0.385626410613902	0	0	1.59795687834586	2.75144563592026	GRHPR;PCCA;MDH2;SHMT1;CAT;ACSS1;GLUL;DLD
Inflammatory mediator regulation of TRP channels	22/98	0.191484098643711	0.40998953561315	0	0	1.27264813334856	2.10362438057548	PRKCH;SRC;PRKCE;PTGER2;PIK3R3;PIK3CD;ADCY3;PRKCA;PIK3R1;MAPK12;PPP1CA;PPP1CB;MAPK11;PLCB3;ADCY9;GNAQ;PLCG2;GNAS;PRKACB;CALM2;ASIC1;MAP2K6
Hippo signaling pathway	35/163	0.192630004034115	0.40998953561315	0	0	1.20252976190476	1.98054728647902	PATJ;BMPR2;PRKCZ;AREG;ACTB;BBC3;PPP1CB;PPP2CA;RASSF1;CCND2;DVL2;CTNNA1;DVL3;YWHAG;SMAD2;WWTR1;TGFB1;AXIN1;BMP8B;CSNK1D;YWHAZ;TGFBR1;PPP1CA;MOB1B;LATS1;MOB1A;LATS2;DLG3;APC;PPP2R2B;ID2;CTNNB1;LLGL1;BIRC2;BMPR1A
Necroptosis	34/159	0.203956804587262	0.426770354676753	0	0	1.19610446137106	1.90162314913681	PYGB;HSP90AB1;FAF1;VPS4B;XIAP;FASLG;SHARPIN;SMPD1;CHMP1A;CASP1;STAT4;RIPK1;TRPM7;CAPN1;FADD;GLUL;JAK1;IFNAR2;STAT5A;TNFRSF1A;SPATA2L;CHMP2B;TRAF5;BCL2;VDAC2;BAX;CHMP4A;VDAC1;RBCK1;CHMP6;SQSTM1;PPID;BIRC2;FTL
mTOR signaling pathway	33/154	0.204465443563397	0.426770354676753	0	0	1.19927312285213	1.90367374447126	PRR5;PRKAA1;IRS1;MAPKAP1;NPRL2;PIK3R3;PIK3CD;SLC3A2;PIK3R1;RPS6KA3;RPS6KA1;DVL2;EIF4EBP1;AKT1;ATP6V1H;DVL3;MAPK1;EIF4E;ATP6V1F;MAP2K2;PRKCA;RHOA;TNFRSF1A;RRAGA;RHEB;ULK2;GRB2;LAMTOR1;SOS1;LPIN1;SOS2;LPIN2;LAMTOR5
Arginine and proline metabolism	12/50	0.204926943237176	0.426770354676753	0	0	1.38783410662947	2.19985825421452	GAMT;ALDH3A2;OAT;P4HA1;SMOX;P4HA2;CARNS1;AZIN2;LAP3;CNDP2;ALDH9A1;SRM
NF-kappa B signaling pathway	23/104	0.205933631463068	0.426770354676753	0	0	1.24831992285206	1.97259681417365	LYN;UBE2I;GADD45B;TNFSF14;BCL2A1;CCL4L2;XIAP;IRAK4;TIRAP;RELA;ICAM1;TNFRSF1A;LCK;TRAF6;TRAF5;CCL4;PLCG2;BCL2;RIPK1;MAP3K7;MYD88;BIRC2;BCL2L1
Mucin type O-glycan biosynthesis	9/36	0.211861837353388	0.43335375822284	0	0	1.46473925965955	2.2730130362699	GALNT6;GALNT3;GALNT2;GALNT1;GCNT1;ST3GAL1;ST6GALNAC4;ST3GAL2;GALNT8
Starch and sucrose metabolism	9/36	0.211861837353388	0.43335375822284	0	0	1.46473925965955	2.2730130362699	GPI;PYGB;UGP2;AGL;PGM2;GYG1;PGM1;PGM2L1;HK1
Proteasome	11/46	0.222206397797288	0.449765616097777	0	0	1.38110686285869	2.07738996695865	PSMA5;PSMD14;PSMD4;PSMD13;PSMD2;PSMC1;PSME3;PSMB1;ADRM1;PSMF1;PSMA7
Fatty acid elongation	7/27	0.222741067019852	0.449765616097777	0	0	1.53780718336484	2.30939473545356	ELOVL1;ECHS1;ACOT2;ELOVL6;HSD17B12;ACOT4;HACD4
Hedgehog signaling pathway	13/56	0.228399404814122	0.458253582907314	0	0	1.32861339489592	1.96190946796724	CSNK1G3;SMURF2;MGRN1;CSNK1A1;ARRB1;CSNK1D;KIF7;HHAT;CCND2;KIF3A;BCL2;SPOPL;PRKACB
Parathyroid hormone synthesis, secretion and action	23/106	0.234642402243786	0.467799725992359	0	0	1.2180896082295	1.76585551112444	CDKN1A;GNAI3;ADCY3;PRKCA;ARRB1;RHOA;GNAI2;NR4A2;SLC9A3R1;AKAP13;CREB3;MMP25;PLCB3;ADCY9;RXRA;MMP15;GNAQ;CREB3L2;BCL2;GNAS;PDE4A;MAPK1;PRKACB
Dopaminergic synapse	28/132	0.245205186728185	0.485783860499234	0	0	1.18353319684118	1.66364518126564	GNAI3;ARRB1;GNAI2;PPP1CB;PPP2CA;PPP3CA;GNGT2;GNG2;GNG5;PPP2R5E;KIF5B;CREB3L2;AKT1;PRKACB;PPP2R5B;PRKCA;MAPK12;PPP1CA;CREB3;MAPK11;PLCB3;CALY;PPP2R2B;GNAQ;GNB2;GNAS;GNB5;CALM2
SNARE interactions in vesicular transport	8/33	0.258953188908149	0.509814090662918	0	0	1.40594273365748	1.8995804348103	VAMP8;SNAP23;STX5;STX4;STX3;STX2;STX1A;VAMP3
Glycerophospholipid metabolism	21/98	0.267091294643582	0.521539554852893	0	0	1.19862490450726	1.58238234922657	LYPLA2;DGKE;LYPLA1;DGKD;PCYT2;CHKA;LPCAT1;AGPAT2;PLD3;PISD;PTDSS1;GPAT4;GPD2;GPAT3;CHPT1;GPAT2;GPD1L;LPIN1;PLPP2;LPIN2;PLPP1
Valine, leucine and isoleucine degradation	11/48	0.268220342495774	0.521539554852893	0	0	1.30629169315301	1.71900993296238	ALDH3A2;ECHS1;AUH;HMGCS1;PCCA;IVD;ACADM;ACAA1;DLD;AACS;ALDH9A1
Cell cycle	26/124	0.276025647185219	0.533423796707632	0	0	1.1660794611004	1.5010491880505	CDKN1A;HDAC2;ANAPC11;ORC5;CCND2;CDC23;PTTG1;CDC26;ABL1;EP300;BUB3;E2F4;YWHAG;SMAD2;CDKN2B;TGFB1;CDKN2C;GADD45B;YWHAZ;RBX1;MAD2L2;CDK6;CDK4;MDM2;MCM3;MCM5
