Term	Overlap	P.value	Adjusted.P.value	Old.P.value	Old.Adjusted.P.value	Odds.Ratio	Combined.Score	Genes
Ubiquitin mediated proteolysis	70/140	3.59161669390339e-12	1.12776764188566e-09	0	0	3.3543082657312	88.3941358078269	UBE3C;UBE3A;UBE3B;BRCA1;UBE2Z;HERC4;HERC2;FBXO4;BTRC;SKP2;PIAS3;ANAPC7;FBXW8;FBXW11;FBXW7;UBE4A;UBE4B;PIAS1;DDB2;DDB1;CDC34;UBE2R2;TRAF6;ANAPC4;ANAPC5;BIRC6;ANAPC1;BIRC2;ANAPC2;BIRC3;CUL5;UBA6;MGRN1;CUL3;CUL2;CUL1;XIAP;CBL;RCHY1;UBE2J1;COP1;FZR1;VHL;UBE2H;MAP3K1;PPIL2;SMURF2;UBE2B;FANCL;HUWE1;SYVN1;WWP1;WWP2;UBE2G2;PML;CUL4A;KLHL9;UBE2W;ITCH;UBE2S;NEDD4;CDC16;MDM2;UBA3;UBE2O;ERCC8;UBA1;TRIM37;TRIP12;CUL4B
Herpes simplex virus 1 infection	178/498	9.03202429967595e-11	1.41802781504912e-08	0	0	1.87985768021559	43.4767083471873	ZNF331;ZNF571;ZNF570;PPP1CB;TBK1;ZFP30;AKT2;ZNF605;ZNF84;ZNF846;ZNF85;ZNF845;AKT1;ZNF569;ZNF568;ZNF689;ZNF567;ZNF721;ZNF324;ZNF566;MAP3K7;ZNF200;ZNF684;ZNF17;IFNAR2;ZNF441;ZNF562;ZNF561;ZNF680;ZNF160;ZNF12;HCFC2;HCFC1;ZNF91;ZNF718;ZNF836;ZNF317;SRSF4;ZNF557;SRSF6;SRSF7;ZNF675;TP53;ZNF432;ZNF398;ZNF430;ZNF551;ZNF550;ZNF671;ZNF792;ZNF791;ZNF273;PIK3R3;PIK3R1;ZNF26;ZNF708;IRAK1;ZNF549;ZNF548;ZNF426;TNFRSF14;ZNF700;ZNF302;ZNF544;ZNF786;ZNF268;ZNF267;ZNF420;EIF2B5;EIF2B4;EIF2B3;ZNF141;ZNF383;POU2F1;ZNF140;EIF2AK3;EIF2AK2;EIF2AK4;POU2F2;NFKB1;SRPK1;NFKBIA;MAVS;ZNF37A;ZNF814;BCL2;TAB2;TAB1;ZNF136;ZNF257;ZNF256;ZNF530;ZNF254;ZNF253;ZNF490;ZNF43;PIK3CD;CGAS;ZNF44;ZFP82;IKBKB;CASP9;ZNF808;CASP8;ZNF41;ZNF527;ZNF765;JAK2;ZNF764;IKBKE;ZNF124;ZNF641;JAK1;ZIK1;ZNF486;ZNF761;ZNF484;APAF1;CHUK;IFNGR1;DDX58;TRAF2;IRAK4;ZFP90;TAPBP;IRF3;TRAF3;TRAF6;OAS3;TRAF5;IRF7;ITGA5;ZNF234;ZNF597;BIRC2;IRF9;BIRC3;ZNF595;ZNF473;RNASEL;ZNF230;SP100;ZNF195;SRSF1;ZNF3;ZNF7;ZNF506;ZNF627;ZNF746;ZNF107;ZNF227;ZNF623;ZNF226;ZNF621;ZNF585B;ZNF101;ZNF286A;ZNF100;ZNF583;ZNF461;ZNF460;ZNF182;ZNF181;ZNF180;ZNF77;ZNF79;PML;ZNF33B;ZNF33A;ZNF737;ZNF615;ZNF736;ZNF614;FAS;ZNF699;ZNF611;ZNF333;ZNF211
Hepatitis B	70/162	1.16017677390296e-08	1.2143183566851e-06	0	0	2.54852101465163	46.5668521352825	RB1;ATF2;PIK3CD;CASP9;IKBKB;TBK1;CASP8;CREB3L4;AKT2;CREB3L2;AKT1;EP300;JAK2;MAP3K7;IKBKE;JAK1;MAP2K4;APAF1;CHUK;PRKCB;DDX58;IRAK4;TGFBR1;DDB2;TGFBR2;DDB1;CREB1;CCNE2;IRF3;TRAF3;TRAF6;IRF7;RAF1;SOS1;TP53;SOS2;ATF4;ATF6B;PIK3R3;PIK3R1;MAPK9;MAPK8;IRAK1;MAPK1;PTK2B;E2F3;STAT6;MAP2K7;MAP2K6;MAPK3;STAT5A;CREBBP;EGR2;JUN;SMAD4;SMAD3;MAP3K1;NFATC3;NFATC2;BRAF;NFATC1;MAPK14;NFKB1;MAPK13;NFKBIA;MAVS;BCL2;FAS;TAB2;TAB1
T cell receptor signaling pathway	50/104	2.21125659957559e-08	1.73583643066683e-06	0	0	3.09551529263383	54.5650188840715	GSK3B;PIK3CD;IKBKB;PPP3CA;PPP3CB;PPP3CC;AKT2;GRAP2;NCK2;AKT1;CTLA4;MAP3K8;MAP3K7;VAV3;CHUK;PDPK1;VAV1;ZAP70;PRKCQ;RAF1;SOS1;SOS2;CARD11;PIK3R3;PIK3R1;RASGRP1;MALT1;MAPK9;MAPK8;PAK1;MAPK1;FYN;PLCG1;ICOS;MAP2K7;MAPK3;PAK4;JUN;NFATC3;NFATC2;NFATC1;MAPK14;IL2;NFKB1;MAPK13;NFKBIA;CD4;CD28;MAP3K14;NFKBIB
Autophagy	60/137	6.97666349007329e-08	4.38134467176603e-06	0	0	2.60683529990027	42.9557186971546	PTEN;PIK3CD;IRS2;ZFYVE1;RPTOR;TBK1;AKT2;RB1CC1;LAMP2;MLST8;AKT1;SUPT20H;MAP3K7;CTSD;GABARAPL1;PDPK1;DAPK2;ATG10;WIPI1;ATG14;ATG13;ATG12;RAB33B;RRAGB;TRAF6;DDIT4;ATG4B;PRKCQ;PIK3C3;SMCR8;RAF1;SQSTM1;ATG4D;RAB1A;PRKAA1;MTMR3;STX17;PIK3R4;PIK3R3;PIK3R1;AMBRA1;HIF1A;TANK;CAMKK2;MAPK9;PPP2CB;MAPK8;MAPK1;ATG7;MAPK3;UVRAG;EIF2AK3;EIF2AK4;CFLAR;VMP1;RPS6KB1;ATG16L1;RPS6KB2;ATG2A;BCL2
TNF signaling pathway	51/112	1.46455741685341e-07	6.83404116281395e-06	0	0	2.79443052473334	43.9746748797099	ATF2;PIK3CD;TNFAIP3;IKBKB;CASP8;CREB3L4;AKT2;CREB3L2;AKT1;MAP3K8;DNM1L;MAP3K7;MAP3K5;MAP2K4;CHUK;RIPK3;IL15;TRAF2;TRAF1;TNFRSF1B;CREB1;TRAF3;IRF1;TRAF5;BIRC2;ATF4;BIRC3;ATF6B;PIK3R3;PIK3R1;MAPK9;MAPK8;MAPK1;RIPK1;MAP2K7;MAP2K6;MAPK3;JUN;MLKL;CCL20;CFLAR;MAPK14;NFKB1;MAPK13;NFKBIA;ITCH;FAS;TAB2;TAB1;MAP3K14;IL18R1
Protein processing in endoplasmic reticulum	70/171	1.56396187508865e-07	6.83404116281395e-06	0	0	2.32005748261737	36.3573270575826	ERO1A;UBXN2A;NGLY1;SEC61A1;MAN1A2;UBXN8;MAN1A1;UBXN4;UBXN6;MAP3K5;SEC63;HSP90AA1;DNAJB12;MOGS;UBE4B;TRAF2;CKAP4;DNAJC3;DNAJC1;DDIT3;DNAJC5;PLAA;PREB;MAN1B1;ATF6;ATF4;PPP1R15A;VCP;SEC23A;ATF6B;SEL1L;CUL1;RRBP1;UBE2J1;DNAJB2;ATXN3;LMAN1;MAPK9;GANAB;MAPK8;HSPH1;OS9;UBQLN1;MAP2K7;SEC23B;SEC31B;SEC31A;UBQLN2;EDEM3;MBTPS1;SEC24B;SEC24A;EDEM1;AMFR;HSPA6;EIF2AK3;SYVN1;EIF2AK2;EIF2AK4;UBE2G2;DNAJC10;BCL2;STT3A;HYOU1;STT3B;SEC24D;SEC24C;HSPA1B;NFE2L2;HSPA1A
Yersinia infection	59/137	1.82662695608925e-07	6.83404116281395e-06	0	0	2.5298051685847	39.2515072519272	GSK3B;WIPF1;WIPF2;PIK3CD;WASL;IKBKB;RPS6KA3;TBK1;AKT2;AKT1;MAP3K7;VAV3;MAP2K4;ACTR2;CHUK;ITGA4;TRAF2;IRAK4;VAV1;ZAP70;IRF3;TRAF6;ELMO1;ELMO2;ITGA5;ARHGEF7;CRK;ROCK1;ROCK2;PXN;PIK3R3;PIK3R1;ACTR3B;MAPK9;ACTR3C;MAPK8;IRAK1;PIP5K1A;MAPK1;PTK2B;PIP5K1C;PLCG1;MAP2K7;MAP2K6;MAPK3;GIT2;JUN;NFATC3;NFATC2;NFATC1;MAPK14;IL2;NFKB1;MAPK13;NFKBIA;CD4;TAB2;TAB1;PKN1
mRNA surveillance pathway	46/98	1.95880160717597e-07	6.83404116281395e-06	0	0	2.95521348880128	45.6455265407174	HBS1L;DAZAP1;RNMT;CSTF3;CSTF2;PPP2R2A;CASC3;MSI2;SMG7;GSPT2;GSPT1;SMG5;PPP1CB;PPP2CB;PPP2R1B;FIP1L1;PABPN1;PCF11;PPP2R5E;PPP2R3C;PAPOLG;SYMPK;PELO;UPF2;UPF1;CPSF7;CPSF6;RNGTT;CPSF1;NCBP1;FUS;NCBP2;CPSF3;PPP2R5B;UPF3B;UPF3A;PPP2R5C;SRRM1;WDR33;DDX19A;WDR82;PPP2R2B;PPP2R2D;ACIN1;ETF1;TARDBP
Salmonella infection	92/249	5.81541055476461e-07	1.82603891419609e-05	0	0	1.96387711314398	28.1965311376158	CYFIP2;CYFIP1;CSE1L;FHOD1;PIK3CD;GCC2;WASL;PIK3C2A;FBXO22;PIK3CG;IKBKB;FYCO1;ACTR1B;TUBA1A;CASP8;AKT2;AKT1;MAP3K7;VPS39;KPNA1;MAP2K4;ACTR2;HSP90AA1;RIPK3;CHUK;DYNLT1;EXOC7;VPS33A;TRAF2;IRAK4;DYNLL2;TUBA4A;RHOB;DNM2;DYNC1LI2;TUBB2A;TRAF6;ELMO1;ELMO2;PIK3C3;RAF1;EXOC2;ARL8A;BIRC2;BIRC3;DCTN6;DYNC1I2;DCTN5;ROCK2;DCTN4;TCF7;KLC1;ACTR3B;DYNC2LI1;CYTH3;MAPK9;ACTR3C;PAK1;MAPK8;KLC2;CYTH4;IRAK1;MYO6;VPS11;FLNA;MAPK1;NCKAP1L;SNX9;RIPK1;MAP2K7;CYTH1;VPS16;MAP2K6;MAPK3;GSDMD;DYNC1H1;JUN;MLKL;TNFRSF10A;TUBB4B;MAPK14;NFKB1;MAPK13;NFKBIA;ABI1;VPS41;BCL2;PLEKHM1;CTNNB1;TAB2;PKN1;TAB1
Measles	58/139	8.28285740995498e-07	2.36437929702351e-05	0	0	2.39382527071134	33.5229080075686	GSK3B;CDKN1B;PIK3CD;TNFAIP3;ADAR;CASP9;IKBKB;TBK1;CASP8;AKT2;AKT1;MAP3K7;IKBKE;JAK1;IFNAR2;CSNK2A1;APAF1;CHUK;DDX58;CSNK2A2;IRAK4;CCNE2;IRF3;TRAF3;OAS3;TRAF6;IRF7;CD46;TP53;IRF9;PIK3R3;PIK3R1;RCHY1;MAPK9;MAPK8;IRAK1;SLAMF1;STAT5A;JUN;MX2;HSPA6;MX1;EIF2AK3;EIF2AK2;EIF2AK4;IL2;NFKB1;NFKBIA;MAVS;CDK6;IL2RA;BCL2;CD28;FAS;TAB2;HSPA1B;NFKBIB;HSPA1A
RNA degradation	38/79	1.03095467982235e-06	2.69766474553515e-05	0	0	3.09306314487051	42.6379537417703	DDX6;ZCCHC7;BTG2;DIS3L;PARN;ENO2;TOB2;TENT4B;TOB1;EDC3;EDC4;EXOSC6;EXOSC10;DHX36;EXOSC8;MTREX;EXOSC2;EXOSC1;HSPA9;TTC37;CNOT6L;PNPT1;DIS3;CNOT10;PATL1;CNOT4;LSM8;CNOT6;PFKL;XRN1;CNOT1;CNOT2;SKIV2L;DCP1A;CNOT9;DCP2;PFKP;DCP1B
PD-L1 expression and PD-1 checkpoint pathway in cancer	41/89	1.63196925562617e-06	3.94183343282013e-05	0	0	2.85113017429194	37.9933713388973	PTEN;PIK3CD;PIK3R3;PIK3R1;HIF1A;RASGRP1;IKBKB;PPP3CA;PPP3CB;PPP3CC;AKT2;AKT1;MAPK1;PLCG1;JAK2;JAK1;MAP2K6;MAPK3;JUN;CHUK;CSNK2A1;IFNGR1;CSNK2A2;NFATC3;NFATC2;NFATC1;MAPK14;NFKB1;BATF;MAPK13;EML4;NFKBIA;ZAP70;CD4;RPS6KB1;TRAF6;RPS6KB2;CD28;PRKCQ;RAF1;NFKBIB
Endocytosis	90/252	3.97287698927713e-06	8.19630267902801e-05	0	0	1.8604565807825	23.1366753282692	WASHC4;WASHC5;TFRC;WIPF1;SH3KBP1;WIPF2;CLTC;WASHC2C;ARRB1;WASL;AP2A2;WASHC2A;EEA1;ZFYVE27;CHMP1B;PSD4;VPS36;SH3GL1;USP8;ACTR2;PDCD6IP;IST1;VPS37A;EPS15L1;ARAP1;VPS37B;RBSN;ARFGAP1;TGFBR1;RNF41;ARFGAP2;DNM2;EPN2;TGFBR2;RUFY1;ACAP2;ZFYVE16;ACAP1;RABEP1;HGS;TRAF6;RUFY2;STAM2;CHMP7;VPS28;AGAP2;CXCR4;ASAP1;VPS26B;CBL;ACTR3B;PRKCZ;CYTH3;ACTR3C;SNX1;RAB11FIP1;GRK2;CYTH4;GRK5;MVB12B;PIP5K1A;PIP5K1C;EPS15;LDLR;RAB11FIP4;CYTH1;SMAD2;ARFGEF1;GIT2;ARFGEF2;SMAD3;SMURF2;IQSEC1;GBF1;HSPA6;WWP1;STAM;AP2B1;IGF2R;PML;EHD1;ITCH;EHD4;NEDD4;IL2RA;MDM2;VPS45;SMAP1;HSPA1B;HSPA1A
NOD-like receptor signaling pathway	69/181	4.11071562932118e-06	8.19630267902801e-05	0	0	2.06036865096762	25.5525136340318	TNFAIP3;ANTXR2;IKBKB;PANX1;PSTPIP1;TBK1;CASP8;NAMPT;DNM1L;MAP3K7;IKBKE;JAK1;IFNAR2;GBP5;GABARAPL1;HSP90AA1;CHUK;RIPK3;TRAF2;IRAK4;ATG12;PLCB3;AIM2;IRF3;TRAF3;OAS3;TRAF6;TRAF5;IRF7;BIRC2;IRF9;BIRC3;RNASEL;NLRX1;ITPR2;XIAP;ITPR3;TANK;MAPK9;MAPK8;SHARPIN;NLRP6;IFI16;MFN1;MAPK1;MFN2;RIPK1;TP53BP1;GBP3;MAPK3;GSDMD;JUN;CARD8;NEK7;TRPV2;ERBIN;MAPK14;NFKB1;MAPK13;NFKBIA;P2RX7;MAVS;ATG16L1;BCL2;TAB2;TAB1;PKN1;MCU;NFKBIB
Th17 cell differentiation	46/107	4.17645996383593e-06	8.19630267902801e-05	0	0	2.51771814720132	31.184574218481	RORC;AHR;HIF1A;IL27RA;IKBKB;RXRB;PPP3CA;MAPK9;PPP3CB;MAPK8;PPP3CC;IL21R;MAPK1;STAT6;PLCG1;JAK2;IL12RB1;IL6R;JAK1;MAPK3;SMAD2;STAT5A;JUN;SMAD4;HSP90AA1;IL4R;SMAD3;CHUK;IFNGR1;NFATC3;NFATC2;NFATC1;MAPK14;IL2;NFKB1;TGFBR1;RUNX1;TGFBR2;MAPK13;NFKBIA;ZAP70;CD4;IRF4;IL2RA;PRKCQ;NFKBIB
Phosphatidylinositol signaling system	42/97	8.66332548441979e-06	0.000145983335206746	0	0	2.54833891321143	29.7044880433121	IPPK;PI4K2B;DGKE;DGKD;MTMR3;INPP1;PTEN;ITPR2;PIK3R3;PIK3CD;ITPR3;PIK3R1;PIK3C2A;MTMR6;MTM1;INPP5B;PIP4P2;PIP4P1;INPP5F;PPIP5K2;INPP5D;PLCG2;PIP4K2A;PIP5K1A;PIP4K2B;PIP4K2C;PIP5K1C;PLCG1;IP6K2;PRKCB;SACM1L;IPMK;SYNJ2;DGKZ;ITPKB;PLCB3;SYNJ1;PIK3C3;PI4KB;PI4K2A;PLCD1;CDS2
Neurotrophin signaling pathway	49/119	8.85559219495467e-06	0.000145983335206746	0	0	2.33725447402881	27.1926969882646	GSK3B;PRDM4;PIK3CD;IKBKB;RPS6KA3;AKT2;AKT1;MAP3K5;PDPK1;IRAK4;TRAF6;MAPKAPK2;RAF1;SOS1;TP53;CRK;SOS2;ATF4;ZNF274;CAMK2D;PSEN2;PIK3R3;PIK3R1;PSEN1;FOXO3;MAPK9;MAPK8;MAPK7;IRAK1;PLCG2;MAPK1;PLCG1;MAP2K7;CAMK2G;SH2B3;MAP2K5;MAPK3;SH2B1;JUN;MAP3K1;KIDINS220;BRAF;MAPK14;NFKB1;MAPK13;NFKBIA;CAMK4;BCL2;NFKBIB
Chronic myeloid leukemia	35/76	9.29830160552524e-06	0.000145983335206746	0	0	2.847014370927	32.9845940335534	RB1;CDKN1B;CTBP1;PIK3CD;PIK3R3;PIK3R1;CBL;IKBKB;AKT2;AKT1;MAPK1;E2F3;POLK;MAPK3;STAT5A;SMAD4;SMAD3;CHUK;GADD45B;GADD45A;BRAF;TGFBR1;NFKB1;DDB2;RUNX1;TGFBR2;GADD45G;NFKBIA;CDK6;MDM2;RAF1;SOS1;CRK;SOS2;TP53
Pancreatic cancer	35/76	9.29830160552524e-06	0.000145983335206746	0	0	2.847014370927	32.9845940335534	RB1;PIK3CD;PIK3R3;PIK3R1;BRCA2;CASP9;IKBKB;MAPK9;MAPK8;AKT2;AKT1;MAPK1;E2F3;POLK;RALGDS;JAK1;MAPK3;SMAD2;SMAD4;SMAD3;CHUK;GADD45B;GADD45A;BRAF;TGFBR1;NFKB1;DDB2;TGFBR2;GADD45G;CDK6;RPS6KB1;RPS6KB2;RAF1;TP53;ARHGEF6
Colorectal cancer	38/86	1.29776561576938e-05	0.00019404685873885	0	0	2.64078489005008	29.7148547957327	GSK3B;TCF7;PIK3CD;PIK3R3;PIK3R1;CASP9;MAPK9;MAPK8;BCL2L11;AKT2;AKT1;MAPK1;POLK;RALGDS;MAPK3;SMAD2;JUN;SMAD4;SMAD3;GADD45B;GADD45A;BRAF;MLH1;TGFBR1;DDB2;TGFBR2;GADD45G;MSH6;APC;RPS6KB1;MSH3;RPS6KB2;BCL2;CTNNB1;RAF1;SOS1;SOS2;TP53
