Term	Overlap	P.value	Adjusted.P.value	Old.P.value	Old.Adjusted.P.value	Odds.Ratio	Combined.Score	Genes
Parkinson disease	134/249	2.62233261661806e-31	8.23412441618072e-29	0	0	4.62306447379932	325.538048473202	NDUFA13;NDUFA11;NDUFA12;NDUFA10;UBE2L6;PARK7;COX6A1;UBE2L3;TXN2;PSMD8;PSMD9;PSMD6;PSMD7;PSMD4;PSMD2;KIF5B;PSMD3;DAXX;SDHC;SDHD;SDHA;SDHB;COX6B1;COX7A2L;DDIT3;UQCRC1;VDAC3;PPIF;VDAC2;VDAC1;UQCRC2;ATF4;PSMD11;NDUFB10;PSMD14;UQCRB;NDUFB11;PSMD13;ATP5MC2;ATP5MC3;HTRA2;COX7A2;TXN;UBE2J2;UQCRH;UBE2J1;KLC2;UBB;CYC1;NDUFV2;XBP1;EIF2AK3;SEM1;UQCRQ;CALM3;UBA1;BCL2L1;COX7B;COX4I1;COX7C;CASP9;CASP3;UQCRFS1;COX8A;NDUFC2;NDUFC1;PSMA5;PSMA6;PSMA3;PSMA4;NDUFS8;PSMA1;ADORA2A;NDUFS7;PSMA2;NDUFS6;NDUFS5;NDUFS4;NDUFS3;NDUFS2;NDUFS1;SLC25A5;SLC25A6;NDUFB9;NDUFB7;NDUFB6;NDUFB5;NDUFB4;NDUFB3;GNAI3;NDUFB2;NDUFB1;UQCR11;UQCR10;COX5B;COX5A;PSMA7;GNAI2;PSMB6;PSMB7;MAPK9;ATP5F1A;PSMB4;ATP5F1B;PSMB2;PSMB3;PSMB1;MFN2;NDUFA9;ATP5PF;NDUFA8;NDUFA7;ATP5PD;NDUFA6;NDUFA5;ATP5PB;NDUFA4;NDUFA3;ADRM1;NDUFA2;NDUFA1;UBE2G1;ATP5F1C;COX6C;ATP5F1D;ATP5F1E;PSMC5;PSMC6;PSMC3;PSMC4;PSMC1;NDUFAB1;PSMC2;BAX
Oxidative phosphorylation	89/133	6.01249726156846e-31	8.85041258031629e-29	0	0	7.97118536772852	554.685278043279	NDUFA13;COX7B;NDUFA11;NDUFA12;COX4I1;NDUFA10;COX6A1;COX7C;UQCRFS1;ATP6V1E1;COX8A;ATP6V1G1;ATP6V0B;ATP6V0E1;ATP6AP1;NDUFC2;SDHC;NDUFC1;SDHD;SDHA;SDHB;COX6B1;COX7A2L;NDUFS8;NDUFS7;PPA1;NDUFS6;NDUFS5;NDUFS4;UQCRC1;ATP6V1B2;NDUFS3;NDUFS2;NDUFS1;UQCRC2;ATP6V0D1;ATP6V0C;ATP6V1A;NDUFB9;NDUFB7;NDUFB10;UQCRB;NDUFB6;COX15;NDUFB11;NDUFB5;NDUFB4;NDUFB3;ATP5MC2;NDUFB2;ATP5MC3;NDUFB1;COX7A2;UQCR11;UQCR10;COX5B;COX5A;UQCRH;ATP5F1A;ATP5F1B;ATP6V0A2;ATP6V1H;CYC1;NDUFV2;ATP5MG;ATP6V1D;ATP5MF;ATP6V1C1;COX10;ATP5ME;ATP6V1F;NDUFA9;ATP5PF;NDUFA8;NDUFA7;ATP5PD;NDUFA6;NDUFA5;ATP5PB;NDUFA4;NDUFA3;NDUFA2;NDUFA1;ATP5F1C;COX6C;ATP5F1D;ATP5F1E;UQCRQ;NDUFAB1
Huntington disease	153/306	8.45580819775442e-31	8.85041258031629e-29	0	0	3.97700277988375	275.38868822211	NDUFA13;NDUFA11;NDUFA12;NDUFA10;COX6A1;PSMD8;PSMD9;PSMD6;PSMD7;PSMD4;CREB3L4;PSMD2;KIF5B;PSMD3;AP2M1;SDHC;SDHD;SDHA;ATG13;SDHB;COX6B1;COX7A2L;UQCRC1;VDAC3;PPIF;TBPL1;VDAC2;VDAC1;UQCRC2;STX1A;PSMD11;NDUFB10;PSMD14;UQCRB;NDUFB11;PSMD13;ATP5MC2;ATP5MC3;COX7A2;UQCRH;KLC2;ATG101;NRBF2;CYC1;MAP2K7;NDUFV2;SEM1;UQCRQ;ATG2A;DNAL4;COX7B;COX4I1;CLTC;CLTB;CLTA;AP2A1;COX7C;CASP9;ACTR1A;ACTR1B;CASP3;RB1CC1;UQCRFS1;COX8A;DNAI2;TBP;GPX7;NDUFC2;NDUFC1;WIPI1;WIPI2;PSMA5;PSMA6;CREB3;PSMA3;PSMA4;NDUFS8;PSMA1;NDUFS7;PSMA2;NDUFS6;NDUFS5;NDUFS4;NDUFS3;NDUFS2;NDUFS1;SLC25A5;SLC25A6;DCTN6;BECN1;DCTN5;NDUFB9;NDUFB7;DCTN2;NDUFB6;DCTN1;HDAC1;NDUFB5;NDUFB4;DCTN3;NDUFB3;NDUFB2;NDUFB1;UQCR11;UQCR10;COX5B;COX5A;PSMA7;PSMB6;PSMB7;MAPK9;ATP5F1A;PSMB4;ATP5F1B;PSMB2;PSMB3;PSMB1;AP2S1;POLR2E;POLR2F;POLR2G;POLR2I;POLR2J;POLR2K;POLR2L;NDUFA9;POLR2J3;ATP5PF;NDUFA8;NDUFA7;ATP5PD;NDUFA6;NDUFA5;ATP5PB;NDUFA4;NDUFA3;ADRM1;NDUFA2;NDUFA1;ATP5F1C;COX6C;ATP5F1D;ATP5F1E;SOD1;PSMC5;REST;PSMC6;PSMC3;PSMC4;PSMC1;NDUFAB1;PSMC2;BAX
Amyotrophic lateral sclerosis	166/364	2.11118350696678e-27	1.64252915722375e-25	0	0	3.33567930829594	204.885925151075	NDUFA13;NDUFA11;NDUFA12;NDUFA10;COX6A1;ACTB;ACTG1;GLE1;PSMD8;PSMD9;PSMD6;PSMD7;TBK1;PSMD4;PSMD2;KIF5B;PSMD3;MAP2K3;GABARAPL2;DAXX;GABARAPL1;ANXA11;SDHC;SDHD;SDHA;ATG13;SDHB;COX6B1;COX7A2L;DDIT3;UQCRC1;SRSF3;VDAC1;UQCRC2;PFN1;OPTN;ATF4;VCP;PSMD11;NDUFB10;PSMD14;UQCRB;NDUFB11;PSMD13;ATP5MC2;ATP5MC3;COX7A2;GABARAP;UQCRH;KLC2;ATG101;NRBF2;CYC1;NDUFV2;MAP2K6;XBP1;EIF2AK3;SEM1;UQCRQ;ATG2A;DNAL4;BCL2L1;COX7B;COX4I1;WDR41;NXT2;COX7C;CASP9;ACTR1A;ACTR1B;CASP3;RB1CC1;CASP1;UQCRFS1;RAC1;RAB8A;COX8A;SEC13;DNAI2;GPX7;NDUFC2;NDUFC1;WIPI1;WIPI2;TNFRSF1B;TOMM40L;TNFRSF1A;PSMA5;PSMA6;PSMA3;PSMA4;NDUFS8;PSMA1;NDUFS7;PSMA2;NDUFS6;NDUFS5;CAT;NDUFS4;NDUFS3;NDUFS2;NDUFS1;DCTN6;BECN1;DCTN5;NDUFB9;RAB1A;NDUFB7;DCTN2;NDUFB6;DCTN1;NDUFB5;NDUFB4;DCTN3;NDUFB3;DERL1;NDUFB2;NDUFB1;UQCR11;UQCR10;COX5B;COX5A;TANK;PSMA7;PSMB6;PSMB7;ATP5F1A;PSMB4;ATP5F1B;PSMB2;PSMB3;PSMB1;BID;HNRNPA1;RAE1;NDUFA9;ATP5PF;NDUFA8;HNRNPA3;NDUFA7;ATP5PD;NDUFA6;NDUFA5;ATP5PB;BAD;NDUFA4;NDUFA3;ADRM1;NDUFA2;NDUFA1;ATP5F1C;COX6C;ATP5F1D;ATP5F1E;SOD1;MAPK11;PSMC5;CCS;PSMC6;PSMC3;PSMC4;PSMC1;NDUFAB1;PSMC2;BAX;NUP37
Prion disease	136/273	2.61549228857284e-27	1.64252915722375e-25	0	0	3.93508168055867	240.859837796917	ATF2;NDUFA13;NDUFA11;NDUFA12;NDUFA10;COX6A1;PSMD8;PSMD9;PSMD6;PSMD7;PSMD4;CREB3L4;PSMD2;KIF5B;PSMD3;CSNK2A1;CSNK2A2;CYBA;SDHC;SDHD;SDHA;SDHB;COX6B1;COX7A2L;DDIT3;CSNK2B;UQCRC1;VDAC3;PPIF;VDAC2;VDAC1;UQCRC2;ATF4;NOTCH1;PSMD11;NDUFB10;PSMD14;UQCRB;NDUFB11;PSMD13;ATP5MC2;PIK3R3;ATP5MC3;COX7A2;UQCRH;KLC2;CYC1;NDUFV2;EIF2AK3;SEM1;UQCRQ;GSK3B;COX7B;COX4I1;PIK3CD;COX7C;CASP9;CASP3;RAC2;UQCRFS1;RAC1;COX8A;NDUFC2;NDUFC1;PSMA5;PSMA6;CREB3;PSMA3;PSMA4;NDUFS8;PSMA1;NDUFS7;PSMA2;NDUFS6;NDUFS5;NDUFS4;NDUFS3;NDUFS2;NDUFS1;SLC25A5;SLC25A6;NDUFB9;NDUFB7;ATF6B;NDUFB6;NDUFB5;NDUFB4;NDUFB3;NDUFB2;NDUFB1;UQCR11;UQCR10;COX5B;COX5A;PSMA7;PSMB6;PSMB7;MAPK9;ATP5F1A;PSMB4;ATP5F1B;PSMB2;PSMB3;CCL5;PSMB1;MAPK1;FYN;MAPK3;NDUFA9;ATP5PF;NDUFA8;NDUFA7;ATP5PD;NDUFA6;NDUFA5;ATP5PB;BAD;NDUFA4;NDUFA3;ADRM1;NDUFA2;NDUFA1;ATP5F1C;COX6C;ATP5F1D;ATP5F1E;SOD1;MAPK11;PSMC5;PSMC6;PSMC3;PSMC4;PSMC1;NDUFAB1;PSMC2;BAX
Pathways of neurodegeneration	199/475	9.96522409767559e-27	5.21513394445023e-25	0	0	2.87852730500002	172.33943340383	ARAF;UBE2L6;UBE2L3;PSMD8;PSMD9;PSMD6;PSMD7;TBK1;FRAT2;PSMD4;PSMD2;PSMD3;GABARAPL2;DAXX;GABARAPL1;CSNK2A1;PRKCB;CSNK2A2;ATG13;COX7A2L;DDIT3;CSNK2B;UQCRC1;VDAC3;VDAC2;VDAC1;UQCRC2;OPTN;STX1A;ATF4;UBE2J2;GABARAP;UBE2J1;NRBF2;FADD;XBP1;EIF2AK3;ATG2A;CALM3;COX7B;WDR41;COX7C;ACTR1A;ACTR1B;RAC1;RAB8A;COX8A;TOMM40L;PSMA5;PSMA6;PSMA3;PSMA4;PSMA1;PSMA2;DERL1;UQCR11;UQCR10;COX5B;TANK;COX5A;PSMA7;PSMB6;PSMB7;NRAS;PSMB4;ATP5F1A;ATP5F1B;PSMB2;PSMB3;PSMB1;MFN2;BID;ATP5PF;ATP5PD;CSNK1A1;ATP5PB;UBE2G1;ATP5F1C;COX6C;ATP5F1D;ATP5F1E;PSMC5;PSMC6;PSMC3;PSMC4;PSMC1;PSMC2;NDUFAB1;NDUFA13;CSF1;NDUFA11;NDUFA12;NDUFA10;PARK7;COX6A1;KIF5B;CAPN2;CAPN1;MAP2K3;MAP2K1;MAP2K2;SDHC;SDHD;SDHA;SDHB;COX6B1;PPIF;PPID;VCP;PSMD11;UQCRB;NDUFB10;PSMD14;NDUFB11;PSMD13;ATP5MC2;ATP5MC3;HTRA2;COX7A2;UQCRH;ATXN1;KLC2;UBB;ATG101;DVL3;CYC1;MAP2K7;NDUFV2;MAP2K6;SEM1;CDK5;UQCRQ;UBA1;DNAL4;BCL2L1;GSK3B;COX4I1;FASLG;CASP9;CASP7;CASP3;RB1CC1;UQCRFS1;DNAI2;AXIN1;GPX7;NDUFC2;NDUFC1;WIPI1;WIPI2;TNFRSF1B;TNFRSF1A;NDUFS8;NDUFS7;NDUFS6;NDUFS5;CAT;NDUFS4;NDUFS3;NDUFS2;NDUFS1;SLC25A5;SLC25A6;DCTN6;BECN1;NDUFB9;RAB1A;DCTN5;NDUFB7;NDUFB6;DCTN2;NDUFB5;DCTN1;NDUFB4;NDUFB3;DCTN3;NDUFB2;NDUFB1;HSD17B10;MAPK9;MAPK1;BAK1;MAPK3;NDUFA9;NDUFA8;NDUFA7;NDUFA6;NDUFA5;NDUFA4;BAD;NDUFA3;ADRM1;NDUFA2;NDUFA1;SOD1;MAPK11;CCS;BAX;KRAS
Proteasome	41/46	2.57508582608715e-23	1.15510992770195e-21	0	0	32.0120422708282	1665.06073834123	PSMD11;PSMD14;PSMD13;POMP;PSMA7;PSMB10;PSMB6;PSMD8;PSMB7;PSMD9;PSMB4;PSMD6;PSMD7;PSMB2;PSMD4;PSMB3;PSMD2;PSMB1;PSMD3;PSMF1;ADRM1;PSMB8;PSMB9;PSMA5;SEM1;PSMA6;PSMA3;PSMC5;PSMA4;PSMC6;IFNG;PSMA1;PSMC3;PSMA2;PSMC4;PSMC1;PSME3;PSMC2;PSME4;PSME1;PSME2
Alzheimer disease	159/369	4.29182166800634e-23	1.68454000469249e-21	0	0	3.00480890913693	154.755909619616	NDUFA13;CSF1;NDUFA11;NDUFA12;NDUFA10;ARAF;COX6A1;PSMD8;PSMD9;PSMD6;FRAT2;PSMD7;PSMD4;AKT2;PSMD2;KIF5B;PSMD3;CAPN2;CAPN1;MAP2K1;MAP2K2;CSNK2A1;CSNK2A2;SDHC;SDHD;SDHA;ATG13;SDHB;COX6B1;COX7A2L;DDIT3;CSNK2B;UQCRC1;VDAC3;PPIF;VDAC2;VDAC1;UQCRC2;PPID;ATF4;PSMD11;NDUFB10;PSMD14;UQCRB;NDUFB11;PSMD13;ATP5MC2;PIK3R3;ATP5MC3;COX7A2;UQCRH;APH1A;KLC2;ATG101;DVL3;FADD;NRBF2;CYC1;MAP2K7;NDUFV2;XBP1;EIF2AK3;EIF2AK2;SEM1;CDK5;UQCRQ;ATG2A;CALM3;GSK3B;COX7B;COX4I1;PIK3CD;COX7C;CASP9;CASP7;CASP3;RB1CC1;UQCRFS1;COX8A;PSENEN;CHUK;AXIN1;NDUFC2;NDUFC1;WIPI1;WIPI2;TNFRSF1A;PSMA5;PSMA6;PSMA3;PSMA4;NDUFS8;PSMA1;NDUFS7;PSMA2;NDUFS6;NDUFS5;NDUFS4;NDUFS3;NDUFS2;NDUFS1;SLC25A5;GAPDH;SLC25A6;BECN1;NDUFB9;NDUFB7;NDUFB6;NDUFB5;NDUFB4;NDUFB3;NDUFB2;NDUFB1;UQCR11;UQCR10;COX5B;COX5A;HSD17B10;PSMA7;PSMB6;PSMB7;MAPK9;ATP5F1A;NRAS;PSMB4;ATP5F1B;PSMB2;PSMB3;PSMB1;MAPK1;BID;MAPK3;NDUFA9;ATP5PF;NDUFA8;NDUFA7;ATP5PD;NDUFA6;NDUFA5;ATP5PB;CSNK1A1;BAD;NDUFA4;NDUFA3;ADRM1;NDUFA2;NDUFA1;ATP5F1C;COX6C;ATP5F1D;ATP5F1E;PSMC5;PSMC6;PSMC3;PSMC4;PSMC1;NDUFAB1;PSMC2;KRAS
Non-alcoholic fatty liver disease	87/155	1.88875526266242e-22	6.58965724973333e-21	0	0	5.03178049743387	251.694460925769	GSK3B;NDUFA13;COX7B;GSK3A;NDUFA11;NDUFA12;COX4I1;NDUFA10;PRKAG1;PIK3CD;FASLG;COX6A1;COX7C;CASP7;AKT2;CASP3;MLX;UQCRFS1;RAC1;COX8A;NDUFC2;SDHC;NDUFC1;SDHD;SDHA;SDHB;COX6B1;TNFRSF1A;COX7A2L;NDUFS8;NDUFS7;NDUFS6;DDIT3;NDUFS5;NDUFS4;UQCRC1;NDUFS3;NDUFS2;NDUFS1;UQCRC2;PPARA;ATF4;NDUFB9;NDUFB7;NDUFB10;UQCRB;NDUFB6;NDUFB11;NDUFB5;NDUFB4;NDUFB3;NDUFB2;PIK3R3;NDUFB1;COX7A2;UQCR11;UQCR10;COX5B;ADIPOR2;COX5A;UQCRH;CDC42;MAPK9;BCL2L11;CYC1;NDUFV2;BID;NDUFA9;NDUFA8;XBP1;NDUFA7;TGFB1;NDUFA6;NDUFA5;NDUFA4;NDUFA3;NDUFA2;EIF2AK3;NDUFA1;NR1H3;COX6C;MAPK11;ITCH;UQCRQ;NDUFAB1;BAX;MAP3K11
Diabetic cardiomyopathy	101/203	1.42123589955656e-20	4.46268072460759e-19	0	0	3.89952997911562	178.209202521838	NDUFA13;NDUFA11;NDUFA12;NDUFA10;COX6A1;PPP1CC;MPC1;AKT2;MPC2;PDK2;G6PD;PRKCB;CYBA;SDHC;SDHD;SDHA;SDHB;COX6B1;COX7A2L;UQCRC1;VDAC3;PPIF;VDAC2;VDAC1;UQCRC2;NDUFB10;UQCRB;NDUFB11;ATP5MC2;PIK3R3;ATP5MC3;COX7A2;PRKCZ;UQCRH;CYC1;NDUFV2;TGFB1;UQCRQ;GSK3B;COX7B;COX4I1;PIK3CD;COX7C;GYS1;RAC2;UQCRFS1;RAC1;CTSD;COX8A;PARP1;NDUFC2;NDUFC1;TGFBR2;NDUFS8;NDUFS7;NDUFS6;NDUFS5;NDUFS4;NDUFS3;NDUFS2;NDUFS1;PPARA;SLC25A5;GAPDH;SLC25A6;NDUFB9;NDUFB7;NDUFB6;NDUFB5;NDUFB4;NDUFB3;NDUFB2;NDUFB1;UQCR11;UQCR10;PDHB;COX5B;COX5A;PTPA;MAPK9;ATP5F1A;ATP5F1B;NDUFA9;ATP5PF;NDUFA8;NDUFA7;ATP5PD;NDUFA6;NDUFA5;ATP5PB;NDUFA4;NDUFA3;NDUFA2;NDUFA1;ATP5F1C;COX6C;ATP5F1D;ATP5F1E;PPP1CA;MAPK11;NDUFAB1
Thermogenesis	109/232	1.19491615652924e-19	3.41094248318347e-18	0	0	3.49222247283708	152.15976765761	ATF2;NDUFA13;SMARCB1;NDUFA11;NDUFA12;NDUFA10;COX6A1;ACTB;ACTG1;RPS6KA3;CREB3L4;RPS6KA1;DPF3;MAP2K3;ACSL5;ACSL4;SDHC;SDHD;SDHA;SDHB;COX6B1;COX7A2L;UQCRC1;UQCRC2;COX19;COX16;NDUFB10;UQCRB;COX15;NDUFB11;ATP5MC2;ATP5MC3;COX7A2;UQCRH;COX14;CYC1;NDUFV2;ATP5MG;ATP5MF;COX10;ATP5ME;COA3;RHEB;UQCRQ;NDUFAF5;GRB2;COX7B;COX4I1;PRKAG1;COX7C;MLST8;UQCRFS1;COA6;COA5;COX8A;NDUFC2;SIRT6;NDUFC1;CREB3;NDUFS8;NDUFS7;NDUFS6;NDUFS5;AKT1S1;NDUFS4;NDUFS3;NDUFS2;NDUFS1;NDUFB9;SMARCD1;SMARCD2;NDUFB7;NDUFB6;NDUFB5;NDUFB4;NDUFB3;NDUFB2;NDUFB1;UQCR11;UQCR10;COX5B;ADCY7;COX5A;ATP5F1A;NRAS;SLC25A29;ATP5F1B;SLC25A20;NDUFA9;SMARCE1;ATP5PF;NDUFA8;NDUFA7;ATP5PD;NDUFA6;NDUFA5;ATP5PB;NDUFA4;NDUFA3;NDUFA2;NDUFA1;ATP5F1C;COX6C;ATP5F1D;ATP5F1E;MAPK11;NDUFAB1;RPS6KB2;KRAS
Epstein-Barr virus infection	94/202	8.446013351726e-17	2.2100401603683e-15	0	0	3.4203648369485	126.588564696374	CDKN1B;PIK3CD;CD3G;RBPJ;CD3E;CD3D;PSMD8;CASP9;PSMD6;CCND3;PSMD7;TBK1;PSMD4;AKT2;PSMD2;CASP3;PSMD3;CIR1;IKBKG;RAC1;HLA-DOA;B2M;IKBKE;JAK3;HLA-DPA1;JAK1;MAP2K3;ENTPD1;CHUK;DDX58;HLA-B;TAP2;HLA-C;TAP1;HLA-A;TYK2;IRAK4;HLA-F;HLA-G;RUNX3;HLA-E;TAPBP;NCOR2;IRF3;OAS1;OAS2;TRAF3;IRF7;IRF9;HLA-DQB1;PSMD11;PSMD14;PSMD13;HDAC1;PIK3R3;RELB;MAPK9;HLA-DMA;HLA-DMB;BCL2L11;PLCG2;E2F3;FADD;CD58;BAK1;BID;MAP2K7;MAP2K6;HLA-DRB5;STAT1;ADRM1;EIF2AK2;ISG15;SEM1;MAPK11;PSMC5;MAVS;SNW1;PSMC6;PSMC3;PSMC4;PSMC1;PSMC2;HLA-DPB1;MDM2;HLA-DRA;BAX;TAB1;CD247;NFKBIE;MAP3K14;HLA-DRB1;MYD88;NFKBIB