Sulfur metabolism	3/10	0.278876097543011	0.535646162963709	0	0	1.88250028902848	2.40392969669303	MPST;TST;SUOX
RNA degradation	17/79	0.288944162403781	0.551620673679945	0	0	1.20487758007739	1.49588180514616	HSPA9;ZCCHC7;CNOT6L;ENO1;ENO2;EDC3;LSM2;EXOSC6;EXOSC10;CNOT7;CNOT2;C1D;XRN2;PABPC1;EXOSC3;CNOT8;PFKP
Influenza A	35/172	0.299485705503927	0.565840259524145	0	0	1.12290580465763	1.35387471680594	NXT1;CALCOCO2;PIK3R3;PIK3CD;FASLG;PIK3R1;ACTB;RELA;ICAM1;CASP9;TBK1;CASP3;CCL5;CASP1;AKT1;EP300;MAPK1;FADD;RAE1;KPNA1;JAK1;IFNAR2;FDPS;MAP2K2;APAF1;PRKCA;IRAK4;TNFRSF1A;RAB11B;DNAJC3;CDK6;CDK4;BAX;VDAC1;MYD88
Progesterone-mediated oocyte maturation	21/100	0.300602693476413	0.565840259524145	0	0	1.16813585376985	1.40405939431019	HSP90AB1;PDE3B;GNAI3;PIK3R3;PIK3CD;ADCY3;PIK3R1;MAPK12;ANAPC11;GNAI2;MAD2L2;RPS6KA3;MAPK11;CDC23;ADCY9;CDC26;RPS6KA1;AKT1;MAPK1;CPEB3;PRKACB
cGMP-PKG signaling pathway	34/167	0.301781471746211	0.565840259524145	0	0	1.1236019864678	1.34613374981615	ROCK1;IRS1;ROCK2;PDE3B;GNAI3;ADCY3;IRS2;ADRB1;ATP2A1;PIK3R6;PIK3CG;GNAI2;PPP1CB;PPP3CA;PPP3R1;CREB3L2;AKT1;MAPK1;GTF2I;VASP;MAP2K2;PPP1R12A;PRKCE;NFATC3;ATP1B1;RHOA;PPP1CA;CREB3;PLCB3;ADCY9;GNAQ;VDAC2;VDAC1;CALM2
Phosphonate and phosphinate metabolism	2/6	0.309039843307094	0.572632650833734	0	0	2.19606256742179	2.57880348056036	PCYT2;CHPT1
Vitamin B6 metabolism	2/6	0.309039843307094	0.572632650833734	0	0	2.19606256742179	2.57880348056036	PDXK;PHOSPHO2
beta-Alanine metabolism	7/30	0.316100840236892	0.581742021348703	0	0	1.33697706912139	1.53978847082099	ALDH3A2;ECHS1;SMOX;CARNS1;MLYCD;CNDP2;ALDH9A1
Basal transcription factors	10/45	0.31764961165707	0.581742021348703	0	0	1.25521235521236	1.43948550435102	GTF2A1;TBP;TAF10;TAF9;TAF7;TBPL1;MNAT1;GTF2E2;GTF2I;TAF1
Oxidative phosphorylation	27/133	0.334207434889174	0.608527988382022	0	0	1.11928852094529	1.22673284983187	NDUFB10;NDUFB6;TCIRG1;COX5A;UQCRH;ATP5MC1;ATP5F1B;ATP6V0A2;ATP6V1H;UQCRFS1;CYC1;NDUFV3;NDUFV1;ATP6V1F;NDUFA6;NDUFA3;SDHD;ATP5F1C;ATP5F1D;COX7A2L;NDUFS8;PPA2;NDUFS7;UQCRC1;NDUFS3;ATP6V0D1;ATP6V0C
PI3K-Akt signaling pathway	69/354	0.343630066170996	0.613698735649798	0	0	1.06423914771824	1.13680917810984	ITGB1;CDKN1A;HSP90AB1;CSF1;IRS1;PIK3CD;FASLG;AREG;PIK3CG;CASP9;GNGT2;CCND2;FGF9;PPP2R5E;CREB3L2;AKT1;ITGAV;ITGB7;RAC1;YWHAG;JAK1;IFNAR2;PDGFRB;IL4R;MAP2K2;ITGA3;ITGA1;PPP2R5B;PRKCA;YWHAZ;CREB3;SOS1;SOS2;PRKAA1;PKN3;PIK3R3;PIK3R1;FOXO3;THBS1;PIK3R6;RELA;HSP90B1;PPP2CA;RXRA;BCL2L11;GNG2;GNG5;PDGFD;EIF4EBP1;MAPK1;EIF4E;VEGFB;EPOR;NR4A1;CDK6;LPAR5;CDK4;RHEB;PPP2R2B;GNB2;IL2RB;BCL2;MDM2;COL9A3;GRB2;PKN1;GNB5;PIK3AP1;BCL2L1
Type II diabetes mellitus	10/46	0.34416161067579	0.613698735649798	0	0	1.22027027027027	1.30159388095727	SOCS1;IRS1;PRKCE;PIK3CD;PIK3R3;MAPK1;IRS2;PIK3R1;PRKCZ;HK1
RNA transport	37/186	0.34641355687061	0.613698735649798	0	0	1.09125177926352	1.1568599822855	CYFIP2;POP5;POP7;NXT1;RBM8A;EIF4A3;DDX20;PHAX;GLE1;POM121C;SUMO1;EIF4EBP1;EIF4EBP2;SAP18;EIF2B1;EIF4E;RAE1;RPP38;RANBP2;UBE2I;EIF1AX;ELAC2;SRRM1;THOC6;EIF5;RPP21;STRAP;RNPS1;NUP54;PABPC1;EIF1B;EIF4G3;EIF3D;EIF4G2;EIF3A;EIF4G1;EIF3B
DNA replication	8/36	0.347661914536562	0.613698735649798	0	0	1.25507447711662	1.32601728755343	RNASEH2C;POLD4;RNASEH1;RFC2;POLE3;RPA1;MCM3;MCM5
Pantothenate and CoA biosynthesis	5/21	0.347814209593174	0.613698735649798	0	0	1.37263832658569	1.44962524842516	ALDH3A2;PANK2;PPCS;PPCDC;AASDHPPT
Circadian rhythm	7/31	0.348736741845441	0.613698735649798	0	0	1.28119092627599	1.34965515931223	PER2;PRKAA1;PRKAG1;PRKAG2;CSNK1D;PRKAB1;RBX1
Oocyte meiosis	26/129	0.353009377197828	0.615789892507253	0	0	1.10913106269041	1.15489454025824	ADCY3;ANAPC11;PPP1CB;PPP2CA;RPS6KA3;PPP3CA;PPP3R1;CDC23;SLK;PTTG1;PPP2R5E;CDC26;RPS6KA1;MAPK1;PRKACB;YWHAG;PPP2R5B;YWHAZ;MAPK12;RBX1;PPP1CA;MAD2L2;MAPK11;ADCY9;CPEB3;CALM2
Melanoma	15/72	0.353834827123215	0.615789892507253	0	0	1.15611423687772	1.20111605844448	PDGFRB;CDKN1A;MAP2K2;GADD45B;PIK3CD;PIK3R3;PIK3R1;CDK6;FGF9;CDK4;PDGFD;MDM2;AKT1;MAPK1;BAX