Epstein-Barr virus infection	73/202	1.96190624294576e-05	0.000280017527402259	0	0	1.89209873771646	20.5084750415891	RB1;CDKN1B;PIK3CD;TNFAIP3;RBPJ;IKBKB;CASP9;TBK1;CASP8;SIN3A;AKT2;AKT1;POLK;SKP2;IKBKE;MAP3K7;JAK1;IFNAR2;MAP2K4;ENTPD1;USP7;APAF1;CHUK;DDX58;TRAF2;IRAK4;RUNX3;DDB2;TAPBP;NCOR2;CCNE2;IRF3;TRAF3;OAS3;TRAF6;TRAF5;IRF7;TP53;IRF9;PIK3R3;PIK3R1;RELB;MAPK9;MAPK8;BCL2L11;IRAK1;SAP30L;PLCG2;RIPK1;E2F3;CD58;MAP2K7;MAP2K6;JUN;GADD45B;GADD45A;EIF2AK2;MAPK14;NFKB1;GADD45G;NFKB2;MAPK13;NFKBIA;MAVS;CDK6;NEDD4;BCL2;MDM2;FAS;TAB2;TAB1;MAP3K14;NFKBIB
Apoptosis	55/142	2.20065966463564e-05	0.000300437884650257	0	0	2.1112400530504	22.6412936548139	PIK3CD;CASP9;IKBKB;PIDD1;CASP8;TUBA1A;AKT2;AKT1;CASP2;CTSF;CTSD;SPTAN1;MAP3K5;DFFB;ENDOG;PARP4;APAF1;CHUK;PARP2;PDPK1;TRAF2;TRAF1;TUBA4A;DDIT3;BIRC6;RAF1;TP53;BIRC2;ATF4;BIRC3;HTRA2;ITPR2;PIK3R3;XIAP;ITPR3;PIK3R1;MAPK9;MAPK8;BCL2L11;LMNA;MAPK1;RIPK1;MAPK3;JUN;GADD45B;GADD45A;EIF2AK3;TNFRSF10A;CFLAR;NFKB1;GADD45G;NFKBIA;BCL2;FAS;MAP3K14
RNA transport	68/186	2.42156550264928e-05	0.000316821486596614	0	0	1.92608193390462	20.4713834683178	CYFIP2;EIF4A2;CYFIP1;EIF4A1;POP5;NUP107;NUP188;POP1;FMR1;GEMIN2;CASC3;XPO1;XPO5;NUP214;NDC1;UPF2;EIF5B;PRMT5;UPF1;NCBP1;NUP133;NCBP2;ELAC2;THOC1;THOC2;TRNT1;THOC5;RANGAP1;SENP2;SRRM1;DDX19A;NUP50;RPP21;GEMIN5;NUP54;NUP98;KPNB1;NUP58;NUP205;POM121;DDX20;AAAS;NUP160;FXR2;POM121C;NUP85;TGS1;TPR;NUP88;RAE1;EIF2B5;EIF2B4;EIF2B3;NUP155;FUS;UPF3B;NUP153;UPF3A;EIF5;XPOT;TACC3;ACIN1;NUP35;EIF3C;TARDBP;EIF4G3;EIF3A;EIF3B
RIG-I-like receptor signaling pathway	32/70	2.66535835979517e-05	0.000334769009990274	0	0	2.80720065002689	29.5670849252798	OTUD5;NLRX1;TANK;IKBKB;MAPK9;MAPK8;CASP8;TBK1;DHX58;TRIM25;RIPK1;AZI2;IKBKE;MAP3K7;MAP3K1;CHUK;DDX58;TRAF2;MAPK14;ATG12;NFKB1;MAPK13;NFKBIA;CYLD;SIKE1;MAVS;RNF125;IRF3;TRAF3;TRAF6;IRF7;NFKBIB
Lipid and atherosclerosis	76/215	3.22692831882121e-05	0.000389713650811485	0	0	1.82814363218536	18.9055549877212	ERO1A;GSK3B;NCF4;PIK3CD;IKBKB;CASP9;PPP3CA;PPP3CB;TBK1;PPP3CC;CASP8;AKT2;AKT1;JAK2;IKBKE;MAP3K7;MAP3K5;VAV3;MAP2K4;HSP90AA1;APAF1;CHUK;PDPK1;TRAF2;IRAK4;VAV1;PLCB3;IRF3;TRAF3;DDIT3;TRAF6;IRF7;ATF6;TP53;ABCG1;ATF4;CAMK2D;ROCK2;PIK3R3;PIK3R1;TANK;RXRB;MAPK9;MAPK8;IRAK1;MAPK1;PLCG1;MAP2K7;LDLR;CAMK2G;MAP2K6;MAPK3;JUN;POU2F1;HSPA4;HSPA6;EIF2AK3;NFATC3;MIB2;NFATC2;NFATC1;TNFRSF10A;POU2F2;MAPK14;SOD2;NFKB1;MIB1;MAPK13;NFKBIA;BCL2;FAS;TAB2;TAB1;HSPA1B;HSPA1A;NFE2L2
Human immunodeficiency virus 1 infection	75/212	3.51227734823491e-05	0.000408464847165096	0	0	1.83026473472056	18.7724045961582	CGAS;PIK3CD;DCAF1;IKBKB;CASP9;PPP3CA;PPP3CB;TBK1;PPP3CC;CASP8;TRIM5;AP1G1;AKT2;CFL2;AKT1;AP1S3;BTRC;MAP3K7;CHUK;PRKCB;FBXW11;AP1B1;TRAF2;IRAK4;TNFRSF1B;TAPBP;DDB1;IRF3;TRAF6;TRAF5;RAF1;CRK;CUL5;PXN;CUL1;PIK3R3;CXCR4;ITPR2;ITPR3;PIK3R1;SAMHD1;MAPK9;PAK1;MAPK8;GNG2;IRAK1;PLCG2;MAPK1;PTK2B;RIPK1;PLCG1;MAP2K7;PAK4;MAP2K6;MAPK3;APOBEC3D;JUN;LIMK2;NFATC3;NFATC2;NFATC1;MAPK14;NFKB1;MAPK13;NFKBIA;CUL4A;CD4;RPS6KB1;RPS6KB2;BCL2;FAS;TAB2;GNB5;TAB1;CUL4B
FoxO signaling pathway	51/131	3.66437857987007e-05	0.000410933883599716	0	0	2.12810862445415	21.7370690552457	CDKN1B;PTEN;PIK3CD;PRKAG2;IRS2;IKBKB;AKT2;AKT1;EP300;SKP2;GABARAPL1;USP7;CHUK;PDPK1;PRKAB1;SIRT1;ATG12;TGFBR1;TGFBR2;RBL2;SGK3;RAF1;SGK1;SOS1;SOS2;PRKAA1;AGAP2;PIK3R3;PIK3R1;FOXO3;STK4;FOXO1;MAPK9;MAPK8;BCL2L11;MAPK1;MAPK3;PLK3;CREBBP;SMAD4;SMAD3;GADD45B;GADD45A;BRAF;FBXO32;MAPK14;SOD2;GADD45G;MAPK13;MDM2;IL7R
Sphingolipid signaling pathway	47/119	4.7676746778481e-05	0.00050674462076592	0	0	2.17834678592205	21.6768743102463	ROCK1;SGMS1;ROCK2;PTEN;PIK3R3;PIK3CD;PPP2R2A;PIK3R1;PRKCZ;SMPD2;MAPK9;PPP2CB;SGPL1;MAPK8;SPTLC1;PPP2R1B;SPTLC2;PPP2R5E;PPP2R3C;AKT2;AKT1;MAPK1;FYN;CTSD;MAP3K5;MAPK3;CERS4;CERS5;CERS6;PRKCB;PDPK1;SPHK2;SPHK1;PPP2R5B;TRAF2;PPP2R5C;MAPK14;NFKB1;SGPP1;MAPK13;PLCB3;PPP2R2B;PPP2R2D;BCL2;RAF1;TP53;NSMAF
Kaposi sarcoma-associated herpesvirus infection	69/193	4.84150911559796e-05	0.00050674462076592	0	0	1.85951443198371	18.4755756676523	RB1;GSK3B;PIK3CD;PIK3CG;IKBKB;CASP9;PREX1;PPP3CA;PPP3CB;ZFP36;TBK1;PPP3CC;CASP8;AKT2;AKT1;EP300;JAK2;IKBKE;JAK1;IFNAR2;MAP2K4;GABARAPL1;CHUK;IFNGR1;TRAF2;ATG14;CD200R1;CREB1;IRF3;TRAF3;MAPKAPK2;IRF7;PIK3C3;RAF1;TP53;IRF9;TCF7;PIK3R3;ITPR2;ITPR3;PIK3R1;HIF1A;PIK3R6;PIK3R5;MAPK9;MAPK8;GNG2;PLCG2;MAPK1;E2F3;PLCG1;MAP2K7;MICA;MAP2K6;MAPK3;CREBBP;JUN;NFATC3;EIF2AK2;NFATC2;NFATC1;MAPK14;NFKB1;MAPK13;NFKBIA;CDK6;CTNNB1;FAS;GNB5
Non-small cell lung cancer	32/72	5.30635633889538e-05	0.000527792185767889	0	0	2.66649271580778	26.2490077676793	RB1;PIK3CD;PIK3R3;PIK3R1;FOXO3;STK4;FHIT;CASP9;RXRB;RASSF1;AKT2;PLCG2;AKT1;MAPK1;E2F3;POLK;PLCG1;MAPK3;STAT5A;GADD45B;PDPK1;PRKCB;GADD45A;BRAF;DDB2;GADD45G;EML4;CDK6;RAF1;SOS1;SOS2;TP53
Shigellosis	84/246	5.37877386769824e-05	0.000527792185767889	0	0	1.73413483859932	17.0473518749816	GSK3B;GSK3A;CGAS;PIK3CD;WASL;HK1;IKBKB;RPTOR;TBK1;AKT2;AKT1;BTRC;MAP3K7;CAST;ACTR2;GABARAPL1;CHUK;FNBP1;FBXW11;ACTN1;TRAF2;WIPI1;ACTN4;ATG14;ATG12;PLCB3;IRF3;RRAGB;TRAF6;TRAF5;ELMO1;HCLS1;ELMO2;PRKCQ;PIK3C3;ARHGEF2;ITGA5;TLN1;TP53;SQSTM1;CRK;PPID;ROCK1;ROCK2;PXN;PIK3R4;CUL1;PIK3R3;ITPR2;ITPR3;PIK3R1;FOXO3;ACTR3B;FOXO1;MALT1;U2AF1L4;CYTH3;MAPK9;ACTR3C;MAPK8;SHARPIN;CYTH4;PLCG2;MAPK1;RIPK1;PLCG1;CYTH1;MAPK3;JUN;GLMN;MAPK14;NFKB1;MAPK13;NFKBIA;DIAPH1;RPS6KB1;ATG16L1;RPS6KB2;BCL2;MDM2;TAB2;TAB1;PLCD1;NFKBIB
Human T-cell leukemia virus 1 infection	76/219	6.52985950105799e-05	0.000621326025252185	0	0	1.77654003515694	17.1196991775995	RB1;ATF2;CRTC2;CRTC3;PTEN;SLC2A1;BUB1B;PIK3CD;ETS1;ELK4;IKBKB;PPP3CA;PPP3CB;ZFP36;PPP3CC;XPO1;KAT5;CREB3L4;AKT2;CHEK2;CREB3L2;AKT1;EP300;JAK1;MAP2K4;TBP;ANAPC7;CHUK;IL15;TGFBR1;TGFBR2;KAT2A;CREB1;CCNE2;ANAPC4;ANAPC5;TLN1;TP53;ANAPC1;ATF4;ANAPC2;VAC14;ATF6B;SRF;PIK3R3;GPS2;XIAP;PIK3R1;ADCY7;RELB;MAPK9;MAPK8;MAPK1;E2F3;MAPK3;STAT5A;SMAD2;EGR1;CREBBP;EGR2;JUN;SMAD4;MAP3K1;SMAD3;NFATC3;NFATC2;NFATC1;IL2;NFKB1;NFKB2;NFKBIA;CD4;IL2RA;CDC16;TCF3;MAP3K14
Inositol phosphate metabolism	32/73	7.36566714890078e-05	0.000680241024927896	0	0	2.60128659995015	24.7540925806361	IPPK;PI4K2B;ISYNA1;MTMR3;INPP1;PTEN;PIK3CD;PIK3C2A;PIK3CG;MTMR6;MTM1;INPP5B;INPP5F;INPP5D;PLCG2;PIP4K2A;PIP5K1A;PIP4K2B;PIP4K2C;PIP5K1C;PLCG1;SACM1L;IPMK;SYNJ2;ITPKB;FIG4;PLCB3;SYNJ1;PIK3C3;PI4KB;PI4K2A;PLCD1
Insulin resistance	43/108	7.87415027726767e-05	0.000706423767732014	0	0	2.20666621956945	20.8515397887107	GSK3B;PYGB;CRTC2;SLC27A1;PRKAA1;PTEN;SLC2A1;PIK3R3;PIK3CD;PRKAG2;IRS2;PIK3R1;PRKCZ;FOXO1;PPP1CB;IKBKB;RPS6KA3;GYS1;MAPK9;MAPK8;CREB3L4;AKT2;CREB3L2;AKT1;PPARGC1B;MLXIP;SREBF1;PTPN1;CPT1A;PRKCB;PDPK1;GFPT1;PRKAB1;NFKB1;NFKBIA;CREB1;RPS6KB1;RPS6KB2;PRKCQ;SLC27A3;PPARA;OGT;SLC27A4
Lysosome	49/128	8.49659585564558e-05	0.000741091971853531	0	0	2.06976667090265	19.4004608751071	SCARB2;CLTC;HEXA;NAGPA;SGSH;AP4M1;GNPTAB;AP1G1;LAMP2;IDS;ACP2;AP3S2;AP1S3;CTSF;GUSB;CTSD;ARSA;MANBA;AP1B1;AP3B1;SUMF1;NPC1;IDUA;GBA;GNS;GGA2;AP3M1;CLN3;GGA1;GGA3;NEU1;ATP6V0A2;SLC17A5;ATP6V1H;AP4S1;ARSG;AGA;AP3D1;CTNS;NAGA;MCOLN1;AP4B1;IGF2R;GALC;GALNS;GLB1;MAN2B1;TPP1;GLA
Nucleotide excision repair	23/47	9.78005199854825e-05	0.000829982791228149	0	0	3.19132486979167	29.4641642857404	RFC5;RFC3;GTF2H2C;RFC4;LIG1;RFC1;XPA;XPC;GTF2H1;GTF2H2;GTF2H3;GTF2H4;DDB2;CUL4A;DDB1;ERCC3;POLD1;ERCC2;ERCC8;ERCC5;ERCC6;MNAT1;CUL4B
C-type lectin receptor signaling pathway	41/104	0.000147590407072522	0.00121956283738873	0	0	2.1701628799668	19.1431578957269	ITPR2;PIK3R3;PIK3CD;ITPR3;PIK3R1;MALT1;RELB;IKBKB;PPP3CA;MAPK9;PPP3CB;MAPK8;PAK1;CASP8;PPP3CC;AKT2;PLCG2;AKT1;MAPK1;IKBKE;MAPK3;PLK3;EGR2;JUN;CHUK;NFATC3;NFATC2;NFATC1;MAPK14;IL2;NFKB1;NFKB2;MAPK13;NFKBIA;CYLD;IRF1;MAPKAPK2;MDM2;RAF1;MAP3K14;IRF9
Fanconi anemia pathway	25/54	0.000153742229306717	0.00123782205134126	0	0	2.87106772276042	25.2086441205965	MUS81;BLM;WDR48;BRCA1;BRCA2;REV3L;POLK;ATRIP;POLH;FAAP100;CENPX;SLX1B;FANCL;TOP3A;REV1;FANCA;FANCC;FANCB;MLH1;FANCG;FANCF;RAD51C;FANCD2;CENPS-CORT;TELO2
Thyroid hormone signaling pathway	46/121	0.000166594295700495	0.00129838938633653	0	0	2.04587131952017	17.7989762801428	NOTCH2;GSK3B;HDAC3;THRA;ATP2A3;SLC2A1;PIK3R3;ATP2A2;PIK3CD;PIK3R1;ATP1A1;HIF1A;FOXO1;MED17;CASP9;MED12;RXRB;MED14;SIN3A;AKT2;PLCG2;AKT1;EP300;MAPK1;PLCG1;MAPK3;NCOA1;MED1;CREBBP;PRKCB;PDPK1;NCOA3;ATP1B3;ATP1B1;MED27;KAT2A;PLCB3;PFKL;MED24;NCOR1;MDM2;CTNNB1;RAF1;TP53;PFKP;PLCD1
Peroxisome	34/82	0.000169534919871968	0.00129838938633653	0	0	2.36075157711551	20.4971113915436	ABCD4;ABCD2;ABCD3;ECI2;HSD17B4;CROT;PEX26;HMGCL;NUDT19;HACL1;MLYCD;ACAA1;ABCD1;PEX16;PHYH;ACSL1;EPHX2;IDH1;ACSL5;ACSL4;PEX10;ACSL3;SOD2;PEX13;PEX14;GNPAT;ACOX1;PEX3;PEX6;AGPS;FAR1;ACOX3;FAR2;PAOX
Small cell lung cancer	37/92	0.000189262359070461	0.00141496144638392	0	0	2.24252186646614	19.2237414399339	RB1;CDKN1B;PTEN;PIK3CD;PIK3R3;XIAP;PIK3R1;FHIT;CASP9;IKBKB;RXRB;AKT2;AKT1;E2F3;POLK;SKP2;ZBTB17;APAF1;CHUK;GADD45B;GADD45A;TRAF2;TRAF1;NFKB1;DDB2;GADD45G;NFKBIA;CDK6;CCNE2;TRAF4;TRAF3;TRAF6;TRAF5;BCL2;TP53;BIRC2;BIRC3
Cellular senescence	56/156	0.000210145970180808	0.00153455429387846	0	0	1.86899234972678	15.8260817943366	RB1;LIN54;MRE11;PTEN;PIK3CD;ETS1;PPP1CB;PPP3CA;PPP3CB;PPP3CC;AKT2;CHEK2;AKT1;BTRC;LIN52;FBXW11;SIRT1;TGFBR1;TGFBR2;RBL2;RBL1;CCNE2;MAPKAPK2;RAF1;SQSTM1;TP53;PPID;LIN37;ITPR2;PIK3R3;ITPR3;PIK3R1;FOXO3;FOXO1;MAPK1;E2F3;E2F4;MAP2K6;MAPK3;SMAD2;SMAD3;GADD45B;GADD45A;NFATC3;NFATC2;NFATC1;MAPK14;NFKB1;HIPK3;GADD45G;MAPK13;RAD50;CDK6;MDM2;MCU;RAD9A
Endometrial cancer	26/58	0.000219048234847963	0.00156320785777865	0	0	2.70603963083605	22.8016814749701	GSK3B;TCF7;PTEN;PIK3CD;PIK3R3;PIK3R1;FOXO3;CASP9;AKT2;AKT1;MAPK1;POLK;MAPK3;GADD45B;PDPK1;GADD45A;BRAF;MLH1;DDB2;GADD45G;APC;CTNNB1;RAF1;SOS1;SOS2;TP53
AMPK signaling pathway	45/120	0.000279551814352739	0.001950650437928	0	0	2.00095944177933	16.3724962629438	CRTC2;PRKAA1;PFKFB3;PIK3R3;PIK3CD;PRKAG2;IRS2;PPP2R2A;PIK3R1;HMGCR;FOXO3;ADIPOR2;FOXO1;CAMKK2;RPTOR;LIPE;GYS1;PPP2CB;EEF2K;PPP2R1B;CREB3L4;PPP2R5E;PPP2R3C;AKT2;CREB3L2;AKT1;MLYCD;MAP3K7;SREBF1;CPT1A;PDPK1;STRADA;STRADB;PPP2R5B;PPP2R5C;PRKAB1;SIRT1;PFKL;CREB1;RPS6KB1;PPP2R2B;FASN;PPP2R2D;RPS6KB2;PFKP
N-Glycan biosynthesis	23/50	0.000313728122192373	0.00214153544279141	0	0	2.83617862654321	22.8794070342691	DPAGT1;ALG8;ST6GAL1;B4GALT1;ALG9;ALG6;ALG13;ALG12;MOGS;DOLK;ALG11;ALG10;DPM2;FUT8;GANAB;MAN1A2;MAN2A1;MGAT5;MGAT4A;STT3A;MAN1A1;MAN1B1;STT3B
NF-kappa B signaling pathway	40/104	0.000325013762956859	0.00217136854400965	0	0	2.08356022653017	16.7344119688535	TNFAIP3;XIAP;MALT1;RELB;IKBKB;PIDD1;IRAK1;PLCG2;TRIM25;RIPK1;PLCG1;MAP3K7;CSNK2A1;GADD45B;CHUK;PRKCB;GADD45A;DDX58;CSNK2A2;TRAF2;IRAK4;TRAF1;CFLAR;NFKB1;GADD45G;NFKB2;NFKBIA;CYLD;ZAP70;TRAF3;TRAF6;TRAF5;BCL2;PRKCQ;TAB2;TAB1;MAP3K14;CARD11;BIRC2;BIRC3