Endocytosis	102/252	3.34814098967767e-13	8.08704823660607e-12	0	0	2.67045908183633	76.7094737426704	TFRC;WIPF1;WIPF2;ARPC5L;CBLB;KIF5B;AP2M1;WASHC3;SH3GLB1;USP8;IST1;HLA-B;HLA-C;HLA-A;HLA-F;HLA-G;HLA-E;RNF41;ACAP2;BIN1;RAB35;CHMP4B;CHMP4A;STAMBP;VPS25;STAM2;VPS28;RAB5C;TSG101;AGAP2;VPS26B;PRKCZ;SNX3;SNX4;SNX1;GRK3;GRK2;PIP5K1A;RAB11FIP4;SNX5;SNX6;RAB4A;IQSEC1;IQSEC3;ARPC4;SNF8;ARPC5;IGF2R;EHD1;ARPC2;ARPC3;CHMP2A;MDM2;ARF3;ARF4;ARF1;SH3KBP1;ARPC1B;CLTC;CLTB;CLTA;AP2A1;ARRB2;CAPZB;CHMP1A;CCR5;RAB8A;ACTR3;ACTR2;ARAP2;EPS15L1;ARAP1;VPS37B;RHOA;EPN1;ARFGAP2;DNM2;TGFBR2;RABEP1;ARF5;ARF6;RAB7A;CHMP5;VPS4B;PARD6G;ASAP1;IL2RG;CDC42;CYTH4;AP2S1;MVB12A;LDLR;GIT2;GBF1;PML;RAB11B;RAB10;ITCH;CAPZA1;CAPZA2;IL2RB;SPG21
Yersinia infection	65/137	1.54243554588525e-12	3.45946258148549e-11	0	0	3.53031863754979	96.0164004372269	GSK3B;WIPF1;WIPF2;ARPC1B;ARPC5L;PIK3CD;ACTB;ACTG1;CRKL;PYCARD;RPS6KA3;TBK1;AKT2;RPS6KA1;CASP1;RAC2;IKBKG;RAC1;MAP2K3;ACTR3;ACTR2;MAP2K1;MAP2K2;ARHGEF12;CHUK;ITGA4;RHOG;IRAK4;RHOA;VAV1;ZAP70;CD8B;IRF3;CD8A;LCK;ARHGEF1;LCP2;ARHGEF7;ARF6;ROCK1;PXN;WAS;PIK3R3;CDC42;MAPK9;PIP5K1A;MAPK1;PTK2B;MAP2K7;WASF2;MAP2K6;MAPK3;GIT2;FYB1;LIMK1;NFATC3;NFATC2;ARPC4;ARPC5;MAPK11;ARPC2;ARPC3;TAB1;LAT;MYD88
Human immunodeficiency virus 1 infection	85/212	5.47179582153194e-11	1.14542925864069e-09	0	0	2.62112779380838	61.9341808375848	PIK3CD;CD3G;FASLG;CD3E;CD3D;CRKL;CASP9;TBK1;GNGT2;TRIM5;AP1G1;AKT2;CASP3;CFL1;RAC2;AP1S1;ELOB;ELOC;IKBKG;RAC1;CCR5;B2M;MAP2K3;MAP2K1;MAP2K2;CHUK;PRKCB;FBXW11;HLA-B;TAP2;HLA-C;TAP1;HLA-A;IRAK4;HLA-F;TNFRSF1B;HLA-G;HLA-E;RBX1;TAPBP;TNFRSF1A;IRF3;PXN;GNAI3;PIK3R3;RNF7;GNAI2;MAPK9;GNG10;NRAS;GNG2;GNG5;PLCG2;MAPK1;PTK2B;FADD;BAK1;BID;MAP2K7;PAK2;AP1M1;MAP2K6;MAPK3;APOBEC3C;APOBEC3D;APOBEC3F;APOBEC3G;APOBEC3H;BAD;LIMK1;NFATC3;NFATC2;BST2;MAPK11;GNB2;GNB1;RPS6KB2;BAX;CALM3;KRAS;TAB1;CD247;MYD88;BCL2L1;CUL4B
Influenza A	72/172	1.59036145517898e-10	3.12108435578876e-09	0	0	2.81545319465082	63.5219441777014	CIITA;CALCOCO2;PIK3CD;ADAR;FASLG;NXT2;ACTB;ACTG1;PYCARD;CASP9;IFIH1;CCND3;TBK1;AKT2;CASP3;KPNA6;TNFSF10;CASP1;TRIM25;IKBKG;HLA-DOA;KPNA2;JAK2;IKBKE;HLA-DPA1;JAK1;MAP2K1;MAP2K2;RSAD2;CHUK;PRKCB;DDX58;IRAK4;TYK2;TNFRSF1A;DNAJC3;IFNG;IRF3;OAS1;OAS2;TRAF3;IRF7;VDAC1;SLC25A5;IRF9;HLA-DQB1;SLC25A6;NLRX1;PIK3R3;HLA-DMA;HLA-DMB;PABPN1;CCL5;MAPK1;FADD;BAK1;BID;RAE1;MAPK3;FDPS;HLA-DRB5;STAT1;EIF2AK2;PML;RAB11B;MAVS;HLA-DPB1;HLA-DRA;BAX;HLA-DRB1;MYD88;NFKBIB
Autophagy	59/137	1.90096700642111e-09	3.51119788244841e-08	0	0	2.95244605637101	59.2877832530534	MTMR14;WDR41;PIK3CD;HMGB1;TBK1;AKT2;RB1CC1;LAMP2;MLST8;CTSD;SNAP29;RAB8A;SH3GLB1;GABARAPL2;GABARAPL1;MAP2K1;MAP2K2;DAPK2;ATG9A;DAPK3;RRAS2;WIPI1;WIPI2;ATG13;ATG12;VAMP8;RRAGC;AKT1S1;ATG4B;ATG4A;ATG4D;RAB7A;BECN1;RAB1A;PIK3R3;HIF1A;TANK;GABARAP;PPP2CA;MAPK9;NRAS;ATG101;TP53INP2;MAPK1;NRBF2;ATG7;ATG5;MAPK3;IGBP1;BAD;EIF2AK3;EIF2AK4;CFLAR;ATG16L1;RHEB;RPS6KB2;ATG2A;KRAS;BCL2L1
Protein processing in endoplasmic reticulum	69/171	2.49125261780338e-09	4.34585178883479e-08	0	0	2.64293928410265	52.3578963406108	UBXN1;PRKCSH;UBE2D2;UBE2D3;UBE2D1;HERPUD1;MAN1A2;SEC61G;CAPN2;UFD1;FBXO6;MAN1A1;CAPN1;SEC61B;UBXN4;SIL1;UBXN6;SEC13;SSR4;SSR2;SSR3;DNAJB12;YOD1;PDIA6;RAD23B;DDOST;RBX1;DNAJC3;DNAJC1;SELENOS;DDIT3;DNAJC5;DNAJB11;ERP29;PLAA;PREB;ATF4;VCP;SAR1A;ATF6B;SAR1B;DERL1;DERL2;RRBP1;UBE2J2;RNF5;UBE2J1;ERLEC1;LMAN1;MAPK9;BAG2;OS9;LMAN2;BAG1;SSR1;BAK1;MAP2K7;SEC23B;XBP1;SEC24A;EIF2AK1;EDEM2;EIF2AK3;EIF2AK2;UBE2G1;EIF2AK4;DNAJA2;BAX;P4HB
T cell receptor signaling pathway	48/104	3.88947077878724e-09	6.18953612444689e-08	0	0	3.34121122599705	64.7025311180528	GSK3B;ITK;PIK3R3;PIK3CD;CBLB;CD3G;CD3E;RASGRP1;CD3D;CDC42;MAPK9;NRAS;AKT2;GRAP2;CTLA4;MAPK1;MAP3K8;FYN;IKBKG;MAP2K7;PAK2;NCK1;MAPK3;MAP2K1;MAP2K2;CHUK;NFATC3;NFATC2;RHOA;VAV1;ZAP70;MAPK11;PTPRC;CD8B;IFNG;CD8A;LCK;GRB2;LCP2;KRAS;PTPN6;CD247;PDCD1;NFKBIE;MAP3K14;CARD11;LAT;NFKBIB
Shigellosis	90/246	3.94237969709993e-09	6.18953612444689e-08	0	0	2.25803673938002	43.6963557637548	GSK3B;ARF1;GSK3A;CALCOCO2;ARPC1B;UBE2D2;UBE2D3;ARPC5L;UBE2D1;ILK;PIK3CD;ACTB;CRKL;ACTG1;HK1;PYCARD;TBK1;CAPNS1;AKT2;CASP4;CAPN2;CASP1;IKBKG;RAC1;CAPN1;ACTR3;GABARAPL2;ACTR2;GABARAPL1;CHUK;FBXW11;WIPI1;ACTN4;WIPI2;ATG12;RHOA;RBX1;TNFRSF1A;MYL5;RRAGC;IRF3;AKT1S1;UBE2V2;HCLS1;VDAC1;RBCK1;UBE2V1;PFN1;TLN1;PPID;ARF6;RNF31;BECN1;ROCK1;PXN;PIK3R3;U2AF1;GABARAP;MYL12A;FOXO1;MYL12B;U2AF1L4;CDC42;MAPK9;CYTH4;UBB;CCL5;PLCG2;MAPK1;WASF2;ATG5;MAPK3;CBX3;GLMN;ARPC4;ARPC5;DIAPH1;MAPK11;ARPC2;TNIP1;ARPC3;ATG16L1;RPS6KB2;MDM2;UBE2N;BAX;TAB1;MYD88;BCL2L1;NFKBIB
Spliceosome	62/150	5.24487905472562e-09	7.84234296754211e-08	0	0	2.75030318002156	52.4373179843615	ISY1;DDX46;USP39;PQBP1;SART1;SNRPD2;SNRPD1;MAGOH;SNRPD3;TXNL4A;CTNNBL1;BUD31;PRPF40A;CRNKL1;CDC40;PRPF18;SYF2;SNRPG;PPIE;SNRNP27;SRSF3;SRSF4;SNRPF;SNRPC;SRSF6;SLU7;SNRPA;SNRPB;SRSF9;RBM22;SF3B4;SF3B5;SF3B2;DHX8;SF3B6;DDX23;SNU13;U2AF1;U2AF1L4;ZMAT2;PUF60;PCBP1;DHX38;SNRPB2;HNRNPA1;SMNDC1;HNRNPA3;PRPF38A;CCDC12;CDC5L;CWC15;LSM2;LSM8;XAB2;LSM7;SNRNP40;HNRNPK;LSM6;SNW1;PHF5A;ACIN1;HNRNPC
Human T-cell leukemia virus 1 infection	82/219	5.59753564442008e-09	7.98920996521775e-08	0	0	2.34081502475373	44.4776844309207	ATF2;ITGB2;PIK3CD;CD3G;TNFRSF13C;CD3E;ELK1;CD3D;ETS1;POLB;CCND3;KAT5;PTTG1;CREB3L4;AKT2;CDC26;CDC27;TSPO;IKBKG;HLA-DOA;B2M;JAK3;HLA-DPA1;JAK1;IL15RA;MAP2K1;MAP2K2;TBP;CHUK;HLA-B;HLA-C;HLA-A;HLA-F;HLA-G;HLA-E;TGFBR2;TNFRSF1A;CREB3;LCK;VDAC3;TBPL1;VDAC2;VDAC1;TLN1;SLC25A5;MAD1L1;ATF4;HLA-DQB1;SLC25A6;ATF6B;SRF;PIK3R3;IL2RG;ADCY7;ANAPC10;ANAPC11;RELB;MAPK9;HLA-DMA;NRAS;HLA-DMB;MAPK1;E2F3;BUB3;MAPK3;STAT5A;FDPS;HLA-DRB5;RANBP3;TGFB1;CDKN2A;NFYB;NFATC3;NFATC2;IL2RB;HLA-DPB1;HLA-DRA;BAX;KRAS;MAP3K14;HLA-DRB1;BCL2L1
Salmonella infection	88/249	3.82472801860555e-08	5.22158520800931e-07	0	0	2.13754783473504	36.5075928400875	ARF1;ARPC1B;ARPC5L;BRK1;PIK3CD;ACTB;PIK3CG;ACTG1;TXN2;PYCARD;ACTR1A;CASP7;ACTR1B;AKT2;KIF5B;CASP3;CASP4;TNFSF10;CASP1;IKBKG;RAC1;KPNA3;MAP2K3;ACTR3;VPS18;ACTR2;MAP2K1;MAP2K2;RIPK3;CHUK;DYNLT1;VPS33A;RHOG;RHOH;IRAK4;DYNLL1;RHOA;DNM2;TNFRSF1A;MYL5;PFN1;GAPDH;ARL8A;ARF6;RAB7A;DCTN6;DCTN5;RALA;RAB5C;DCTN2;DCTN1;DCTN3;TXN;MYL12A;MYL12B;STX10;CDC42;MAPK9;KLC2;CYTH4;VPS11;FLNA;MAPK1;NCKAP1L;SNX9;FADD;BAK1;MAP2K7;VPS16;MAP2K6;MAPK3;GSDMD;MLKL;ARPC4;ARPC5;MAPK11;SNX18;PTPRC;ARPC2;ARPC3;ABI1;VPS41;BAX;DYNLRB2;DYNLRB1;TAB1;ACBD3;MYD88
Antigen processing and presentation	37/78	9.52802250976452e-08	1.21928190570012e-06	0	0	3.51160228273041	56.7701200717629	CIITA;IFI30;CTSS;HLA-DMA;HLA-DMB;KLRC1;HLA-DOA;B2M;HLA-DPA1;CD74;HLA-DRB5;HSPA4;NFYB;KLRC4;NFYC;HLA-B;TAP2;HLA-C;TAP1;RFXANK;HLA-A;HLA-F;HLA-G;HLA-E;TAPBP;CD8B;IFNG;CD8A;PSME3;RFX5;PSME1;HLA-DPB1;PSME2;HLA-DRA;KLRD1;HLA-DRB1;HLA-DQB1
Spinocerebellar ataxia	57/143	9.70765848487354e-08	1.21928190570012e-06	0	0	2.5844421875269	41.7329667425241	GTF2B;PIK3CD;RBPJ;PSMD8;PSMD9;PSMD6;PSMD7;KAT5;PSMD4;AKT2;PSMD2;RB1CC1;PSMD3;TBP;PRKCB;WIPI1;WIPI2;ATG13;PSMA5;PSMA6;PSMA3;PSMA4;PSMA1;PSMA2;PPIF;VDAC3;TBPL1;VDAC2;VDAC1;SLC25A5;SLC25A6;BECN1;PSMD11;PSMD14;PSMD13;PIK3R3;PSMA7;PSMB6;MAPK9;PSMB7;PSMB4;ATXN1;PSMB2;ATG101;PSMB3;PSMB1;NRBF2;XBP1;ADRM1;SEM1;PSMC5;PSMC6;PSMC3;PSMC4;PSMC1;PSMC2;ATG2A
Th1 and Th2 cell differentiation	41/92	1.72882578553046e-07	2.08788960252525e-06	0	0	3.12934719230528	48.7259799037655	NOTCH1;CD3G;GATA3;CD3E;RBPJ;IL2RG;CD3D;MAPK9;HLA-DMA;HLA-DMB;TBX21;MAPK1;IKBKG;HLA-DOA;JAK2;IL12RB1;JAK3;HLA-DPA1;JAK1;MAPK3;STAT5A;HLA-DRB5;CHUK;STAT1;NFATC3;NFATC2;TYK2;RUNX3;ZAP70;MAPK11;IFNG;LCK;IL2RB;HLA-DPB1;HLA-DRA;CD247;NFKBIE;HLA-DRB1;LAT;HLA-DQB1;NFKBIB
PD-L1 expression and PD-1 checkpoint pathway in cancer	40/89	1.84105102382522e-07	2.14107415363377e-06	0	0	3.17725517725518	49.2721076778122	PIK3CD;PIK3R3;CD3G;CD3E;CD3D;HIF1A;RASGRP1;NRAS;AKT2;MAPK1;IKBKG;JAK2;JAK1;MAP2K6;MAPK3;MAP2K3;MAP2K1;MAP2K2;CHUK;CSNK2A1;STAT1;CSNK2A2;NFATC3;NFATC2;PTPN11;BATF;ZAP70;MAPK11;IFNG;LCK;CSNK2B;RPS6KB2;KRAS;PTPN6;CD247;PDCD1;NFKBIE;LAT;MYD88;NFKBIB
Fc gamma R-mediated phagocytosis	42/97	3.261455147485e-07	3.65748898682246e-06	0	0	2.97251273799946	44.397218966253	ARPC1B;ARPC5L;INPPL1;WAS;PIK3R3;PIK3CD;ASAP1;CRKL;CDC42;FCGR3A;FCGR3B;AKT2;INPP5D;CFL1;PLCG2;RAC2;PIP5K1A;MAPK1;RAC1;WASF2;MAPK3;VASP;ACTR3;ACTR2;MAP2K1;MARCKSL1;PRKCB;SPHK2;SPHK1;LIMK1;ARPC4;ARPC5;VAV1;DNM2;PTPRC;ARPC2;BIN1;ARPC3;RPS6KB2;PLPP1;LAT;ARF6
NOD-like receptor signaling pathway	66/181	5.10864209904192e-07	5.53142627275574e-06	0	0	2.23874338794994	32.433038173701	YWHAE;TXN2;PYCARD;PANX1;PSTPIP1;TBK1;NAMPT;CASP4;CASP1;IKBKG;IKBKE;JAK1;GABARAPL2;GBP5;GABARAPL1;CHUK;RIPK3;CYBA;IRAK4;TYK2;ATG12;RHOA;AIM2;IRF3;OAS1;OAS2;TRAF3;CARD17;VDAC3;IRF7;VDAC2;VDAC1;CARD16;RBCK1;IRF9;RNF31;NLRX1;BRCC3;TXN;TANK;GABARAP;TRPM2;MAPK9;IFI16;CCL5;MAPK1;MFN2;FADD;GBP2;GBP1;GBP4;ATG5;GBP3;MAPK3;GSDMD;STAT1;TRPV2;ERBIN;MAPK11;MAVS;ATG16L1;TAB1;SUGT1;MYD88;BCL2L1;NFKBIB
Human cytomegalovirus infection	78/225	5.39852301457405e-07	5.60515399621116e-06	0	0	2.07178287981859	29.8999088872858	ATF2;GSK3B;PIK3CD;FASLG;ELK1;CRKL;CASP9;AKAP13;TBK1;GNGT2;CREB3L4;AKT2;CASP3;RAC2;IKBKG;RAC1;CCR5;B2M;JAK1;MAP2K1;MAP2K2;ARHGEF12;CHUK;PRKCB;HLA-B;TAP2;HLA-C;TAP1;HLA-A;HLA-F;HLA-G;RHOA;HLA-E;TAPBP;TNFRSF1A;CREB3;IRF3;ARHGEF1;ATF4;ATF6B;ROCK1;PXN;GNAI3;PIK3R3;ADCY7;GNAI2;GNG10;NRAS;GNG2;GNG5;CCL5;CCL4;EIF4EBP1;CCL3;MAPK1;PTK2B;E2F3;FADD;BAK1;BID;MAP2K6;MAPK3;CCR1;CDKN2A;IL10RB;IL10RA;NFATC3;NFATC2;MAPK11;RHEB;GNB2;GNB1;RPS6KB2;MDM2;BAX;CALM3;GRB2;KRAS
Measles	54/139	5.53375076059064e-07	5.60515399621116e-06	0	0	2.47554820744866	35.6657919266052	GSK3B;CDKN1B;PIK3CD;CBLB;ADAR;CD3G;FASLG;CD3E;CD3D;CASP9;IFIH1;CCND3;TBK1;AKT2;CASP3;RACK1;IKBKG;IKBKE;JAK3;JAK1;CSNK2A1;CHUK;DDX58;CSNK2A2;IRAK4;TYK2;IRF3;OAS1;OAS2;TRAF3;CSNK2B;IRF7;IRF9;PIK3R3;IL2RG;MAPK9;FADD;BAK1;BID;STAT5A;BAD;STAT1;EIF2AK1;EIF2AK3;EIF2AK2;MSN;EIF2AK4;MAVS;IL2RB;BAX;EIF3H;MYD88;BCL2L1;NFKBIB
Mitophagy	32/68	8.63717176629732e-07	8.47522479567924e-06	0	0	3.45572448367936	48.2488959576745	BECN1;CALCOCO2;HIF1A;GABARAP;BCL2L13;MAPK9;NRAS;TBK1;UBB;MFN2;TBC1D17;TBC1D15;ATG5;BNIP3L;GABARAPL2;USP8;FIS1;GABARAPL1;CSNK2A1;ATG9A;CSNK2A2;TFEB;EIF2AK3;RRAS2;CSNK2B;NBR1;TAX1BP1;KRAS;OPTN;ATF4;RAB7A;BCL2L1
Hepatitis B	60/162	9.06382618175254e-07	8.62436794263726e-06	0	0	2.29310094408134	31.9057577856941	ATF2;YWHAB;ARAF;PIK3CD;FASLG;ELK1;CASP9;IFIH1;TBK1;YWHAQ;CREB3L4;AKT2;CASP3;IKBKG;JAK2;IKBKE;JAK3;JAK1;MAP2K3;MAP2K1;MAP2K2;ATP6AP1;CHUK;PRKCB;DDX58;IRAK4;TYK2;YWHAZ;TGFBR2;CREB3;IRF3;TRAF3;VDAC3;IRF7;ATF4;ATF6B;PIK3R3;MAPK9;NRAS;MAPK1;PTK2B;E2F3;FADD;MAP2K7;BID;MAP2K6;MAPK3;STAT5A;TGFB1;BAD;STAT1;NFATC3;NFATC2;MAPK11;MAVS;BAX;GRB2;KRAS;TAB1;MYD88
Viral carcinogenesis	70/203	2.49955612409922e-06	2.30841359696222e-05	0	0	2.05276185513288	26.4793909209382	YWHAE;ATF2;CDKN1B;HDAC10;YWHAB;GTF2B;PIK3CD;RBPJ;POLB;CCND3;YWHAQ;CREB3L4;CASP3;IKBKG;RAC1;CCR5;JAK3;JAK1;TBP;HLA-B;HLA-C;ACTN4;HLA-A;HLA-F;HLA-G;YWHAZ;RHOA;HLA-E;CREB3;PKM;IRF3;TRAF3;MAPKAPK2;VDAC3;IRF7;TBPL1;ATP6V0D1;MAD1L1;IRF9;ATF4;GTF2A1;HDAC5;SP100;GTF2A2;HDAC3;ATF6B;HDAC1;SRF;PXN;PIK3R3;HDAC8;GTF2E2;CDC42;NRAS;PMAIP1;MAPK1;BAK1;MAPK3;STAT5A;CDKN2A;BAD;EIF2AK2;GTF2H3;HNRNPK;SNW1;PSMC1;MDM2;BAX;GRB2;KRAS
Th17 cell differentiation	43/107	2.70000298188485e-06	2.42228838946241e-05	0	0	2.61448088271453	33.5235475790449	CD3G;GATA3;CD3E;IL2RG;HIF1A;CD3D;MAPK9;HLA-DMA;HLA-DMB;TBX21;IL21R;MAPK1;IKBKG;HLA-DOA;JAK2;IL12RB1;JAK3;HLA-DPA1;JAK1;MAPK3;STAT5A;HLA-DRB5;TGFB1;CHUK;STAT1;NFATC3;NFATC2;TYK2;TGFBR2;ZAP70;MAPK11;IFNG;IRF4;LCK;IL2RB;HLA-DPB1;HLA-DRA;CD247;NFKBIE;HLA-DRB1;LAT;NFKBIB;HLA-DQB1