Pyruvate metabolism	10/47	0.371010658316545	0.63703656809012	0	0	1.18721694667641	1.17715467540166	ALDH3A2;GRHPR;PDHA1;MDH2;GLO1;PDHB;ME2;ACSS1;DLD;ALDH9A1
Synaptic vesicle cycle	16/78	0.371343681116014	0.63703656809012	0	0	1.1336954433519	1.1230696345197	NAPA;CLTC;AP2A1;TCIRG1;AP2B1;DNM1;DNM2;ATP6V0A2;ATP6V1H;STX3;ATP6V0D1;STX2;ATP6V0C;AP2M1;STX1A;ATP6V1F
Graft-versus-host disease	9/42	0.374594041064505	0.63703656809012	0	0	1.19798088968583	1.17631228642604	PRF1;FASLG;KIR3DL1;KLRD1;KIR2DL1;KLRC1;KIR3DL2;KIR3DL3;KIR2DL3
JAK-STAT signaling pathway	32/162	0.377118337190068	0.63703656809012	0	0	1.08152423976241	1.05469838185889	CDKN1A;PIK3R3;PIK3CD;PIK3R1;CCND2;SOCS1;PIM1;IL21R;STAT4;AKT1;EP300;SOCS5;JAK1;IL12RB2;IFNAR2;PDGFRB;STAT5A;PIAS3;IL4R;CISH;IL15;PTPN11;STAM;EPOR;IL2RB;BCL2;GRB2;PTPN6;SOS1;SOS2;IL9R;BCL2L1
Aldosterone-regulated sodium reabsorption	8/37	0.378177264231277	0.63703656809012	0	0	1.21172152983476	1.1782686130083	SLC9A3R2;IRS1;PIK3CD;PIK3R3;MAPK1;PRKCA;PIK3R1;ATP1B1
Thyroid cancer	8/37	0.378177264231277	0.63703656809012	0	0	1.21172152983476	1.1782686130083	CDKN1A;RXRA;MAP2K2;GADD45B;TPM3;MAPK1;BAX;CTNNB1
Histidine metabolism	5/22	0.388007293449491	0.650118603386116	0	0	1.29181551162975	1.22300197455956	ALDH3A2;CARNMT1;CARNS1;CNDP2;ALDH9A1
cAMP signaling pathway	42/216	0.394024307960069	0.656707179933449	0	0	1.06054224795999	0.987728255498837	ROCK1;GIPR;ROCK2;PTGER2;PDE3B;GNAI3;PIK3R3;ADCY3;PIK3CD;ADRB1;ATP2A1;PIK3R1;RELA;GNAI2;PPP1CB;RAP1B;RAP1A;RRAS;CREB3L2;RAC2;AKT1;EP300;PDE4A;MAPK1;RAC1;PRKACB;VAV3;ABCC4;MAP2K2;PPP1R12A;RRAS2;ARAP3;ATP1B1;RHOA;PPP1CA;POMC;CREB3;ADCY9;CAMK4;GNAS;PPARA;CALM2
Fatty acid degradation	9/43	0.403290128384927	0.668612581269748	0	0	1.16267463483637	1.05582373659067	ALDH3A2;ECHS1;ACSL1;ECI2;ACSL5;ACADM;ACSL3;ACAA1;ALDH9A1
Spinocerebellar ataxia	28/143	0.408493100463473	0.67369280966489	0	0	1.06959828070756	0.957590221237386	BECN1;PSMD14;PSMD13;PIK3R3;PIK3CD;ATP2A1;OMA1;PIK3R1;PSMA7;KAT5;PSMD4;ATG101;PSMD2;PSMB1;AKT1;TBP;ADRM1;PRKCA;WIPI1;PSMA5;AFG3L2;PLCB3;GNAQ;PSMC1;TBPL1;ULK2;VDAC2;VDAC1
Chemical carcinogenesis	46/239	0.416231779987265	0.682880264041607	0	0	1.04710444147793	0.917800666253147	HSP90AB1;SRC;MGST3;GSTP1;GNAI3;MGST2;PIK3R3;ADCY3;XIAP;PIK3CD;ADRB1;ARRB1;PIK3R1;AHR;DLL1;RELA;GNAI2;HSP90B1;RPS6KA3;RXRA;FGF9;CREB3L2;RPS6KA1;EIF4EBP1;AKT1;MAPK1;KPNA4;PRKACB;KPNA3;KPNA1;GSTM4;STAT5A;CBR1;GSTM1;MAP2K2;PTGES3;ARNT;PRKCA;CREB3;ADCY9;BCL2;GNAS;GRB2;PPARA;SOS1;SOS2
Gastric cancer	29/149	0.419529626020362	0.684374186506956	0	0	1.06160010866612	0.922128289554815	CDKN1A;ABCB1;PIK3R3;PIK3CD;PIK3R1;FRAT1;RXRA;FGF9;DVL2;CTNNA1;AKT1;DVL3;MAPK1;SMAD2;CDKN2B;MAP2K2;TGFB1;GADD45B;CSNK1A1;AXIN1;TGFBR1;APC;BCL2;BAX;CTNNB1;GRB2;SOS1;CDH17;SOS2
Morphine addiction	18/91	0.422813387861345	0.684374186506956	0	0	1.0830748452782	0.932337211304414	PDE3B;GNAI3;ADCY3;ARRB1;PRKCA;GNAI2;GNGT2;ADCY9;GNG2;GNG5;GRK5;GRK4;GNB2;GRK6;GNAS;PDE4A;GNB5;PRKACB
RIG-I-like receptor signaling pathway	14/70	0.424697097960959	0.684374186506956	0	0	1.098079004329	0.940371881825002	OTUD5;ISG15;ATG12;RELA;MAPK12;MAPK11;TBK1;RNF125;TRAF6;PIN1;RIPK1;FADD;MAP3K7;ATG5
Mismatch repair	5/23	0.428021768542198	0.684374186506956	0	0	1.21997300944669	1.03524618913211	POLD4;RFC2;MSH3;RPA1;PMS2
Renin-angiotensin system	5/23	0.428021768542198	0.684374186506956	0	0	1.21997300944669	1.03524618913211	CTSA;ATP6AP2;PREP;LNPEP;PRCP
Cushing syndrome	30/155	0.430178060090087	0.684374186506956	0	0	1.05423913043478	0.8893098100926	CDKN1A;GNAI3;ADCY3;AHR;GNAI2;RAP1B;RAP1A;CREB3L2;DVL2;DVL3;MAPK1;PRKACB;USP8;CDKN2B;MAP2K2;CDKN2C;AXIN1;ARNT;POMC;NR4A1;CREB3;PLCB3;ADCY9;CDK6;NCEH1;APC;CDK4;GNAQ;GNAS;CTNNB1
Other glycan degradation	4/18	0.43562270185564	0.689058145990527	0	0	1.25479916737337	1.0427114724553	MANBA;MAN2B2;FUCA1;FUCA2