Th1 and Th2 cell differentiation	36/92	0.000430401580648237	0.00281554367340721	0	0	2.14234416291	16.6048637347934	NOTCH2;MAML1;RBPJ;IKBKB;PPP3CA;MAPK9;PPP3CB;MAPK8;PPP3CC;MAPK1;STAT6;PLCG1;JAK2;IL12RB1;JAK1;IL12RB2;MAPK3;STAT5A;JUN;IL4R;CHUK;IFNGR1;NFATC3;NFATC2;NFATC1;MAPK14;RUNX3;IL2;NFKB1;MAPK13;NFKBIA;ZAP70;CD4;IL2RA;PRKCQ;NFKBIB
Longevity regulating pathway	39/102	0.00044049849034449	0.00282278624424836	0	0	2.06340219014435	15.9451540684558	ATF2;PRKAA1;CLPB;ATF6B;EHMT2;EHMT1;PIK3R3;PIK3CD;PRKAG2;IRS2;PIK3R1;FOXO3;ADIPOR2;ADCY7;FOXO1;CAMKK2;RPTOR;SESN3;CREB3L4;AKT2;SESN1;RB1CC1;CREB3L2;SESN2;AKT1;HSPA6;SOD2;ATG13;PRKAB1;SIRT1;NFKB1;CREB1;RPS6KB1;CAMK4;RPS6KB2;TP53;HSPA1B;ATF4;HSPA1A
Hepatitis C	55/157	0.000478746585381032	0.00300652855619288	0	0	1.79899604072398	13.7521358645463	RB1;GSK3B;CD81;PIK3CD;PPP2R2A;CASP9;IKBKB;TBK1;CASP8;PPP2R1B;AKT2;AKT1;IKBKE;JAK1;IFNAR2;APAF1;CHUK;DDX58;TRAF2;PIAS1;IRF3;TRAF3;OAS3;TRAF6;IRF7;RAF1;PPARA;SOS1;TP53;SOS2;IRF9;RNASEL;PIK3R3;PIK3R1;PPP2CB;MAPK1;RIPK1;E2F3;LDLR;MAPK3;MX2;MX1;EIF2AK3;EIF2AK2;BRAF;EIF2AK4;CFLAR;NFKB1;NFKBIA;MAVS;CDK6;PPP2R2B;PPP2R2D;CTNNB1;FAS
Prostate cancer	37/97	0.000642455733129511	0.00395551176867973	0	0	2.05497387897257	15.1044949830149	RB1;GSK3B;CDKN1B;TCF7;PTEN;PIK3R3;PIK3CD;PIK3R1;FOXO1;CASP9;IKBKB;CREB3L4;AKT2;CREB3L2;AKT1;EP300;MAPK1;E2F3;MAPK3;CREBBP;HSP90AA1;CHUK;PDPK1;BRAF;NFKB1;NFKBIA;CREB1;ZEB1;CCNE2;BCL2;MDM2;CTNNB1;RAF1;SOS1;TP53;SOS2;ATF4
B cell receptor signaling pathway	32/81	0.000720730181128855	0.00435210147835501	0	0	2.17545074128804	15.739920663649	GSK3B;CD81;PIK3CD;DAPP1;PIK3R3;PIK3R1;MALT1;IKBKB;PPP3CA;PPP3CB;PPP3CC;AKT2;INPP5D;PLCG2;AKT1;MAPK1;MAPK3;VAV3;JUN;CHUK;PRKCB;NFATC3;NFATC2;NFATC1;VAV1;NFKB1;NFKBIA;RAF1;SOS1;SOS2;CARD11;NFKBIB
Osteoclast differentiation	45/127	0.00113996301966011	0.00675374317308063	0	0	1.82930818078351	12.3967815120565	NCF4;PIK3R3;PIK3CD;PIK3R1;RELB;IKBKB;PPP3CA;MAPK9;PPP3CB;MAPK8;PPP3CC;AKT2;PLCG2;AKT1;MAPK1;FYN;MAP2K7;MAP3K7;MAP2K6;JAK1;MAPK3;IFNAR2;JUN;CHUK;IFNGR1;NFATC2;NFATC1;TRAF2;MAPK14;NFKB1;TGFBR1;FOSL2;NFKB2;TGFBR2;MAPK13;NFKBIA;CYLD;CREB1;TRAF6;CAMK4;TAB2;TAB1;SQSTM1;MAP3K14;IRF9
Cell cycle	44/124	0.001243169982585	0.00722880323206835	0	0	1.83321342925659	12.2643641580438	RB1;GSK3B;CDKN1B;MCM7;PRKDC;CUL1;BUB1B;CDC14B;ORC4;FZR1;ORC1;CHEK2;ORC3;ORC2;EP300;E2F3;E2F4;SKP2;SMAD2;ZBTB17;CREBBP;SMAD4;SMAD3;ANAPC7;GADD45B;GADD45A;CDC7;SMC1A;GADD45G;RBL2;STAG1;CDK6;STAG2;DBF4;RBL1;CCNE2;CDC16;MDM2;ANAPC4;ANAPC5;MCM6;TP53;ANAPC1;ANAPC2
Basal transcription factors	20/45	0.00129480844093987	0.00739217909918396	0	0	2.66215571459553	17.701718287258	GTF2H2C;TAF15;TBP;TAF13;TAF11;GTF2H1;GTF2H2;GTF2H3;GTF2F2;GTF2H4;TAF5L;TAF6L;ERCC3;ERCC2;TAF4B;MNAT1;TAF3;TAF2;GTF2I;TAF1
Terpenoid backbone biosynthesis	12/22	0.00140847020344986	0.00789749364077244	0	0	3.99021433210652	26.1967591355739	IDI1;NUS1;HMGCS1;FNTA;FNTB;PDSS2;MVD;PDSS1;HMGCR;RCE1;DHDDS;PCYOX1
Mitophagy	27/68	0.00166226663309679	0.00915704776828757	0	0	2.1924519505838	14.0307566714827	AMBRA1;FOXO3;HIF1A;BCL2L13;MAPK9;MAPK8;RHOT2;TBK1;RHOT1;MFN1;MFN2;USP30;TBC1D17;TBC1D15;USP8;GABARAPL1;JUN;CSNK2A1;CSNK2A2;TFE3;EIF2AK3;SP1;NBR1;TAX1BP1;SQSTM1;TP53;ATF4
Sphingolipid metabolism	21/49	0.00173768437093461	0.00940746366333564	0	0	2.49582429501085	15.8614672352971	ARSA;CERS4;CERS5;CERS6;CERK;SGMS1;SPHK2;SPHK1;GBA;SGPP1;GALC;SMPD2;UGCG;SGPL1;SMPD4;SPTLC1;SPTLC2;GLB1;NEU1;ACER3;GLA
Glioma	29/75	0.0018509068961289	0.00985058924380466	0	0	2.09912042023317	13.2078326604963	RB1;CAMK2D;PTEN;PIK3CD;PIK3R3;PIK3R1;AKT2;PLCG2;AKT1;MAPK1;E2F3;POLK;PLCG1;CAMK2G;MAPK3;CAMK1D;GADD45B;PRKCB;GADD45A;BRAF;DDB2;GADD45G;CDK6;CAMK4;MDM2;RAF1;SOS1;SOS2;TP53
Adipocytokine signaling pathway	27/69	0.00213660286204567	0.011181554978039	0	0	2.14011108352985	13.1585546614123	PRKAA1;SLC2A1;PRKAG2;IRS2;ADIPOR2;CAMKK2;IKBKB;RXRB;MAPK9;MAPK8;AKT2;AKT1;JAK2;CPT1A;CHUK;ACSL1;ACSL5;ACSL4;TRAF2;ACSL3;TNFRSF1B;PRKAB1;NFKB1;NFKBIA;PRKCQ;PPARA;NFKBIB
Other types of O-glycan biosynthesis	20/47	0.00245643069520752	0.0125920297586708	0	0	2.4646377021133	14.8101211271113	GALNT7;GALNT11;GALNT6;ST6GAL1;B4GALT1;POGLUT1;GALNT3;GALNT2;GALNT1;B3GLCT;GXYLT1;PLOD3;RFNG;POFUT1;EOGT;POC1B-GALNT4;XXYLT1;COLGALT1;OGT;ST3GAL3
p53 signaling pathway	28/73	0.00252525392757874	0.0125920297586708	0	0	2.07146064161054	12.390262969458	GORAB;PTEN;PPM1D;RCHY1;THBS1;CASP9;PIDD1;COP1;CASP8;SESN3;ZMAT3;CHEK2;SESN1;SESN2;APAF1;GADD45B;GADD45A;TNFRSF10A;DDB2;GADD45G;CDK6;CCNE2;RRM2B;BCL2;MDM2;FAS;MDM4;TP53
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	13/26	0.00252642635285433	0.0125920297586708	0	0	3.32524902555219	19.8881464419744	PIGU;PIGT;PIGO;PIGN;PIGQ;PIGW;PIGV;DPM2;PIGB;PIGA;PIGM;MPPE1;PIGH
Nicotinate and nicotinamide metabolism	16/35	0.00271874285889769	0.0133388321514668	0	0	2.80093516564977	16.5467645024907	SIRT5;SIRT6;SIRT7;NADSYN1;NT5C2;SIRT1;SIRT2;SIRT3;NT5C;NT5E;NNT;NAPRT;NMRK1;NAMPT;CD38;NADK
Viral carcinogenesis	64/203	0.00371320575917937	0.0179376401289588	0	0	1.53544429619431	8.59213084245131	RB1;ATF2;CDKN1B;GTF2H2C;HDAC10;PIK3CD;UBE3A;CHD4;RBPJ;CASP8;CREB3L4;CREB3L2;EP300;SKP2;JAK1;USP7;TBP;ACTN1;TRAF2;ACTN4;TRAF1;SND1;DDB1;RBL2;KAT2A;CREB1;RBL1;CCNE2;IRF3;TRAF3;MAPKAPK2;RASA2;TRAF5;IRF7;TP53;IRF9;ATF4;VAC14;SP100;HDAC3;ATF6B;SRF;PXN;PIK3R3;PIK3R1;HDAC8;HDAC7;MAPK1;MAPK3;STAT5A;CREBBP;EGR2;JUN;EIF2AK2;GTF2H1;GTF2H2;GTF2H3;GTF2H4;NFKB1;NFKB2;NFKBIA;CDK6;DNAJA3;MDM2
ErbB signaling pathway	31/85	0.0038126496516178	0.0181389695546665	0	0	1.9112922705314	10.6448102016363	GSK3B;CAMK2D;CDKN1B;PIK3CD;PIK3R3;PIK3R1;CBL;MAPK9;MAPK8;PAK1;AKT2;NCK2;PLCG2;AKT1;MAPK1;PLCG1;MAP2K7;CAMK2G;MAPK3;PAK4;STAT5A;MAP2K4;JUN;PRKCB;BRAF;RPS6KB1;RPS6KB2;RAF1;SOS1;CRK;SOS2
Glucagon signaling pathway	37/107	0.00476073902714029	0.0223115232018217	0	0	1.76025561291125	9.41270701468345	ATF2;PYGB;CRTC2;CAMK2D;PRKAA1;SLC2A1;ITPR2;PRKAG2;ITPR3;FOXO1;GYS1;PPP3CA;PPP3CB;PPP3CC;CREB3L4;AKT2;CREB3L2;PHKG2;AKT1;EP300;CAMK2G;CPT1A;CREBBP;PPP4R3A;PHKB;PPP4R3B;PRKAB1;SIRT1;PLCB3;PFKL;CREB1;GNAS;SIK1;SIK2;PPARA;PFKP;ATF4
Toll-like receptor signaling pathway	36/104	0.00521199881026978	0.024067170976834	0	0	1.76290085130897	9.26720282397044	PIK3R3;PIK3CD;PIK3R1;IKBKB;MAPK9;MAPK8;TBK1;CASP8;IRAK1;AKT2;AKT1;MAPK1;MAP3K8;RIPK1;MAP2K7;MAP3K7;IKBKE;MAP2K6;MAPK3;IFNAR2;MAP2K4;JUN;CHUK;IRAK4;MAPK14;NFKB1;MAPK13;NFKBIA;TLR1;IRF3;TRAF3;TRAF6;IRF7;TAB2;IRF5;TAB1
Lysine degradation	24/63	0.0054777567036364	0.0249277623904613	0	0	2.04772002471156	10.6626002588264	GCDH;SETD2;KMT2A;SETDB1;EHMT2;SETD1B;SETD1A;SETDB2;EHMT1;PLOD3;SETMAR;DLST;PRDM2;PLOD1;DHTKD1;CAMKMT;NSD3;TMLHE;NSD2;KMT5B;KMT5A;SMYD3;COLGALT1;EZH2
Toxoplasmosis	38/112	0.00610219300247141	0.0273726943253718	0	0	1.71003465908757	8.71964980951117	XIAP;PIK3R6;PIK3CG;PIK3R5;CASP9;IKBKB;MAPK9;MAPK8;CASP8;IRAK1;AKT2;AKT1;MAPK1;JAK2;MAP3K7;LDLR;MAP2K6;JAK1;MAPK3;CHUK;IFNGR1;PDPK1;IL10RA;HSPA6;IRAK4;MAPK14;NFKB1;MAPK13;NFKBIA;TRAF6;BCL2;TAB2;TAB1;BIRC2;HSPA1B;NFKBIB;BIRC3;HSPA1A
Chagas disease	35/102	0.0067896755231174	0.0300275790740685	0	0	1.73924762609927	8.6829365838279	PIK3R3;PIK3CD;PPP2R2A;PIK3R1;IKBKB;MAPK9;PPP2CB;MAPK8;CASP8;PPP2R1B;IRAK1;AKT2;AKT1;MAPK1;MAPK3;SMAD2;MAP2K4;JUN;CHUK;IFNGR1;IRAK4;CFLAR;MAPK14;IL2;NFKB1;TGFBR1;TGFBR2;MAPK13;NFKBIA;PLCB3;PPP2R2B;TRAF6;PPP2R2D;GNAS;FAS
Pathogenic Escherichia coli infection	61/197	0.0069772688343051	0.0304286446384972	0	0	1.49506532372249	7.42314543494415	CYFIP2;CYFIP1;WIPF1;WIPF2;WASL;IKBKB;CASP9;TUBA1A;CASP8;NCK2;MAP3K7;ACTR2;CHUK;F2R;TRAF2;IRAK4;TUBA4A;TUBB2A;TRAF6;HCLS1;MYH9;ARHGEF2;EZR;RAB1A;ROCK1;ROCK2;LPAR2;ACTR3B;CYTH3;MAPK9;ACTR3C;PAK1;MAPK8;CYTH4;IRAK1;MYO6;MAPK1;NCKAP1L;RIPK1;FYN;CYTH1;MAPK3;JUN;SEC24B;SEC24A;TNFRSF10A;TUBB4B;MAPK14;NFKB1;MAPK13;NFKBIA;MYO1C;ABI1;FAS;TAB2;TAB1;SEC24D;SEC24C;MYO1F;NFKBIB;MYO1G
Valine, leucine and isoleucine degradation	19/48	0.00798778229466456	0.0343584060345846	0	0	2.17917277267697	10.5250604395428	ACAD8;MCCC2;HIBADH;HMGCS1;BCKDHB;MCCC1;ABAT;ACADSB;ACSF3;AACS;HMGCL;AUH;PCCA;OXCT1;IVD;DBT;ACAA1;ACADS;HIBCH
MAPK signaling pathway	86/294	0.00877266128916387	0.0372245357405062	0	0	1.3792058051959	6.53207739159456	ATF2;ARRB1;DUSP16;ELK4;IKBKB;RPS6KA3;PPP3CA;PPP3CB;PPP3CC;AKT2;AKT1;MAP3K8;MAP3K6;MAP3K7;MAP3K4;MAP3K5;MAP4K1;MAP4K2;MAP2K4;CHUK;PRKCB;TRAF2;CACNA2D4;IRAK4;DUSP6;TGFBR1;TGFBR2;PPM1A;PPM1B;DDIT3;RASA1;TRAF6;MAPKAPK2;RASA2;MAPKAPK5;RAF1;SOS1;TP53;CRK;SOS2;ATF4;SRF;RASGRP2;STK4;RASGRP1;RELB;MAPK9;PAK1;MAPK8;MAPK7;IRAK1;MKNK1;MKNK2;FLNA;MAPK1;MAP2K7;MAP2K5;MAP2K6;MAPK3;MAP3K2;JUN;MAP3K1;GADD45B;GADD45A;HSPA6;NFATC3;VEGFB;BRAF;NFATC1;MAPK14;NFKB1;GADD45G;NFKB2;MAPK13;NR4A1;TAOK3;TAOK1;NF1;FAS;TAB2;TAB1;PTPN7;MAP3K14;HSPA1B;MAP3K11;HSPA1A
Insulin signaling pathway	44/137	0.0100851540445579	0.0413538317747164	0	0	1.57561692581419	7.24262387932177	GSK3B;PYGB;PRKAA1;PIK3R3;PIK3CD;PRKAG2;IRS2;PIK3R1;CBL;PRKCZ;FOXO1;HK1;PPP1CB;SOCS2;IKBKB;RPTOR;LIPE;GYS1;MAPK9;MAPK8;AKT2;PRKAR2A;MKNK1;MKNK2;PHKG2;AKT1;MAPK1;SOCS4;MAPK3;SREBF1;PTPN1;EXOC7;PDPK1;BRAF;PHKB;PRKAB1;PPP1R3F;RPS6KB1;FASN;RPS6KB2;RAF1;SOS1;CRK;SOS2
Ribosome biogenesis in eukaryotes	36/108	0.0101247330854291	0.0413538317747164	0	0	1.6645266594124	7.64479481071222	POP5;RBM28;POP1;NVL;WDR3;HEATR1;FCF1;NAT10;WDR43;NOL6;EMG1;XPO1;TCOF1;BMS1;GAR1;DROSHA;RIOK2;RIOK1;UTP14C;NOP56;WDR36;NOP58;UTP6;CSNK2A1;EFL1;CSNK2A2;WDR75;GNL2;GTPBP4;GNL3;RCL1;TBL3;LSG1;GNL3L;XRN1;MPHOSPH10
VEGF signaling pathway	22/59	0.0101409077918891	0.0413538317747164	0	0	1.97793975359608	9.08107300535023	PRKCB;SPHK2;SPHK1;PXN;PIK3CD;PIK3R3;NFATC2;PIK3R1;MAPK14;MAPK13;CASP9;PPP3CA;PPP3CB;PPP3CC;AKT2;MAPKAPK2;PLCG2;AKT1;MAPK1;PLCG1;RAF1;MAPK3
Growth hormone synthesis, secretion and action	39/119	0.0104014188184874	0.0418723783205775	0	0	1.62312445557491	7.41088283286299	ATF2;GSK3B;ATF6B;ITPR2;PIK3R3;PIK3CD;IRS2;ITPR3;PIK3R1;ADCY7;SOCS2;MAPK9;MAPK8;CREB3L4;AKT2;CREB3L2;PLCG2;AKT1;EP300;MAPK1;PLCG1;JAK2;MAP2K6;MAPK3;STAT5A;MAP2K4;CREBBP;MAP3K1;PRKCB;MAPK14;MAPK13;PLCB3;CREB1;GNAS;RAF1;SOS1;CRK;SOS2;ATF4
Circadian rhythm	13/31	0.0155132676211701	0.0606850770989538	0	0	2.40078677638227	10.0018209068621	PRKAA1;FBXW11;CUL1;RORC;PRKAG2;CSNK1D;PRKAB1;ARNTL;CREB1;BHLHE40;CRY2;CRY1;BTRC
AGE-RAGE signaling pathway in diabetic complications	33/100	0.0156451306941954	0.0606850770989538	0	0	1.63914875383846	6.81491756173156	CDKN1B;PIK3R3;PIK3CD;PIK3R1;PRKCZ;FOXO1;MAPK9;MAPK8;AKT2;PLCG2;AKT1;MAPK1;PLCG1;JAK2;MAPK3;SMAD2;STAT5A;EGR1;JUN;SMAD4;SMAD3;PRKCB;VEGFB;NFATC1;MAPK14;NFKB1;TGFBR1;TGFBR2;MAPK13;DIAPH1;PLCB3;BCL2;PLCD1
Fc epsilon RI signaling pathway	24/68	0.0156544307166091	0.0606850770989538	0	0	1.8144325828285	7.54259858595281	VAV3;MAP2K4;PDPK1;PIK3CD;PIK3R3;PIK3R1;MAPK14;VAV1;MAPK13;MAPK9;MAPK8;AKT2;INPP5D;PLCG2;AKT1;MAPK1;FYN;PLCG1;RAF1;SOS1;MAP2K7;SOS2;MAP2K6;MAPK3