Kaposi sarcoma-associated herpesvirus infection	67/193	3.12249530951159e-06	2.72350979774067e-05	0	0	2.07332289004315	26.2832615330161	CD86;GSK3B;PIK3CD;PIK3CG;CASP9;PREX1;TBK1;GNGT2;AKT2;CASP3;IKBKG;RAC1;CCR5;JAK2;IKBKE;JAK1;GABARAPL2;GABARAPL1;MAP2K1;MAP2K2;CHUK;HLA-B;HLA-C;HLA-A;TYK2;HLA-F;HLA-G;HLA-E;TNFRSF1A;IRF3;TRAF3;MAPKAPK2;IRF7;IRF9;BECN1;PIK3R3;HIF1A;GABARAP;PIK3R5;MAPK9;GNG10;NRAS;GNG2;UBB;GNG5;PLCG2;MAPK1;E2F3;FADD;BAK1;BID;MAP2K7;MICB;MAP2K6;MAPK3;CCR1;STAT1;NFATC3;EIF2AK2;NFATC2;MAPK11;CLEC2B;GNB2;GNB1;BAX;CALM3;KRAS
Hepatitis C	57/157	3.4660594236759e-06	2.94146664603846e-05	0	0	2.22065136935603	27.9191220691707	YWHAE;SCARB1;GSK3B;CD81;YWHAB;ARAF;PIK3CD;FASLG;CASP9;TBK1;YWHAQ;PPP2R1A;AKT2;CASP3;IKBKG;IKBKE;JAK1;MAP2K1;MAP2K2;RSAD2;CHUK;DDX58;TYK2;YWHAZ;TNFRSF1A;IFNG;IRF3;OAS1;OAS2;TRAF3;PSME3;IRF7;PPARA;IRF9;PIK3R3;PPP2CA;NRAS;MAPK1;E2F3;FADD;BAK1;BID;LDLR;MAPK3;BAD;STAT1;EIF2AK1;EIF2AK3;EIF2AK2;NR1H3;EIF2AK4;CFLAR;MAVS;PPP2R2D;BAX;GRB2;KRAS
Graft-versus-host disease	22/42	4.90554154521783e-06	4.05352643473263e-05	0	0	4.27030332681018	52.2050776386853	CD86;HLA-DRB5;PRF1;HLA-B;GZMB;HLA-C;FASLG;HLA-A;HLA-F;HLA-G;HLA-E;HLA-DMA;HLA-DMB;IFNG;HLA-DPB1;HLA-DRA;KLRD1;KLRC1;HLA-DOA;HLA-DRB1;HLA-DPA1;HLA-DQB1
Natural killer cell mediated cytotoxicity	49/131	6.3505338110504e-06	5.11299388889699e-05	0	0	2.32608813160281	27.836230805055	ITGB2;ARAF;PRF1;PIK3CD;FASLG;FCGR3A;FCGR3B;CASP3;TNFSF10;RAC2;RAC1;MAP2K1;MAP2K2;PRKCB;HLA-B;HLA-C;HLA-A;HLA-G;VAV1;HLA-E;ZAP70;IFNG;LCK;LCP2;HCST;PIK3R3;NRAS;KLRK1;KLRC4-KLRK1;SH3BP2;PLCG2;MAPK1;PTK2B;FYN;KLRC1;BID;MAPK3;MICB;SH2D1A;NFATC2;GZMB;PTPN11;GRB2;KLRD1;KRAS;PTPN6;CD247;LAT;CD244
Ubiquitin mediated proteolysis	51/140	9.90925146029254e-06	7.77876239632964e-05	0	0	2.23072323675229	25.7024862581896	UBE2D2;UBE2D3;KEAP1;UBE2D1;CBLB;UBE2L6;UBE2Z;UBE2L3;HERC2;UBE2Q1;CDC26;CDC27;ELOB;ELOC;PIAS4;FBXW8;FBXW11;FBXW7;UBE2E3;RBX1;CDC34;UBE2R2;BIRC6;UBA6;RNF7;UBE2J2;ANAPC10;ANAPC11;UBE2J1;UBB;VHL;UBE2F;UBE2H;UBE2I;UBE2B;UBE2G1;UBE2A;PML;UBE2W;UBOX5;ITCH;MDM2;UBA3;UBE2N;UBE2O;ERCC8;UBA1;TRIP12;UBE2K;UBE2M;CUL4B
mRNA surveillance pathway	39/98	1.01627330482763e-05	7.78316628575305e-05	0	0	2.57051322083859	29.552633087206	CSTF3;CSTF2;CSTF2T;MSI2;NXT2;GSPT2;GSPT1;GLE1;PPP2CA;PPP1CC;PABPN1;PPP2R1A;PPP2R5E;PPP2R3C;PAPOLG;MAGOH;PAPOLA;CSTF1;SAP18;PELO;UPF1;CPSF6;CPSF3;CPSF2;SSU72;PYM1;PPP2R5B;UPF3B;PPP2R5A;UPF3A;PPP2R5D;WDR33;PPP1CA;NUDT21;DDX19B;WDR82;PPP2R2D;ACIN1;ETF1
Toxoplasmosis	43/112	1.07444114406393e-05	8.03272664847793e-05	0	0	2.42425959383229	27.7362565716747	CIITA;GNAI3;PIK3CG;PIK3R5;GNAI2;CASP9;MAPK9;HLA-DMA;HLA-DMB;AKT2;CASP3;MAPK1;IKBKG;HLA-DOA;CCR5;JAK2;LDLR;MAP2K6;HLA-DPA1;JAK1;MAPK3;MAP2K3;HLA-DRB5;TGFB1;CHUK;BAD;IL10RB;STAT1;IL10RA;IRAK4;TYK2;TNFRSF1A;MAPK11;IFNG;PPIF;HLA-DPB1;HLA-DRA;TAB1;HLA-DRB1;MYD88;BCL2L1;NFKBIB;HLA-DQB1
Allograft rejection	20/38	1.20271658122545e-05	8.58302287510887e-05	0	0	4.31187177397446	48.8463609144057	CD86;HLA-DRB5;PRF1;HLA-B;GZMB;HLA-C;FASLG;HLA-A;HLA-F;HLA-G;HLA-E;HLA-DMA;HLA-DMB;IFNG;HLA-DPB1;HLA-DRA;HLA-DOA;HLA-DRB1;HLA-DPA1;HLA-DQB1
Primary immunodeficiency	20/38	1.20271658122545e-05	8.58302287510887e-05	0	0	4.31187177397446	48.8463609144057	CIITA;DCLRE1C;TAP2;TAP1;RFXANK;TNFRSF13C;CD3E;IL2RG;CD3D;CD79A;ZAP70;PTPRC;CD8B;CD8A;LCK;RFX5;ORAI1;IKBKG;JAK3;ADA
Citrate cycle (TCA cycle)	17/30	1.50339999866121e-05	0.000104903911017693	0	0	5.0726192937285	56.3324327893319	MDH1;IDH3G;MDH2;IDH1;IDH2;DLST;SDHC;PDHB;SDHD;SDHA;SDHB;ACLY;IDH3B;SUCLG1;ACO2;DLD;PCK2
Apoptosis	51/142	1.55931451699215e-05	0.000106440164855551	0	0	2.18142020581045	24.145440354816	PRF1;PIK3CD;FASLG;ACTB;CTSS;ACTG1;LMNB1;CASP9;CASP7;AIFM1;AKT2;CASP3;CAPN2;TNFSF10;CAPN1;IKBKG;CTSD;CTSC;DAXX;MAP2K1;DFFA;PARP3;MAP2K2;CHUK;PARP1;TNFRSF1A;DDIT3;BIRC6;ATF4;BECN1;DIABLO;HTRA2;PIK3R3;MAPK9;NRAS;BCL2L11;PMAIP1;MAPK1;FADD;BAK1;BID;MAPK3;NTRK1;BAD;EIF2AK3;GZMB;CFLAR;BAX;KRAS;MAP3K14;BCL2L1
Viral myocarditis	27/60	1.70856332184458e-05	0.000112666649149043	0	0	3.17754325028388	34.8807584892391	CD86;ITGB2;PRF1;ACTB;ACTG1;CASP9;HLA-DMA;HLA-DMB;CASP3;RAC2;FYN;RAC1;HLA-DOA;BID;HLA-DPA1;HLA-DRB5;HLA-B;HLA-C;HLA-A;HLA-F;HLA-G;HLA-E;HLA-DPB1;HLA-DRA;EIF4G3;HLA-DRB1;HLA-DQB1
SNARE interactions in vesicular transport	18/33	1.72229272584524e-05	0.000112666649149043	0	0	4.65542521994135	51.0666119269507	GOSR2;STX8;SNAP23;USE1;STX11;VAMP8;VAMP7;BNIP1;STX6;VTI1A;STX5;SEC22B;VAMP4;SNAP29;YKT6;VAMP5;STX1A;VTI1B
Tuberculosis	61/180	1.96763736818539e-05	0.000126089415022492	0	0	1.99661499571426	21.6355036772219	CIITA;ITGB2;LSP1;CTSS;CASP9;FCGR3A;FCGR3B;AKT2;CASP3;LAMP2;HLA-DOA;JAK2;CTSD;HLA-DPA1;JAK1;ATP6V0B;ARHGEF12;ATP6AP1;KSR1;SPHK2;SPHK1;IRAK4;RHOA;TNFRSF1A;IFNG;RFX5;ATP6V0D1;ATP6V0C;HLA-DQB1;RAB7A;CEBPB;RAB5C;CORO1A;MAPK9;HLA-DMA;HLA-DMB;IRAK2;ATP6V0A2;ATP6V1H;MAPK1;FADD;BID;MAPK3;CD74;HLA-DRB5;TGFB1;VDR;BAD;IL10RB;NFYB;STAT1;IL10RA;NFYC;RFXANK;MAPK11;HLA-DPB1;HLA-DRA;BAX;CALM3;HLA-DRB1;MYD88
Valine, leucine and isoleucine degradation	23/48	2.03611687508474e-05	0.000127868139755322	0	0	3.57127477367262	38.5764849937475	ACAD8;BCKDHA;MCCC2;ACAA2;ECHS1;HMGCS1;ABAT;HSD17B10;ACSF3;ACAT1;HADHB;HMGCL;HADHA;AUH;PCCA;IVD;DBT;PCCB;ACADM;ACAA1;ACADS;DLD;ALDH9A1
Type I diabetes mellitus	21/43	3.23204737819301e-05	0.000198992720931883	0	0	3.70426198892817	38.3013639160134	CD86;HLA-DRB5;PTPRN2;PRF1;HLA-B;GZMB;HLA-C;FASLG;HLA-A;HLA-F;HLA-G;HLA-E;HLA-DMA;HLA-DMB;IFNG;HLA-DPB1;HLA-DRA;HLA-DOA;HLA-DRB1;HLA-DPA1;HLA-DQB1
Renal cell carcinoma	29/69	4.10829352679195e-05	0.000248077724502437	0	0	2.81579269786817	28.4392745734238	PRCC;ARAF;PIK3CD;PIK3R3;ETS1;HIF1A;CRKL;CDC42;RAP1B;NRAS;AKT2;MAPK1;ELOB;ELOC;RAC1;VHL;PAK2;MAPK3;MAP2K1;EGLN3;MAP2K2;EGLN2;TGFB1;BAD;PTPN11;RBX1;RAPGEF1;GRB2;KRAS
Pathogenic Escherichia coli infection	64/197	5.44251947529994e-05	0.000322443606649846	0	0	1.8740276296277	18.4004839265864	ARF1;WIPF1;WIPF2;ARPC1B;ARPC5L;BRK1;FASLG;ACTB;ACTG1;PYCARD;CASP9;CASP7;CASP3;CASP4;TNFSF10;CASP1;IKBKG;RAC1;NCK1;ACTR3;ACTR2;ARHGEF12;CHUK;F2R;IRAK4;RHOA;TNFRSF1A;HCLS1;MYH9;ARHGEF1;EZR;GAPDH;ARF6;RAB1A;ROCK1;CDC42;SLC9A3R1;MAPK9;CYTH4;MAPK1;NCKAP1L;FYN;FADD;BAK1;PAK2;WASF2;MAPK3;SEC24A;ARPC4;PTPN11;ARPC5;MAPK11;MYO1E;LPAR5;ARPC2;ARPC3;ABI1;BAX;PTPN6;TAB1;MYD88;MYO1F;NFKBIB;MYO1G
mTOR signaling pathway	52/154	8.64672414249749e-05	0.000502790996434113	0	0	1.98343625276626	18.5565236610476	PRR5;GSK3B;CAB39L;PIK3CD;RPS6KA3;AKT2;RPS6KA1;SESN2;MLST8;ATP6V1E1;ATP6V1G1;MAP2K1;SEC13;MAP2K2;CHUK;MIOS;PRKCB;STRADA;RHOA;TNFRSF1A;SLC7A5;CLIP1;RRAGC;AKT1S1;TBC1D7;ATP6V1B2;EIF4E2;ATP6V1A;CAB39;NPRL2;PIK3R3;NRAS;EIF4EBP1;ATP6V1H;DVL3;MAPK1;ATP6V1D;EIF4E;ATP6V1C1;ATP6V1F;MAPK3;CASTOR1;RHEB;RPS6KB2;GRB2;KRAS;LAMTOR2;LAMTOR1;LPIN1;LAMTOR3;LPIN2;LAMTOR5
Pancreatic cancer	30/76	0.000122691679863352	0.000700457954128956	0	0	2.53260869565217	22.8082586090851	RALA;ARAF;PIK3CD;PIK3R3;CASP9;CDC42;MAPK9;AKT2;RAC2;MAPK1;E2F3;IKBKG;RAC1;BAK1;RALGDS;JAK1;MAPK3;MAP2K1;RALBP1;TGFB1;CHUK;BAD;CDKN2A;STAT1;TGFBR2;RPS6KB2;BAX;KRAS;ARHGEF6;BCL2L1
Propanoate metabolism	17/34	0.00012540387703226	0.00070315745335946	0	0	3.87808453457122	34.840599044244	BCKDHA;ECHS1;ABAT;ACAT1;LDHB;HADHA;LDHA;PCCA;ACOX1;DBT;PCCB;ECHDC1;SUCLG1;ACOX3;ACSS1;ACADS;DLD
Cytosolic DNA-sensing pathway	26/63	0.00014497821158765	0.000798651902430213	0	0	2.72770468803769	24.1099828653827	ADAR;PYCARD;TBK1;CCL5;CCL4;CASP1;POLR2E;POLR2F;IKBKG;IKBKE;POLR2K;POLR2L;ZBP1;CHUK;RIPK3;DDX58;POLR3GL;MAVS;AIM2;IRF3;POLR3D;IRF7;POLR1D;POLR3F;POLR3K;NFKBIB
Vibrio cholerae infection	22/50	0.000152006467215891	0.000822931563892928	0	0	3.04867906066536	26.8027286924478	ATP6V1A;ARF1;ATP6V0B;ATP6V1G1;ATP6V0E1;ATP6AP1;KDELR1;ACTB;ACTG1;SEC61G;ATP6V1B2;ATP6V0A2;PLCG2;ATP6V1H;KDELR2;SEC61B;ATP6V1E1;ATP6V0D1;ATP6V0C;ATP6V1D;ATP6V1C1;ATP6V1F
Leishmaniasis	30/77	0.000161860372798292	0.000861426390824808	0	0	2.47856695869837	21.6348569996748	ITGB2;ELK1;FCGR3A;HLA-DMA;FCGR3B;HLA-DMB;MAPK1;HLA-DOA;JAK2;HLA-DPA1;JAK1;MAPK3;HLA-DRB5;MARCKSL1;TGFB1;ITGA4;PRKCB;STAT1;CYBA;IRAK4;MAPK11;IFNG;HLA-DPB1;HLA-DRA;PTPN6;TAB1;HLA-DRB1;MYD88;HLA-DQB1;NFKBIB
Retrograde endocannabinoid signaling	49/148	0.000232709970362143	0.00121784884489522	0	0	1.92458691818455	16.1005507353134	NDUFA13;NDUFA11;NDUFA12;NDUFA10;GNGT2;PRKCB;NDUFC2;NDUFC1;NDUFS8;NDUFS7;NDUFS6;NDUFS5;NDUFS4;NDUFS3;NDUFS2;NDUFS1;NDUFB9;NDUFB7;NDUFB10;NDUFB6;NDUFB11;NDUFB5;NDUFB4;NDUFB3;GNAI3;NDUFB2;NDUFB1;ADCY7;GNAI2;MAPK9;GNG10;GNG2;GNG5;MAPK1;NDUFV2;MAPK3;NDUFA9;NDUFA8;NDUFA7;NDUFA6;NDUFA5;NDUFA4;NDUFA3;NDUFA2;NDUFA1;MAPK11;GNB2;GNB1;NDUFAB1
Phagosome	50/152	0.000241020192259675	0.00124066131753341	0	0	1.90621076016614	15.8799362450655	SCARB1;TFRC;ITGB2;ACTB;CTSS;ACTG1;FCGR3A;FCGR3B;SEC61G;LAMP2;RAC1;SEC61B;ATP6V1E1;HLA-DOA;HLA-DPA1;ATP6V1G1;ATP6V0B;ATP6V0E1;ATP6AP1;ITGA2;HLA-B;TAP2;HLA-C;TAP1;CYBA;HLA-A;HLA-F;HLA-G;HLA-E;ATP6V1B2;ATP6V0D1;SEC22B;ATP6V0C;HLA-DQB1;RAB7A;ATP6V1A;RAB5C;C1R;CORO1A;HLA-DMA;HLA-DMB;ATP6V0A2;ATP6V1H;ATP6V1D;ATP6V1C1;ATP6V1F;HLA-DRB5;HLA-DPB1;HLA-DRA;HLA-DRB1
Cellular senescence	51/156	0.000248883638572838	0.00126047520180437	0	0	1.88888888888889	15.6749918285327	MRE11;PIK3CD;ETS1;PPP1CC;CCND3;AKT2;RASSF5;CAPN2;CAPN1;NBN;MAP2K3;MAP2K1;MAP2K2;FBXW11;HLA-B;HLA-C;RRAS2;HLA-A;HLA-F;HLA-G;HLA-E;TGFBR2;MAPKAPK2;VDAC3;VDAC2;VDAC1;SLC25A5;PPID;SLC25A6;LIN37;PIK3R3;FOXO1;NRAS;RBBP4;EIF4EBP1;MAPK1;E2F3;E2F5;MAP2K6;MAPK3;TGFB1;CDKN2A;NFATC3;NFATC2;PPP1CA;MAPK11;RHEB;MDM2;CALM3;KRAS;RAD9A
Basal transcription factors	20/45	0.000254520242015519	0.00126856120623608	0	0	3.10317848410758	25.6823091333395	GTF2A1;GTF2A2;TBP;TAF12;TAF13;GTF2B;TAF10;TAF9;TAF11;GTF2F1;GTF2H3;GTF2E2;GTF2H5;CDK7;ERCC3;TAF8;TBPL1;MNAT1;TAF2;GTF2I
Neurotrophin signaling pathway	41/119	0.00028504881223229	0.00139852073501467	0	0	2.04262371527056	16.6736312421102	YWHAE;GSK3B;MAGED1;PIK3R3;PIK3CD;FASLG;CRKL;RAP1B;CDC42;RPS6KA3;MAPK9;NRAS;MAPK7;IRAK2;AKT2;ARHGDIB;RPS6KA1;PLCG2;MAPK1;RAC1;MAP2K7;MAPK3;NTRK1;MAP2K1;MAP2K2;BAD;MATK;PTPN11;IRAK4;RHOA;MAPK11;CAMK4;MAPKAPK2;RAPGEF1;BAX;CALM3;GRB2;KRAS;NFKBIE;ATF4;NFKBIB
Lysosome	43/128	0.000383374975772112	0.00185199603680682	0	0	1.96593818250192	15.4650468123325	CLTC;HEXA;GBA;AP4E1;CLTB;CLTA;NAGPA;GNS;LITAF;CTSS;GGA2;AP3M1;CLN3;GGA1;GM2A;AP1G1;SMPD1;LAMP2;ATP6V0A2;AP1S1;ATP6V1H;ACP5;ACP2;CTSD;CTSC;AP1M1;CTSA;ARSA;ABCA2;CD164;NAPSA;ATP6V0B;MANBA;ATP6AP1;LAPTM5;IGF2R;GALNS;NPC1;MAN2B1;DNASE2;PPT2;ATP6V0D1;ATP6V0C
B cell receptor signaling pathway	30/81	0.000453660466508566	0.00215832403763166	0	0	2.28359284890427	17.5794665758747	GSK3B;CD81;INPPL1;PIK3CD;PIK3R3;CD79A;NRAS;AKT2;INPP5D;RAC2;PLCG2;MAPK1;IKBKG;RAC1;MAPK3;MAP2K1;MAP2K2;CD72;CHUK;PRKCB;NFATC3;NFATC2;VAV1;GRB2;KRAS;PTPN6;NFKBIE;PIK3AP1;CARD11;NFKBIB
Sphingolipid signaling pathway	40/119	0.000593038142145942	0.00273844540450544	0	0	1.96697042266663	14.615085603	ROCK1;SGMS1;GNAI3;PIK3R3;PIK3CD;PRKCZ;GNAI2;PPP2CA;MAPK9;SGPL1;NRAS;PPP2R1A;PPP2R5E;PPP2R3C;AKT2;SMPD1;RAC2;MAPK1;FYN;RAC1;BID;CTSD;S1PR4;MAPK3;MAP2K1;CERS5;MAP2K2;CERS6;PRKCB;SPHK2;SPHK1;PPP2R5B;PPP2R5A;PPP2R5D;RHOA;TNFRSF1A;MAPK11;PPP2R2D;BAX;KRAS