Viral myocarditis	12/60	0.437497235549541	0.689058145990527	0	0	1.09802595997837	0.907721472081185	CASP9;CASP3;PRF1;RAC2;ABL1;FYN;RAC1;EIF4G3;ACTB;EIF4G2;ICAM1;EIF4G1
Propanoate metabolism	7/34	0.447648838793279	0.701539224974542	0	0	1.13862633900441	0.915166588539081	ECHS1;PCCA;ECHDC1;SUCLG2;MLYCD;ACSS1;DLD
Cysteine and methionine metabolism	10/50	0.452238552723755	0.705223485683083	0	0	1.09797297297297	0.871291475437035	MPST;GCLC;TST;MAT2A;MDH2;DNMT3A;MAT2B;GCLM;ENOPH1;SRM
Phagosome	29/152	0.466025891280737	0.723143624401143	0	0	1.03551526957812	0.790630494292397	ITGB1;RAB5B;RAB5C;NCF1;TCIRG1;THBS1;ACTB;EEA1;LAMP1;ATP6V0A2;ATP6V1H;ITGAV;RAC1;RILP;ATP6V1F;DYNC2H1;DYNC1H1;CYBA;TUBB4B;TUBB4A;DYNC1LI1;HGS;CANX;CALR;ATP6V0D1;RAB5A;ATP6V0C;RAB7A;VAMP3
Nicotinate and nicotinamide metabolism	7/35	0.480190004159946	0.741469859364623	0	0	1.09789359978396	0.805385553353331	NT5C;SIRT5;SIRT6;SIRT7;NADSYN1;NT5C2;SIRT3
Homologous recombination	8/41	0.499831182607754	0.768033280592402	0	0	1.06458425421148	0.738273075643946	MUS81;BABAM2;POLD4;BLM;TOP3A;RPA1;NBN;SYCP3
Hypertrophic cardiomyopathy	17/90	0.509775334312065	0.776824909582523	0	0	1.02262703596957	0.68903093258464	ITGB1;PRKAA1;TGFB1;ITGA3;TPM3;ITGA1;TPM1;PRKAG1;PRKAG2;ATP2A1;PRKAB1;ACTB;TTN;CACNB1;ITGAV;ITGB7;EMD
Cytosolic DNA-sensing pathway	12/63	0.510484940582801	0.776824909582523	0	0	1.03324531543283	0.694748096478689	TBK1;POLR3GL;POLR3C;CCL4L2;CCL5;CCL4;CASP1;POLR2E;RIPK1;RELA;POLR2K;POLR2L
Melanogenesis	19/101	0.5134028652486	0.777509146890909	0	0	1.01747824305661	0.678347076917952	MAP2K2;GNAI3;ADCY3;PRKCA;GNAI2;POMC;CREB3;PLCB3;ADCY9;GNAQ;CREB3L2;DVL2;GNAS;EP300;DVL3;MAPK1;CTNNB1;PRKACB;CALM2
Other types of O-glycan biosynthesis	9/47	0.516844324173654	0.77897589528565	0	0	1.04003185483298	0.686435130767495	GALNT6;B4GALT1;POGLUT1;GALNT3;GALNT2;GALNT1;MFNG;GXYLT1;GALNT8
Dilated cardiomyopathy	18/96	0.521358209172037	0.782037313758055	0	0	1.01333444453704	0.660002894718853	ITGB1;TGFB1;ITGA3;TPM3;ITGA1;TPM1;ADCY3;ATP2A1;ADRB1;ACTB;TTN;CACNB1;ADCY9;GNAS;ITGAV;ITGB7;EMD;PRKACB
Amphetamine addiction	13/69	0.524050323915426	0.782350009636774	0	0	1.01936898643688	0.658683171996021	HDAC2;PRKCA;PPP1CA;PPP1CB;PPP3CA;CREB3;PPP3R1;CAMK4;CREB3L2;GNAS;PRKACB;CALM2;STX1A
Amoebiasis	19/102	0.532260455180635	0.790858695197642	0	0	1.00515744908651	0.633874734607501	RAB5B;RAB5C;TGFB1;PIK3R3;HSPB1;PIK3CD;PRKCA;SERPINB9;ACTN4;PIK3R1;RELA;SERPINB6;PLCB3;GNAQ;CASP3;GNAS;PRKACB;RAB5A;RAB7A
Circadian entrainment	18/97	0.540647027092441	0.795887103905638	0	0	1.00044571224817	0.615262766348717	GNAI3;ADCY3;PRKCA;GNAI2;PER2;PLCB3;RPS6KA5;ADCY9;GNGT2;GNG2;GNG5;GNAQ;GNB2;GNAS;MAPK1;GNB5;PRKACB;CALM2
Folate biosynthesis	5/26	0.543436110575926	0.795887103905638	0	0	1.04549836128784	0.637589994279679	CBR1;FPGS;AKR1B1;MOCS1;GPHN
African trypanosomiasis	7/37	0.543446707052003	0.795887103905638	0	0	1.02457466918715	0.624809846357729	PLCB3;GNAQ;FASLG;PRKCA;APOL1;MYD88;ICAM1
Thiamine metabolism	3/15	0.545751156963866	0.795887103905638	0	0	1.09778796870785	0.664811791146271	AK2;AK4;ACP1
Aldosterone synthesis and secretion	18/98	0.559696309103975	0.812462384183189	0	0	0.987879198266522	0.573326507546245	PRKCE;ADCY3;PRKCA;ATP1B1;NR4A2;POMC;NR4A1;CREB3;PLCB3;ADCY9;PRKD3;GNAQ;CAMK4;CREB3L2;GNAS;PRKD2;PRKACB;CALM2
Retrograde endocannabinoid signaling	27/148	0.571873655323073	0.822173396829438	0	0	0.979624946425726	0.547450856529532	NDUFB10;NDUFB6;GNAI3;ADCY3;ABHD6;GNAI2;GNGT2;GNG2;GNG5;MAPK1;NDUFV3;PRKACB;NDUFV1;NDUFA6;NDUFA3;PRKCA;MAPK12;MAPK11;PLCB3;ADCY9;NDUFS8;NDUFS7;GNAQ;GNB2;NDUFS3;GNB5;MGLL
Synthesis and degradation of ketone bodies	2/10	0.578890698927924	0.822173396829438	0	0	1.097761596548	0.600082149878964	BDH2;HMGCS1
Signaling pathways regulating pluripotency of stem cells	26/143	0.579283789420161	0.822173396829438	0	0	0.97557003257329	0.532624931282203	BMPR2;RIF1;PIK3R3;PIK3CD;PIK3R1;ACVR1B;DVL2;AKT1;DVL3;MAPK1;JAK1;SMAD2;MAP2K2;SETDB1;PCGF5;AXIN1;SMAD5;MAPK12;MAPK11;REST;APC;ID2;ID3;CTNNB1;GRB2;BMPR1A