Glycosaminoglycan degradation	9/19	0.0176361870725388	0.0675160697222435	0	0	2.9907183037646	12.075929556981	GALNS;IDUA;GLB1;HEXA;IDS;HPSE;GUSB;GNS;SGSH
Amino sugar and nucleotide sugar metabolism	18/48	0.0178466044170261	0.0675160697222435	0	0	1.99510080208108	8.03216014842631	GALT;PMM1;HEXA;GFPT1;PMM2;RENBP;HK1;GMPPB;CYB5R4;NAGK;GMDS;AMDHD2;FPGT;GMPPA;UAP1L1;PGM3;NANS;GNE
Human cytomegalovirus infection	66/225	0.0184425164166993	0.0688472285222137	0	0	1.38304160036372	5.52261871905579	RB1;ATF2;GSK3B;CGAS;PIK3CD;IKBKB;CASP9;PPP3CA;PPP3CB;TBK1;PPP3CC;CASP8;CREB3L4;AKT2;CREB3L2;AKT1;IL6R;JAK1;CHUK;PRKCB;TRAF2;TAPBP;PLCB3;CREB1;IRF3;TRAF5;RAF1;SOS1;TP53;CRK;SOS2;ATF4;ATF6B;ROCK1;ROCK2;PXN;PIK3R3;CXCR4;ITPR2;ITPR3;PIK3R1;ADCY7;GNG2;MAPK1;PTK2B;RIPK1;E2F3;MAP2K6;MAPK3;IL10RA;NFATC3;NFATC2;NFATC1;MAPK14;NFKB1;MAPK13;NFKBIA;CDK6;RPS6KB1;SP1;RPS6KB2;GNAS;MDM2;CTNNB1;FAS;GNB5
Hepatocellular carcinoma	51/168	0.0186916471966967	0.0688472285222137	0	0	1.45159556600605	5.77688370665686	RB1;GSK3B;PTEN;PIK3CD;FRAT2;AKT2;AKT1;POLK;SMARCC1;PBRM1;SMARCC2;PRKCB;ARID1A;TGFBR1;DDB2;TGFBR2;RAF1;SOS1;TP53;SOS2;SMARCD1;SMARCD2;TCF7;PIK3R3;PIK3R1;PLCG2;DVL3;MAPK1;E2F3;PLCG1;BRD7;MAPK3;GSTM4;SMAD2;SMAD4;SMAD3;GADD45B;PHF10;GADD45A;CSNK1A1;TXNRD2;BRAF;SMARCA2;GADD45G;SMARCA4;CDK6;APC;RPS6KB1;RPS6KB2;CTNNB1;NFE2L2
Renal cell carcinoma	24/69	0.0188562473022623	0.0688472285222137	0	0	1.77399609290211	7.04438059593669	CREBBP;JUN;TFE3;CUL2;SLC2A1;PIK3CD;ARNT;PIK3R3;BRAF;PIK3R1;ETS1;HIF1A;PAK1;AKT2;AKT1;EP300;MAPK1;VHL;RAF1;SOS1;CRK;SOS2;MAPK3;PAK4
Glycerophospholipid metabolism	32/98	0.0199912079049957	0.0718204396050045	0	0	1.61331514756172	6.31203534920379	AGPAT5;DGKE;DGKD;LPGAT1;LPCAT1;TAZ;LCLAT1;AGPAT3;PGS1;PTDSS2;GPAT4;CEPT1;PLA2G12A;PCYT2;CHKB;PCYT1A;GPCPD1;DGKZ;CRLS1;PISD;GNPAT;PLPP5;LPCAT4;GPD2;ETNK1;LPCAT3;GPD1L;PNPLA6;ADPRM;LPIN1;LPIN2;CDS2
HIF-1 signaling pathway	35/109	0.0201280212905745	0.0718204396050045	0	0	1.57400383412133	6.14749601897721	CAMK2D;PFKFB3;CDKN1B;TFRC;CUL2;SLC2A1;PIK3R3;PIK3CD;PIK3R1;ENO2;HIF1A;HK1;AKT2;MKNK1;MKNK2;PLCG2;AKT1;EP300;MAPK1;PLCG1;VHL;IL6R;CAMK2G;PDK1;MAPK3;CREBBP;PRKCB;IFNGR1;ARNT;NFKB1;PFKL;RPS6KB1;RPS6KB2;BCL2;PFKP
Spliceosome	46/150	0.0205338369927977	0.0722240768536009	0	0	1.47259038671252	5.72201673462422	TCERG1;DDX5;SF3B3;DHX8;DDX46;DDX23;SRSF1;DDX42;HNRNPU;PRPF8;U2AF1L4;EFTUD2;U2AF2;TRA2B;DHX15;DHX38;DHX16;SF3B1;BCAS2;AQR;CCDC12;NCBP1;FUS;NCBP2;HSPA6;THOC1;THOC2;CRNKL1;CDC40;U2SURP;CHERP;LSM8;XAB2;RBMXL1;PRPF3;ACIN1;SRSF4;SNRPA1;PRPF31;SNRNP200;SRSF6;SRSF7;RBMX;HSPA1B;RBM22;HSPA1A
Notch signaling pathway	21/59	0.0207011685249175	0.0722240768536009	0	0	1.8378296609202	7.12630420774222	TLE4;NOTCH2;TLE3;CREBBP;DTX3L;MAML1;CTBP1;PSEN2;DTX2;DTX3;PSEN1;RFNG;RBPJ;NCOR2;ADAM17;KAT2A;APH1B;ATXN1;NUMB;EP300;DVL3
mTOR signaling pathway	47/154	0.0211189271658187	0.0728719025282096	0	0	1.4624496419892	5.64152470672865	PRR5;GSK3B;PRKAA1;MAPKAP1;NPRL2;NPRL3;PTEN;PIK3R3;PIK3CD;PIK3R1;WDR24;IKBKB;RPTOR;RPS6KA3;AKT2;SESN2;MLST8;AKT1;ATP6V1H;DVL3;MAPK1;SLC38A9;SKP2;FNIP1;MAPK3;CHUK;MIOS;PRKCB;PDPK1;STRADA;STRADB;BRAF;TTI1;SLC7A5;CLIP1;RPS6KB1;RRAGB;DDIT4;TBC1D7;RPS6KB2;RAF1;SGK1;SOS1;LPIN1;SOS2;LPIN2;TELO2
Prolactin signaling pathway	24/70	0.0225488368923179	0.0761119209877502	0	0	1.73531771123338	6.58044934538735	STAT5A;GSK3B;GALT;PIK3CD;PIK3R3;PIK3R1;FOXO3;MAPK14;NFKB1;MAPK13;SOCS2;MAPK9;MAPK8;AKT2;IRF1;AKT1;MAPK1;JAK2;RAF1;SOS1;SOS2;SOCS4;MAPK3;SOCS5
Hedgehog signaling pathway	20/56	0.0227320504266092	0.0761119209877502	0	0	1.84739391310634	6.99050057967733	GSK3B;CSNK1G3;SMURF2;FBXW11;MGRN1;CSNK1A1;CUL3;IQCE;CUL1;ARRB1;CSNK1D;EFCAB7;GRK2;KIF3A;SUFU;BCL2;SPOPL;BTRC;CSNK1G2;CSNK1G1
Cytosolic DNA-sensing pathway	22/63	0.0227923592734889	0.0761119209877502	0	0	1.78450433669014	6.74779963850247	ZBP1;CHUK;RIPK3;DDX58;CGAS;ADAR;NFKB1;IKBKB;NFKBIA;MAVS;TBK1;AIM2;POLR3A;IRF3;POLR3C;POLR1C;POLR3E;IRF7;POLR3F;RIPK1;IKBKE;NFKBIB
Various types of N-glycan biosynthesis	15/39	0.0230274920185868	0.0761119209877502	0	0	2.07769172443674	7.83511360056336	B4GALT1;ALG9;HEXA;ALG13;ALG12;ALG11;FUT8;MAN1A2;MAN2A1;MGAT4A;STT3A;MAN1A1;MAN1B1;STT3B;ST3GAL3
Mismatch repair	10/23	0.0246692872716366	0.0803437457600358	0	0	2.55622326169827	9.46364014639116	RFC5;MSH6;RFC3;RFC4;LIG1;RFC1;MSH3;POLD1;MLH1;MLH3
Acute myeloid leukemia	23/67	0.0248195647730047	0.0803437457600358	0	0	1.73845387468434	6.42553941097321	STAT5A;CHUK;ZBTB16;TCF7;PIK3CD;PIK3R3;BRAF;PIK3R1;DUSP6;NFKB1;PML;RUNX1;IKBKB;RPS6KB1;AKT2;RPS6KB2;AKT1;MAPK1;RAF1;SOS1;SOS2;PPARD;MAPK3
SNARE interactions in vesicular transport	13/33	0.0270899740890358	0.0867984884077268	0	0	2.16042659159809	7.79609720627209	STX17;GOSR2;GOSR1;STX18;STX7;USE1;STX6;VTI1A;STX4;SEC22B;YKT6;VAMP2;BET1
Influenza A	51/172	0.0287425626318942	0.091163279458735	0	0	1.40324082428092	4.98062963546611	PIK3CD;ADAR;CASP9;IKBKB;TBK1;CASP8;XPO1;AKT2;KPNA6;AKT1;EP300;TRIM25;JAK2;IKBKE;KPNA1;JAK1;IFNAR2;APAF1;CHUK;PRKCB;DDX58;IFNGR1;IRAK4;DNAJC3;IRF3;TRAF3;OAS3;IRF7;NUP98;RAF1;IRF9;RNASEL;NLRX1;PIK3R3;PIK3R1;PABPN1;MAPK1;RAE1;MAPK3;CREBBP;MX2;MX1;EIF2AK2;TNFRSF10A;NFKB1;PML;NFKBIA;MAVS;CDK6;FAS;NFKBIB
Biosynthesis of unsaturated fatty acids	11/27	0.0315009572821696	0.0989130058660125	0	0	2.28467261904762	7.89979783301479	FADS2;ELOVL5;ACOX1;TECR;HSD17B4;ELOVL6;HSD17B12;ACOX3;HACD3;ACAA1;HACD2
IL-17 signaling pathway	30/94	0.0322313180115596	0.100204295600294	0	0	1.55927379917409	5.35581966976841	GSK3B;SRSF1;TNFAIP3;IKBKB;MAPK9;MAPK8;CASP8;TBK1;MAPK7;MAPK1;IKBKE;MAP3K7;MAPK3;USP25;HSP90AA1;JUN;CHUK;CCL20;TRAF2;MAPK14;NFKB1;IL17RA;MAPK13;NFKBIA;TRAF4;TRAF3;TRAF6;TRAF5;ANAPC5;TAB2
Other glycan degradation	8/18	0.0375666579036431	0.115646378252392	0	0	2.65784122863941	8.72207378350519	MANBA;GLB1;MAN2B2;GBA;HEXA;NEU1;MAN2B1;AGA
Pyrimidine metabolism	19/56	0.0437525049146036	0.133381422749374	0	0	1.70710953798551	5.34189811332029	ENTPD1;CAD;ENTPD6;NME3;CTPS1;NT5C2;AK9;TYMP;DHODH;UCKL1;NT5C3A;NT5C;NT5C3B;NT5E;RRM2B;NME7;DPYD;TK2;UPP1
Adherens junction	23/71	0.0475735845661575	0.143635630324745	0	0	1.59316677517361	4.85195375533088	PTPN1;CREBBP;SMAD4;SMAD3;YES1;CSNK2A1;ACTN1;CSNK2A2;TCF7;PTPRJ;LMO7;WASL;ACTN4;IQGAP1;TGFBR1;TGFBR2;EP300;MAPK1;CTNNB1;FYN;MAP3K7;NECTIN3;MAPK3
Glycosaminoglycan biosynthesis	18/53	0.0483697301039323	0.144648526215569	0	0	1.70952897092069	5.1779599420341	HS3ST3B1;B4GALT1;CHPF2;GLCE;CSGALNACT2;HS2ST1;NDST2;EXT2;FUT8;CHST11;CHSY1;CHST12;DSE;B4GALT7;ST3GAL1;B4GALT4;ST3GAL2;ST3GAL3
Choline metabolism in cancer	30/98	0.0543055372146585	0.1602557938393	0	0	1.4671682626539	4.27405053523077	DGKE;DGKD;SLC44A1;PIK3R3;PIK3CD;PIK3R1;HIF1A;MAPK9;MAPK8;AKT2;AKT1;PIP5K1A;MAPK1;PIP5K1C;PLCG1;RALGDS;MAPK3;JUN;CHKB;PCYT1A;PRKCB;PDPK1;GPCPD1;DGKZ;RPS6KB1;SP1;RPS6KB2;RAF1;SOS1;SOS2
Fatty acid degradation	15/43	0.0546094584102072	0.1602557938393	0	0	1.780414397128	5.17664064051001	GCDH;ACADVL;CPT1A;ACSL1;ECI1;ECI2;ACSL5;ACSL4;ACSL3;ACADSB;CPT2;ACOX1;ACOX3;ACAA1;ACADS
Non-homologous end-joining	6/13	0.0577889715299453	0.168016083892619	0	0	2.84701158301158	8.11670852834001	RAD50;DCLRE1C;MRE11;PRKDC;LIG4;POLL
Chemokine signaling pathway	54/192	0.0623136443993357	0.177877130376286	0	0	1.30215348956503	3.61422449723652	GSK3B;GSK3A;PIK3CD;ARRB1;PIK3CG;IKBKB;PREX1;AKT2;CCR9;AKT1;CCR7;CCR6;JAK2;VAV3;CHUK;PRKCB;VAV1;TIAM1;PLCB3;ELMO1;RAF1;DOCK2;SOS1;CRK;SOS2;ROCK1;ROCK2;PXN;CXCR5;PIK3R3;CXCR4;PIK3R1;FOXO3;RASGRP2;PRKCZ;ADCY7;PIK3R6;PIK3R5;PAK1;GRK2;GNG2;GRK5;PLCG2;MAPK1;PTK2B;PLCG1;MAPK3;CCL20;BRAF;NFKB1;NFKBIA;GNB5;CCL28;NFKBIB
Transcriptional misregulation in cancer	54/192	0.0623136443993357	0.177877130376286	0	0	1.30215348956503	3.61422449723652	CCNT2;CDKN1B;CCNT1;LDB1;JMJD1C;AFF1;ELK4;SIN3A;ITGB7;POLK;MEN1;KDM6A;SS18;TFE3;TRAF1;RUNX2;DUSP6;SUPT3H;RUNX1;DDB2;ETV6;TGFBR2;NCOR1;ZEB1;EWSR1;DDIT3;TP53;BIRC2;BIRC3;DDX5;KMT2A;MLLT3;FOXO1;RXRB;FUT8;NSD2;ZBTB17;TAF15;BCL11B;GADD45B;FUS;GADD45A;ZBTB16;ASPSCR1;PBX3;KLF3;NFKB1;PML;GADD45G;CDK9;SP1;ID2;MDM2;TCF3
Vasopressin-regulated water reabsorption	15/44	0.0657252893196431	0.185925593210522	0	0	1.71890874320206	4.67933629372659	DCTN6;NSF;DCTN5;DYNC1I2;DYNC1H1;DCTN4;DYNLL2;DYNC2LI1;DYNC1LI2;CREB1;CREB3L4;CREB3L2;GNAS;STX4;VAMP2
Thyroid cancer	13/37	0.0670450809198472	0.187965673293143	0	0	1.79988631442183	4.86399484257165	GADD45B;GADD45A;TCF7;BRAF;DDB2;GADD45G;RXRB;TPR;MAPK1;CTNNB1;POLK;TP53;MAPK3
Steroid biosynthesis	8/20	0.069701835250575	0.193684745740536	0	0	2.21457927752542	5.89859531097836	SQLE;SOAT1;CYP51A1;CYP2R1;SC5D;HSD17B7;LBR;TM7SF2
Homologous recombination	14/41	0.0729617356220252	0.200964780572947	0	0	1.72300435588285	4.51051551244262	MUS81;BLM;MRE11;TOP3A;BRCA1;BRCA2;RAD54B;BABAM2;RAD50;RAD51D;RAD51C;POLD1;UIMC1;TOPBP1
GnRH signaling pathway	28/93	0.0737125270102802	0.201267247662852	0	0	1.43221644746737	3.73462257503143	CAMK2D;ITPR2;ITPR3;ADCY7;MAPK9;MAPK8;MAPK7;MAPK1;PTK2B;MAP2K7;CAMK2G;MAP3K4;MAP2K6;MAPK3;MAP3K2;MAP2K4;EGR1;JUN;MAP3K1;PRKCB;MAPK14;MAPK13;PLCB3;GNAS;RAF1;SOS1;SOS2;ATF4
Regulation of actin cytoskeleton	60/218	0.0745889762077065	0.201904642493274	0	0	1.26369046465195	3.28024038888311	CYFIP2;CYFIP1;PIK3CD;WASL;ITGAE;PPP1CB;CFL2;PIP4K2A;PIP4K2B;ITGB7;PIP4K2C;VAV3;ACTR2;PPP1R12A;ITGA4;ACTN1;F2R;ITGA1;ACTN4;VAV1;TIAM1;SPATA13;MYH9;ITGA5;EZR;ARHGEF7;RAF1;SOS1;CRK;SOS2;ARHGEF6;ROCK1;ROCK2;PXN;LPAR2;PIK3R3;CXCR4;IQGAP1;PIK3R1;IQGAP2;ACTR3B;FGD3;ACTR3C;PAK1;PIP5K1A;MAPK1;NCKAP1L;PIP5K1C;PAK4;MAPK3;LIMK2;RDX;BRAF;SSH2;SSH3;SSH1;DIAPH1;DIAPH2;ABI2;APC
Fc gamma R-mediated phagocytosis	29/97	0.0753507321535216	0.202223332446203	0	0	1.41795446992356	3.66626539898669	PIK3R3;PIK3CD;ASAP1;PIK3R1;ACTR3B;ACTR3C;PAK1;AKT2;CFL2;INPP5D;PLCG2;AKT1;PIP5K1A;MAPK1;PIP5K1C;PLCG1;MAPK3;VAV3;ACTR2;PRKCB;SPHK2;SPHK1;LIMK2;VAV1;DNM2;RPS6KB1;RPS6KB2;RAF1;CRK
Dopaminergic synapse	38/132	0.0779418623739201	0.207404616825516	0	0	1.34443718702373	3.43072417180347	ATF2;GSK3B;GSK3A;CAMK2D;ATF6B;ITPR2;PPP2R2A;ITPR3;ARRB1;ARNTL;PPP1CB;PPP3CA;MAPK9;PPP2CB;PPP3CB;MAPK8;PPP3CC;GNG2;PPP2R1B;CREB3L4;PPP2R5E;PPP2R3C;AKT2;CREB3L2;AKT1;CAMK2G;PRKCB;PPP2R5B;PPP2R5C;MAPK14;MAPK13;PLCB3;CREB1;PPP2R2B;PPP2R2D;GNAS;GNB5;ATF4
RNA polymerase	11/31	0.0826988402721115	0.218213746600361	0	0	1.8272619047619	4.55454111319837	POLR2J3;POLR3A;POLR2A;POLR2B;POLR1A;POLR3C;POLR1B;POLR1C;POLR3E;POLR3F;POLR1E
Sulfur relay system	4/8	0.0898163480556561	0.235019444078967	0	0	3.32072617246596	8.00291112560192	CTU2;CTU1;NFS1;MOCS3
Adrenergic signaling in cardiomyocytes	42/150	0.0961045469275598	0.249395270539287	0	0	1.29327377061088	3.02925927191765	ATF2;CAMK2D;ATF6B;CREM;ATP2A3;ATP2A2;PPP2R2A;ADRB2;ATP1A1;ADCY7;PIK3R6;PIK3CG;PIK3R5;PPP1CB;PPP2CB;PPP2R1B;CREB3L4;PPP2R5E;PPP2R3C;AKT2;CREB3L2;AKT1;MAPK1;CAMK2G;MAPK3;TPM1;PPP2R5B;ATP1B3;CACNA2D4;PPP2R5C;ATP2B1;ATP1B1;MAPK14;MAPK13;PLCB3;CREB1;PPP2R2B;KCNQ1;PPP2R2D;BCL2;GNAS;ATF4