Rheumatoid arthritis	33/93	0.000593039132185891	0.00273844540450544	0	0	2.135516311013	15.8674204349674	CD86;ATP6V1A;FLT1;CSF1;ITGB2;HLA-DMA;HLA-DMB;CCL5;ATP6V0A2;CCL3;ACP5;CTLA4;ATP6V1H;ATP6V1E1;HLA-DOA;ATP6V1D;ATP6V1C1;HLA-DPA1;ATP6V1F;ATP6V0B;ATP6V1G1;HLA-DRB5;ATP6V0E1;TGFB1;ATP6AP1;IFNG;ATP6V1B2;HLA-DPB1;HLA-DRA;ATP6V0D1;ATP6V0C;HLA-DRB1;HLA-DQB1
Regulation of actin cytoskeleton	65/218	0.000718165014472031	0.00326817122527852	0	0	1.65281918288535	11.9644459963681	ARPC1B;ITGB2;ARAF;ARPC5L;BRK1;PIK3CD;ITGAE;ACTB;ARHGAP35;CRKL;ACTG1;PPP1CC;TMSB4X;CFL1;RAC2;PIP4K2A;ITGB7;RAC1;ACTR3;ACTR2;MAP2K1;MAP2K2;ARHGEF12;PPP1R12A;ITGA4;ITGA2;F2R;ITGA1;RRAS2;ACTN4;RHOA;VAV1;MYL5;SPATA13;MYH9;ARHGEF1;EZR;PFN1;ARHGEF7;ARHGEF6;ROCK1;PXN;PIK3R3;IQGAP1;MYL12A;MYL12B;CDC42;NRAS;PIP5K1A;MAPK1;NCKAP1L;PAK2;WASF2;MAPK3;RDX;LIMK1;MSN;ARPC4;ARPC5;PPP1CA;DIAPH1;LPAR5;ARPC2;ARPC3;KRAS
Chronic myeloid leukemia	28/76	0.000762328426926569	0.00341958751507061	0	0	2.26388208394578	16.2527107776999	CDKN1B;CTBP1;HDAC1;ARAF;PIK3CD;PIK3R3;CRKL;NRAS;AKT2;MAPK1;E2F3;IKBKG;BAK1;MAPK3;STAT5A;MAP2K1;MAP2K2;TGFB1;CHUK;BAD;CDKN2A;PTPN11;TGFBR2;MDM2;BAX;GRB2;KRAS;BCL2L1
VEGF signaling pathway	23/59	0.000896743944742245	0.00396588167111359	0	0	2.47833238180681	17.3898144375719	MAP2K1;MAP2K2;PRKCB;SPHK2;BAD;SPHK1;SH2D2A;PXN;PIK3CD;PIK3R3;NFATC2;CASP9;CDC42;MAPK11;NRAS;AKT2;MAPKAPK2;RAC2;PLCG2;MAPK1;KRAS;RAC1;MAPK3
Human papillomavirus infection	92/331	0.000914775963935377	0.00398943962049595	0	0	1.49941580877682	10.4911595687636	GSK3B;CDKN1B;PIK3CD;FASLG;RBPJ;OASL;CCND3;TBK1;CREB3L4;PPP2R1A;PPP2R5E;AKT2;CASP3;ITGB7;IKBKG;ATP6V1E1;IKBKE;JAK1;ATP6V1G1;ATP6V0B;MAP2K1;ATP6V0E1;MAP2K2;TBP;ATP6AP1;CHUK;ITGA4;ITGA2;ITGA1;HLA-B;AXIN1;PPP2R5B;HLA-C;PPP2R5A;PPP2R5D;HLA-A;TYK2;HLA-F;HLA-G;HLA-E;TNFRSF1A;CREB3;PKM;IRF3;TRAF3;MFNG;IRF1;ATP6V1B2;TBPL1;ATP6V0D1;ATP6V0C;IRF9;LLGL2;ATP6V1A;NOTCH1;HDAC1;PXN;PIK3R3;PARD6G;PRKCZ;FOXO1;PPP2CA;CDC42;SLC9A3R1;NRAS;PPP2R3C;ATP6V0A2;EIF4EBP1;ATP6V1H;DVL3;MAPK1;FADD;BAK1;ATP6V1D;ATP6V1C1;ATP6V1F;MAPK3;CSNK1A1;STAT1;BAD;EIF2AK2;ISG15;DLG3;RHEB;PSMC1;TADA3;PPP2R2D;RPS6KB2;MDM2;BAX;GRB2;KRAS
Chemokine signaling pathway	58/192	0.000951874462870117	0.00409436412796187	0	0	1.68306051185337	11.7091822474932	GSK3B;ITK;GSK3A;PIK3CD;ARRB2;PIK3CG;CRKL;PREX1;GNGT2;AKT2;RAC2;IKBKG;RAC1;CCR5;JAK2;JAK3;MAP2K1;CHUK;PRKCB;RHOA;VAV1;FGR;CX3CR1;ROCK1;PXN;GNAI3;WAS;PIK3R3;CXCR6;PRKCZ;ADCY7;PIK3R5;GNAI2;RAP1B;CDC42;GNG10;GRK3;NRAS;GRK2;GNG2;GNG5;CCL5;CXCR3;CCL4;PLCG2;CCL3;MAPK1;PTK2B;MAPK3;CCR1;CCL25;BAD;STAT1;GNB2;GNB1;GRB2;KRAS;NFKBIB
Central carbon metabolism in cancer	26/70	0.00100700033491421	0.0042159747355075	0	0	2.29273884783189	15.8216848563042	PIK3CD;PIK3R3;PDHB;SLC1A5;HIF1A;HK1;LDHB;LDHA;NRAS;AKT2;MAPK1;SLC16A3;MAPK3;NTRK1;G6PD;MAP2K1;TIGAR;MAP2K2;PGAM1;IDH1;IDH2;SIRT6;SLC7A5;PKM;SCO2;KRAS
Epithelial cell signaling in Helicobacter pylori infection	26/70	0.00100700033491421	0.0042159747355075	0	0	2.29273884783189	15.8216848563042	ATP6V1A;CDC42;MAPK9;CASP3;CCL5;ATP6V0A2;PLCG2;ATP6V1H;CSK;IKBKG;RAC1;ATP6V1E1;ATP6V1D;ATP6V1C1;ATP6V1F;ATP6V0B;ATP6V1G1;ATP6V0E1;ATP6AP1;CHUK;PTPN11;MAPK11;ATP6V1B2;ATP6V0D1;ATP6V0C;MAP3K14
Biosynthesis of unsaturated fatty acids	13/27	0.00123192041376431	0.00508977644634203	0	0	3.59824261654869	24.1052786247756	ELOVL1;ACOT7;ELOVL5;SCD5;HACD4;FADS2;SCP2;ACOX1;SCD;ACOT2;ACOX3;ACAA1;FADS1
TNF signaling pathway	37/112	0.00133392918135588	0.00543965925903568	0	0	1.9155577379491	12.6802766118093	ATF2;CEBPB;CSF1;ATF6B;PIK3R3;PIK3CD;MAPK9;CASP7;CREB3L4;AKT2;CASP3;CCL5;MAPK1;MAP3K8;FADD;IKBKG;MAP2K7;MAP2K6;MAPK3;MAP2K3;MAP2K1;VCAM1;MLKL;CHUK;RIPK3;CFLAR;TNFRSF1B;TNFRSF1A;CREB3;MAPK11;ITCH;TRAF3;IRF1;BCL3;TAB1;MAP3K14;ATF4
Platelet activation	40/124	0.00145753317514221	0.00586750534608533	0	0	1.84930384930385	12.0778217078243	ROCK1;SNAP23;GNAI3;PIK3R3;PIK3CD;PRKCZ;RASGRP1;ADCY7;ACTB;ARHGAP35;MYL12A;PIK3CG;ACTG1;MYL12B;PIK3R5;GNAI2;RAP1B;PPP1CC;AKT2;P2RY1;PLCG2;MAPK1;FYN;MAPK3;VASP;ARHGEF12;PPP1R12A;ITGA2;F2R;RHOA;PPP1CA;APBB1IP;VAMP8;MAPK11;STIM1;ORAI1;ARHGEF1;LCP2;TLN1;FERMT3
RNA polymerase	14/31	0.00175394524724059	0.00697137731181701	0	0	3.19137752757353	20.2521230838061	POLR2J3;POLR3GL;POLR3D;POLR2E;POLR1D;POLR3F;POLR2F;POLR1E;POLR2G;POLR2I;POLR2J;POLR3K;POLR2K;POLR2L
Insulin signaling pathway	43/137	0.00181504525616935	0.00712405263046469	0	0	1.77669775933957	11.2138853107976	GSK3B;PDE3B;ARAF;INPPL1;PRKAG1;PIK3R3;PIK3CD;CBLB;ELK1;PRKCZ;FOXO1;CRKL;HK1;PPP1CC;GYS1;MAPK9;NRAS;AKT2;PRKAR2A;MKNK2;PHKG2;EIF4EBP1;MAPK1;EIF4E;SOCS4;PCK2;MAPK3;PTPN1;MAP2K1;MAP2K2;BAD;PPP1CA;G6PC3;PRKAR1B;PRKAR1A;RHEB;FASN;RPS6KB2;RAPGEF1;CALM3;GRB2;KRAS;EIF4E2
Leukocyte transendothelial migration	37/114	0.00190354621091793	0.00737917913862014	0	0	1.86556703792157	11.6859804023375	ITK;ROCK1;PXN;ITGB2;GNAI3;PIK3R3;PIK3CD;ACTB;ARHGAP35;MYL12A;ACTG1;MYL12B;GNAI2;RAP1B;CDC42;RASSF5;PLCG2;RAC2;PTK2B;RAC1;CD99;VASP;VCAM1;ITGA4;PRKCB;MSN;RHOH;CYBA;PTPN11;ACTN4;RHOA;VAV1;MYL5;MAPK11;PECAM1;EZR;SIPA1
RIG-I-like receptor signaling pathway	25/70	0.00235012022284742	0.00899924085334255	0	0	2.15490276077791	13.0442487328478	NLRX1;TANK;IFIH1;MAPK9;TBK1;TKFC;TRIM25;IKBKG;FADD;AZI2;IKBKE;ATG5;CHUK;DDX58;ISG15;ATG12;CYLD;MAPK11;SIKE1;MAVS;IRF3;TRAF3;IRF7;PIN1;NFKBIB
Osteoclast differentiation	40/127	0.00238989215149623	0.00904127874180503	0	0	1.78519585416137	10.7763473395563	CSF1;SIRPG;FHL2;PIK3R3;PIK3CD;RELB;MAPK9;FCGR3A;FCGR3B;AKT2;PLCG2;ACP5;MAPK1;FYN;IKBKG;RAC1;MAP2K7;MAP2K6;JAK1;MAPK3;MAP2K1;TGFB1;CHUK;STAT1;NFATC2;CYBA;TYK2;FOSL2;TGFBR2;TNFRSF1A;CYLD;MAPK11;IFNG;LCK;CAMK4;GRB2;LCP2;TAB1;MAP3K14;IRF9
C-type lectin receptor signaling pathway	34/104	0.00248345109519655	0.00928337671299662	0	0	1.88518155053974	11.3075189871176	PIK3R3;PIK3CD;CBLB;LSP1;RELB;PYCARD;MAPK9;NRAS;AKT2;PLCG2;CASP1;MAPK1;IKBKG;IKBKE;MAPK3;ARHGEF12;CHUK;KSR1;STAT1;NFATC3;NFATC2;RRAS2;PTPN11;RHOA;CYLD;MAPK11;IRF1;MAPKAPK2;BCL3;MDM2;CALM3;KRAS;MAP3K14;IRF9
AMPK signaling pathway	38/120	0.00272121468570242	0.0100524871918889	0	0	1.79903205711821	10.626301135038	CAB39;CAB39L;PRKAG1;PIK3R3;PIK3CD;ADIPOR2;ELAVL1;FOXO1;PPP2CA;GYS1;EEF2K;CREB3L4;PPP2R1A;PPP2R5E;PPP2R3C;AKT2;EIF4EBP1;RAB8A;PCK2;RAB2A;STRADA;SCD5;PPP2R5B;PPP2R5A;PPP2R5D;EEF2;RAB11B;RAB10;CREB3;TBC1D1;G6PC3;RAB14;RHEB;SCD;FASN;AKT1S1;PPP2R2D;RPS6KB2
Peroxisome	28/82	0.00284961075790799	0.0104043927672455	0	0	2.01157747654563	11.7889963853519	ABCD4;ABCD2;PEX11B;HMGCL;PRDX5;SCP2;NUDT19;MPV17;ACAA1;ABCD1;PEX16;ACOT8;PEX19;IDH1;ECH1;IDH2;ACSL5;ACSL4;PEX2;PEX14;SOD1;ACOX1;AGPS;CAT;ACOX3;SLC27A2;CRAT;PAOX
Autoimmune thyroid disease	20/53	0.00297926974994755	0.0106712353548775	0	0	2.34970734237238	13.6660789689781	CD86;HLA-DRB5;PRF1;HLA-B;HLA-C;GZMB;FASLG;HLA-A;HLA-F;HLA-G;HLA-E;HLA-DMA;HLA-DMB;HLA-DPB1;CTLA4;HLA-DRA;HLA-DOA;HLA-DRB1;HLA-DPA1;HLA-DQB1
Colorectal cancer	29/86	0.00299066468544336	0.0106712353548775	0	0	1.97387551210789	11.4726769210249	GSK3B;RALA;ARAF;PIK3CD;PIK3R3;CASP9;MAPK9;NRAS;BCL2L11;AKT2;CASP3;RAC2;MAPK1;PMAIP1;RAC1;BAK1;RALGDS;MAPK3;MAP2K1;MAP2K2;TGFB1;BAD;AXIN1;RHOA;TGFBR2;RPS6KB2;BAX;GRB2;KRAS
Protein export	11/23	0.00311679289787683	0.0109963255048688	0	0	3.55082540457022	20.4916384363807	SRP19;OXA1L;SPCS1;SRP72;SEC61G;SRP68;SEC61B;SRP14;SEC11A;SRP9;SEC11C
Fc epsilon RI signaling pathway	24/68	0.00339642534307163	0.0118497506413832	0	0	2.1153384060873	12.0257660431648	MAP2K3;MAP2K1;MAP2K2;PIK3CD;PIK3R3;VAV1;MAPK9;MAPK11;NRAS;AKT2;INPP5D;ALOX5AP;RAC2;PLCG2;MAPK1;LCP2;FYN;GRB2;KRAS;RAC1;MAP2K7;LAT;MAP2K6;MAPK3
Glyoxylate and dicarboxylate metabolism	13/30	0.00396305442569198	0.013674715271069	0	0	2.96269867478356	16.3859167541725	MDH1;GLDC;SHMT2;MDH2;GLYCTK;ACAT1;GRHPR;PCCA;CAT;PCCB;ACO2;ACSS1;DLD
Bacterial invasion of epithelial cells	26/77	0.00468291367363292	0.0159829879730515	0	0	1.97717539513357	10.6052421563884	ARPC1B;CLTC;PXN;ARPC5L;CLTB;CLTA;ILK;PIK3CD;PIK3R3;ACTB;ACTG1;CRKL;CDC42;RAC1;WASF2;ACTR3;ACTR2;RHOG;ARPC4;ARPC5;RHOA;DNM2;MAD2L2;ARPC2;ARPC3;HCLS1
HIF-1 signaling pathway	34/109	0.00572316533160453	0.0193233754206863	0	0	1.75894667975139	9.08185197658797	CDKN1B;FLT1;TFRC;PIK3R3;PIK3CD;ENO1;PDHB;HIF1A;HK1;LDHB;LDHA;AKT2;MKNK2;EIF4EBP1;PGK1;PLCG2;HMOX1;MAPK1;ELOB;ELOC;VHL;EIF4E;MAPK3;MAP2K1;EGLN3;MAP2K2;EGLN2;PRKCB;RBX1;IFNG;RPS6KB2;ALDOA;EIF4E2;GAPDH
Longevity regulating pathway	32/102	0.00655211575885922	0.0218868547689553	0	0	1.77341834232467	8.91668937213534	ATF2;ATF6B;HDAC1;PRKAG1;EHMT1;PIK3R3;PIK3CD;ADIPOR2;ADCY7;FOXO1;NRAS;CREB3L4;ATG101;AKT2;RB1CC1;SESN2;EIF4EBP1;EIF4EBP2;EIF4E;ATG5;ATG13;SOD1;CREB3;RHEB;CAMK4;AKT1S1;CAT;RPS6KB2;BAX;KRAS;EIF4E2;ATF4
Necroptosis	46/159	0.00730299932641391	0.024138334615726	0	0	1.58033847815483	7.77442796793241	RNF31;VPS4B;SPATA2;FASLG;HMGB1;PYCARD;MAPK9;AIFM1;SMPD1;CHMP1A;CAPN2;TNFSF10;CASP1;CAPN1;FADD;JAK2;BID;JAK3;JAK1;ZBP1;STAT5A;MLKL;PARP1;RIPK3;STAT1;USP21;EIF2AK2;TYK2;CFLAR;TNFRSF1A;CYLD;IFNG;VDAC3;CHMP2A;CHMP4B;VDAC2;BAX;CHMP4A;VDAC1;RBCK1;SLC25A5;PPIA;PPID;IRF9;CHMP5;SLC25A6
Base excision repair	13/33	0.0102588424700136	0.0335549639123361	0	0	2.51781791554796	11.5306373612664	PARP3;PARP1;MPG;OGG1;APEX2;XRCC1;HMGB1;POLB;SMUG1;POLD4;NTHL1;TDG;POLL
Intestinal immune network for IgA production	17/48	0.0121104829801339	0.0392030067604335	0	0	2.12481577516295	9.37826504866602	CD86;CCL25;IL15RA;HLA-DRB5;TGFB1;ITGA4;TNFRSF13C;HLA-DMA;HLA-DMB;HLA-DPB1;HLA-DRA;ITGB7;HLA-DOA;MAP3K14;HLA-DRB1;HLA-DPA1;HLA-DQB1
Glycolysis / Gluconeogenesis	22/67	0.0125691400909518	0.0402725509036619	0	0	1.89492280930637	8.293149890629	GPI;TPI1;PGAM1;ENO1;BPGM;PDHB;ADH5;HK1;MINPP1;LDHB;LDHA;PKM;G6PC3;PGK1;PGM2;GALM;ALDOA;ACSS1;DLD;GAPDH;ALDH9A1;PCK2
Ferroptosis	15/41	0.0130029020826594	0.0412415278177279	0	0	2.23499577345731	9.70565400118917	TFRC;GSS;NCOA4;ACSL5;ACSL4;SAT1;MAP1LC3B;MAP1LC3A;PCBP1;LPCAT3;VDAC3;HMOX1;VDAC2;ATG7;ATG5
Collecting duct acid secretion	11/27	0.0133839833093142	0.0417600306331888	0	0	2.66244815808734	11.4849934670057	ATP6V1A;ATP6V1G1;ATP6V0E1;ATP6V0A2;ATP6V1B2;ATP6V1E1;ATP6V0D1;ATP6V1D;ATP6V0C;ATP6V1C1;ATP6V1F
RNA degradation	25/79	0.0134323665412486	0.0417600306331888	0	0	1.7947323088082	7.73545431469187	BTG3;WDR61;ENO1;EXOSC7;EXOSC4;EXOSC9;NUDT16;EXOSC3;DCPS;EXOSC1;CNOT6L;LSM1;LSM2;LSM8;CNOT6;LSM7;LSM6;XRN1;CNOT1;CNOT2;C1D;XRN2;CNOT3;CNOT8;DCP2
Lipid and atherosclerosis	58/215	0.0138260379223344	0.0425625088981666	0	0	1.43440056337674	6.1409580710758	GSK3B;PIK3CD;FASLG;PYCARD;CASP9;CASP7;TBK1;AKT2;CASP3;TNFSF10;CASP1;IKBKG;RAC1;JAK2;IKBKE;MAP2K3;CHUK;APOA1;CYBA;IRAK4;RHOA;VAV1;TNFRSF1A;IRF3;TRAF3;DDIT3;IRF7;ARHGEF1;ABCG1;ATF4;PIK3R3;TANK;RAP1B;CDC42;MAPK9;NRAS;CCL5;CCL3;MAPK1;BID;MAP2K7;LDLR;MAP2K6;MAPK3;XBP1;VCAM1;HSPA4;BAD;EIF2AK3;NFATC3;NFATC2;MAPK11;BAX;CALM3;KRAS;TAB1;MYD88;BCL2L1
Non-small cell lung cancer	23/72	0.0153773822318434	0.0468786215611536	0	0	1.81932259079311	7.59541262746567	STAT5A;MAP2K1;MAP2K2;PRKCB;BAD;CDKN2A;ARAF;PIK3CD;PIK3R3;CASP9;NRAS;AKT2;KIF5B;RASSF5;PLCG2;MAPK1;BAX;E2F3;GRB2;KRAS;BAK1;JAK3;MAPK3
Toll-like receptor signaling pathway	31/104	0.0159696398928718	0.0482160281380937	0	0	1.64668012237756	6.81242412648305	CD86;PIK3R3;PIK3CD;MAPK9;TBK1;AKT2;CCL5;CCL4;CCL3;MAPK1;MAP3K8;FADD;IKBKG;RAC1;MAP2K7;IKBKE;MAP2K6;MAPK3;MAP2K3;MAP2K1;MAP2K2;CHUK;STAT1;IRAK4;MAPK11;IRF3;TRAF3;TOLLIP;IRF7;TAB1;MYD88