Collecting duct acid secretion	5/27	0.579432329188835	0.822173396829438	0	0	0.997914366335419	0.544568253867405	ATP6V0A2;TCIRG1;ATP6V0D1;ATP6V0C;ATP6V1F
Leishmaniasis	14/77	0.57943648919408	0.822173396829438	0	0	0.975649350649351	0.532411087766792	ITGB1;TGFB1;NCF1;CYBA;IRAK4;RELA;MAPK12;MAPK11;TRAF6;MAPK1;PTPN6;MAP3K7;MYD88;JAK1
Wnt signaling pathway	30/166	0.594700688463512	0.840048057695095	0	0	0.968310421994885	0.503228064570991	INVS;ROCK2;PRICKLE3;PSEN1;PPP3CA;FRAT1;PPP3R1;CCND2;DVL2;RAC2;EP300;DVL3;RAC1;TBL1X;MAP3K7;PRKACB;TLE3;TLE1;CSNK1A1;RYK;SIAH1;NFATC3;AXIN1;PRKCA;RHOA;RBX1;PLCB3;APC;TBL1XR1;CTNNB1
GABAergic synapse	16/89	0.59830932672454	0.841372490706385	0	0	0.962211954224177	0.49423765891284	GABARAPL1;SRC;GNAI3;ADCY3;PRKCA;GPHN;GNAI2;GNGT2;ADCY9;GNG2;GNG5;GNB2;HAP1;GNB5;GLUL;PRKACB
PPAR signaling pathway	13/74	0.632954489202676	0.882506165791952	0	0	0.935525924874843	0.427869102544648	SLC27A1;HMGCS1;ACSL1;ILK;ACSL5;DBI;ACSL3;RXRA;SCP2;UBC;ACADM;ACAA1;PPARA
Drug metabolism	19/108	0.63987947646844	0.882506165791952	0	0	0.937046992532702	0.418368466774211	GSTM4;GSTM1;TPMT;MGST3;GSTP1;GMPS;NME2;MGST2;FMO5;TYMP;NME6;RRM2B;NME7;IMPDH1;TK2;HPRT1;UPP1;GUSB;ITPA
Protein export	4/23	0.640701984567278	0.882506165791952	0	0	0.92430482574488	0.411492053660704	HSPA5;SRP14;SEC11A;SEC63
D-Glutamine and D-glutamate metabolism	1/5	0.641567974496371	0.882506165791952	0	0	1.09773523860879	0.487218960601053	DGLUCY
Neomycin, kanamycin and gentamicin biosynthesis	1/5	0.641567974496371	0.882506165791952	0	0	1.09773523860879	0.487218960601053	HK1
Renin secretion	12/69	0.64617758445454	0.88498234392687	0	0	0.924141071987703	0.403554768387868	PPP3CA;PLCB3;PPP3R1;PTGER2;GNAQ;PDE3B;GNAI3;GNAS;ADRB1;PRKACB;CALM2;GNAI2
Thyroid hormone synthesis	13/75	0.653172976251352	0.890690422160934	0	0	0.920380081495895	0.392002108620536	HSPA5;ADCY3;PRKCA;ATP1B1;HSP90B1;CREB3;PLCB3;ADCY9;GNAQ;CREB3L2;CANX;GNAS;PRKACB
GnRH secretion	11/64	0.660453738783817	0.896736757400441	0	0	0.911041739990921	0.377925802541652	PLCB3;MAP2K2;GNAQ;KISS1R;PIK3CD;AKT1;PIK3R3;MAPK1;ARRB1;PRKCA;PIK3R1
Fatty acid biosynthesis	3/18	0.675649493211998	0.913431718290899	0	0	0.878068519018074	0.344273841261219	ACSL1;ACSL5;ACSL3
Cortisol synthesis and secretion	11/65	0.681385934689519	0.917250296697429	0	0	0.894115526718933	0.343006334782187	POMC;CREB3;NR4A1;PLCB3;ADCY9;NCEH1;GNAQ;CREB3L2;GNAS;ADCY3;PRKACB
Fanconi anemia pathway	9/54	0.692913719469651	0.928799240991234	0	0	0.877870845717374	0.322046735813917	MUS81;BLM;WDR48;FANCL;ERCC1;TOP3A;RPA1;PMS2;FANCF
Long-term depression	10/60	0.697224854447538	0.930617920131247	0	0	0.877837837837838	0.316589860996835	PPP2CA;LYN;PLCB3;MAP2K2;GNAQ;GNAI3;GNAS;MAPK1;PRKCA;GNAI2
Breast cancer	25/147	0.71730876129674	0.953385062483009	0	0	0.899081344395756	0.29871878917231	CDKN1A;NOTCH1;PIK3R3;PIK3CD;PIK3R1;DLL1;FRAT1;FGF9;DVL2;AKT1;DVL3;MAPK1;JAG2;MAP2K2;GADD45B;CSNK1A1;AXIN1;CDK6;APC;CDK4;BAX;CTNNB1;GRB2;SOS1;SOS2
Non-homologous end-joining	2/13	0.725076059908362	0.959659491055185	0	0	0.798224968127881	0.256612340556215	XRCC6;XRCC5
Malaria	8/50	0.733404799309265	0.966621388210956	0	0	0.835995986725322	0.25920680847319	KLRK1;TGFB1;GYPC;KLRC4-KLRK1;PECAM1;THBS1;MYD88;ICAM1
ABC transporters	7/45	0.754329114236487	0.985948842259308	0	0	0.808476768480748	0.22793103794084	ABCA2;ABCC4;ABCC1;ABCB1;ABCA5;ABCA3;ABCC5
Glycosphingolipid biosynthesis	7/45	0.754329114236487	0.985948842259308	0	0	0.808476768480748	0.22793103794084	B4GALT1;B3GALT4;B3GNT2;A4GALT;ST3GAL1;ST6GALNAC4;ST3GAL2
Gastric acid secretion	12/76	0.774927225836682	0.99999609479223	0	0	0.822708220659816	0.209779206847098	PLCB3;ADCY9;GNAQ;GNAI3;GNAS;ADCY3;PRKCA;ATP1B1;PRKACB;CALM2;ACTB;GNAI2
IL-17 signaling pathway	15/94	0.779407874743132	0.99999609479223	0	0	0.833027868655898	0.207607857297424	USP25;CEBPB;HSP90AB1;ELAVL1;RELA;MAPK12;HSP90B1;MAPK11;TBK1;CASP3;TRAF6;TRAF5;MAPK1;FADD;MAP3K7