Fatty acid biosynthesis	7/18	0.100204520088625	0.257903436949412	0	0	2.11359704309531	4.86241872789014	MECR;ACSL1;FASN;ACSL5;ACSL4;ACSL3;ACSF3
Relaxin signaling pathway	36/129	0.120408266197102	0.307383703950325	0	0	1.28689669697076	2.72418926906106	ATF2;ATF6B;PIK3R3;PIK3CD;ARRB1;PIK3R1;PRKCZ;ADCY7;MAPK9;MAPK8;GNG2;CREB3L4;AKT2;CREB3L2;AKT1;MAPK1;MAP2K7;MAPK3;SMAD2;MAP2K4;JUN;VEGFB;MAPK14;NFKB1;TGFBR1;TGFBR2;MAPK13;NFKBIA;PLCB3;CREB1;GNAS;GNB5;RAF1;SOS1;SOS2;ATF4
Ferroptosis	13/41	0.133696093102777	0.338553009953806	0	0	1.54235754501021	3.10351028477748	TFRC;ACSL1;GSS;ACSL5;SAT2;ACSL4;ACSL3;GCLC;MAP1LC3A;LPCAT3;SLC39A8;ATG7;TP53
Phosphonate and phosphinate metabolism	3/6	0.141325149457368	0.354572251224645	0	0	3.32022471910112	6.49665720874533	PCYT1A;PCYT2;CEPT1
Spinocerebellar ataxia	39/143	0.142280584886323	0.354572251224645	0	0	1.24659734320557	2.43080775139375	PIK3R4;ATP2A3;ITPR2;PIK3R3;ATP2A2;PIK3CD;ITPR3;PIK3R1;AMBRA1;RBPJ;ATXN3;MAPK9;ATXN2;MAPK8;ATXN1;KAT5;OPA1;AKT2;RB1CC1;AKT1;CIC;MAP3K5;NOP56;TBP;NFYA;PRKCB;TRAF2;WIPI1;ATG14;PUM1;ATG13;PUM2;ATXN2L;AFG3L2;PLCB3;SP1;ATG2A;PIK3C3;MCU
Central carbon metabolism in cancer	20/70	0.174093980667235	0.42732282094139	0	0	1.32890913034049	2.32314579433532	IDH1;PTEN;SLC2A1;PIK3CD;PIK3R3;SIRT6;PIK3R1;HIF1A;HK1;SIRT3;SLC7A5;PFKL;AKT2;AKT1;MAPK1;RAF1;TP53;PFKP;PDK1;MAPK3
Wnt signaling pathway	44/166	0.17419529006528	0.42732282094139	0	0	1.19880489051382	2.09500535558306	GSK3B;CAMK2D;CTBP1;ROCK2;CHD8;TCF7;CUL1;CBY1;PRICKLE3;PSEN1;PPP3CA;MAPK9;PPP3CB;MAPK8;FRAT2;PPP3CC;EP300;DVL3;TBL1X;BTRC;MAP3K7;CAMK2G;TLE4;TLE3;CREBBP;JUN;SMAD4;SMAD3;CSNK2A1;FBXW11;PRKCB;CSNK1A1;CSNK2A2;NFATC3;NFATC2;NFATC1;SENP2;PLCB3;DAAM1;APC;TBL1XR1;CTNNB1;TP53;PPARD
Synthesis and degradation of ketone bodies	4/10	0.182667696823007	0.444632998468404	0	0	2.21352928463367	3.76319156665785	HMGCL;BDH1;HMGCS1;OXCT1
Long-term potentiation	19/67	0.191306108737874	0.462077831874558	0	0	1.31495284041631	2.17477482210524	CAMK2D;CREBBP;PRKCB;ITPR2;ITPR3;BRAF;PPP1CB;PPP3CA;RPS6KA3;PPP3CB;PLCB3;PPP3CC;CAMK4;EP300;MAPK1;RAF1;CAMK2G;ATF4;MAPK3
Tight junction	44/169	0.210187904483572	0.500602587979805	0	0	1.16980335731415	1.82460472306369	PRKAA1;ROCK1;ROCK2;PRKAG2;PPP2R2A;F11R;ACTR3B;PRKCZ;YBX3;MAPK9;PPP2CB;ACTR3C;MAPK8;TUBA1A;PPP2R1B;SYMPK;WHAMM;MAP2K7;MAP3K5;RAB8B;ACTR2;JUN;MAP3K1;HSPA4;ACTN1;RDX;ARHGEF18;ACTN4;PRKAB1;TUBA4A;TJAP1;RUNX1;RAP2C;TIAM1;DLG3;PPP2R2B;NEDD4;PPP2R2D;HCLS1;MYH9;NF2;ARHGEF2;EZR;RAPGEF6
Melanoma	20/72	0.211566371869973	0.500602587979805	0	0	1.27763041556145	1.98443666118082	RB1;GADD45B;GADD45A;PTEN;PIK3CD;PIK3R3;BRAF;PIK3R1;DDB2;GADD45G;CDK6;AKT2;MDM2;AKT1;MAPK1;E2F3;POLK;RAF1;TP53;MAPK3
Pathways in cancer	131/531	0.214676925593545	0.500602587979805	0	0	1.08941055555556	1.67619001576318	RB1;ETS1;RASSF1;FRAT2;AKT2;AKT1;EP300;SKP2;IL6R;IFNAR2;IL4R;PRKCB;DAPK2;F2R;RUNX1;EML4;MSH6;CCNE2;MSH3;RAF1;TP53;NOTCH2;CTBP1;CUL2;TCF7;CUL1;LPAR2;PIK3R3;PIK3R1;RASGRP2;STK4;HIF1A;RASGRP1;FOXO1;BCL2L11;TPR;PLCG2;DVL3;PLCG1;RALGDS;GSTM4;STAT5A;SMAD2;ZBTB17;CREBBP;JUN;SMAD4;SMAD3;GADD45B;GADD45A;ZBTB16;BRAF;NFKB1;IL2;NFKB2;GADD45G;NFKBIA;CDK6;SP1;BCL2;MDM2;GNAS;GNB5;IL7R;NFE2L2;GSK3B;CDKN1B;PTEN;SLC2A1;PIK3CD;BRCA2;IKBKB;CASP9;CASP8;SUFU;POLK;JAK2;JAK1;NCOA1;HSP90AA1;APAF1;CHUK;IFNGR1;IL15;NCOA3;ARNT;TRAF2;TRAF1;TGFBR1;DDB2;TGFBR2;PLCB3;TRAF4;TRAF3;TRAF6;TRAF5;SOS1;CRK;SOS2;BIRC2;PPARD;BIRC3;CAMK2D;ROCK1;ROCK2;CXCR4;XIAP;CBL;ADCY7;RXRB;MAPK9;MAPK8;GNG2;MAPK1;STAT6;E2F3;VHL;IL12RB1;CAMK2G;IL12RB2;MAPK3;TXNRD2;VEGFB;MLH1;PML;APC;RPS6KB1;IL2RA;RPS6KB2;CTNNB1;FAS
Gastric cancer	39/149	0.215839884290107	0.500602587979805	0	0	1.17813786822933	1.80634268394827	RB1;GSK3B;ABCB1;CDKN1B;TCF7;PIK3R3;PIK3CD;PIK3R1;RXRB;FRAT2;AKT2;AKT1;DVL3;MAPK1;E2F3;POLK;MAPK3;SMAD2;SMAD4;SMAD3;GADD45B;GADD45A;CSNK1A1;BRAF;MLH1;TGFBR1;GADD45G;DDB2;TGFBR2;CCNE2;APC;RPS6KB1;RPS6KB2;BCL2;CTNNB1;RAF1;SOS1;TP53;SOS2
Base excision repair	10/33	0.216821503074056	0.500602587979805	0	0	1.44388095932557	2.20723314392096	MBD4;PARP4;LIG1;PARP2;OGG1;POLD1;TDG;POLL;LIG3;MUTYH
Fructose and mannose metabolism	10/33	0.216821503074056	0.500602587979805	0	0	1.44388095932557	2.20723314392096	GMPPB;PFKL;PFKFB3;GMDS;PMM1;FPGT;GMPPA;PMM2;PFKP;HK1
Aldosterone-regulated sodium reabsorption	11/37	0.22096238422839	0.506439333194996	0	0	1.40503663003663	2.12127203534961	PDPK1;PRKCB;PIK3CD;PIK3R3;MAPK1;ATP1B3;ATP1A1;PIK3R1;ATP1B1;SGK1;MAPK3
Bladder cancer	12/41	0.224120554879835	0.509955465451218	0	0	1.37423386163597	2.05526455869196	RB1;RASSF1;DAPK2;MDM2;MAPK1;E2F3;BRAF;RAF1;THBS1;TP53;TYMP;MAPK3
Ubiquinone and other terpenoid-quinone biosynthesis	4/11	0.237256951278377	0.535961746053312	0	0	1.89718731668159	2.72931557213735	COQ2;GGCX;COQ7;COQ6
Breast cancer	38/147	0.245518598766019	0.543751743006073	0	0	1.15828434574352	1.62667435309536	RB1;NOTCH2;GSK3B;TCF7;PTEN;PIK3R3;PIK3CD;PIK3R1;BRCA1;BRCA2;FRAT2;AKT2;AKT1;DVL3;MAPK1;E2F3;POLK;MAPK3;NCOA1;JUN;GADD45B;GADD45A;CSNK1A1;NCOA3;BRAF;GADD45G;NFKB2;DDB2;CDK6;APC;RPS6KB1;SP1;RPS6KB2;CTNNB1;RAF1;SOS1;TP53;SOS2
Aldosterone synthesis and secretion	26/98	0.246492308796628	0.543751743006073	0	0	1.1995475931958	1.67987582358012	ATF2;CAMK2D;ATF6B;ITPR2;ITPR3;ATP1A1;ADCY7;LIPE;CREB3L4;CREB3L2;CAMK2G;LDLR;CAMK1D;PRKCB;ATP1B3;ATP2B1;ATP1B1;NR4A1;PLCB3;CREB1;PRKD3;CAMK4;GNAS;PRKD2;DAGLB;ATF4
Propanoate metabolism	10/34	0.247554235941992	0.543751743006073	0	0	1.38362908461372	1.93171996637041	PCCA;ACOX1;DBT;BCKDHB;ABAT;MLYCD;ACOX3;ACSS1;ACADS;HIBCH
TGF-beta signaling pathway	25/94	0.247632163216142	0.543751743006073	0	0	1.20353414261172	1.67990601063641	ROCK1;CUL1;THBS1;PPP2CB;PPP2R1B;EP300;MAPK1;E2F4;MAPK3;SMAD2;CREBBP;SMAD4;TGIF2;SMAD3;SMURF2;SMAD5;TGFBR1;TGFBR2;SMAD7;RBL1;ZFYVE16;RPS6KB1;SP1;ID2;RPS6KB2
Epithelial cell signaling in Helicobacter pylori infection	19/70	0.253104919341007	0.548112224526497	0	0	1.23736033875823	1.70007269166526	MAP2K4;JUN;CHUK;ADAM10;F11R;MAPK14;NFKB1;MAPK13;IKBKB;NFKBIA;MAPK9;ADAM17;MAPK8;PAK1;ATP6V0A2;PLCG2;ATP6V1H;PLCG1;MAP3K14
Type II diabetes mellitus	13/46	0.253109148268605	0.548112224526497	0	0	1.30824048190874	1.79743668948904	PIK3CD;PIK3R3;IRS2;PIK3R1;PRKCZ;HK1;IKBKB;SOCS2;MAPK9;MAPK8;MAPK1;SOCS4;MAPK3
Fatty acid elongation	8/27	0.275347878240091	0.592186532653346	0	0	1.39804410442069	1.80308539899546	MECR;ELOVL5;TECR;THEM4;ELOVL6;HSD17B12;HACD3;HACD2
Progesterone-mediated oocyte maturation	26/100	0.283802770099171	0.606218161980543	0	0	1.16697479238196	1.46977645602049	PIK3R3;PIK3CD;PIK3R1;ADCY7;RPS6KA3;STK10;MAPK9;FZR1;MAPK8;AKT2;AKT1;MAPK1;MAPK3;HSP90AA1;ANAPC7;BRAF;KIF22;MAPK14;MAPK13;CDC16;ANAPC4;ANAPC5;RAF1;ANAPC1;ANAPC2;CPEB4
Oocyte meiosis	33/129	0.286574528973959	0.608002716877182	0	0	1.1418211722488	1.42699859242085	CAMK2D;CUL1;ITPR2;ITPR3;ADCY7;PPP1CB;RPS6KA3;PPP3CA;PPP2CB;PPP3CB;SLK;PPP3CC;PPP2R1B;PPP2R5E;MAPK1;BTRC;CAMK2G;MAPK3;ANAPC7;FBXW11;PPP2R5B;PPP2R5C;SMC1A;MAPK14;REC8;MAPK13;CCNE2;CDC16;ANAPC4;ANAPC5;ANAPC1;ANAPC2;CPEB4
Necroptosis	40/159	0.301978102795614	0.636383384414919	0	0	1.11654332828753	1.33694984274413	PYGB;CAMK2D;FAF1;TNFAIP3;XIAP;MAPK9;MAPK8;SHARPIN;CASP8;CHMP1B;RIPK1;STAT6;DNM1L;JAK2;CAMK2G;JAK1;IFNAR2;ZBP1;STAT5A;HSP90AA1;MLKL;RIPK3;IFNGR1;USP21;EIF2AK2;TNFRSF10A;TRAF2;CFLAR;SPATA2L;CYLD;GLUD1;TRAF5;BCL2;FAS;SQSTM1;CHMP7;PPID;BIRC2;IRF9;BIRC3
Cushing syndrome	39/155	0.304555767495044	0.637536739956292	0	0	1.1167604079058	1.32771763732427	RB1;ATF2;GSK3B;CAMK2D;CDKN1B;KMT2A;ATF6B;TCF7;ITPR2;ITPR3;ASH2L;AHR;ADCY7;CREB3L4;CREB3L2;WDR5;DVL3;MAPK1;E2F3;CAMK2G;LDLR;MEN1;MAPK3;USP8;ARNT;BRAF;NR4A1;PLCB3;CDK6;NCEH1;CREB1;ARMC5;CCNE2;APC;SP1;GNAS;WDR5B;CTNNB1;ATF4
DNA replication	10/36	0.312911023867821	0.642780140866816	0	0	1.27702961396967	1.48369948638296	RFC5;PRIM2;RFC3;POLA2;RFC4;MCM7;LIG1;RFC1;POLD1;MCM6
Mucin type O-glycan biosynthesis	10/36	0.312911023867821	0.642780140866816	0	0	1.27702961396967	1.48369948638296	GALNT7;GALNT11;GALNT6;GALNT3;GALNT2;GALNT1;GCNT1;POC1B-GALNT4;ST3GAL1;ST3GAL2
Butanoate metabolism	8/28	0.313201788384149	0.642780140866816	0	0	1.32805537529743	1.54174958483541	HMGCL;ALDH5A1;HMGCS1;BDH1;OXCT1;ABAT;ACADS;AACS
Leishmaniasis	20/77	0.318817018498301	0.648376322454386	0	0	1.16517709367759	1.33195815483322	JUN;ITGA4;IFNGR1;PRKCB;NCF4;IRAK4;MAPK14;NFKB1;MAPK13;NFKBIA;IRAK1;TRAF6;MAPK1;TAB2;TAB1;JAK2;MAP3K7;JAK1;MAPK3;NFKBIB
Parathyroid hormone synthesis, secretion and action	27/106	0.320058375733853	0.648376322454386	0	0	1.13503392756986	1.29308953091868	ATF2;ATF6B;ITPR2;ITPR3;ARRB1;ADCY7;RXRB;MMP25;CREB3L4;CREB3L2;PDE4A;MAPK1;MEF2D;MAPK3;MEF2A;EGR1;PRKCB;PDE4D;BRAF;RUNX2;PLCB3;CREB1;SP1;BCL2;GNAS;RAF1;ATF4
D-Glutamine and D-glutamate metabolism	2/5	0.328313328584876	0.66083580240802	0	0	2.21300496867574	2.4648158474852	GLUD1;DGLUCY
Legionellosis	15/57	0.332798067501505	0.665596135003009	0	0	1.18585974251052	1.30470586692254	HBS1L;RAB1A;VCP;APAF1;HSPA6;CLK4;NFKB1;NFKB2;CASP9;NFKBIA;BCL2L13;CASP8;SEC22B;HSPA1B;HSPA1A
Platelet activation	31/124	0.345422475638839	0.685203432071145	0	0	1.10695652173913	1.17668044093799	ROCK1;ROCK2;ITPR2;PIK3R3;PIK3CD;ITPR3;PIK3R1;RASGRP2;PRKCZ;RASGRP1;ADCY7;PIK3R6;PIK3CG;PIK3R5;PPP1CB;AKT2;PLCG2;AKT1;MAPK1;FYN;MAPK3;PPP1R12A;F2R;MAPK14;MAPK13;APBB1IP;PLCB3;STIM1;TBXAS1;GNAS;TLN1
Alanine, aspartate and glutamate metabolism	10/37	0.346966069106089	0.685203432071145	0	0	1.2296520714612	1.30162150126768	GLUD1;ALDH5A1;GOT1;CAD;GFPT1;ASNS;ABAT;ASL;NIT2;ASRGL1
Apelin signaling pathway	34/137	0.353199386602319	0.69315379620705	0	0	1.09620668608273	1.14084701431308	PRKAA1;PIK3R4;ITPR2;PRKAG2;ITPR3;NRF1;ADCY7;PIK3R6;PIK3CG;PIK3R5;LIPE;GNG2;AKT2;AKT1;MAPK1;MEF2D;MAPK3;MEF2A;SMAD2;EGR1;GABARAPL1;SMAD4;SMAD3;SPHK2;SPHK1;PRKAB1;TGFBR1;PLCB3;RPS6KB1;CAMK4;RPS6KB2;PIK3C3;GNB5;RAF1
Selenocompound metabolism	5/17	0.355800327706859	0.693921136024558	0	0	1.38321444012105	1.42939386021531	TXNRD2;MTR;KYAT1;SCLY;PAPSS1
Proteoglycans in cancer	50/205	0.362785590874824	0.703177009473424	0	0	1.07132546070375	1.08626324940074	PIK3CD;PPP1CB;AKT2;AKT1;VAV3;PPP1R12A;PRKCB;PDPK1;VAV1;TIAM1;HCLS1;ITGA5;EZR;RAF1;SOS1;TP53;SOS2;DDX5;CAMK2D;SDC4;ROCK1;ROCK2;PXN;PIK3R3;ITPR2;ITPR3;IQGAP1;PIK3R1;CBL;HIF1A;THBS1;PAK1;PLCG2;FLNA;DROSHA;MAPK1;PLCG1;CAMK2G;MAPK3;SMAD2;RDX;BRAF;MAPK14;MAPK13;RPS6KB1;RPS6KB2;MDM2;CTNNB1;FAS;HPSE
Focal adhesion	49/201	0.366116619684785	0.70527986859523	0	0	1.07059804957614	1.07574052097254	GSK3B;PTEN;PIK3CD;ARHGAP5;PPP1CB;AKT2;AKT1;ITGB7;VAV3;PPP1R12A;ITGA4;PRKCB;PDPK1;ACTN1;ITGA1;ACTN4;VAV1;ITGA5;TLN1;RAF1;SOS1;CRK;SOS2;BIRC2;BIRC3;ROCK1;ROCK2;PXN;PIK3R3;XIAP;PIK3R1;THBS1;MAPK9;PAK1;MAPK8;PIP5K1A;FLNA;MAPK1;FYN;PIP5K1C;PAK4;MAPK3;JUN;VEGFB;BRAF;DIAPH1;PARVG;BCL2;CTNNB1