Ribosome	44/158	0.0170119295649855	0.050873770318147	0	0	1.49753626565183	6.10072380224365	MRPS17;MRPS15;MRPS16;MRPS14;RPS10-NUDT3;MRPS11;MRPL19;MRPS12;MRPL16;MRPS10;MRPL36;MRPL15;MRPL12;MRPL34;MRPL13;MRPL35;MRPL10;MRPL32;MRPL11;MRPL33;RPS15;MRPL20;MRPL2;MRPL1;RPS15A;RPL36AL;MRPL9;RPS11;MRPL27;MRPS18A;MRPL28;MRPS2;MRPS21;MRPS7;MRPL21;MRPS18C;MRPL22;MRPL30;RPS26;MRPS9;RPL28;RSL24D1;RPS24;RPL26L1
ErbB signaling pathway	26/85	0.0185938551605771	0.0550799105700114	0	0	1.70822058799117	6.80712942431862	GSK3B;CDKN1B;ARAF;PIK3CD;PIK3R3;CBLB;ELK1;CRKL;MAPK9;NRAS;AKT2;EIF4EBP1;PLCG2;MAPK1;MAP2K7;PAK2;NCK1;MAPK3;STAT5A;MAP2K1;MAP2K2;PRKCB;BAD;RPS6KB2;GRB2;KRAS
Endometrial cancer	19/58	0.0199960852585183	0.0586801006651845	0	0	1.88762699860231	7.38480975895024	GSK3B;MAP2K1;MAP2K2;BAD;ARAF;AXIN1;ILK;PIK3CD;PIK3R3;ELK1;CASP9;NRAS;AKT2;MAPK1;BAX;GRB2;KRAS;BAK1;MAPK3
Adherens junction	22/71	0.0249041319813093	0.0724064577975104	0	0	1.73979591836735	6.42458187383991	PTPN1;CSNK2A1;CSNK2A2;WAS;PTPRJ;ACTN4;IQGAP1;NLK;ACTB;RHOA;ACTG1;TGFBR2;CDC42;CSNK2B;RAC2;MAPK1;FYN;PTPN6;RAC1;ACP1;WASF2;MAPK3
Insulin resistance	31/108	0.0269928500480768	0.0777592194045514	0	0	1.56074349773786	5.63769153736996	GSK3B;PRKAG1;PIK3R3;PIK3CD;PRKCZ;FOXO1;PTPA;PPP1CC;RPS6KA3;GYS1;MAPK9;CREB3L4;AKT2;RPS6KA1;MLX;PPARGC1B;PCK2;PTPN1;PRKCB;NR1H3;PTPN11;TNFRSF1A;PPP1CA;CREB3;G6PC3;RPS6KB2;TRIB3;SLC27A3;PPARA;SLC27A2;SLC27A4
Homologous recombination	14/41	0.0298889651997439	0.0853194097519963	0	0	2.00811993634259	7.04903498298193	MUS81;BARD1;MRE11;BRCC3;BABAM1;SEM1;BABAM2;POLD4;RAD51D;RPA3;UIMC1;RBBP8;NBN;SSBP1
Pentose phosphate pathway	11/30	0.0307522230809256	0.0869927752018976	0	0	2.24163788343755	7.80491907321766	GPI;G6PD;RPE;GLYCTK;PGM2;TALDO1;IDNK;PGLS;PGD;ALDOA;TKT
Tight junction	45/169	0.0337530372746812	0.0946290509308027	0	0	1.40751101059398	4.76961126932057	ROCK1;ARPC1B;ARPC5L;PRKAG1;WAS;PARD6G;ARHGAP17;MYL6B;PRKCZ;YBX3;ACTB;MYL12A;ACTG1;MYL12B;CDC42;PPP2CA;SLC9A3R1;MAPK9;PPP2R1A;RAC1;MAP2K7;RAB8A;RAB8B;VASP;ACTR3;ACTR2;HSPA4;RDX;MSN;ARHGEF18;ARPC4;ACTN4;ARPC5;RHOA;MYL6;ARPC2;DLG3;ARPC3;PPP2R2D;HCLS1;MYH9;RAPGEF2;NF2;EZR;LLGL2
Chagas disease	29/102	0.0356214164841384	0.0989834050975173	0	0	1.53968776119203	5.13456342592426	GNAI3;PIK3R3;PIK3CD;CD3G;FASLG;CD3E;CD3D;GNAI2;PPP2CA;MAPK9;PPP2R1A;AKT2;CCL5;CCL3;MAPK1;FADD;IKBKG;MAPK3;TGFB1;CHUK;IRAK4;CFLAR;TGFBR2;TNFRSF1A;MAPK11;IFNG;PPP2R2D;CD247;MYD88
Fatty acid elongation	10/27	0.0360310018109664	0.0992432856898547	0	0	2.27733142037303	7.56842756102456	HADHB;ELOVL1;HADHA;ACAA2;ECHS1;ACOT7;ELOVL5;ACOT2;PPT2;HACD4
Sulfur metabolism	5/10	0.0365271403708062	0.0997349745776797	0	0	3.86967113276492	12.8074494758391	MPST;TST;ETHE1;SQOR;BPNT1
Synaptic vesicle cycle	23/78	0.0387197089403956	0.104810246614519	0	0	1.62023711546589	5.26804954326737	NSF;ATP6V1A;NAPA;ATP6V0B;ATP6V1G1;ATP6V0E1;CLTC;CLTB;CLTA;AP2A1;DNM2;ATP6V1B2;AP2S1;ATP6V0A2;ATP6V1H;ATP6V1E1;ATP6V0D1;ATP6V0C;ATP6V1D;AP2M1;STX1A;ATP6V1C1;ATP6V1F
Fatty acid degradation	14/43	0.0443232436469182	0.118952978676345	0	0	1.86939318426724	5.82548913056079	ACAA2;ECHS1;ACSL5;ACSL4;ADH5;ACAT1;HADHB;HADHA;ACOX1;ACADM;ACOX3;ACAA1;ACADS;ALDH9A1
NF-kappa B signaling pathway	29/104	0.0450737363499559	0.119941976388866	0	0	1.49843992485502	4.64434793345254	TNFRSF13C;RELB;CCL4;PLCG2;TRIM25;IKBKG;PIAS4;UBE2I;VCAM1;CSNK2A1;CHUK;PARP1;PRKCB;DDX58;CSNK2A2;IRAK4;CFLAR;TNFRSF1A;CYLD;ZAP70;LCK;TRAF3;CSNK2B;TAB1;MAP3K14;CARD11;LAT;MYD88;BCL2L1
FoxO signaling pathway	35/131	0.053296839738871	0.140631997294164	0	0	1.41306237218814	4.14292682293161	CDKN1B;ARAF;FBXO25;AGAP2;PRKAG1;PIK3R3;PIK3CD;FASLG;NLK;FOXO1;GABARAP;MAPK9;NRAS;BCL2L11;AKT2;TNFSF10;MAPK1;S1PR4;PCK2;MAPK3;GABARAPL2;GABARAPL1;MAP2K1;MAP2K2;TGFB1;CHUK;ATG12;TGFBR2;MAPK11;G6PC3;CCNG2;CAT;MDM2;GRB2;KRAS
Choline metabolism in cancer	27/98	0.0590558478186543	0.154529468458812	0	0	1.47334706253687	4.16849916245309	WAS;PIK3R3;PIK3CD;HIF1A;MAPK9;NRAS;AKT2;EIF4EBP1;RAC2;PIP5K1A;MAPK1;RAC1;RALGDS;WASF2;MAPK3;MAP2K1;LYPLA1;MAP2K2;CHKB;PCYT1A;PRKCB;RHEB;RPS6KB2;GRB2;KRAS;PLPP1;DGKH
Riboflavin metabolism	4/8	0.0614289459334927	0.158104008386203	0	0	3.86897223575256	10.7939455222675	RFK;ACP5;ACP2;ACP1
Sulfur relay system	4/8	0.0614289459334927	0.158104008386203	0	0	3.86897223575256	10.7939455222675	MPST;MOCS2;TST;URM1
Bladder cancer	13/41	0.0625792571453322	0.159755176777515	0	0	1.79753478154747	4.98154662764519	MAP2K1;MAP2K2;CDKN2A;DAPK2;DAPK3;ARAF;TYMP;NRAS;MDM2;MAPK1;E2F3;KRAS;MAPK3
Hepatocellular carcinoma	43/168	0.0658070490020073	0.166640430537341	0	0	1.33345463486599	3.6283678231702	GSK3B;SMARCD1;SMARCD2;SMARCB1;GSTP1;ARAF;KEAP1;PIK3R3;PIK3CD;ELK1;ACTB;ACTG1;NRAS;FRAT2;AKT2;PLCG2;DPF3;DVL3;HMOX1;MAPK1;E2F3;BAK1;BRD7;MAPK3;GSTM4;SMARCE1;MAP2K1;GSTM2;MAP2K2;GSTM1;TGFB1;PRKCB;GSTO1;BAD;CDKN2A;CSNK1A1;AXIN1;TGFBR2;RPS6KB2;BAX;GRB2;KRAS;BCL2L1
Thyroid hormone signaling pathway	32/121	0.0702308550397436	0.176419907859836	0	0	1.39314821651944	3.70015643317429	GSK3B;NOTCH1;HDAC3;HDAC1;PIK3R3;PIK3CD;ATP1A3;MED16;HIF1A;ACTB;FOXO1;ACTG1;CASP9;NRAS;MED13;AKT2;PLCG2;MAPK1;MAPK3;NCOA1;MAP2K1;MAP2K2;PRKCB;BAD;STAT1;ATP1B3;MED4;MED27;NCOR1;RHEB;MDM2;KRAS
Cardiac muscle contraction	24/87	0.0710031234612391	0.176944291800231	0	0	1.47560776635667	3.90302889158617	COX8A;COX7B;TPM4;UQCRB;TPM3;COX4I1;ATP1A3;ATP1B3;COX7A2;UQCR11;UQCR10;COX6A1;COX5B;COX6C;COX7C;COX5A;UQCRH;COX6B1;COX7A2L;UQCRQ;UQCRC1;UQCRFS1;UQCRC2;CYC1
MAPK signaling pathway	71/294	0.0732772327829554	0.180837503693557	0	0	1.23499578659638	3.22766806038691	ATF2;FLT1;CSF1;ARAF;FASLG;ARRB2;ECSIT;ELK1;CRKL;RPS6KA3;DUSP10;AKT2;CASP3;RPS6KA1;RAC2;MAP3K8;IKBKG;RAC1;DUSP4;MAP4K1;MAP2K3;DUSP5;DAXX;DUSP2;MAP2K1;MAP2K2;CHUK;PRKCB;RRAS2;IRAK4;CDC25B;TGFBR2;TNFRSF1A;PPM1A;DDIT3;MAPKAPK2;RAPGEF2;ATF4;SRF;NLK;RASGRP1;RELB;RAP1B;CDC42;MAPK9;NRAS;MAPK7;MKNK2;FLNA;MAPK1;MAP2K7;PAK2;MAP2K6;MAPK3;NTRK1;TGFB1;NFATC3;MAPK11;PPP5C;TAOK3;TAOK1;TAOK2;NF1;GRB2;KRAS;TAB1;PTPN7;LAMTOR3;MAP3K14;MAP3K11;MYD88
N-Glycan biosynthesis	15/50	0.0737171989578833	0.180837503693557	0	0	1.65934065934066	4.32676253330923	B4GALT3;ST6GAL1;B4GALT1;ALG6;ALG2;ALG12;ALG1;DDOST;DPM1;FUT8;MAN1A2;DOLPP1;MAN1A1;MGAT1;MGAT2
Glioma	21/75	0.0762075832153543	0.185497528136599	0	0	1.50610037770713	3.87714562355235	MAP2K1;MAP2K2;PRKCB;CDKN2A;ARAF;PIK3CD;PIK3R3;NRAS;AKT2;CAMK4;PLCG2;MDM2;MAPK1;BAX;E2F3;CALM3;GRB2;KRAS;BAK1;CAMK1;MAPK3
Focal adhesion	50/201	0.0775387495968337	0.187285902872352	0	0	1.2836427103383	3.28224549343424	GSK3B;FLT1;ILK;PIK3CD;ELK1;ACTB;ARHGAP35;CRKL;ACTG1;PPP1CC;CCND3;AKT2;RAC2;CAPN2;ITGB7;RAC1;MAP2K1;PPP1R12A;ITGA4;PRKCB;ITGA2;ITGA1;ACTN4;RHOA;VAV1;MYL5;RAPGEF1;TLN1;ROCK1;PXN;PIK3R3;MYL12A;MYL12B;RAP1B;CDC42;MAPK9;PIP5K1A;FLNA;MAPK1;FYN;PAK2;MAPK3;VASP;BAD;PARVB;PPP1CA;DIAPH1;PARVG;ZYX;GRB2
Rap1 signaling pathway	52/210	0.0781889290997018	0.187414685017606	0	0	1.27590444878377	3.25180479944504	FLT1;CSF1;ITGB2;PIK3CD;ACTB;CRKL;ACTG1;SIPA1L1;AKT2;RASSF5;RAC2;RAC1;MAP2K3;MAP2K1;MAP2K2;PRKCB;F2R;RHOA;VAV1;APBB1IP;ADORA2A;RAPGEF1;RAPGEF2;PRKD2;EVL;LCP2;PFN1;TLN1;SKAP1;RALA;GNAI3;PIK3R3;PARD6G;PRKCZ;ADCY7;GNAI2;RAP1B;CDC42;NRAS;P2RY1;MAPK1;RALGDS;MAP2K6;MAPK3;VASP;FYB1;MAPK11;LPAR5;CALM3;KRAS;SIPA1;LAT
Acute myeloid leukemia	19/67	0.0795822840306287	0.189309372618314	0	0	1.53282612238247	3.87952738656665	STAT5A;MAP2K1;MAP2K2;CHUK;BAD;ARAF;PIK3CD;PIK3R3;PML;NRAS;AKT2;RPS6KB2;PIM1;EIF4EBP1;MAPK1;GRB2;KRAS;IKBKG;MAPK3
Pyruvate metabolism	14/47	0.0864279805497252	0.20310845355115	0	0	1.6423857717803	4.02128927103691	MDH1;MDH2;ACYP2;PDHB;ADH5;ACAT1;LDHB;GRHPR;LDHA;PKM;ACSS1;DLD;PCK2;ALDH9A1
Dopaminergic synapse	34/132	0.0866768559740577	0.20310845355115	0	0	1.3441749614468	3.28727177566224	ATF2;GSK3B;GSK3A;ATF6B;GNAI3;ARRB2;COMT;ARNTL;GNAI2;PPP2CA;PPP1CC;MAPK9;GNG10;GNGT2;GNG2;GNG5;CREB3L4;PPP2R1A;PPP2R5E;PPP2R3C;AKT2;KIF5B;PRKCB;PPP2R5B;PPP2R5A;PPP2R5D;PPP1CA;CREB3;MAPK11;GNB2;GNB1;PPP2R2D;CALM3;ATF4
Various types of N-glycan biosynthesis	12/39	0.0875539487112297	0.203643999224638	0	0	1.7204056179166	4.19004808701239	B4GALT3;FUT8;B4GALT1;MAN1A2;HEXA;ALG2;MAN1A1;MGAT1;ALG12;MGAT2;ALG1;DDOST
RNA transport	46/186	0.0942466969016235	0.217598991375807	0	0	1.27337598425197	3.00750969719972	POP7;POP1;FMR1;POP4;PHAX;NXT2;GLE1;FXR1;FXR2;SUMO1;SUMO3;MAGOH;SUMO2;EIF4EBP1;EIF4EBP2;SAP18;EIF2B1;EIF4E;RAE1;UPF1;SEC13;EIF2B2;UBE2I;EIF1AY;PYM1;UPF3B;UPF3A;THOC5;EIF2S2;RPP25L;THOC7;DDX19B;CLNS1A;EIF3I;EIF3J;EIF3G;STRAP;ACIN1;EIF3H;GEMIN7;EIF3F;GEMIN8;EIF4E2;EIF4G3;EIF3D;NUP37
One carbon pool by folate	7/20	0.0974829931306728	0.221809129297328	0	0	2.08363486379572	4.85086312295082	MTFMT;MTHFD1;SHMT2;MTHFD2;MTHFD2L;ST20-MTHFS;MTHFR
Steroid biosynthesis	7/20	0.0974829931306728	0.221809129297328	0	0	2.08363486379572	4.85086312295082	SQLE;DHCR24;MSMO1;HSD17B7;LBR;TM7SF2;FDFT1
Inositol phosphate metabolism	20/73	0.0986254146062109	0.222794102060074	0	0	1.4611800525903	3.38471589695192	IPPK;MTMR2;TPI1;INPP1;MTMR14;ITPK1;INPPL1;PIK3CD;SYNJ2;PIK3CG;MINPP1;IMPA1;SYNJ1;INPP5D;PLCG2;PIP4K2A;INPP5K;PIP5K1A;CDIPT;PI4K2A
Fluid shear stress and atherosclerosis	35/139	0.107378167716703	0.240833890450321	0	0	1.30370457763096	2.90908430556957	GSTP1;KEAP1;PIK3R3;PIK3CD;TXN;PRKCZ;ACTB;ACTG1;TXN2;MAPK9;MAPK7;SUMO1;AKT2;SUMO3;SUMO2;RAC2;HMOX1;IKBKG;RAC1;MAP2K7;MAP2K6;PIAS4;GSTM4;GSTM2;GSTM1;VCAM1;CHUK;GSTO1;CYBA;RHOA;TNFRSF1A;MAPK11;IFNG;PECAM1;CALM3
Cell adhesion molecules	37/148	0.108680580562162	0.24192883716042	0	0	1.29134953760537	2.86594646241527	CD86;SELPLG;ITGB2;GLG1;SPN;HLA-DMA;HLA-DMB;CTLA4;ITGB7;CD58;HLA-DOA;TIGIT;CD99;HLA-DPA1;HLA-DRB5;VCAM1;CADM1;ITGA4;HLA-B;HLA-C;HLA-A;PDCD1LG2;HLA-F;HLA-G;HLA-E;CD2;PTPRC;CD8B;CD6;CD8A;PECAM1;HLA-DPB1;HLA-DRA;CD226;PDCD1;HLA-DRB1;HLA-DQB1
Glutathione metabolism	16/57	0.109421251791308	0.24192883716042	0	0	1.51074147771277	3.3425912833809	GSTM4;G6PD;GSTM2;GSTM1;GSTO1;GSTP1;GSS;IDH1;ODC1;IDH2;GPX7;TXNDC12;PGD;PRDX6;GGCT;LAP3
PPAR signaling pathway	20/74	0.110177782528472	0.24192883716042	0	0	1.43403060762474	3.16298396871174	HMGCS1;SCD5;ILK;ACSL5;APOA1;NR1H3;DBI;ACSL4;FADS2;SCP2;FABP5;ACOX1;SCD;ACADM;ACOX3;ACAA1;PPARA;SLC27A2;SLC27A4;PCK2
AGE-RAGE signaling pathway in diabetic complications	26/100	0.111584413989923	0.243316013839138	0	0	1.36066919024803	2.98391201853935	CDKN1B;PIK3R3;PIK3CD;PRKCZ;FOXO1;CDC42;MAPK9;NRAS;AKT2;CASP3;PIM1;PLCG2;MAPK1;RAC1;JAK2;MAPK3;STAT5A;TGFB1;VCAM1;PRKCB;STAT1;TGFBR2;DIAPH1;MAPK11;BAX;KRAS
Thyroid cancer	11/37	0.121217281851271	0.262498113802064	0	0	1.63739748906863	3.45518808448587	NTRK1;NRAS;MAP2K1;MAP2K2;TPM3;NCOA4;MAPK1;BAX;KRAS;BAK1;MAPK3
Lysine degradation	17/63	0.134583705930017	0.289447148370036	0	0	1.43058668564569	2.86914020067317	KMT2E;ECHS1;KMT5C;PHYKPL;DOT1L;EHMT1;DLST;PLOD1;DHTKD1;ACAT1;NSD3;HADHA;NSD1;KMT5B;DLD;ALDH9A1;EZH2
Pertussis	20/76	0.13567855065302	0.289816768061552	0	0	1.38264058679707	2.76177865337925	C1R;ITGB2;GNAI3;IRAK4;RHOA;GNAI2;PYCARD;MAPK9;MAPK11;CASP7;IRF3;CASP3;IRF1;CFL1;CASP1;IRF8;MAPK1;CALM3;MYD88;MAPK3
Phospholipase D signaling pathway	36/148	0.149710903032323	0.317629888865874	0	0	1.24484536082474	2.36402253389301	AGPAT5;ARF1;RALA;PIK3R3;PIK3CD;AGPAT1;ADCY7;AGPAT2;PIK3CG;PIK3R5;NRAS;CYTH4;AKT2;PLCG2;PIP5K1A;MAPK1;PTK2B;FYN;RALGDS;MAPK3;MAP2K1;MAP2K2;SPHK2;SPHK1;F2R;RRAS2;PTPN11;RHOA;DNM2;LPAR5;RHEB;GRB2;KRAS;PLPP1;DGKH;ARF6