Pentose and glucuronate interconversions	5/34	0.782349845031268	0.99999609479223	0	0	0.756712736749034	0.185737612897341	UGDH;UGP2;DCXR;AKR1B1;GUSB
Butanoate metabolism	4/28	0.790101606652047	0.99999609479223	0	0	0.731516459794927	0.172340688229667	ECHS1;BDH2;HMGCS1;AACS
Carbohydrate digestion and absorption	7/47	0.794263875115202	0.99999609479223	0	0	0.767958412098299	0.176891184716565	PLCB3;PIK3CD;PIK3R3;AKT1;PIK3R1;ATP1B1;HK1
Arginine biosynthesis	3/22	0.803051471105356	0.99999609479223	0	0	0.693041614016157	0.152009300195433	ASL;NAGS;GLUL
Glutamatergic synapse	18/114	0.809457515096084	0.99999609479223	0	0	0.822420097508126	0.173852198721003	GNAI3;ADCY3;PRKCA;GNAI2;PPP3CA;PPP3R1;PLCB3;ADCY9;GNGT2;GNG2;GNG5;GNAQ;GNB2;GNAS;MAPK1;GNB5;GLUL;PRKACB
Tryptophan metabolism	6/42	0.816995893627365	0.99999609479223	0	0	0.731371490280778	0.147825690790561	ALDH3A2;ECHS1;CAT;DLST;DLD;ALDH9A1
Vascular smooth muscle contraction	21/133	0.824106640892952	0.99999609479223	0	0	0.822275684467335	0.159073621197264	MAP2K2;PRKCH;ARHGEF12;PPP1R12A;ROCK1;ROCK2;PRKCE;ADCY3;PRKCA;RHOA;PPP1CA;PPP1CB;ACTA2;PLCB3;ADCY9;GNAQ;GNAS;MYH9;MAPK1;PRKACB;CALM2
Mannose type O-glycan biosynthesis	3/23	0.827403851375082	0.99999609479223	0	0	0.658349069328298	0.124732375076418	B4GALT1;CHST10;LARGE2
Cocaine addiction	7/49	0.829077297866997	0.99999609479223	0	0	0.731298946799892	0.137076053739939	CREB3;CREB3L2;GNAI3;GNAS;PRKACB;RELA;GNAI2
Ether lipid metabolism	7/49	0.829077297866997	0.99999609479223	0	0	0.731298946799892	0.137076053739939	LPCAT1;CHPT1;PAFAH1B3;PLPP2;PLPP1;PLD3;PAFAH1B1
Transcriptional misregulation in cancer	31/192	0.82973267011809	0.99999609479223	0	0	0.844138040481565	0.157559812333719	CDKN1A;CEBPB;HDAC2;CCNT2;BCL2A1;HPGD;RELA;HHEX;CCND2;RXRA;SIX4;ITGB7;SS18;CDKN2C;GADD45B;ZBTB16;MLF1;SUPT3H;BAIAP3;CDK9;PER2;NR4A3;NCOR1;ID2;IL2RB;MDM2;REL;RARA;BAX;BIRC2;BCL2L1
Ascorbate and aldarate metabolism	4/30	0.83393261174417	0.99999609479223	0	0	0.675162937440325	0.122611399654954	ALDH3A2;UGDH;GUSB;ALDH9A1
Porphyrin and chlorophyll metabolism	6/43	0.83448988551281	0.99999609479223	0	0	0.711560912964801	0.128746029273429	FECH;UROS;HMOX1;BLVRB;GUSB;HMOX2
Cholesterol metabolism	7/50	0.84465186471626	0.99999609479223	0	0	0.71424803270761	0.120587017432061	STARD3;LRPAP1;NCEH1;VAPA;VDAC2;VDAC1;LIPA
Basal cell carcinoma	9/63	0.850547918644212	0.99999609479223	0	0	0.731153742231829	0.118355166188064	CDKN1A;GADD45B;APC;AXIN1;DVL2;DVL3;BAX;CTNNB1;KIF7
Nitrogen metabolism	2/17	0.851235432881289	0.99999609479223	0	0	0.585221143473571	0.0942595413701413	GLUL;CA13
Selenocompound metabolism	2/17	0.851235432881289	0.99999609479223	0	0	0.585221143473571	0.0942595413701413	MARS2;SEPHS2
Ovarian steroidogenesis	7/51	0.859065166442366	0.99999609479223	0	0	0.697972160164977	0.106029297553955	ADCY9;ACOT2;GNAS;ADCY3;HSD17B7;PRKACB;ACOT4
Arrhythmogenic right ventricular cardiomyopathy	11/77	0.86887979779048	0.99999609479223	0	0	0.731008380643417	0.102743582975582	ITGB1;CACNB1;ITGA3;ITGA1;CTNNA1;CTNNB1;ATP2A1;ITGAV;ITGB7;EMD;ACTB
Ribosome biogenesis in eukaryotes	16/108	0.87165155589663	0.99999609479223	0	0	0.762599750476684	0.104754916456381	POP5;POP7;NXT1;IMP3;IMP4;UTP18;GTPBP4;RRP7A;FBL;EMG1;EIF6;XRN2;NHP2;MPHOSPH10;RPP38;NOP10
Inflammatory bowel disease	9/65	0.874972283124338	0.99999609479223	0	0	0.704954259466553	0.0941558547906192	SMAD2;IL18RAP;IL4R;TGFB1;TBX21;IL21R;STAT4;RELA;IL12RB2
Glycine, serine and threonine metabolism	5/40	0.887581778187852	0.99999609479223	0	0	0.626759205706574	0.0747439293039041	GAMT;GRHPR;SHMT1;PGAM1;DLD
Mineral absorption	8/60	0.890356318883424	0.99999609479223	0	0	0.67481195195944	0.0783682995210484	SLC31A1;HMOX1;TRPM7;ATP7A;ATP1B1;SLC39A4;HMOX2;FTL
Glycosaminoglycan degradation	2/19	0.89211043085781	0.99999609479223	0	0	0.516308141379529	0.0589445010391323	IDS;GUSB