Cholinergic synapse	28/113	0.375857563722426	0.719629725663669	0	0	1.09379305056804	1.07032575047373	CAMK2D;ITPR2;PIK3R3;PIK3CD;ITPR3;PIK3R1;ADCY7;PIK3R6;PIK3CG;PIK3R5;GNG2;CREB3L4;AKT2;CREB3L2;AKT1;MAPK1;FYN;JAK2;CAMK2G;MAPK3;PRKCB;PLCB3;CREB1;KCNQ1;CAMK4;BCL2;GNB5;ATF4
beta-Alanine metabolism	8/30	0.391285564325785	0.744628286050281	0	0	1.20716575226634	1.13270492219823	ACOX1;DPYD;ABAT;MLYCD;ACOX3;ACADS;HIBCH;CNDP2
Phospholipase D signaling pathway	36/148	0.398655080128563	0.75116362453233	0	0	1.06725478004042	0.981510140149192	AGPAT5;DGKE;DGKD;LPAR2;PIK3R3;PIK3CD;PIK3R1;ADCY7;PIK3R6;PIK3CG;AGPAT3;PIK3R5;CYTH3;CYTH4;AKT2;PLCG2;AKT1;PIP5K1A;MAPK1;PTK2B;FYN;PIP5K1C;PLCG1;RALGDS;CYTH1;MAPK3;SPHK2;SPHK1;F2R;DGKZ;DNM2;PLCB3;GNAS;RAF1;SOS1;SOS2
Human papillomavirus infection	79/331	0.399504220690761	0.75116362453233	0	0	1.0410939199933	0.955235892303964	RB1;GSK3B;CDKN1B;MAML1;PTEN;PIK3CD;PPP2R2A;UBE3A;CHD4;RBPJ;IKBKB;TBK1;CASP8;PPP2R1B;CREB3L4;PPP2R5E;AKT2;CREB3L2;AKT1;EP300;ITGB7;IKBKE;JAK1;IFNAR2;HES6;TBP;CHUK;ITGA4;ITGA1;PPP2R5B;PPP2R5C;RBL2;CREB1;RBL1;CCNE2;IRF3;NFX1;TRAF3;IRF1;ITGA5;RAF1;SOS1;TP53;SOS2;IRF9;NOTCH2;PXN;TCF7;PIK3R3;PIK3R1;RFNG;PSEN1;PRKCZ;THBS1;FOXO1;PPP2CB;PPP2R3C;ATP6V0A2;ATP6V1H;DVL3;MAPK1;MAPK3;CREBBP;CSNK1A1;MX2;MX1;EIF2AK2;NFKB1;CDK6;DLG3;APC;RPS6KB1;PPP2R2B;PPP2R2D;RPS6KB2;GNAS;MDM2;CTNNB1;FAS
Carbohydrate digestion and absorption	12/47	0.404027116933317	0.755145920934891	0	0	1.13820554851081	1.03152527821187	PLCB3;PRKCB;AKT2;PIK3CD;PIK3R3;AKT1;ATP1B3;ATP1A1;PIK3R1;SLC37A4;ATP1B1;HK1
Bacterial invasion of epithelial cells	19/77	0.418908582909379	0.778327189547603	0	0	1.08752654245297	0.946259630916637	ACTR2;CLTC;PXN;PIK3CD;PIK3R3;WASL;PIK3R1;CBL;ACTR3B;CD2AP;DNM2;ARHGAP10;ACTR3C;ELMO1;ELMO2;HCLS1;CTNNB1;ITGA5;CRK
Galactose metabolism	8/31	0.430674496457478	0.790365358645559	0	0	1.15460504660065	0.972642411973876	PFKL;B4GALT1;GALT;GLB1;GALM;GLA;PFKP;HK1
Amphetamine addiction	17/69	0.430801808391306	0.790365358645559	0	0	1.08527975059184	0.913921822483359	ATF2;CAMK2D;JUN;ATF6B;PRKCB;SIRT1;PPP1CB;PPP3CA;PPP3CB;PPP3CC;CREB1;CREB3L4;CAMK4;CREB3L2;GNAS;CAMK2G;ATF4
cGMP-PKG signaling pathway	40/167	0.432938986264446	0.790365358645559	0	0	1.04566105886731	0.875384012418649	ATF2;ATF6B;ROCK1;ROCK2;SRF;ATP2A3;ITPR2;ATP2A2;IRS2;ITPR3;ADRB2;ATP1A1;ADCY7;PIK3R6;PIK3CG;PIK3R5;PPP1CB;PPP3CA;PPP3CB;PPP3CC;CREB3L4;AKT2;CREB3L2;AKT1;MAPK1;MEF2D;GTF2I;MAPK3;MEF2A;PPP1R12A;NFATC3;NFATC2;ATP1B3;NFATC1;ATP2B1;ATP1B1;PLCB3;CREB1;RAF1;ATF4
Tuberculosis	43/180	0.43606473891166	0.791470104151799	0	0	1.04203284989722	0.864850338806337	CAMK2D;MALT1;CASP9;EEA1;PPP3CA;MAPK9;PPP3CB;MAPK8;CASP8;PPP3CC;IRAK1;AKT2;LAMP2;ATP6V0A2;AKT1;EP300;ATP6V1H;MAPK1;JAK2;CTSD;CAMK2G;JAK1;MAPK3;HSPA9;PLK3;CREBBP;APAF1;NFYA;IFNGR1;SPHK2;SPHK1;IL10RA;IRAK4;MAPK14;NFKB1;MAPK13;TLR1;CREB1;TRAF6;RFXAP;BCL2;PIK3C3;RAF1
Non-alcoholic fatty liver disease	37/155	0.447037006201877	0.806721953720629	0	0	1.04094323472768	0.838077867256603	GSK3B;GSK3A;NDUFB8;PRKAA1;PIK3R3;PIK3CD;PRKAG2;IRS2;PIK3R1;ADIPOR2;IKBKB;MAPK9;MAPK8;BCL2L11;CASP8;AKT2;AKT1;IL6R;NDUFV1;MAP3K5;MLXIP;SREBF1;JUN;EIF2AK3;TRAF2;MAPK14;PRKAB1;NFKB1;MAPK13;ITCH;DDIT3;NDUFS2;FAS;NDUFS1;PPARA;MAP3K11;ATF4
Thyroid hormone synthesis	18/75	0.475618827664136	0.849193923951632	0	0	1.04820473033875	0.778961320101575	ATF2;ATF6B;PRKCB;GSR;ITPR2;ATP1B3;ITPR3;TTF2;ATP1A1;TTF1;ATP1B1;ADCY7;PLCB3;CREB1;CREB3L4;CREB3L2;GNAS;ATF4
Glycosphingolipid biosynthesis	11/45	0.475981307692635	0.849193923951632	0	0	1.07387955182073	0.797223152589375	B4GALT1;GLB1;HEXA;ST3GAL5;NAGA;ST3GAL1;GLA;ST3GAL2;B4GALT4;ST3GAL3;ST6GALNAC6
Cysteine and methionine metabolism	12/50	0.498282791531788	0.88395930249142	0	0	1.04814211323937	0.730122703366611	MTAP;DNMT1;GCLC;AHCYL1;MAT2A;GOT1;GSS;AMD1;DNMT3A;MRI1;MTR;KYAT1
Oxytocin signaling pathway	36/154	0.50536629470639	0.891488856953968	0	0	1.01258921819959	0.691063562694054	CAMK2D;PRKAA1;ROCK1;ROCK2;ITPR2;PRKAG2;ITPR3;ADCY7;PIK3R6;PIK3CG;PIK3R5;CAMKK2;PPP1CB;PPP3CA;PPP3CB;EEF2K;PPP3CC;MAPK7;CD38;MAPK1;CAMK2G;MAP2K5;MAPK3;JUN;CAMK1D;PPP1R12A;PRKCB;NFATC3;NFATC2;NFATC1;CACNA2D4;PRKAB1;PLCB3;CAMK4;GNAS;RAF1
Estrogen signaling pathway	32/137	0.510832527454796	0.896097282797798	0	0	1.01149939427826	0.679437775536224	ATF2;ATF6B;ITPR2;PIK3R3;PIK3CD;ITPR3;PIK3R1;ADCY7;CREB3L4;AKT2;CREB3L2;AKT1;MAPK1;CTSD;MAPK3;NCOA1;JUN;HSP90AA1;NCOA3;HSPA6;PLCB3;CREB1;SP1;BCL2;GNAS;RAF1;SOS1;SOS2;HSPA1B;ATF4;FKBP5;HSPA1A
Fluid shear stress and atherosclerosis	32/139	0.548008090185027	0.953217641574163	0	0	0.992462806827165	0.596931869413776	PRKAA1;SDC4;PIK3R3;PIK3CD;PIK3R1;PRKCZ;IKBKB;MAPK9;MAPK8;MAPK7;AKT2;AKT1;MAP2K7;MAP3K7;MAP2K5;MAP3K5;MAP2K6;MEF2A;GSTM4;MAP2K4;JUN;HSP90AA1;CHUK;MAPK14;NFKB1;MAPK13;BCL2;CTNNB1;ARHGEF2;SQSTM1;TP53;NFE2L2
Cortisol synthesis and secretion	15/65	0.554139997421502	0.953217641574163	0	0	0.995602253032929	0.587741764429315	ATF2;ATF6B;ITPR2;ITPR3;ADCY7;NR4A1;PLCB3;CREB1;NCEH1;CREB3L4;SP1;CREB3L2;GNAS;LDLR;ATF4
Inflammatory bowel disease	15/65	0.554139997421502	0.953217641574163	0	0	0.995602253032929	0.587741764429315	SMAD2;JUN;IL4R;SMAD3;IFNGR1;RORC;NFATC1;IL2;NFKB1;IL18RAP;IL21R;STAT6;IL12RB1;IL18R1;IL12RB2
PPAR signaling pathway	17/74	0.559991138472051	0.953217641574163	0	0	0.989756576095636	0.573894830805899	SLC27A1;CPT1A;HMGCS1;ACSL1;PDPK1;ACSL5;ACSL4;ACSL3;RXRB;FADS2;CPT2;ACOX1;ACOX3;ACAA1;PPARA;PPARD;SLC27A4
Glyoxylate and dicarboxylate metabolism	7/30	0.561397440394996	0.953217641574163	0	0	1.01006092974274	0.583134612468837	CS;PCCA;GLYCTK;PGP;HYI;ACO1;ACSS1
Natural killer cell mediated cytotoxicity	30/131	0.561609120035733	0.953217641574163	0	0	0.98566605193447	0.568679227339296	PIK3R3;PIK3CD;PIK3R1;PPP3CA;PPP3CB;PAK1;KLRK1;PPP3CC;SH3BP2;PLCG2;MAPK1;PTK2B;FYN;PLCG1;MICA;MAPK3;IFNAR2;VAV3;PRKCB;IFNGR1;NFATC2;BRAF;NFATC1;TNFRSF10A;VAV1;ZAP70;FAS;RAF1;SOS1;SOS2
JAK-STAT signaling pathway	37/162	0.568674383558244	0.959779244858701	0	0	0.98219939050936	0.554399764118217	PIK3R3;PIK3CD;PIK3R1;IL27RA;SOCS2;AKT2;IL21R;AKT1;EP300;STAT6;JAK2;IL12RB1;IL6R;SOCS4;SOCS5;JAK1;IL12RB2;IFNAR2;STAT5A;PIAS3;CREBBP;IL4R;IFNGR1;IL15;IL10RA;STAM;IL2;PIAS1;IL2RA;BCL2;RAF1;IL7R;SOS1;STAM2;SOS2;IRF9;PTPN2
Leukocyte transendothelial migration	26/114	0.571588276396742	0.959779244858701	0	0	0.980421478629948	0.548385364739277	ROCK1;ROCK2;TXK;NCF4;PXN;PIK3R3;PIK3CD;CXCR4;CD99L2;PIK3R1;F11R;ARHGAP5;PLCG2;PTK2B;PLCG1;VAV3;ITGA4;PRKCB;ACTN1;ACTN4;MAPK14;VAV1;MAPK13;CTNNB1;EZR;SIPA1
Riboflavin metabolism	2/8	0.585323928198178	0.977615497096957	0	0	1.10628645495787	0.592515809281851	FLAD1;ACP2
Inflammatory mediator regulation of TRP channels	22/98	0.6049233977759	0.999996242493092	0	0	0.96049491269941	0.482796076018507	CAMK2D;PRKCH;PRKCB;TRPV2;ITPR2;PIK3R3;PIK3CD;ITPR3;PIK3R1;MAPK14;ADCY7;MAPK13;PPP1CB;MAPK9;PLCB3;MAPK8;PLCG2;GNAS;PRKCQ;PLCG1;CAMK2G;MAP2K6
Amyotrophic lateral sclerosis	82/364	0.632892022908123	0.999996242493092	0	0	0.964387777533524	0.441164446011709	NUP107;NUP188;CASP9;PPP3CA;PPP3CB;TBK1;ACTR1B;PPP3CC;TUBA1A;RB1CC1;SPG11;MAP3K5;NUP214;NDC1;GABARAPL1;APAF1;NCBP1;NUP133;TRAF2;WIPI1;ATG14;TNFRSF1B;ATG13;TUBA4A;ATXN2L;TUBB2A;ALS2;DDIT3;NUP50;NDUFS2;NDUFS1;NUP54;PIK3C3;SMCR8;NUP98;ATF6;TP53;SQSTM1;SRSF7;NUP58;ATF4;DCTN6;DCTN5;RAB1A;NUP205;POM121;VCP;NDUFB8;DCTN4;PIK3R4;ITPR3;AMBRA1;KLC1;TANK;NUP160;ATXN2;KLC2;POM121C;NUP85;TPR;UBQLN1;NUP88;RAE1;NDUFV1;MAP2K6;UBQLN2;NUP155;FUS;EIF2AK3;NUP153;TUBB4B;MAPK14;MAPK13;SETX;FIG4;CCS;VAPB;ATG2A;BCL2;NUP35;TARDBP;MCU
Insulin secretion	19/86	0.633706246249178	0.999996242493092	0	0	0.940887496601986	0.429204429071733	ATF2;CAMK2D;ATF6B;PRKCB;SLC2A1;ATP1B3;ITPR3;ATP1A1;ATP1B1;ADCY7;PLCB3;CREB1;CREB3L4;CREB3L2;GNAS;KCNN4;CAMK2G;VAMP2;ATF4
Mannose type O-glycan biosynthesis	5/23	0.643662299012346	0.999996242493092	0	0	0.921782677619253	0.406119999177011	B4GALT1;CHST10;RXYLT1;POMGNT1;ST3GAL3
Protein export	5/23	0.643662299012346	0.999996242493092	0	0	0.921782677619253	0.406119999177011	SEC61A1;IMMP2L;SRP54;SRPRA;SEC63
GnRH secretion	14/64	0.643668403897134	0.999996242493092	0	0	0.929027507039203	0.4093031224606	PRKCB;PIK3CD;ITPR2;PIK3R3;ARRB1;ITPR3;PIK3R1;PLCB3;AKT2;AKT1;MAPK1;RAF1;KCNN4;MAPK3
Gap junction	19/88	0.676232143417207	0.999996242493092	0	0	0.913495984011463	0.357376852426176	MAP3K2;PRKCB;ITPR2;CSNK1D;ITPR3;TUBB4B;ADCY7;TUBA4A;PLCB3;TUBA1A;TUBB2A;MAPK7;GNAS;MAPK1;RAF1;SOS1;SOS2;MAP2K5;MAPK3
Glycerolipid metabolism	13/61	0.681679103594747	0.999996242493092	0	0	0.898535621481161	0.344315484648233	AGPAT5;DGKE;DGKD;AGK;GLYCTK;LCLAT1;DGKZ;AGPAT3;PLPP5;GPAT4;LPIN1;GLA;LPIN2
Intestinal immune network for IgA production	10/48	0.702141539403158	0.999996242493092	0	0	0.873073725213271	0.308736568358931	ITGA4;IL15;CCR9;CD28;CXCR4;ITGB7;ICOS;CCL28;MAP3K14;IL2
Thiamine metabolism	3/15	0.710451905430981	0.999996242493092	0	0	0.829570008643042	0.283591846387555	THTPA;NFS1;TPK1
Endocrine and other factor-regulated calcium reabsorption	11/53	0.711359589059105	0.999996242493092	0	0	0.868877551020408	0.295919905964555	PLCB3;PRKCB;CLTC;GNAS;ATP1B3;ATP1A1;AP2B1;ATP2B1;ATP1B1;AP2A2;DNM2
Sulfur metabolism	2/10	0.711898224085405	0.999996242493092	0	0	0.829606826528408	0.281917258499406	BPNT1;PAPSS1
cAMP signaling pathway	47/216	0.712335485381817	0.999996242493092	0	0	0.922168179518159	0.312805248046271	CAMK2D;ROCK1;ROCK2;ATP2A3;PIK3R3;ATP2A2;PIK3CD;PIK3R1;ADRB2;ATP1A1;ADCY7;PPP1CB;LIPE;MAPK9;PAK1;MAPK8;CREB3L4;AKT2;CREB3L2;AKT1;EP300;PDE4A;MAPK1;CAMK2G;MAPK3;VAV3;CREBBP;JUN;PPP1R12A;PDE4D;F2R;BRAF;NFATC1;ATP1B3;ATP2B1;ATP1B1;VAV1;NFKB1;NFKBIA;TIAM1;CREB1;ACOX1;CAMK4;GNAS;ACOX3;PPARA;RAF1
PI3K-Akt signaling pathway	78/354	0.712442255832209	0.999996242493092	0	0	0.936835722266255	0.317640161032349	ATF2;GSK3B;CRTC2;CDKN1B;PTEN;PIK3CD;PPP2R2A;BRCA1;PIK3CG;IKBKB;RPTOR;CASP9;GYS1;PPP2R1B;CREB3L4;PPP2R5E;AKT2;CREB3L2;MYB;MLST8;AKT1;ITGB7;JAK2;IL6R;JAK1;IFNAR2;HSP90AA1;IL4R;CHUK;ITGA4;PDPK1;F2R;ITGA1;PPP2R5B;PPP2R5C;RBL2;CREB1;CCNE2;DDIT4;SGK3;ITGA5;SGK1;RAF1;SOS1;TP53;SOS2;ATF4;PRKAA1;ATF6B;LPAR2;PIK3R3;PIK3R1;FOXO3;THBS1;PIK3R6;PIK3R5;PPP2CB;BCL2L11;GNG2;PPP2R3C;THEM4;MAPK1;MAPK3;VEGFB;IL2;NFKB1;NR4A1;CDK6;RPS6KB1;PPP2R2B;IL2RA;PPP2R2D;RPS6KB2;BCL2;MDM2;PKN1;GNB5;IL7R
One carbon pool by folate	4/20	0.714142466561459	0.999996242493092	0	0	0.829533174843311	0.279281259610049	MTHFD2L;MTHFR;MTR;GART
alpha-Linolenic acid metabolism	5/25	0.719714046834306	0.999996242493092	0	0	0.829496325118893	0.272822422193859	FADS2;PLA2G12A;ACOX1;ACOX3;ACAA1