Nucleotide excision repair	13/47	0.152173356864122	0.320687476881438	0	0	1.47976281066491	2.78600109081375	RFC1;GTF2H3;RAD23B;GTF2H5;RBX1;POLD4;CDK7;ERCC3;ERCC4;RPA3;ERCC8;MNAT1;CUL4B
Mineral absorption	16/60	0.155051024291323	0.324573477516504	0	0	1.40746991162233	2.62352536109792	SLC31A1;VDR;ATP2B4;ATP1A3;CYBRD1;MT1X;ATP1B3;SLC30A1;ATOX1;MT2A;MT1F;HMOX1;SLC39A4;HMOX2;SLC26A6;MT1E
Porphyrin and chlorophyll metabolism	12/43	0.156743751172581	0.325943959391989	0	0	1.49803995654843	2.77608220705344	ALAS1;FECH;COX15;UROD;UROS;HMBS;HMOX1;HCCS;PPOX;COX10;HMOX2;BLVRA
Progesterone-mediated oocyte maturation	25/100	0.163109958117782	0.336950834532786	0	0	1.29049367605059	2.34009182149476	PDE3B;ARAF;GNAI3;PIK3R3;PIK3CD;ADCY7;ANAPC10;ANAPC11;GNAI2;RPS6KA3;STK10;MAPK9;AKT2;CDC26;CDC27;RPS6KA1;MAPK1;MAPK3;MAP2K1;CDC25B;MAD2L2;MAPK11;KRAS;MAD1L1;CPEB4
Inflammatory bowel disease	17/65	0.166192121133556	0.341074026378671	0	0	1.37080584738171	2.46006298337636	HLA-DRB5;TGFB1;STAT1;GATA3;IL2RG;HLA-DMA;HLA-DMB;IFNG;TBX21;IL21R;HLA-DPB1;HLA-DRA;HLA-DOA;IL12RB1;HLA-DRB1;HLA-DPA1;HLA-DQB1
Asthma	9/31	0.170083824129899	0.346794290758366	0	0	1.58289552437321	2.80404224777955	HLA-DMA;HLA-DRB5;HLA-DMB;HLA-DPB1;HLA-DRA;HLA-DOA;HLA-DRB1;HLA-DPA1;HLA-DQB1
Prolactin signaling pathway	18/70	0.176678362515782	0.357117599753641	0	0	1.33978118655538	2.32240934634839	STAT5A;GSK3B;MAP2K1;MAP2K2;STAT1;PIK3CD;PIK3R3;MAPK9;MAPK11;NRAS;AKT2;IRF1;MAPK1;GRB2;KRAS;JAK2;SOCS4;MAPK3
Growth hormone synthesis, secretion and action	29/119	0.177650495069998	0.357117599753641	0	0	1.24751558713823	2.15562855285522	ATF2;GSK3B;ATF6B;GNAI3;PIK3R3;PIK3CD;ADCY7;CRKL;GNAI2;MAPK9;NRAS;CREB3L4;AKT2;PLCG2;MAPK1;JAK2;MAP2K6;MAPK3;MAP2K3;STAT5A;MAP2K1;MAP2K2;PRKCB;STAT1;CREB3;MAPK11;GRB2;KRAS;ATF4
Legionellosis	15/57	0.17855879987682	0.357117599753641	0	0	1.38217338217338	2.38125988680675	RAB1A;ARF1;VCP;SAR1A;SAR1B;RAB1B;ITGB2;CASP9;PYCARD;BCL2L13;CASP7;CASP3;CASP1;SEC22B;MYD88
Prostate cancer	24/97	0.183111244863078	0.363904625867129	0	0	1.27266509766057	2.16055443103435	GSK3B;MAP2K1;MAP2K2;CDKN1B;CHUK;BAD;GSTP1;ARAF;PIK3R3;PIK3CD;FOXO1;CASP9;CREB3;NRAS;CREB3L4;AKT2;MDM2;MAPK1;GRB2;E2F3;KRAS;IKBKG;ATF4;MAPK3
Oocyte meiosis	31/129	0.190059193195779	0.372991166646717	0	0	1.2246699120933	2.03346606298464	YWHAE;YWHAB;ADCY7;ANAPC10;ANAPC11;PPP2CA;PPP1CC;RPS6KA3;PTTG1;YWHAQ;PPP2R1A;PPP2R5E;CDC26;CDC27;RPS6KA1;MAPK1;MAPK3;MAP2K1;FBXW11;PPP2R5B;PPP2R5A;PPP2R5D;YWHAZ;REC8;RBX1;PPP1CA;MAD2L2;MAPK11;CALM3;MAD1L1;CPEB4
Relaxin signaling pathway	31/129	0.190059193195779	0.372991166646717	0	0	1.2246699120933	2.03346606298464	ATF2;ATF6B;GNAI3;PIK3R3;PIK3CD;ARRB2;PRKCZ;ADCY7;GNAI2;MAPK9;GNG10;NRAS;GNGT2;GNG2;GNG5;CREB3L4;AKT2;MAPK1;MAP2K7;MAPK3;MAP2K1;MAP2K2;TGFB1;TGFBR2;CREB3;MAPK11;GNB2;GNB1;GRB2;KRAS;ATF4
cGMP-PKG signaling pathway	39/167	0.208739642667644	0.407107129177889	0	0	1.17968174281503	1.848169085087	ATF2;ATF6B;ROCK1;SRF;PDE3B;GNAI3;ATP1A3;ADCY7;PIK3CG;PIK3R5;GNAI2;PPP1CC;RGS2;CREB3L4;AKT2;MAPK1;MEF2D;GTF2I;MAPK3;VASP;MAP2K1;MAP2K2;PPP1R12A;BAD;NFATC3;ATP2B4;NFATC2;ATP1B3;RHOA;PPP1CA;CREB3;PPIF;VDAC3;VDAC2;VDAC1;CALM3;SLC25A5;ATF4;SLC25A6
Notch signaling pathway	15/59	0.217800209221998	0.422155961084613	0	0	1.31918081918082	2.01066520573463	PSENEN;NOTCH1;DTX3L;CTBP1;HDAC1;DTX2;DTX3;RBPJ;NCOR2;APH1A;ATXN1;SNW1;MFNG;DVL3;CIR1
Apelin signaling pathway	32/137	0.23571420040203	0.454075208136425	0	0	1.17966323361125	1.7047728902566	BECN1;HDAC5;PDE3B;PRKAG1;GNAI3;ADCY7;GABARAP;PIK3CG;PIK3R5;GNAI2;GNG10;NRAS;GNGT2;GNG2;GNG5;AKT2;MAPK1;MEF2D;MAPK3;GABARAPL2;GABARAPL1;MAP2K1;MAP2K2;SPHK2;SPHK1;RRAS2;GNB2;CAMK4;GNB1;RPS6KB2;CALM3;KRAS
Adipocytokine signaling pathway	17/69	0.239596284999276	0.458739228596174	0	0	1.26503974891466	1.8074886893546	CHUK;PRKAG1;ACSL5;ACSL4;PTPN11;TNFRSF1B;ADIPOR2;TNFRSF1A;MAPK9;G6PC3;AKT2;IKBKG;JAK2;PPARA;NFKBIE;PCK2;NFKBIB
Phosphatidylinositol signaling system	23/97	0.25444001175734	0.484207052677604	0	0	1.20278536427301	1.64624051788628	IPPK;MTMR2;PRKCB;INPP1;MTMR14;ITPK1;INPPL1;PIK3R3;PIK3CD;SYNJ2;SYNJ1;IMPA1;INPP5D;PLCG2;PIP4K2A;PIP5K1A;CALM3;IP6K1;CDIPT;PI4K2A;DGKH;IP6K2;CDS2
Ras signaling pathway	52/232	0.262902767505296	0.496184081832113	0	0	1.11839439242101	1.49414249772534	FLT1;CSF1;PIK3CD;FASLG;ELK1;ETS1;TBK1;GNGT2;AKT2;RASSF5;RAC2;IKBKG;RAC1;MAP2K1;RALBP1;MAP2K2;CHUK;KSR1;PRKCB;RRAS2;RHOA;ZAP70;RASA3;ARF6;RALA;RAB5C;PIK3R3;RASAL3;RASGRP1;RAP1B;CDC42;MAPK9;GNG10;NRAS;GNG2;GNG5;PLCG2;MAPK1;RALGDS;PAK2;MAPK3;NTRK1;BAD;PTPN11;GNB2;GNB1;NF1;CALM3;GRB2;KRAS;LAT;BCL2L1
beta-Alanine metabolism	8/30	0.263894081738735	0.496184081832113	0	0	1.40667523602677	1.87398324587019	HADHA;ECHS1;ACOX1;ABAT;ACOX3;ACADS;CNDP2;ALDH9A1
Non-homologous end-joining	4/13	0.26969081991402	0.504064984839299	0	0	1.71900200248958	2.25271617572667	DCLRE1C;MRE11;LIG4;POLL
Nicotinate and nicotinamide metabolism	9/35	0.282430874160206	0.524753221812454	0	0	1.33903550728715	1.69297131628527	NT5C;NNT;NAPRT;NAMPT;CD38;SIRT6;SIRT7;NADK;SIRT2
Vasopressin-regulated water reabsorption	11/44	0.284399122104812	0.525301907887711	0	0	1.28950150443198	1.62138910488234	DCTN6;NSF;DCTN5;CREB3;RAB5C;DCTN2;DCTN1;CREB3L4;ARHGDIB;DYNLL1;RAB11B
Hematopoietic cell lineage	23/99	0.289633649345996	0.531288253161014	0	0	1.17098502311566	1.4510125462907	HLA-DRB5;CSF1;TFRC;ITGA4;ITGA2;ITGA1;CD3G;CD3E;CD3D;CD2;HLA-DMA;HLA-DMB;CD8B;CD8A;CD7;HLA-DPB1;HLA-DRA;CD38;CD37;HLA-DOA;HLA-DRB1;HLA-DPA1;HLA-DQB1
Cholinergic synapse	26/113	0.291849462875381	0.531288253161014	0	0	1.15639951816452	1.42412583626635	GNAI3;PIK3R3;PIK3CD;ADCY7;PIK3CG;PIK3R5;GNAI2;GNG10;NRAS;GNGT2;GNG2;GNG5;CREB3L4;AKT2;MAPK1;FYN;JAK2;MAPK3;MAP2K1;PRKCB;CREB3;GNB2;CAMK4;GNB1;KRAS;ATF4
Long-term potentiation	16/67	0.292716139480431	0.531288253161014	0	0	1.21375135300823	1.49115658766471	MAP2K1;MAP2K2;PRKCB;ARAF;PPP1CA;RAP1B;PPP1CC;RPS6KA3;NRAS;CAMK4;RPS6KA1;MAPK1;CALM3;KRAS;ATF4;MAPK3
Sphingolipid metabolism	12/49	0.297483072541129	0.535074904035511	0	0	1.25463970559139	1.52112261286497	SMPD3;ARSA;CERS5;SGPL1;CERS6;SGMS1;SPHK2;SMPD1;SPHK1;GBA;GBA2;PLPP1
Glycine, serine and threonine metabolism	10/40	0.298210535688581	0.535074904035511	0	0	1.28943089430894	1.56015406217578	GRHPR;ALAS1;GLDC;SHMT2;PSAT1;GLYCTK;PGAM1;PHGDH;BPGM;DLD
Other glycan degradation	5/18	0.304524548867453	0.543299479229433	0	0	1.48758549611168	1.76874447273828	MANBA;GBA;HEXA;MAN2B1;GBA2
Cell cycle	28/124	0.32028348388098	0.568186519427275	0	0	1.12851135064511	1.28486523077708	YWHAE;GSK3B;CDKN1B;YWHAB;HDAC1;ANAPC10;ANAPC11;CCND3;PTTG1;YWHAQ;CDC26;CDC27;E2F3;BUB3;E2F5;ZBTB17;TGFB1;CDKN2A;YWHAZ;CDC25B;RBX1;MAD2L2;CDK7;STAG2;TFDP1;TFDP2;MDM2;MAD1L1
p53 signaling pathway	17/73	0.323675655961079	0.570978404335835	0	0	1.17438309308576	1.32471977934115	CD82;CDKN2A;EI24;SHISA5;PPM1D;CASP9;CCND3;AIFM2;CASP3;CCNG2;SESN2;CCNG1;MDM2;PMAIP1;BAX;BID;BCL2L1
Proteoglycans in cancer	45/205	0.33507977507751	0.587793571923676	0	0	1.08833025830258	1.18996576536631	ROCK1;PXN;ARAF;PIK3R3;PIK3CD;FASLG;IQGAP1;ELK1;HIF1A;ACTB;ACTG1;CDC42;PPP1CC;NRAS;AKT2;CASP3;PLCG2;FLNA;MAPK1;RAC1;MAPK3;MAP2K1;MAP2K2;TGFB1;ARHGEF12;PPP1R12A;PRKCB;ITGA2;RDX;RRAS2;MSN;PTPN11;NUDT16L1;RHOA;VAV1;PPP1CA;MAPK11;RPS6KB2;MDM2;HCLS1;GRB2;ARHGEF1;KRAS;PTPN6;EZR
Synthesis and degradation of ketone bodies	3/10	0.338849859533762	0.591104754964451	0	0	1.65741417092768	1.79365056934828	HMGCL;HMGCS1;ACAT1
Butanoate metabolism	7/28	0.348662544338652	0.60246337478749	0	0	1.28921927045251	1.35838684634805	HMGCL;HADHA;ECHS1;HMGCS1;ABAT;ACADS;ACAT1
Oxytocin signaling pathway	34/154	0.349198516596571	0.60246337478749	0	0	1.09621360811253	1.1533424547578	ROCK1;PRKAG1;GNAI3;MYL6B;ELK1;ADCY7;ACTB;PIK3CG;ACTG1;PIK3R5;GNAI2;PPP1CC;TRPM2;RGS2;NRAS;EEF2K;MAPK7;CD38;MAPK1;MAPK3;MAP2K1;MAP2K2;PPP1R12A;PRKCB;NFATC3;NFATC2;EEF2;RHOA;PPP1CA;MYL6;CAMK4;CALM3;KRAS;CAMK1
Vitamin B6 metabolism	2/6	0.358155733657788	0.61454043917238	0	0	1.93354430379747	1.9853388839199	PSAT1;PNPO
Hedgehog signaling pathway	13/56	0.3605253326864	0.615244317736574	0	0	1.16938088561682	1.19299425669578	EVC2;GSK3B;CSNK1G3;FBXW11;CSNK1A1;IQCE;CSNK1D;ARRB2;KIF7;GRK3;GRK2;SPOP;CSNK1G1
Other types of O-glycan biosynthesis	11/47	0.368481466178938	0.625422596649657	0	0	1.1818194139492	1.17988697839223	B4GALT3;GALNT11;C1GALT1C1;ST6GAL1;B4GALT1;GALNT2;GALNT1;MFNG;C1GALT1;GXYLT1;XXYLT1
Amino sugar and nucleotide sugar metabolism	11/48	0.397258859197455	0.670641299935489	0	0	1.14980581948135	1.06146298729327	GPI;CYB5R4;CMAS;GMDS;PMM1;HEXA;UAP1L1;PGM2;RENBP;HK1;GALK1
Endocrine and other factor-regulated calcium reabsorption	12/53	0.40561493744652	0.681086044696297	0	0	1.13195014819841	1.02141634745178	PRKCB;VDR;CLTC;CLTB;AP2S1;ATP2B4;CLTA;ATP1A3;AP2A1;ATP1B3;AP2M1;DNM2
Melanoma	16/72	0.407934378560226	0.681337206744207	0	0	1.10503175378603	0.990825566584301	MAP2K1;MAP2K2;BAD;CDKN2A;ARAF;PIK3CD;PIK3R3;NRAS;AKT2;MDM2;MAPK1;BAX;E2F3;KRAS;BAK1;MAPK3
Parathyroid hormone synthesis, secretion and action	23/106	0.422518786142983	0.70196242777194	0	0	1.0717526332391	0.923337795742123	ATF2;MAP2K1;ATF6B;PRKCB;VDR;PDE4D;ARAF;GNAI3;GATA3;ARRB2;ADCY7;RUNX2;RHOA;GNAI2;SLC9A3R1;AKAP13;CREB3;CREB3L4;MAPK1;ARHGEF1;MEF2D;ATF4;MAPK3
Pantothenate and CoA biosynthesis	5/21	0.439189382819322	0.725818243185616	0	0	1.20843483556638	0.994329865473971	PANK3;VNN2;COASY;PPCDC;AASDHPPT
Glycosphingolipid biosynthesis	10/45	0.448566120552626	0.736535577361484	0	0	1.10487804878049	0.885779828323778	B4GALT3;B4GALT1;FUT7;HEXA;GCNT2;B3GALT4;ST3GAL5;B3GNT2;ST6GALNAC4;ST6GALNAC6
GnRH signaling pathway	20/93	0.450365703354793	0.736535577361484	0	0	1.05951703118197	0.845171811283663	MAP2K3;MAP2K1;MAP2K2;PRKCB;ELK1;ADCY7;CDC42;MAPK9;MAPK11;NRAS;MAPK7;MAPK1;PTK2B;CALM3;GRB2;KRAS;MAP2K7;ATF4;MAP2K6;MAPK3
Cysteine and methionine metabolism	11/50	0.454973993543862	0.74021675633561	0	0	1.09070379892532	0.858945622619014	MPST;LDHB;LDHA;TST;GOT1;MDH1;MDH2;PSAT1;GSS;PHGDH;MAT2B
Mucin type O-glycan biosynthesis	8/36	0.466922112273783	0.755739913680247	0	0	1.10482691370063	0.841428243008279	GALNT11;C1GALT1C1;GALNT2;GALNT1;GCNT1;C1GALT1;ST6GALNAC4;B4GALT5
Terpenoid backbone biosynthesis	5/22	0.483139637597631	0.777978698490544	0	0	1.13727878483915	0.827312954307197	FDPS;HMGCS1;MVD;ACAT1;ZMPSTE24
Pyrimidine metabolism	12/56	0.487998023160757	0.781792751390193	0	0	1.05457207506988	0.756596327718273	DCTD;NT5C3A;NT5C;ENTPD1;UCK2;CANT1;UCK1;NME7;NUDT2;CMPK2;TYMP;UCKL1
Aldosterone-regulated sodium reabsorption	8/37	0.500587982561877	0.797891505200148	0	0	1.06666218329158	0.738100264394745	PRKCB;ATP1A3;PIK3CD;PIK3R3;MAPK1;ATP1B3;KRAS;MAPK3
Tryptophan metabolism	9/42	0.504789129355826	0.800524174837018	0	0	1.05453215402008	0.720893473886681	HADHA;ECHS1;ASMT;CAT;DLST;DLD;ACAT1;DHTKD1;ALDH9A1
Adrenergic signaling in cardiomyocytes	31/150	0.518437319849475	0.818036776043896	0	0	1.00721053314682	0.661673005941573	ATF2;ATF6B;CREM;GNAI3;ATP1A3;ADCY7;PIK3CG;PIK3R5;GNAI2;PPP2CA;PPP1CC;CREB3L4;PPP2R1A;PPP2R5E;PPP2R3C;AKT2;MAPK1;MAPK3;TPM4;TPM3;PPP2R5B;ATP2B4;PPP2R5A;ATP1B3;PPP2R5D;PPP1CA;CREB3;MAPK11;PPP2R2D;CALM3;ATF4
Fatty acid biosynthesis	4/18	0.522538434043262	0.820385341447922	0	0	1.10472479298587	0.717029072589957	FASN;ACSL5;ACSL4;ACSF3