Taurine and hypotaurine metabolism	1/11	0.895399224591487	0.99999609479223	0	0	0.438932326772715	0.048495701117178	ADO
Insulin secretion	12/86	0.895684642996788	0.99999609479223	0	0	0.711092920936079	0.0783388948191096	CREB3;PLCB3;ADCY9;GNAQ;CREB3L2;SLC2A1;GNAS;ADCY3;PRKCA;ATP1B1;PRKACB;STX1A
Rheumatoid arthritis	13/93	0.901766731251949	0.99999609479223	0	0	0.712503381119827	0.0736724257881843	TGFB1;CSF1;CCL3L1;IL15;TCIRG1;ICAM1;CCL5;ATP6V0A2;ACP5;ATP6V1H;ATP6V0D1;ATP6V0C;ATP6V1F
One carbon pool by folate	2/20	0.908381221506961	0.99999609479223	0	0	0.487594390507012	0.0468535013375547	ATIC;SHMT1
MicroRNAs in cancer	49/310	0.909681662161255	0.99999609479223	0	0	0.821981934462979	0.0778092722597154	CDKN1A;BMPR2;IRS1;PIK3CD;IRS2;CRKL;RASSF1;RPS6KA5;CCND2;CASP3;PIM1;EP300;PDGFRB;ABCC1;MAP2K2;PRKCE;TPM1;DNMT3A;PRKCA;DICER1;RHOA;ZEB2;SOS1;SOS2;HDAC5;HDAC2;ABCB1;NOTCH1;ROCK1;PIK3R3;PIK3R1;THBS1;BCL2L11;SOCS1;PLCG2;ABL1;HMOX1;MAPK1;BMF;UBE2I;HNRNPK;CDK6;APC;BCL2;MDM2;PDCD4;SPRY2;GRB2;BCL2L2
Alanine, aspartate and glutamate metabolism	4/37	0.931668489571215	0.99999609479223	0	0	0.53171760781043	0.0376340287250667	ASNS;ASL;GLUL;NIT2
Primary immunodeficiency	4/38	0.940252625089081	0.99999609479223	0	0	0.516047109615568	0.0317919541682313	LCK;RFXAP;CD3E;UNG
Viral protein interaction with cytokine and cytokine receptor	13/100	0.946063686692131	0.99999609479223	0	0	0.654892596979844	0.0363107755207358	CSF1;CCL3L1;TNFSF14;CCL4L2;TNFRSF1A;IL18RAP;CCL5;CCL4;IL2RB;CCR9;XCL2;XCL1;CCR5
Cardiac muscle contraction	11/87	0.946322115983972	0.99999609479223	0	0	0.634431780993441	0.0350030381766317	CACNB1;COX7A2L;TPM3;TPM1;UQCRC1;UQCRFS1;ATP2A1;CYC1;ATP1B1;COX5A;UQCRH
Neutrophil extracellular trap formation	27/189	0.95003388489748	0.99999609479223	0	0	0.729839804507195	0.0374098562579035	HDAC5;HDAC2;HDAC10;NCF1;SRC;PIK3R3;PIK3CD;PIK3R1;ACTB;RELA;PLCG2;CASP1;RAC2;AKT1;MAPK1;RAC1;MAP3K7;ATG7;MAP2K2;CYBA;PRKCA;MAPK12;MAPK11;PLCB3;HAT1;VDAC2;VDAC1
Pancreatic secretion	13/102	0.954994971448905	0.99999609479223	0	0	0.640096889977601	0.0294759522751767	ADCY3;PRKCA;ATP2A1;ATP1B1;RHOA;RAP1B;PLCB3;ADCY9;RAP1A;GNAQ;GNAS;RAC1;RAB8A
Bile secretion	11/90	0.959883790047947	0.99999609479223	0	0	0.610226506650788	0.0249845367414376	ABCC4;ADCY9;ABCB1;RXRA;NCEH1;SLC2A1;GNAS;ADCY3;HMGCR;ATP1B1;PRKACB
Phenylalanine metabolism	1/17	0.969485960393297	0.99999609479223	0	0	0.274231598813696	0.00849824136092039	MIF
Primary bile acid biosynthesis	1/17	0.969485960393297	0.99999609479223	0	0	0.274231598813696	0.00849824136092039	SCP2
Serotonergic synapse	14/113	0.97009995920287	0.99999609479223	0	0	0.619490358126722	0.0188053497117638	GNAI3;PRKCA;GNAI2;PLCB3;GNGT2;GNG2;GNG5;GNAQ;GNB2;CASP3;GNAS;MAPK1;GNB5;PRKACB
Fat digestion and absorption	4/43	0.970152913855938	0.99999609479223	0	0	0.449748848021919	0.013628099240443	SLC27A1;AGPAT2;PLPP2;PLPP1
Alcoholism	24/186	0.984761093528603	0.99999609479223	0	0	0.648218484355218	0.00995418038365908	HDAC5;HDAC2;HDAC10;GNAI3;CAMKK2;GNAI2;PPP1CA;PPP1CB;CREB3;GNGT2;GNG2;GNG5;GNB2;CAMK4;CREB3L2;HAT1;GNAS;MAPK1;GRB2;GNB5;SOS1;PRKACB;CALM2;SOS2
Intestinal immune network for IgA production	4/48	0.985570561813861	0.99999609479223	0	0	0.398518373154099	0.00579228718859234	TGFB1;IL15;CCR9;ITGB7
Salivary secretion	10/93	0.985857519375271	0.99999609479223	0	0	0.527743406056659	0.00751688074655487	PLCB3;ADCY9;GNAQ;GNAS;ADCY3;PRKCA;ADRB1;ATP1B1;PRKACB;CALM2
Proximal tubule bicarbonate reclamation	1/23	0.991100930131083	0.99999609479223	0	0	0.199367631559597	0.00178212793706197	ATP1B1
Metabolism of xenobiotics by cytochrome P450	7/76	0.992266357375794	0.99999609479223	0	0	0.44439878359497	0.0034501798668663	GSTM4;CBR1;AKR7A2;GSTM1;GSTP1;MGST3;MGST2
Vitamin digestion and absorption	1/24	0.992753166076285	0.99999609479223	0	0	0.190687751298252	0.00138691392414414	ABCC1
Hematopoietic cell lineage	10/99	0.992902368093786	0.99999609479223	0	0	0.491982994230185	0.00350436530855577	IL4R;CSF1;ITGA3;ITGA1;CD7;CD9;CD3G;CD3E;IL9R;EPOR