Citrate cycle (TCA cycle)	6/30	0.726025881212486	0.999996242493092	0	0	0.829459459459459	0.26556771640683	CS;IDH1;IDH3B;OGDH;DLST;ACO1
Pentose phosphate pathway	6/30	0.726025881212486	0.999996242493092	0	0	0.829459459459459	0.26556771640683	PFKL;H6PD;RPE;GLYCTK;PFKP;RBKS
Neomycin, kanamycin and gentamicin biosynthesis	1/5	0.732074621825128	0.999996242493092	0	0	0.829643628509719	0.258743304516578	HK1
Axon guidance	39/182	0.736829649904701	0.999996242493092	0	0	0.904299968324359	0.276171902161236	EPHB6;GSK3B;SEMA7A;CAMK2D;ROCK1;ROCK2;PIK3R3;PIK3CD;CXCR4;PIK3R1;PRKCZ;PPP3CA;PPP3CB;ABLIM1;PAK1;PPP3CC;CFL2;PLCG2;NCK2;MAPK1;FYN;PLCG1;SRGAP2;CAMK2G;MAPK3;PAK4;SEMA4D;PDPK1;LIMK2;SEMA4B;NFATC3;NFATC2;SEMA4F;SSH2;SSH3;SSH1;RASA1;EPHA1;RAF1
ABC transporters	9/45	0.745710495365019	0.999996242493092	0	0	0.829348766767633	0.243345715472672	ABCD4;ABCD2;ABCB1;ABCD3;ABCB10;ABCB7;ABCB8;ABCD1;ABCG1
Regulation of lipolysis in adipocytes	11/55	0.758289600734598	0.999996242493092	0	0	0.829274891774892	0.22945199292238	LIPE;AKT2;GNAS;PIK3CD;AKT1;PIK3R3;IRS2;ABHD5;ADRB2;PIK3R1;ADCY7
Phenylalanine, tyrosine and tryptophan biosynthesis	1/6	0.794127971194865	0.999996242493092	0	0	0.663671706263499	0.152983401661942	GOT1
Vitamin B6 metabolism	1/6	0.794127971194865	0.999996242493092	0	0	0.663671706263499	0.152983401661942	PDXK
Gastric acid secretion	15/76	0.798688003394523	0.999996242493092	0	0	0.815481433076683	0.183307906951803	CAMK2D;PRKCB;ITPR2;ATP1B3;ITPR3;SLC4A2;ATP1A1;ATP1B1;ADCY7;PLCB3;HRH2;KCNQ1;GNAS;EZR;CAMK2G
Pertussis	15/76	0.798688003394523	0.999996242493092	0	0	0.815481433076683	0.183307906951803	JUN;IRAK4;MAPK14;NFKB1;MAPK13;MAPK9;MAPK8;IRF3;IRAK1;CFL2;IRF1;TRAF6;MAPK1;ITGA5;MAPK3
Primary immunodeficiency	7/38	0.809877300566992	0.999996242493092	0	0	0.749009376046434	0.157945497305639	ZAP70;CD4;DCLRE1C;RFXAP;ICOS;IL7R;ADA
Proximal tubule bicarbonate reclamation	4/23	0.814491764401447	0.999996242493092	0	0	0.698417753915803	0.143309010959795	GLUD1;ATP1B3;ATP1A1;ATP1B1
Signaling pathways regulating pluripotency of stem cells	29/143	0.819878704034503	0.999996242493092	0	0	0.84325464900844	0.167469421743032	GSK3B;RIF1;TCF7;PIK3R3;PIK3CD;PIK3R1;AKT2;AKT1;SMARCAD1;DVL3;MAPK1;JAK2;JARID2;SKIL;JAK1;MAPK3;SMAD2;SMAD4;SMAD3;SETDB1;MAPK14;SMAD5;MAPK13;APC;KAT6A;ID2;CTNNB1;TCF3;RAF1
Basal cell carcinoma	12/63	0.821234693503327	0.999996242493092	0	0	0.780306407039976	0.153678496723014	GSK3B;GADD45B;APC;GADD45A;SUFU;TCF7;DVL3;CTNNB1;POLK;TP53;DDB2;GADD45G
Cocaine addiction	9/49	0.832399175179489	0.999996242493092	0	0	0.746219169190827	0.136888813909048	ATF2;JUN;CREB1;ATF6B;CREB3L4;CREB3L2;GNAS;NFKB1;ATF4
Thermogenesis	48/232	0.834767788436832	0.999996242493092	0	0	0.864347446612718	0.156102610027289	ATF2;COX19;SMARCD1;KDM3A;NDUFB8;PRKAA1;SMARCD2;KDM3B;KDM1A;PRKAG2;ADCY7;RPTOR;LIPE;RPS6KA3;CPT2;CREB3L4;CREB3L2;MLST8;COX11;NDUFV1;COX10;MAP3K5;CPT1A;SMARCC1;SMARCC2;COA1;ACSL1;ACSL5;ACSL4;SIRT6;ACSL3;ARID1A;MAPK14;PRKAB1;SMARCA2;SMARCA4;MAPK13;CREB1;NDUFAF6;RPS6KB1;NDUFAF7;NDUFAF5;RPS6KB2;GNAS;NDUFS2;NDUFS1;SOS1;SOS2
Vitamin digestion and absorption	4/24	0.840744234820833	0.999996242493092	0	0	0.663453641668468	0.115087834049453	SLC5A6;LMBRD1;BTD;SLC19A1
Long-term depression	11/60	0.851651613607741	0.999996242493092	0	0	0.7444120505345	0.119536004698544	PPP2CB;PLCB3;PPP2R1B;PRKCB;GNAS;ITPR2;MAPK1;ITPR3;BRAF;RAF1;MAPK3
Hippo signaling pathway	32/163	0.879143774416847	0.999996242493092	0	0	0.809362805389157	0.104251456297032	GSK3B;TCF7;PPP2R2A;PRKCZ;PPP1CB;PPP2CB;RASSF1;PAK1;RASSF2;PPP2R1B;TP53BP2;DVL3;BTRC;SMAD2;SMAD4;SMAD3;FBXW11;CSNK1D;TGFBR1;SMAD7;TGFBR2;MOB1B;LATS1;DLG3;APC;PPP2R2B;ID2;PPP2R2D;CTNNB1;NF2;BIRC2;BIRC3
Folate biosynthesis	4/26	0.88392625237403	0.999996242493092	0	0	0.603061084150343	0.0744066684416398	GCH1;FPGS;PCBD2;PTS
Pantothenate and CoA biosynthesis	3/21	0.895542720597028	0.999996242493092	0	0	0.552830596369922	0.0609912305609948	PANK2;PANK3;DPYD
Purine metabolism	24/129	0.911609544352639	0.999996242493092	0	0	0.757307203324134	0.0700838680876749	ENTPD1;PDE4D;ENTPD6;ADK;NME3;ADA2;AMPD2;NT5C2;FHIT;PFAS;ADCY7;AK9;PAPSS1;NT5C3A;NT5C;NT5C3B;NT5E;RRM2B;NME7;PDE4A;ENPP4;ADPRM;GART;ADA
Arginine biosynthesis	3/22	0.913031147889547	0.999996242493092	0	0	0.52370013192012	0.0476490047042948	GLUD1;GOT1;ASL
Pathways of neurodegeneration	98/475	0.916760009992385	0.999996242493092	0	0	0.859723068262743	0.0747181476449591	APP;ZFYVE1;TBK1;FRAT2;MAP3K5;GABARAPL1;CSNK2A1;PRKCB;CSNK2A2;ATG14;ATG13;TUBA4A;ATXN2L;DDIT3;RAF1;ATF6;SQSTM1;PPID;ATF4;VCP;PIK3R4;PSEN2;ITPR2;HTRA2;ITPR3;PSEN1;KLC1;UBE2J1;ATXN3;ATXN2;ATXN1;KLC2;DVL3;PLCG1;MAP2K7;NDUFV1;MAP2K6;TRAP1;FUS;EIF2AK3;BRAF;NFKB1;ATG2A;BCL2;UBA1;MCU;GSK3B;HIP1;ATP2A3;ATP2A2;CASP9;PPP3CA;PPP3CB;TUBA1A;ACTR1B;PPP3CC;CASP8;RB1CC1;IFT57;SPG11;APAF1;TRAF2;WIPI1;TNFRSF1B;PLCB3;TUBB2A;ALS2;NDUFS2;PIK3C3;SMCR8;NDUFS1;DCTN6;RAB1A;DCTN5;NDUFB8;CAMK2D;DCTN4;AMBRA1;TANK;MAPK9;MAPK8;MFN1;MFN2;MAPK1;CAMK2G;MAPK3;CSNK1A1;UBE2G2;TUBB4B;MAPK14;MAPK13;FIG4;CCS;APC;VAPB;CTNNB1;FAS;TARDBP
Vibrio cholerae infection	8/50	0.919616704976694	0.999996242493092	0	0	0.631500880689719	0.0529187133708071	ERO1A;SEC61A1;KCNQ1;ATP6V0A2;PLCG2;GNAS;ATP6V1H;PLCG1
Melanogenesis	18/101	0.921551428217795	0.999996242493092	0	0	0.718629123038871	0.0587096236981571	GSK3B;CREBBP;CAMK2D;PRKCB;TCF7;ADCY7;PLCB3;CREB1;CREB3L4;CREB3L2;GNAS;EP300;DVL3;MAPK1;CTNNB1;RAF1;CAMK2G;MAPK3
Aminoacyl-tRNA biosynthesis	11/66	0.923471582310924	0.999996242493092	0	0	0.662943722943723	0.052780431260637	RARS2;LARS2;AARS2;NARS2;GATB;TARS2;QRSL1;YARS2;HARS2;EARS2;WARS2
Renin-angiotensin system	3/23	0.927812000769029	0.999996242493092	0	0	0.497482713915298	0.037274465488609	PREP;LNPEP;THOP1
Arrhythmogenic right ventricular cardiomyopathy	13/77	0.929835416862677	0.999996242493092	0	0	0.673197948245994	0.0489735886540999	ITGA4;ITGA1;TCF7;ATP2A3;ATP2A2;CACNA2D4;SGCB;LMNA;DAG1;CTNNB1;ITGB7;ITGA5;EMD
Nitrogen metabolism	2/17	0.930515200808338	0.999996242493092	0	0	0.442255346727155	0.0318498444237933	GLUD1;CA5B
Rap1 signaling pathway	40/210	0.935890783400734	0.999996242493092	0	0	0.778966520173741	0.0516115903470152	RGS14;LPAR2;PIK3R3;PIK3CD;PIK3R1;RASGRP2;PRKCZ;ADCY7;THBS1;SIPA1L1;AKT2;KRIT1;AKT1;MAPK1;PLCG1;RALGDS;MAP2K6;MAPK3;VAV3;PRKCB;F2R;VEGFB;BRAF;MAPK14;VAV1;MAPK13;APBB1IP;TIAM1;PLCB3;PRKD3;GNAS;CTNNB1;PRKD2;EVL;TLN1;RAF1;RAPGEF6;CRK;SKAP1;SIPA1
Starch and sucrose metabolism	5/36	0.942980421348501	0.999996242493092	0	0	0.534775392940323	0.0313965342540961	PYGB;GYS1;AGL;PGM2L1;HK1
Taurine and hypotaurine metabolism	1/11	0.944865576763667	0.999996242493092	0	0	0.331727861771058	0.0188131523257522	GGT1
Diabetic cardiomyopathy	38/203	0.946846792833733	0.999996242493092	0	0	0.76236169665301	0.0416386562624374	GSK3B;CAMK2D;NDUFB8;NCF4;ATP2A3;PTEN;SLC2A1;PIK3R3;ATP2A2;PIK3CD;PIK3R1;PRKCZ;PPP1CB;GYS1;MAPK9;MAPK8;CPT2;AKT2;AKT1;PDK3;CTSD;NDUFV1;CAMK2G;SMAD2;SMAD3;PRKCB;GSR;GFPT1;MAPK14;NFKB1;TGFBR1;TGFBR2;MAPK13;PLCB3;SP1;NDUFS2;NDUFS1;PPARA
Hypertrophic cardiomyopathy	15/90	0.94835010589346	0.999996242493092	0	0	0.66265164644714	0.0351414339091894	PRKAA1;ITGA4;ITGA1;TPM1;ATP2A3;ATP2A2;PRKAG2;CACNA2D4;PRKAB1;SGCB;LMNA;DAG1;ITGB7;ITGA5;EMD
African trypanosomiasis	5/37	0.951542509539325	0.999996242493092	0	0	0.518029885430177	0.0257310193919462	PLCB3;PRKCB;FAS;APOL1;THOP1
Porphyrin and chlorophyll metabolism	6/43	0.953818335406009	0.999996242493092	0	0	0.537571950328707	0.0254175037101494	MMAB;CPOX;PPOX;GUSB;COX10;EARS2
Ether lipid metabolism	7/49	0.956522211155663	0.999996242493092	0	0	0.552443771626298	0.0245568267496747	PLA2G12A;LPCAT4;AGPS;LPCAT1;CEPT1;PAFAH1B2;PAFAH1B1
Pancreatic secretion	17/102	0.957360777136262	0.999996242493092	0	0	0.662505418292154	0.0288686543681941	PLA2G12A;PRKCB;ATP2A3;ITPR2;ATP2A2;ATP1B3;ITPR3;SLC4A2;ATP1A1;ATP2B1;ATP1B1;ADCY7;TPCN2;PLCB3;KCNQ1;GNAS;CD38
Arginine and proline metabolism	7/50	0.962530052628961	0.999996242493092	0	0	0.539561036452885	0.0206058304770121	GOT1;P4HA1;AMD1;AZIN2;SAT2;PYCR3;CNDP2
Cholesterol metabolism	7/50	0.962530052628961	0.999996242493092	0	0	0.539561036452885	0.0206058304770121	MYLIP;STARD3;NCEH1;NPC1;SOAT1;VAPB;LDLR
Salivary secretion	15/93	0.963049405438441	0.999996242493092	0	0	0.637040061325157	0.0239849181254308	PRKCB;ITPR2;ATP1B3;ITPR3;SLC4A2;ADRB2;ATP1A1;ATP2B1;ATP1B1;ADCY7;PLCB3;GNAS;CD38;KCNN4;VAMP2
Ras signaling pathway	43/232	0.963183165621054	0.999996242493092	0	0	0.752757365660591	0.0282371950240907	PIK3R3;PIK3CD;PIK3R1;RASAL3;RASGRP2;STK4;ETS1;RASGRP1;IKBKB;MAPK9;RASSF1;PAK1;MAPK8;SYNGAP1;TBK1;GNG2;AKT2;PLCG2;AKT1;MAPK1;SHOC2;PLCG1;RALGDS;PAK4;MAPK3;BRAP;PLA2G12A;CHUK;PRKCB;VEGFB;NFKB1;TIAM1;ZAP70;RASA3;RASA1;RASA2;NF1;GNB5;RAF1;SOS1;RGL2;SOS2;EXOC2
Viral protein interaction with cytokine and cytokine receptor	16/100	0.969896386069103	0.999996242493092	0	0	0.630862095650828	0.019282950798643	CCL20;IL10RA;CXCR5;CXCR4;TNFRSF10A;TNFRSF1B;IL2;IL18RAP;IL2RA;CCR9;TNFRSF14;CCR7;CCR6;IL6R;CCL28;IL18R1
Alzheimer disease	71/369	0.970659944887696	0.999996242493092	0	0	0.787443335688214	0.0234493406617409	APP;GSK3B;ATP2A3;ATP2A2;PIK3CD;IRS2;IDE;IKBKB;CASP9;PPP3CA;PPP3CB;FRAT2;PPP3CC;TUBA1A;CASP8;AKT2;RB1CC1;AKT1;MAP3K5;CSNK2A1;APAF1;CHUK;CSNK2A2;ADAM10;TRAF2;WIPI1;ATG14;ATG13;TUBA4A;PLCB3;ADAM17;TUBB2A;DDIT3;NDUFS2;NDUFS1;PIK3C3;RAF1;ATF6;PPID;ATF4;NDUFB8;PIK3R4;PSEN2;PIK3R3;ITPR2;ITPR3;PIK3R1;PSEN1;AMBRA1;KLC1;MAPK9;MAPK8;APH1B;KLC2;DVL3;MAPK1;APBB1;MAP2K7;NDUFV1;MAPK3;CSNK1A1;EIF2AK3;EIF2AK2;BRAF;TUBB4B;NFKB1;APC;ATG2A;CTNNB1;FAS;MCU
Histidine metabolism	2/22	0.976822988304152	0.999996242493092	0	0	0.331583495355368	0.00777557399815637	CARNMT1;CNDP2
Chemical carcinogenesis	43/239	0.978624009504887	0.999996242493092	0	0	0.725538449904809	0.0156772649653466	RB1;NOTCH2;ATF2;ATF6B;PIK3R3;XIAP;PIK3CD;ARRB1;PIK3R1;AHR;ADRB2;ADCY7;RXRB;RPS6KA3;CREB3L4;AKT2;CREB3L2;KPNA6;AKT1;MAPK1;JAK2;IKBKE;KPNA1;MAPK3;GSTM4;STAT5A;JUN;HSP90AA1;PRKCB;EPHX2;ARNT;NFKB1;CREB1;RPS6KB1;RPS6KB2;BCL2;GNAS;PPARA;RAF1;SOS1;SOS2;KPNB1;ATF4
Viral myocarditis	8/60	0.980495368515096	0.999996242493092	0	0	0.509725619394665	0.0100402474727447	CASP9;CASP8;SGCB;DAG1;CD28;FYN;EIF4G3;CD55
Coronavirus disease	41/232	0.983061004851038	0.999996242493092	0	0	0.709826734649648	0.0121267515504492	PIK3R3;CGAS;PIK3CD;ADAR;PIK3R1;IKBKB;MAPK9;MAPK8;TBK1;IRAK1;PLCG2;MAPK1;PLCG1;IKBKE;IL6R;MAP3K7;JAK1;MAPK3;IFNAR2;JUN;CHUK;PRKCB;DDX58;MX2;MX1;EIF2AK2;IRAK4;MAPK14;IL2;NFKB1;MAPK13;NFKBIA;ADAM17;MAVS;IRF3;TRAF3;OAS3;TRAF6;TAB2;IRF9;NFKBIB
Antigen processing and presentation	11/78	0.983466450523237	0.999996242493092	0	0	0.543781094527363	0.0090657846731969	HSP90AA1;CD4;CREB1;NFYA;HSPA4;KLRC4;HSPA6;RFXAP;HSPA1B;TAPBP;HSPA1A