Fructose and mannose metabolism	7/33	0.531229293550189	0.829880587934126	0	0	1.04096439753276	0.6584740385888	TIGAR;TKFC;TPI1;GMDS;PMM1;ALDOA;HK1
Glycosaminoglycan biosynthesis	11/53	0.539750242486828	0.839017703667644	0	0	1.01260470033341	0.624421433164577	HS3ST3B1;B4GALT3;FUT8;B4GALT1;CHPF;CHST11;CHSY1;CHST12;CSGALNACT2;B3GNT2;CHST2
PI3K-Akt signaling pathway	72/354	0.560870761524602	0.867553788762193	0	0	0.986879959533369	0.570677914408968	YWHAE;ATF2;GSK3B;CDKN1B;FLT1;CSF1;YWHAB;PIK3CD;FASLG;PIK3CG;CASP9;GYS1;CCND3;GNGT2;YWHAQ;CREB3L4;PPP2R1A;PPP2R5E;AKT2;MLST8;ITGB7;IKBKG;RAC1;JAK2;JAK3;JAK1;MAP2K1;MAP2K2;CHUK;ITGA4;ITGA2;F2R;ITGA1;PPP2R5B;PPP2R5A;PPP2R5D;YWHAZ;CREB3;EIF4E2;ATF4;ATF6B;PKN3;PIK3R3;IL2RG;PIK3R5;PPP2CA;GNG10;NRAS;BCL2L11;GNG2;GNG5;PPP2R3C;EIF4EBP1;MAPK1;EIF4E;PCK2;MAPK3;NTRK1;BAD;G6PC3;LPAR5;RHEB;GNB2;GNB1;IL2RB;PPP2R2D;RPS6KB2;MDM2;GRB2;KRAS;PIK3AP1;BCL2L1
Purine metabolism	26/129	0.579328287938739	0.891711188297863	0	0	0.975775700579101	0.532662265622298	CANT1;PDE1B;GMPR2;PDE3B;NUDT2;AK3;NUDT5;ADCY7;NT5C;DGUOK;GUK1;PDE6D;PGM2;PDE6B;NUDT16;ENTPD1;ADSL;PDE4D;NT5C3A;PKM;NME7;HPRT1;PDE7B;PDE7A;ADA;ITPA
Long-term depression	12/60	0.593124383761692	0.901515967186573	0	0	0.966447047340166	0.504824725226826	PPP2CA;MAP2K1;NRAS;MAP2K2;PPP2R1A;PRKCB;ARAF;GNAI3;MAPK1;KRAS;GNAI2;MAPK3
Cholesterol metabolism	10/50	0.594311481552932	0.901515967186573	0	0	0.966463414634146	0.502900897550918	SCARB1;STARD3;LRPAP1;NPC1;VDAC3;TSPO;APOA1;VDAC2;VDAC1;LDLR
Malaria	10/50	0.594311481552932	0.901515967186573	0	0	0.966463414634146	0.502900897550918	KLRK1;TGFB1;VCAM1;IFNG;GYPC;CD81;ITGB2;KLRC4-KLRK1;PECAM1;MYD88
Pathways in cancer	107/531	0.608674809803747	0.91886485710758	0	0	0.97501284414048	0.48406572648332	ARAF;KEAP1;ELK1;ETS1;CRKL;CCND3;FRAT2;AKT2;RASSF5;PIM1;IL15RA;MAP2K1;RALBP1;MAP2K2;PRKCB;TPM3;DAPK2;DAPK3;F2R;RBX1;NOTCH1;CTBP1;PIK3R3;HIF1A;RASGRP1;FOXO1;GNG10;BCL2L11;PLCG2;HMOX1;DVL3;PMAIP1;FADD;RALGDS;GSTM4;STAT5A;ZBTB17;GSTM2;GSTM1;TGFB1;LPAR5;GNB2;GNB1;MDM2;CALM3;GRB2;BCL2L1;GSK3B;CDKN1B;PIK3CD;FASLG;CASP9;CASP7;GNGT2;CASP3;RAC2;ELOB;ELOC;IKBKG;RAC1;JAK2;JAK3;JAK1;NCOA1;ARHGEF12;CHUK;GSTO1;ITGA2;NCOA4;AXIN1;KIF7;RHOA;TGFBR2;IFNG;TRAF3;ARHGEF1;RALA;ROCK1;HDAC1;GSTP1;GNAI3;IL2RG;ADCY7;GNAI2;CDC42;MAPK9;NRAS;GNG2;GNG5;MAPK1;E2F3;BAK1;VHL;BID;IL12RB1;MAPK3;NTRK1;EGLN3;EGLN2;CDKN2A;STAT1;BAD;PML;IL2RB;RPS6KB2;BAX;KRAS
Morphine addiction	18/91	0.61359231200076	0.92185639219253	0	0	0.953099264853573	0.465517087491635	PRKCB;PDE1B;PDE4D;PDE3B;GNAI3;ARRB2;ADCY7;GNAI2;GNG10;GRK3;GNGT2;GNG2;GRK2;GNG5;GNB2;GNB1;PDE7B;PDE7A
Glycerolipid metabolism	12/61	0.617891724307598	0.923895244917074	0	0	0.946663877849822	0.455763788792572	AGPAT5;PLPP5;TKFC;AGK;GLYCTK;AGPAT1;LPIN1;AGPAT2;LPIN2;PLPP1;ALDH9A1;DGKH
Type II diabetes mellitus	9/46	0.623715211305819	0.928182826303446	0	0	0.940291425295083	0.443875293148457	MAPK9;PKM;PIK3CD;PIK3R3;MAPK1;PRKCZ;SOCS4;HK1;MAPK3
DNA replication	7/36	0.630730477350655	0.933112507207494	0	0	0.933101935505559	0.43004488800942	RNASEH2C;POLD4;RNASEH2B;RNASEH1;RFC1;RPA3;SSBP1
Circadian rhythm	6/31	0.635942918924853	0.933112507207494	0	0	0.927777777777778	0.419955335858824	FBXW11;BHLHE40;PRKAG1;CSNK1D;ARNTL;RBX1
Galactose metabolism	6/31	0.635942918924853	0.933112507207494	0	0	0.927777777777778	0.419955335858824	B4GALT1;G6PC3;PGM2;GALM;HK1;GALK1
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	5/26	0.643018144432203	0.93910556907773	0	0	0.920422249289484	0.406442207629739	PIGS;PIGB;PIGT;GPAA1;MPPE1
African trypanosomiasis	7/37	0.661097036060072	0.961039209828067	0	0	0.901941668697701	0.373272751814053	VCAM1;IFNG;PRKCB;APOA1;FASLG;APOL1;MYD88
IL-17 signaling pathway	18/94	0.671735312047235	0.970212833237481	0	0	0.915303287544374	0.364190846046323	GSK3B;USP25;CEBPB;CHUK;ELAVL1;MAPK9;MAPK11;TBK1;MAPK7;IFNG;TRAF3;CASP3;MAPK1;IKBKG;FADD;MAPK6;IKBKE;MAPK3
GABAergic synapse	17/89	0.673587253648952	0.970212833237481	0	0	0.91248608735782	0.360557689393978	NSF;GABARAPL2;GABARAPL1;SLC38A1;PRKCB;GNAI3;ABAT;ADCY7;GABARAP;GNAI2;GNG10;GNGT2;GNG2;GNG5;GNB2;GNB1;SLC38A5
Neomycin, kanamycin and gentamicin biosynthesis	1/5	0.683470413412525	0.979953012838049	0	0	0.966536870284741	0.367836783430537	HK1
Ubiquinone and other terpenoid-quinone biosynthesis	2/11	0.693912907947857	0.990402968616487	0	0	0.859082548955967	0.313916339827147	GGCX;COQ5
Axon guidance	35/182	0.699032607940664	0.991294144239021	0	0	0.919836400817996	0.329354679370564	GSK3B;SEMA7A;ROCK1;GNAI3;PIK3R3;ILK;PIK3CD;PARD6G;PRKCZ;MYL12A;MYL12B;GNAI2;CDC42;NRAS;RGS3;CFL1;PLCG2;RAC2;MAPK1;FYN;SRGAP3;RAC1;SRGAP2;PAK2;NCK1;MAPK3;ARHGEF12;LIMK1;NFATC3;NFATC2;PTPN11;RHOA;MYL5;CDK5;KRAS
Cocaine addiction	9/49	0.702016885373821	0.991294144239021	0	0	0.869604974396489	0.30766434594753	ATF2;CREB3;ATF6B;CDK5;CREB3L4;GNAI3;RGS9;ATF4;GNAI2
Herpes simplex virus 1 infection	98/498	0.704008261672935	0.991294144239021	0	0	0.945924725822532	0.331986648817913	PPP1CC;TBK1;AKT2;ZSCAN32;ZNF689;ZNF688;HLA-DOA;B2M;ZNF200;ZNF561;DAXX;ZNF282;TAP2;HLA-B;TAP1;HLA-C;ZNF12;HLA-A;HCFC2;HLA-F;HLA-G;HLA-E;SRSF3;SRSF4;SRSF6;SRSF9;ZNF791;PIK3R3;ZFP57;EIF4EBP1;TNFRSF14;FADD;HLA-DRB5;EIF2B2;EIF2AK1;EIF2AK3;EIF2AK2;PILRB;EIF2AK4;BST2;MAVS;RHEB;HLA-DRA;ZNF778;ZNF777;TAB1;RBAK;HLA-DRB1;MYD88;BCL2L1;ZNF490;PIK3CD;FASLG;IFIH1;CASP9;CASP3;IKBKG;JAK2;EIF2B1;IKBKE;HLA-DPA1;JAK1;ZNF484;CHUK;DDX58;TYK2;IRAK4;TNFRSF1A;TAPBP;IFNG;IRF3;OAS1;TRAF3;OAS2;IRF7;ZNF234;IRF9;HLA-DQB1;SP100;ZNF195;HLA-DMA;HLA-DMB;CCL5;BAK1;BID;ZNF621;ZNF101;ZNF286A;CD74;STAT1;BAD;PTPN11;ZNF79;PML;PPP1CA;HLA-DPB1;ZNF614;BAX
Selenocompound metabolism	3/17	0.709817025569045	0.99483395229704	0	0	0.828341855368882	0.283912557836257	SCLY;SEPHS1;SEPHS2
Hippo signaling pathway	31/163	0.715831050921202	0.99483395229704	0	0	0.907267081206772	0.303309457967488	YWHAE;GSK3B;YWHAB;ITGB2;PARD6G;LIMD1;PRKCZ;ACTB;ACTG1;PPP2CA;PPP1CC;CCND3;RASSF2;YWHAQ;PPP2R1A;DVL3;TGFB1;FBXW11;AXIN1;CSNK1D;YWHAZ;SMAD7;TGFBR2;PPP1CA;MOB1B;MOB1A;DLG3;ID2;PPP2R2D;NF2;LLGL2
Glucagon signaling pathway	20/107	0.719532336278676	0.99483395229704	0	0	0.888233145041171	0.292365324707942	ATF2;PGAM1;PDE3B;PRKAG1;PDHB;FOXO1;LDHB;GYS1;CREB3;LDHA;PPP4C;G6PC3;PKM;CREB3L4;AKT2;PHKG2;CALM3;PPARA;ATF4;PCK2
Mannose type O-glycan biosynthesis	4/23	0.725531767758032	0.99483395229704	0	0	0.813751377957802	0.261092471570294	B4GALT3;B4GALT1;CHST10;POMK
Mismatch repair	4/23	0.725531767758032	0.99483395229704	0	0	0.813751377957802	0.261092471570294	POLD4;RFC1;RPA3;SSBP1
Proximal tubule bicarbonate reclamation	4/23	0.725531767758032	0.99483395229704	0	0	0.813751377957802	0.261092471570294	MDH1;ATP1A3;ATP1B3;PCK2
ABC transporters	8/45	0.733342539707448	0.999995789590505	0	0	0.835610842436781	0.25915833061079	ABCD4;ABCA2;ABCD2;ABCB10;TAP2;TAP1;ABCD1;ABCG1
Glycerophospholipid metabolism	18/98	0.741235480594212	0.999995789590505	0	0	0.869318181818182	0.260305955902123	AGPAT5;LYPLA2;LYPLA1;LPGAT1;CHKB;PCYT1A;LPCAT1;AGPAT1;AGPAT2;PLPP5;ETNK1;LPCAT3;CDIPT;LPIN1;LPIN2;PLPP1;DGKH;CDS2
Caffeine metabolism	1/6	0.748533264634269	0.999995789590505	0	0	0.77318082258457	0.223943810763647	NAT1
Phenylalanine, tyrosine and tryptophan biosynthesis	1/6	0.748533264634269	0.999995789590505	0	0	0.77318082258457	0.223943810763647	GOT1
Phosphonate and phosphinate metabolism	1/6	0.748533264634269	0.999995789590505	0	0	0.77318082258457	0.223943810763647	PCYT1A
TGF-beta signaling pathway	17/94	0.760654335366886	0.999995789590505	0	0	0.85296404060147	0.233350702361939	TGIF2;TGFB1;ROCK1;RHOA;RBX1;TGFBR2;SMAD7;PPP2CA;TFDP1;IFNG;PPP2R1A;ID2;RPS6KB2;MAPK1;E2F5;NBL1;MAPK3
Carbohydrate digestion and absorption	8/47	0.778047743651264	0.999995789590505	0	0	0.792658990611209	0.198931557657712	G6PC3;PRKCB;AKT2;ATP1A3;PIK3CD;PIK3R3;ATP1B3;HK1
Starch and sucrose metabolism	6/36	0.77844935335382	0.999995789590505	0	0	0.772904483430799	0.193574968615153	GPI;GYS1;G6PC3;PGM2;GYG1;HK1
Glycosaminoglycan degradation	3/19	0.78074956497354	0.999995789590505	0	0	0.724707815924032	0.179365793202703	GALNS;HEXA;GNS
Neutrophil extracellular trap formation	35/189	0.781755747059771	0.999995789590505	0	0	0.877635248187395	0.216085146927721	HDAC5;HDAC3;SELPLG;HDAC10;HDAC1;ITGB2;PIK3R3;PIK3CD;HMGB1;HDAC8;ACTB;ACTG1;FCGR3A;FCGR3B;AKT2;CASP4;PLCG2;CASP1;RAC2;MAPK1;RAC1;ATG7;MAPK3;GSDMD;MAP2K1;MAP2K2;PRKCB;CYBA;MAPK11;PPIF;VDAC3;VDAC2;VDAC1;SLC25A5;SLC25A6
Amphetamine addiction	12/69	0.784924115877562	0.999995789590505	0	0	0.813387788651717	0.196976683964245	ATF2;PPP1CC;CREB3;ATF6B;CREB3L4;PRKCB;HDAC1;CAMK4;CALM3;STX1A;ATF4;PPP1CA
alpha-Linolenic acid metabolism	4/25	0.786076369375434	0.999995789590505	0	0	0.73615846728365	0.177194321589964	FADS2;ACOX1;ACOX3;ACAA1
GnRH secretion	11/64	0.79152175769145	0.999995789590505	0	0	0.801884490925076	0.187478918722877	MAP2K1;NRAS;MAP2K2;PRKCB;AKT2;PIK3CD;PIK3R3;MAPK1;KRAS;ARRB2;MAPK3
Fat digestion and absorption	7/43	0.80914653126573	0.999995789590505	0	0	0.751333712459718	0.159113886228392	SCARB1;APOA1;AGPAT1;AGPAT2;PLPP1;ACAT1;SLC27A4
Folate biosynthesis	4/26	0.812086915432847	0.999995789590505	0	0	0.702652437674357	0.146255633434087	MOCS2;GCH1;PCBD1;PTS
Aldosterone synthesis and secretion	17/98	0.81810916199753	0.999995789590505	0	0	0.810637251796955	0.162743130493753	ATF2;SCARB1;ATF6B;PRKCB;ATP2B4;ATP1A3;ATP1B3;ADCY7;CREB3;CREB3L4;CAMK4;ORAI1;PRKD2;CALM3;CAMK1;LDLR;ATF4
Arginine and proline metabolism	8/50	0.834407901698428	0.999995789590505	0	0	0.735901186413132	0.133222329881186	ALDH4A1;GOT1;ODC1;LAP3;SAT1;CNDP2;ALDH9A1;AGMAT
Viral protein interaction with cytokine and cytokine receptor	17/100	0.842763172964326	0.999995789590505	0	0	0.791003741327391	0.13531645162961	CCR1;CX3CR1;CCL25;CSF1;IL10RB;IL10RA;TNFRSF1B;IL2RG;TNFRSF1A;CCL5;CXCR3;CCL4;IL2RB;TNFSF10;CCL3;TNFRSF14;CCR5
Coronavirus disease	42/232	0.843754695362015	0.999995789590505	0	0	0.853128396211768	0.144940945240787	RPS10-NUDT3;C1R;PIK3R3;PIK3CD;ADAR;RPS15;IFIH1;MAPK9;TBK1;RPS15A;RPL36AL;PLCG2;CASP1;MAPK1;IKBKG;RPS11;IKBKE;JAK1;MAPK3;CHUK;PRKCB;STAT1;DDX58;EIF2AK2;ISG15;TYK2;IRAK4;TNFRSF1A;RPS26;MAPK11;MAVS;IRF3;OAS1;OAS2;TRAF3;RPL28;RSL24D1;RPS24;MYD88;IRF9;RPL26L1;NFKBIB
Phototransduction	4/28	0.856322207969762	0.999995789590505	0	0	0.644016885858094	0.0998925333819543	GNB1;PDE6B;CALM3;RGS9
Transcriptional misregulation in cancer	34/192	0.858146518277173	0.999995789590505	0	0	0.830561111042099	0.127059593292584	CD86;CEBPB;CDKN1B;FLT1;HPGD;HDAC1;DOT1L;PRCC;FOXO1;FUT8;NFKBIZ;ITGB7;BAK1;MEN1;NTRK1;ZBTB17;BCL11B;ASPSCR1;GZMB;ETV1;RUNX2;FLI1;SUPT3H;PML;TGFBR2;ETV7;NCOR1;EWSR1;DDIT3;ID2;IL2RB;MDM2;BAX;BCL2L1
Arginine biosynthesis	3/22	0.859751815606343	0.999995789590505	0	0	0.610164930221829	0.0922029487678062	ACY1;GOT1;ASL
Histidine metabolism	3/22	0.859751815606343	0.999995789590505	0	0	0.610164930221829	0.0922029487678062	CARNMT1;CNDP2;ALDH9A1
Wnt signaling pathway	29/166	0.861413296644725	0.999995789590505	0	0	0.817097927551033	0.121895380029996	GSK3B;CTBP1;CHD8;NLK;MAPK9;CCND3;PORCN;FRAT2;RUVBL1;RAC2;DVL3;RAC1;TBL1X;CSNK2A1;FBXW11;PRKCB;CSNK1A1;CSNK2A2;CTNNBIP1;NFATC3;AXIN1;NFATC2;CACYBP;RHOA;RBX1;VANGL1;TBL1XR1;CSNK2B;ROR2