alpha-Linolenic acid metabolism	1/25	0.994098619054489	0.99999609479223	0	0	0.182731194392019	0.00108156088833781	ACAA1
Maturity onset diabetes of the young	1/26	0.995194238205492	0.99999609479223	0	0	0.175411162038285	0.000845016364783299	HHEX
ECM-receptor interaction	8/88	0.995609450357891	0.99999609479223	0	0	0.437871420853593	0.00192672901173636	ITGB1;ITGA3;ITGA1;ITGAV;ITGB7;COL9A3;AGRN;THBS1
Allograft rejection	2/38	0.996052864526288	0.99999609479223	0	0	0.243527508090615	0.000963138137301791	PRF1;FASLG
Aminoacyl-tRNA biosynthesis	5/66	0.99660855724938	0.99999609479223	0	0	0.359040729187407	0.0012197355809684	MARS2;TARS2;FARSA;HARS2;FARSB
Phototransduction	1/28	0.996812885704561	0.99999609479223	0	0	0.162397771187202	0.000518406808492247	CALM2
Arachidonic acid metabolism	4/61	0.998057358386785	0.99999609479223	0	0	0.30738205470503	0.000597713930759624	CBR1;PTGIS;PTGES2;PTGES3
Asthma	1/31	0.998278357451158	0.99999609479223	0	0	0.146131032623349	0.000251802222430483	FCER1G
Type I diabetes mellitus	2/43	0.998419533825877	0.99999609479223	0	0	0.213763254137396	0.000338112850832381	PRF1;FASLG
Coronavirus disease	26/232	0.999184949280167	0.99999609479223	0	0	0.551036758272456	0.000449306034971352	CFD;PIK3R3;RPS27L;PIK3CD;PIK3R1;RPL8;RELA;TBK1;RPS19;PLCG2;CASP1;MAPK1;RPL15;MAP3K7;JAK1;IFNAR2;PRKCA;ISG15;IRAK4;MAPK12;TNFRSF1A;MAPK11;TRAF6;RPS20;RSL24D1;MYD88
Calcium signaling pathway	27/240	0.999269495180047	0.99999609479223	0	0	0.55333412366679	0.000404360956185319	PTGER1;ADCY3;ADRB1;ATP2A1;PPP3CA;PPP3R1;FGF9;PDGFD;PHKG2;PLCG2;PTK2B;PRKACB;PDGFRB;SPHK1;VEGFB;PRKCA;P2RX7;PLCB3;ADCY9;P2RX4;CAMK4;GNAQ;ORAI3;GNAS;VDAC2;VDAC1;CALM2
Cell adhesion molecules	14/148	0.999291889759141	0.99999609479223	0	0	0.456693803708729	0.000323504111152564	ITGB1;L1CAM;ICAM1;SPN;CLDN7;PECAM1;ITGAV;ITGB7;NCAM1;CD58;TIGIT;NECTIN3;CD99;JAM3
Tyrosine metabolism	1/36	0.999382238079167	0.99999609479223	0	0	0.125216654469822	7.73779840331363e-05	MIF
Cytokine-cytokine receptor interaction	34/295	0.999631409215896	0.99999609479223	0	0	0.568027466136355	0.000209408284488973	BMPR2;CSF1;CCL3L1;CCL4L2;FASLG;ACVR1B;IL18RAP;CCL5;CCL4;CCR9;IL21R;CCR5;IL12RB2;IL32;IFNAR2;GDF11;IL4R;TGFB1;TNFSF14;TNFRSF12A;IL15;TNFSF12;TNFRSF9;TNFRSF18;BMP8B;TGFBR1;EPOR;TNFRSF1A;CLCF1;IL2RB;XCL2;XCL1;IL9R;BMPR1A
Autoimmune thyroid disease	2/53	0.999752576631316	0.99999609479223	0	0	0.171743130909322	4.24985217784474e-05	PRF1;FASLG
Protein digestion and absorption	7/103	0.999823682003724	0.99999609479223	0	0	0.318879962192817	5.62292332449355e-05	KCNK5;COL18A1;COL23A1;COL9A3;PRCP;SLC3A2;ATP1B1
Steroid hormone biosynthesis	2/61	0.999943059694059	0.99999609479223	0	0	0.148382791216426	8.44920208057675e-06	HSD17B12;HSD17B7
Taste transduction	4/86	0.999966338142506	0.99999609479223	0	0	0.21333894936359	7.18150618351388e-06	KCNK5;PLCB3;P2RY1;PRKACB
Ribosome	12/158	0.999969137485414	0.99999609479223	0	0	0.358816687287464	1.10741561342825e-05	MRPL20;MRPL1;RPS19;MRPS12;RPS27L;RPS20;MRPL36;RPL15;RPL8;RSL24D1;MRPS18C;MRPL33
Retinol metabolism	2/68	0.999982532592791	0.99999609479223	0	0	0.132588016083162	2.31598909519155e-06	RDH13;DHRS3
Complement and coagulation cascades	3/85	0.999991004819732	0.99999609479223	0	0	0.159961049300269	1.43888494578213e-06	CFD;F8;CD46
Olfactory transduction	5/440	0.999993901170475	0.99999609479223	0	0	0.049187956628973	2.99989876955656e-07	ADCY3;ARRB1;PRKACB;CALM2;NCALD
Neuroactive ligand-receptor interaction	21/341	0.999994312144502	0.99999609479223	0	0	0.284096299810247	1.61590329626985e-06	CHRNB1;P2RY10;P2RY11;CHRNA5;GIPR;GPR35;PTGER1;PTGER2;GZMA;ADRB1;NR3C1;P2RX7;POMC;P2RX4;CNR2;CHRNE;P2RY1;KISS1R;NMUR1;S1PR3;PTGDR
Systemic lupus erythematosus	3/135	0.99999569316761	0.99999609479223	0	0	0.0990631973906859	4.26649505950256e-07	SSB;ACTN4;SNRPB
Staphylococcus aureus infection	2/95	0.99999609479223	0.99999609479223	0	0	0.0939381285450813	3.66848625798264e-07	CFD;ICAM1