Dilated cardiomyopathy	14/96	0.986542788390534	0.999996242493092	0	0	0.565296861545614	0.00765897004713585	ITGA4;ITGA1;TPM1;ATP2A3;ATP2A2;CACNA2D4;ADCY7;SGCB;LMNA;DAG1;GNAS;ITGB7;ITGA5;EMD
Glutathione metabolism	7/57	0.987471136353608	0.999996242493092	0	0	0.463810553633218	0.00584772886037274	GSTM4;GCLC;RRM2B;GSS;IDH1;GSR;GGT1
Renin secretion	9/69	0.988094699984223	0.999996242493092	0	0	0.496830376460407	0.00595040607735664	PPP3CA;PPP3CB;PLCB3;PPP3CC;CREB1;GNAS;ITPR2;ITPR3;ADRB2
Phenylalanine metabolism	1/17	0.988659053492361	0.999996242493092	0	0	0.207248920086393	0.00236382842274259	GOT1
Primary bile acid biosynthesis	1/17	0.988659053492361	0.999996242493092	0	0	0.207248920086393	0.00236382842274259	HSD17B4
Calcium signaling pathway	41/240	0.991561463808538	0.999996242493092	0	0	0.68093189257836	0.00577044988206147	CAMK2D;ATP2A3;CXCR4;ITPR2;ATP2A2;ITPR3;ADRB2;ADCY7;PPP3CA;PPP3CB;CYSLTR1;PPP3CC;HRH2;PHKG2;PLCG2;CD38;PTK2B;PLCG1;CAMK2G;CAMK1D;PRKCB;SPHK2;SPHK1;F2R;VEGFB;PHKB;ATP2B1;MCOLN1;TPCN2;ITPKB;P2RX7;PLCB3;P2RX5;P2RX4;STIM1;STIM2;CAMK4;ORAI2;GNAS;PLCD1;MCU
Tryptophan metabolism	4/42	0.993665627534615	0.999996242493092	0	0	0.348776631442449	0.00221630798512817	GCDH;DLST;KYAT1;DHTKD1
Glutamatergic synapse	16/114	0.994621069543889	0.999996242493092	0	0	0.540243659760762	0.00291377662040194	SLC38A1;PRKCB;ITPR2;ITPR3;ADCY7;PPP3CA;PPP3CB;PLCB3;GRK2;PPP3CC;GNG2;GNAS;MAPK1;GNB5;SLC38A2;MAPK3
Type I diabetes mellitus	4/43	0.994802253568557	0.999996242493092	0	0	0.339811474455953	0.0017708601169192	ICA1;CD28;FAS;IL2
MicroRNAs in cancer	53/310	0.99649400403397	0.999996242493092	0	0	0.680751963799121	0.00239090734809561	CDKN1B;PTEN;PIK3CD;IRS2;BRCA1;IKBKB;RPTOR;RASSF1;EP300;PRKCB;TPM1;DNMT3A;DICER1;SIRT1;FOXP1;ZEB2;ZEB1;CCNE2;DDIT4;ITGA5;EZR;RAF1;SOS1;TP53;CRK;SOS2;NOTCH2;DNMT1;ABCB1;ROCK1;PIK3R3;PIK3R1;SLC7A1;THBS1;BCL2L11;MAPK7;PLCG2;MAPK1;BMF;E2F3;PLCG1;PAK4;MAPK3;CREBBP;RDX;NFKB1;CDK6;APC;BCL2;MDM2;MDM4;RECK;EZH2
Allograft rejection	3/38	0.996585254812	0.999996242493092	0	0	0.283998024447463	0.000971440443744451	CD28;FAS;IL2
GABAergic synapse	11/89	0.996663024815815	0.999996242493092	0	0	0.466758241758242	0.0015601652362758	NSF;GABARAPL1;SLC38A1;GNG2;PRKCB;ABAT;GNB5;ADCY7;SLC38A2;SLC38A5;TRAK2
Huntington disease	52/306	0.996792892838261	0.999996242493092	0	0	0.675782801663878	0.00217079070584106	HIP1;CLTC;AP2A2;CASP9;ACTR1B;TUBA1A;CASP8;CREB3L4;SIN3A;RB1CC1;CREB3L2;EP300;IFT57;MAP3K5;TBP;APAF1;TRAF2;WIPI1;ATG14;ATG13;TUBA4A;PLCB3;TUBB2A;CREB1;NDUFS2;NDUFS1;PIK3C3;TP53;DCTN6;DCTN5;NDUFB8;DCTN4;PIK3R4;NRF1;AMBRA1;KLC1;MAPK9;MAPK8;KLC2;POLR2A;POLR2B;MAP2K7;NDUFV1;POLR2J3;CREBBP;AP2B1;TUBB4B;SOD2;SP1;ATG2A;TAF4B;RCOR1
Bile secretion	11/90	0.997136964079607	0.999996242493092	0	0	0.460819770946353	0.00132123583367782	ABCB1;NCEH1;SLC2A1;GNAS;ATP1B3;SLC4A2;ATP1A1;HMGCR;ATP1B1;ADCY7;LDLR
Phagosome	22/152	0.9972150905054	0.999996242493092	0	0	0.559537360014687	0.00156043475119697	DYNC1I2;STX12;DYNC1H1;TFRC;NCF4;STX7;STX18;TUBB4B;THBS1;TUBA4A;EEA1;SEC61A1;DYNC1LI2;TUBA1A;TUBB2A;HGS;LAMP2;ATP6V0A2;ATP6V1H;PIK3C3;ITGA5;SEC22B
Circadian entrainment	12/97	0.997589678229553	0.999996242493092	0	0	0.467144658252996	0.00112732809790413	PLCB3;CAMK2D;CREB1;GNG2;PRKCB;GNAS;MAPK1;ITPR3;GNB5;ADCY7;CAMK2G;MAPK3
Glycolysis / Gluconeogenesis	7/67	0.997715528799604	0.999996242493092	0	0	0.386256487889273	0.000883401259548339	PFKL;ADPGK;GALM;ENO2;ACSS1;PFKP;HK1
Vascular smooth muscle contraction	18/133	0.998113701668166	0.999996242493092	0	0	0.517576979990386	0.000977226554392324	PLA2G12A;PRKCH;PPP1R12A;ROCK1;PRKCB;ROCK2;ITPR2;ITPR3;BRAF;ADCY7;PPP1CB;PLCB3;GNAS;MYH9;MAPK1;PRKCQ;RAF1;MAPK3
Hematopoietic cell lineage	12/99	0.998221693678046	0.999996242493092	0	0	0.456345977260341	0.000812245361133083	CD4;IL4R;TFRC;ITGA4;CD5;IL2RA;ITGA1;CD38;ITGA5;IL7R;IL6R;CD55
Prion disease	44/273	0.998432644388401	0.999996242493092	0	0	0.634182610243683	0.000994769455494131	ATF2;GSK3B;NDUFB8;ATF6B;NCF4;PIK3R3;ITPR2;PIK3CD;ITPR3;PIK3R1;KLC1;CASP9;PPP3CA;MAPK9;PPP3CB;MAPK8;PPP3CC;TUBA1A;KLC2;CREB3L4;CREB3L2;MAPK1;FYN;NDUFV1;MAPK3;EGR1;CSNK2A1;APAF1;CSNK2A2;HSPA6;EIF2AK3;TUBB4B;MAPK14;TUBA4A;MAPK13;TUBB2A;CREB1;DDIT3;NDUFS2;NDUFS1;HSPA1B;MCU;ATF4;HSPA1A
Pentose and glucuronate interconversions	2/34	0.998554930060272	0.999996242493092	0	0	0.207077662562108	0.000299458126475175	RPE;GUSB
Graft-versus-host disease	3/42	0.998567372918302	0.999996242493092	0	0	0.25480353699887	0.000365300179606182	CD28;FAS;IL2
Fat digestion and absorption	3/43	0.998849726191835	0.999996242493092	0	0	0.24841724286949	0.00028591231823788	SLC27A1;PLA2G12A;SLC27A4
Ovarian steroidogenesis	4/51	0.998978373873791	0.999996242493092	0	0	0.281824076075211	0.000288066012063016	GNAS;HSD17B7;ADCY7;LDLR
Synaptic vesicle cycle	8/78	0.998991141775313	0.999996242493092	0	0	0.378208337196008	0.000381751190434724	NSF;CLTC;ATP6V0A2;ATP6V1H;AP2B1;AP2A2;VAMP2;DNM2
Morphine addiction	10/91	0.999068450962311	0.999996242493092	0	0	0.408441334647783	0.000380660461727406	GNG2;GRK2;GRK5;PRKCB;PDE4D;GNAS;PDE4A;ARRB1;GNB5;ADCY7
Collecting duct acid secretion	1/27	0.999185928546926	0.999996242493092	0	0	0.127454726698787	0.000103799510408676	ATP6V0A2
Mineral absorption	5/60	0.999302260102868	0.999996242493092	0	0	0.300947215344103	0.000210056169886564	ATP1B3;ATP1A1;ATP2B1;ATP7A;ATP1B1
Autoimmune thyroid disease	4/53	0.999326620944511	0.999996242493092	0	0	0.270285767213737	0.000182066081263291	CD28;CTLA4;FAS;IL2
Arachidonic acid metabolism	5/61	0.999428437721531	0.999996242493092	0	0	0.295553857081094	0.000168975730641855	PLA2G12A;PTGES2;EPHX2;TBXAS1;GGT1
Retrograde endocannabinoid signaling	19/148	0.999475419373037	0.999996242493092	0	0	0.486697997135884	0.000255379329861378	NDUFB8;PRKCB;ITPR2;ITPR3;MAPK14;ADCY7;MAPK13;MAPK9;PLCB3;MAPK8;GNG2;NAPEPLD;NDUFS2;MAPK1;NDUFS1;GNB5;DAGLB;NDUFV1;MAPK3
Linoleic acid metabolism	1/29	0.999518565175895	0.999996242493092	0	0	0.118335390311632	5.69844960814071e-05	PLA2G12A
Pyruvate metabolism	3/47	0.999525413207402	0.999996242493092	0	0	0.225774927319871	0.000107175232592876	ME2;HAGH;ACSS1
Ascorbate and aldarate metabolism	1/30	0.999629562830336	0.999996242493092	0	0	0.114247411931183	4.23293285797004e-05	GUSB
Malaria	3/50	0.999756882617923	0.999996242493092	0	0	0.211322385479689	5.13823913614978e-05	KLRK1;CD81;THBS1
Serotonergic synapse	12/113	0.999808235541677	0.999996242493092	0	0	0.392729985273912	7.5318874865543e-05	APP;PLCB3;GNG2;PRKCB;GNAS;ITPR2;MAPK1;ITPR3;BRAF;GNB5;RAF1;MAPK3
ECM-receptor interaction	8/88	0.999832082326942	0.999996242493092	0	0	0.330715985290937	5.55377217060384e-05	ITGA4;SDC4;ITGA1;DAG1;ITGB7;CD47;ITGA5;THBS1
Drug metabolism	11/108	0.999845193647915	0.999996242493092	0	0	0.37486499754541	5.80359750791821e-05	GSTM4;RRM2B;NME7;DPYD;NME3;TK2;UPP1;GUSB;CES2;UCKL1;TYMP
Amoebiasis	10/102	0.999855556323053	0.999996242493092	0	0	0.359347214512199	5.1909182031541e-05	PLCB3;PRKCB;ACTN1;GNAS;PIK3R3;PIK3CD;SERPINB9;ACTN4;PIK3R1;NFKB1
Protein digestion and absorption	10/103	0.999878320577497	0.999996242493092	0	0	0.355459996788853	4.32547987949741e-05	DPP4;KCNK5;COL18A1;KCNQ1;ATP1B3;ATP1A1;ATP1B1;KCNN4;SLC38A2;SLC36A4
Parkinson disease	35/249	0.999882201495553	0.999996242493092	0	0	0.539299716128612	6.35324420955875e-05	CAMK2D;NDUFB8;HTRA2;ITPR2;ITPR3;KLC1;UBE2J1;CASP9;MAPK9;MAPK8;TUBA1A;KLC2;MFN1;MFN2;PLCG1;NDUFV1;CAMK2G;MAP3K5;TRAP1;APAF1;EIF2AK3;UBE2G2;TUBB4B;TUBA4A;TUBB2A;DDIT3;GNAS;NDUFS2;UBA1;NDUFS1;ATF6;TP53;MCU;ATF4;NFE2L2
Neutrophil extracellular trap formation	24/189	0.999902863627631	0.999996242493092	0	0	0.480028415257415	4.66304836868629e-05	GSDMD;HDAC3;HDAC10;PRKCB;NCF4;PIK3R3;PIK3CD;PIK3R1;CLCN3;HDAC8;MAPK14;NFKB1;HDAC7;MAPK13;PLCB3;AKT2;PLCG2;AKT1;MAPK1;PLCG1;RAF1;MAP3K7;ATG7;MAPK3
Tyrosine metabolism	1/36	0.999921642339941	0.999996242493092	0	0	0.0946251157050293	7.41489316011554e-06	GOT1
Alcoholism	23/186	0.999932774126998	0.999996242493092	0	0	0.465631923142468	3.13035647474318e-05	ATF2;HDAC3;HDAC10;ATF6B;BRAF;HDAC8;CAMKK2;HDAC7;PPP1CB;CREB1;GNG2;CREB3L4;CAMK4;CREB3L2;GNAS;MAPK1;GNB5;RAF1;SOS1;SOS2;SLC29A3;ATF4;MAPK3
Cardiac muscle contraction	7/87	0.999942653836465	0.999996242493092	0	0	0.289313905709343	1.65915182842744e-05	TPM1;ATP2A3;ATP2A2;ATP1B3;CACNA2D4;ATP1A1;ATP1B1
Glycine, serine and threonine metabolism	1/40	0.999970761553467	0.999996242493092	0	0	0.0848978235587307	2.48231676457383e-06	GLYCTK
Steroid hormone biosynthesis	3/61	0.999977380252927	0.999996242493092	0	0	0.171121062200101	3.87075892374361e-06	SRD5A1;HSD17B12;HSD17B7
Rheumatoid arthritis	7/93	0.999979783805657	0.999996242493092	0	0	0.269023597811217	5.43868831109114e-06	JUN;IL15;CCL20;ATP6V0A2;CD28;CTLA4;ATP6V1H
Cell adhesion molecules	14/148	0.999991229473275	0.999996242493092	0	0	0.344751227617598	3.0236631148711e-06	SDC4;ITGA4;CD99L2;F11R;GLG1;CD4;CD6;CD28;CTLA4;CD226;ITGB7;CD58;ICOS;NECTIN3
Proteasome	1/46	0.99999148040654	0.999996242493092	0	0	0.0735493160547156	6.26612941306142e-07	PSME4
Retinol metabolism	3/68	0.999992681639254	0.999996242493092	0	0	0.152622830928795	1.11695302196216e-06	RETSAT;RDH11;RDH13
Olfactory transduction	5/440	0.99999362386732	0.999996242493092	0	0	0.0371066088226963	2.36597415441555e-07	CAMK2D;GRK2;ARRB1;CAMK2G;NCALD
Cytokine-cytokine receptor interaction	36/295	0.999993755495121	0.999996242493092	0	0	0.457068914087412	2.85417797536124e-06	CXCR5;CXCR4;IL27RA;IL18RAP;CCR9;IL21R;CCR7;TNFRSF14;CCR6;IL12RB1;RELT;IL6R;TNFRSF4;IL12RB2;IFNAR2;IL4R;IFNGR1;IL15;CCL20;CD70;IL10RA;TNFRSF9;TNFRSF18;TNFRSF10A;TNFRSF1B;IL2;TGFBR1;IL17RA;TGFBR2;CD4;IL2RA;FAS;TNFSF8;IL7R;CCL28;IL18R1
Neuroactive ligand-receptor interaction	11/341	0.999994044316742	0.999996242493092	0	0	0.108506493506494	6.4623223117703e-07	P2RY8;P2RX7;CYSLTR1;P2RX5;P2RX4;THRA;HRH2;F2R;LPAR2;ADRB2;NR3C1
Ribosome	3/158	0.99999523321419	0.999996242493092	0	0	0.0636267320935679	3.03295726572525e-07	MRPS9;MRPL1;MRPS5
Oxidative phosphorylation	9/133	0.999995386753623	0.999996242493092	0	0	0.23939678396449	1.10439889367449e-06	NDUFB8;PPA2;ATP6V0A2;ATP6V1H;COX11;NDUFS2;NDUFS1;NDUFV1;COX10
Systemic lupus erythematosus	3/135	0.999995460621098	0.999996242493092	0	0	0.0748261569890783	3.39665049279741e-07	ACTN1;CD28;ACTN4
Taste transduction	3/86	0.999996032107151	0.999996242493092	0	0	0.119383324134915	4.73701177878028e-07	KCNK5;PLCB3;ITPR3
Complement and coagulation cascades	3/85	0.99999603398181	0.999996242493092	0	0	0.120847123553344	4.792828406009e-07	F2R;CD46;CD55
Metabolism of xenobiotics by cytochrome P450	1/76	0.999996242493092	0.999996242493092	0	0	0.0440431965442765	1.6549292618406e-07	GSTM4