JAK-STAT signaling pathway	28/162	0.872212089392745	0.999995789590505	0	0	0.806540545679247	0.110272371114751	PIK3R3;PIK3CD;IL2RG;CCND3;AKT2;PIM1;IL21R;JAK2;IL12RB1;JAK3;SOCS4;JAK1;PIAS4;STAT5A;IL15RA;IL10RB;STAT1;IL10RA;IFNLR1;PTPN11;TYK2;IFNG;IL2RB;GRB2;PTPN6;STAM2;IRF9;BCL2L1
Small cell lung cancer	15/92	0.874715520704765	0.999995789590505	0	0	0.752247752247752	0.100693299905475	ZBTB17;CDKN1B;CHUK;ITGA2;PIK3CD;PIK3R3;CASP9;TRAF3;AKT2;CASP3;BAX;E2F3;IKBKG;BAK1;BCL2L1
Alcoholism	32/186	0.891752314376606	0.999995789590505	0	0	0.801819073520888	0.0918618930815611	ATF2;HDAC5;HDAC3;HDAC10;ATF6B;HDAC1;ARAF;GNAI3;HDAC8;GNAI2;PPP1CC;GNG10;NRAS;GNGT2;GNG2;GNG5;CREB3L4;MAPK1;MAPK3;MAP2K1;PPP1CA;CREB3;ADORA2A;GNB2;PKIA;CAMK4;GNB1;CALM3;GRB2;KRAS;SLC29A3;ATF4
Primary bile acid biosynthesis	2/17	0.892016935246915	0.999995789590505	0	0	0.515254787406686	0.0588782474509125	ACOT8;SCP2
Cushing syndrome	26/155	0.899968662472537	0.999995789590505	0	0	0.777824598167172	0.08197908466988	ATF2;SCARB1;GSK3B;CDKN1B;ATF6B;GNAI3;ADCY7;GNAI2;RAP1B;CREB3L4;DVL3;MAPK1;E2F3;LDLR;MEN1;MAPK3;USP8;MAP2K1;MAP2K2;CDKN2A;AIP;AXIN1;CREB3;ARMC5;ORAI1;ATF4
Alanine, aspartate and glutamate metabolism	5/37	0.902622760808427	0.999995789590505	0	0	0.603608404384896	0.061840028085335	ALDH4A1;ADSL;GOT1;ABAT;ASL
cAMP signaling pathway	37/216	0.911488948719238	0.999995789590505	0	0	0.797330012193667	0.0738932040925829	ROCK1;PDE3B;GNAI3;PIK3R3;PIK3CD;ATP1A3;ADCY7;GNAI2;RAP1B;PPP1CC;MAPK9;CREB3L4;AKT2;RAC2;MAPK1;RAC1;MAPK3;MAP2K1;MAP2K2;PPP1R12A;BAD;PDE4D;F2R;ATP2B4;RRAS2;ATP1B3;RHOA;VAV1;PPP1CA;CREB3;ADORA2A;ACOX1;CAMK4;ORAI1;CALM3;ACOX3;PPARA
Chemical carcinogenesis	41/239	0.919759720788687	0.999995789590505	0	0	0.798563169170198	0.0667940723082854	ATF2;ATF6B;GSTP1;GNAI3;PIK3R3;PIK3CD;ARRB2;ADCY7;GNAI2;RPS6KA3;NRAS;CCND3;CREB3L4;AKT2;RPS6KA1;KPNA6;EIF4EBP1;MAPK1;JAK2;KPNA2;IKBKE;KPNA3;MAPK3;GSTM4;STAT5A;GSTM2;MAP2K1;GSTM1;MAP2K2;PRKCB;GSTO1;VDR;BAD;AIP;CREB3;NAT1;RPS6KB2;GRB2;KRAS;PPARA;ATF4
Estrogen signaling pathway	22/137	0.924449589219292	0.999995789590505	0	0	0.738215774695822	0.0579918374163153	NCOA1;ATF2;MAP2K1;MAP2K2;ATF6B;GNAI3;PIK3R3;PIK3CD;ADCY7;GNAI2;CREB3;NRAS;CREB3L4;AKT2;MAPK1;CALM3;GRB2;KRAS;CTSD;ATF4;FKBP5;MAPK3
Inflammatory mediator regulation of TRP channels	15/98	0.925447441570181	0.999995789590505	0	0	0.697603601218059	0.0540488884300911	MAP2K3;NTRK1;PRKCH;PRKCB;TRPV2;PIK3R3;PIK3CD;ADCY7;PPP1CA;PPP1CC;MAPK9;MAPK11;PLCG2;CALM3;MAP2K6
Signaling pathways regulating pluripotency of stem cells	23/143	0.927162385112254	0.999995789590505	0	0	0.739560394747574	0.0559304056356448	GSK3B;MAP2K1;PCGF6;MAP2K2;PCGF5;AXIN1;PIK3R3;PIK3CD;MAPK11;NRAS;REST;AKT2;ID2;DVL3;MAPK1;PCGF1;GRB2;KRAS;JAK2;JARID2;JAK3;JAK1;MAPK3
Gastric cancer	24/149	0.929780210561114	0.999995789590505	0	0	0.74079295154185	0.0539349520522198	GSK3B;MAP2K1;MAP2K2;TGFB1;CDKN1B;CSNK1A1;REG4;ARAF;AXIN1;PIK3R3;PIK3CD;TGFBR2;NRAS;FRAT2;AKT2;RPS6KB2;DVL3;MAPK1;BAX;GRB2;E2F3;KRAS;BAK1;MAPK3
Gastric acid secretion	11/76	0.932477649215631	0.999995789590505	0	0	0.653348846810667	0.0456756808770727	PRKCB;GNAI3;ATP1A3;ATP1B3;CALM3;SLC4A2;EZR;ADCY7;ACTB;ACTG1;GNAI2
Vascular smooth muscle contraction	21/133	0.933139148914046	0.999995789590505	0	0	0.723495964783566	0.0500666065419062	MAP2K1;MAP2K2;PRKCH;CALCB;ARHGEF12;PPP1R12A;ROCK1;PRKCB;ARAF;MYL6B;ADCY7;RHOA;PPP1CA;PPP1CC;MYL6;ADORA2A;MYH9;MAPK1;CALM3;ARHGEF1;MAPK3
Gap junction	13/88	0.934963545348566	0.999995789590505	0	0	0.669091204946709	0.0449948709754218	MAP2K1;MAP2K2;PRKCB;GNAI3;CSNK1D;ADCY7;GNAI2;NRAS;MAPK7;MAPK1;GRB2;KRAS;MAPK3
Cortisol synthesis and secretion	9/65	0.938313524520746	0.999995789590505	0	0	0.620519385515728	0.0395091753861243	ATF2;SCARB1;CREB3;ATF6B;CREB3L4;ORAI1;ADCY7;LDLR;ATF4
Staphylococcus aureus infection	14/95	0.942231150053695	0.999995789590505	0	0	0.667094666280864	0.0396952361578613	HLA-DRB5;SELPLG;C1R;ITGB2;FCGR3A;HLA-DMA;FCGR3B;HLA-DMB;HLA-DPB1;HLA-DRA;HLA-DOA;HLA-DRB1;HLA-DPA1;HLA-DQB1
Melanogenesis	15/101	0.94349998630817	0.999995789590505	0	0	0.673140812675696	0.0391491485195543	GSK3B;MAP2K1;MAP2K2;PRKCB;GNAI3;ADCY7;GNAI2;CREB3;NRAS;CREB3L4;DVL3;MAPK1;CALM3;KRAS;MAPK3
Drug metabolism	16/108	0.94972899676001	0.999995789590505	0	0	0.671098744716552	0.0346143348230321	GSTM4;GSTM2;GSTM1;TPMT;GSTO1;GSTP1;ADH5;UCKL1;TYMP;UCK2;UCK1;NAT1;NME7;HPRT1;ITPA;CES1
Ribosome biogenesis in eukaryotes	16/108	0.94972899676001	0.999995789590505	0	0	0.671098744716552	0.0346143348230321	POP7;CSNK2A1;POP1;POP4;CSNK2A2;SNU13;NXT2;REXO2;RPP25L;XRN1;EIF6;NOB1;CSNK2B;XRN2;NOP10;RMRP
Regulation of lipolysis in adipocytes	7/55	0.952844336424155	0.999995789590505	0	0	0.563073767162239	0.0271985627983133	AKT2;PDE3B;GNAI3;PIK3CD;PIK3R3;ADCY7;GNAI2
Ether lipid metabolism	6/49	0.954801629262949	0.999995789590505	0	0	0.538793689650483	0.0249201123106035	AGPS;LPCAT1;PAFAH1B3;PLPP1;PAFAH2;PAFAH1B1
Tyrosine metabolism	4/36	0.955576019040424	0.999995789590505	0	0	0.482769118363371	0.0219374917290777	GSTZ1;GOT1;COMT;ADH5
Thyroid hormone synthesis	10/75	0.960748049508124	0.999995789590505	0	0	0.593808630393996	0.0237779263226425	ATF2;CREB3;ATF6B;CREB3L4;PRKCB;GPX7;ATP1A3;ATP1B3;ADCY7;ATF4
Renin-angiotensin system	2/23	0.965069751239555	0.999995789590505	0	0	0.367900032456994	0.0130806485616075	CTSA;PREP
Breast cancer	22/147	0.96680379461385	0.999995789590505	0	0	0.678727984344423	0.022913656689116	NCOA1;GSK3B;MAP2K1;MAP2K2;NOTCH1;CSNK1A1;ARAF;AXIN1;PIK3R3;PIK3CD;NRAS;FRAT2;AKT2;RPS6KB2;DVL3;MAPK1;BAX;GRB2;E2F3;KRAS;BAK1;MAPK3
Thiamine metabolism	1/15	0.968315916915653	0.999995789590505	0	0	0.275979557069847	0.00888568192319916	ACP1
Serotonergic synapse	16/113	0.968938198919984	0.999995789590505	0	0	0.636304574458977	0.0200782391803732	MAP2K1;PRKCB;ARAF;GNAI3;GNAI2;GNG10;NRAS;GNGT2;GNG2;GNG5;GNB2;CASP3;GNB1;MAPK1;KRAS;MAPK3
Vitamin digestion and absorption	2/24	0.971221323216242	0.999995789590505	0	0	0.351155173939984	0.0102540483063997	SCARB1;APOA1
Circadian entrainment	13/97	0.97440097792961	0.999995789590505	0	0	0.59706289154666	0.0154832608349723	PRKCB;GNAI3;ADCY7;GNAI2;GNG10;GNGT2;GNG2;GNG5;GNB2;GNB1;MAPK1;CALM3;MAPK3
Fanconi anemia pathway	6/54	0.977508264348076	0.999995789590505	0	0	0.482517056530214	0.0109765549820023	MUS81;WDR48;SLX1B;ERCC4;RPA3;FANCA
Systemic lupus erythematosus	19/135	0.979756578131449	0.999995789590505	0	0	0.631550333364239	0.0129159166006862	CD86;HLA-DRB5;C1R;ACTN4;FCGR3A;HLA-DMA;FCGR3B;HLA-DMB;IFNG;SNRPD1;HLA-DPB1;HLA-DRA;SNRPD3;HLA-DOA;TRIM21;HLA-DRB1;SNRPB;HLA-DPA1;HLA-DQB1
Phenylalanine metabolism	1/17	0.980007304458022	0.999995789590505	0	0	0.241451691409102	0.00487617819247914	GOT1
Glutamatergic synapse	15/114	0.984962311318671	0.999995789590505	0	0	0.584267584267584	0.00885276468940308	SLC38A1;PRKCB;GNAI3;ADCY7;GNAI2;GNG10;GRK3;GRK2;GNGT2;GNG2;GNG5;GNB2;GNB1;MAPK1;MAPK3
Ovarian steroidogenesis	5/51	0.987403921781163	0.999995789590505	0	0	0.419530794894879	0.00531800648034039	SCARB1;ACOT2;HSD17B7;ADCY7;LDLR
Insulin secretion	10/86	0.9897454773919	0.999995789590505	0	0	0.507509627727856	0.00523113643145145	ATF2;CREB3;ATF6B;CREB3L4;PRKCB;ATP1A3;ATP1B3;ADCY7;STX1A;ATF4
Pancreatic secretion	12/102	0.99310720502459	0.999995789590505	0	0	0.514071904994306	0.00355566058983534	RAP1B;PRKCB;ATP2B4;CD38;ATP1A3;ATP1B3;SLC4A2;RAC1;ADCY7;RAB8A;RHOA;TPCN2
Hypertrophic cardiomyopathy	10/90	0.993923472172789	0.999995789590505	0	0	0.482012195121951	0.0029378956866838	TGFB1;ITGA4;TPM4;TPM3;ITGA2;ITGA1;PRKAG1;ITGB7;ACTB;ACTG1
Basal cell carcinoma	6/63	0.994141953719316	0.999995789590505	0	0	0.406099312609008	0.00238594389590443	GSK3B;AXIN1;DVL3;BAX;BAK1;KIF7
Amoebiasis	11/102	0.997036836670071	0.999995789590505	0	0	0.465911010190103	0.00138261989785318	RAB5C;TGFB1;IFNG;PRKCB;CASP3;ITGB2;PIK3R3;PIK3CD;SERPINB9;ACTN4;RAB7A
Dilated cardiomyopathy	10/96	0.997310714853988	0.999995789590505	0	0	0.448213272830403	0.00120699700484886	TGFB1;ITGA4;TPM4;TPM3;ITGA2;ITGA1;ITGB7;ADCY7;ACTB;ACTG1
Metabolism of xenobiotics by cytochrome P450	7/76	0.997630092683357	0.999995789590505	0	0	0.391184251890628	0.000928170694906564	GSTM4;AKR7A2;GSTM2;GSTM1;GSTO1;GSTP1;ADH5
Renin secretion	6/69	0.997731141204322	0.999995789590505	0	0	0.367283950617284	0.000834262191710675	PDE1B;PDE3B;GNAI3;ORAI1;CALM3;GNAI2
Aminoacyl-tRNA biosynthesis	5/66	0.998946641265664	0.999995789590505	0	0	0.31606796988878	0.000333108428879387	MTFMT;SARS2;GATC;YARS2;WARS2
Ascorbate and aldarate metabolism	1/30	0.998996622187394	0.999995789590505	0	0	0.1331056301978	0.000133622284107191	ALDH9A1
Arrhythmogenic right ventricular cardiomyopathy	6/77	0.999390454629911	0.999995789590505	0	0	0.32573511242896	0.000198610866974937	ITGA4;ITGA2;ITGA1;ITGB7;ACTB;ACTG1
Salivary secretion	8/93	0.999477424273437	0.999995789590505	0	0	0.362635156451659	0.000189553862798628	PRKCB;ATP2B4;CD38;ATP1A3;ATP1B3;CALM3;SLC4A2;ADCY7
Pentose and glucuronate interconversions	1/34	0.999599187001361	0.999995789590505	0	0	0.116942115238538	4.6881315824143e-05	RPE
Steroid hormone biosynthesis	3/61	0.999886471977898	0.999995789590505	0	0	0.199390443565653	2.26376877142901e-05	SRD5A1;COMT;HSD17B7
Calcium signaling pathway	28/240	0.999899944372323	0.999995789590505	0	0	0.507270760725874	5.07578337123682e-05	FLT1;PDE1B;ADCY7;PHKG2;PLCG2;CD38;PTK2B;NTRK1;PRKCB;SPHK2;SPHK1;F2R;ATP2B4;MCOLN2;TPCN2;STIM1;ADORA2A;CAMK4;ORAI3;VDAC3;PPIF;ORAI1;VDAC2;VDAC1;CALM3;CAMK1;SLC25A5;SLC25A6
Bile secretion	6/90	0.999932054214907	0.999995789590505	0	0	0.27509746588694	1.86923483371324e-05	SCARB1;ATP1A3;ATP1B3;SLC4A2;ADCY7;LDLR
ECM-receptor interaction	5/88	0.999976400344961	0.999995789590505	0	0	0.231968067152899	5.47443096248201e-06	ITGA4;ITGA2;ITGA1;ITGB7;CD47
Arachidonic acid metabolism	2/61	0.999983399760911	0.999995789590505	0	0	0.130633901605796	2.16857199919877e-06	PTGES2;GPX7
MicroRNAs in cancer	36/310	0.999983969154456	0.999995789590505	0	0	0.503617384947809	8.07347722383372e-06	HDAC5;CDKN1B;NOTCH1;ROCK1;HDAC1;PIK3R3;PIK3CD;CRKL;NRAS;BCL2L11;MAPK7;CASP3;PLCG2;PIM1;HMOX1;MAPK1;E2F3;BAK1;SOX4;MAPK3;MAP2K1;MAP2K2;UBE2I;PRKCB;CDKN2A;RDX;RHOA;CDC25B;ZEB2;HNRNPK;CCNG1;MDM2;GRB2;KRAS;EZR;EZH2
Cytokine-cytokine receptor interaction	33/295	0.999988123285148	0.999995789590505	0	0	0.482808980559347	5.73421864211842e-06	CX3CR1;CSF1;FASLG;TNFRSF13C;CXCR6;IL2RG;CXCR3;CCL5;CCL4;TNFSF10;CCL3;IL21R;TNFRSF14;CCR5;IL12RB1;CCR1;CCL25;IL32;IL15RA;TGFB1;CD70;IL10RB;IL10RA;TNFRSF9;IFNLR1;TNFRSF1B;TGFBR2;TNFRSF1A;IFNG;TNFSF4;IL2RB;CD27;TNFSF9
Complement and coagulation cascades	4/85	0.99999006433424	0.999995789590505	0	0	0.190134281058132	1.88912005098449e-06	PROCR;C1R;ITGB2;F2R
Retinol metabolism	2/68	0.999993584087102	0.999995789590505	0	0	0.116727154701838	7.48913659904739e-07	RDH10;ADH5
Olfactory transduction	8/440	0.999993770943947	0.999995789590505	0	0	0.0697852899218087	4.34697836490808e-07	RGS2;GRK3;GRK2;PDE1B;GNB1;CALM3;ARRB2;NCALD
Neuroactive ligand-receptor interaction	13/341	0.999994186292424	0.999995789590505	0	0	0.150545908070748	8.75232430531587e-07	CHRNA1;CHRNB1;P2RY11;CALCB;GPR35;GZMA;F2R;NPW;ADORA2A;P2RY1;TSPO;NMUR1;S1PR4
Taste transduction	3/86	0.99999553694864	0.999995789590505	0	0	0.139113062916384	6.20870130167502e-07	KCNK5;PDE1B;P2RY1
Protein digestion and absorption	4/103	0.999995789590505	0.999995789590505	0	0	0.155387287389236	6.54245487607668e-07	KCNK5;ATP1A3;ATP1B3;SLC1A5