Term	Overlap	P.value	Adjusted.P.value	Old.P.value	Old.Adjusted.P.value	Odds.Ratio	Combined.Score	Genes
T cell receptor signaling pathway	24/104	1.54129758255068e-11	4.28480727949088e-09	0	0	6.69742086752638	166.737726618355	JUN;MAP2K2;CD8B2;CD3G;PIK3R1;FOS;CD3E;TNF;CD3D;IL2;RHOA;CDC42;PPP3CA;CD8B;IFNG;CD8A;LCK;GRAP2;AKT3;MAPK1;MAP3K8;LCP2;FYN;PTPN6
Chagas disease	23/102	6.75804198650493e-11	9.19139861099344e-09	0	0	6.49233688079922	152.035615693582	JUN;TGFB1;CCL3L1;IFNGR1;CD3G;FASLG;PIK3R1;FOS;CD3E;TNF;CD3D;IL2;TGFBR1;TNFRSF1A;GNAO1;IFNG;PPP2R2B;CCL5;AKT3;GNAS;CCL3;MAPK1;CALR
Antigen processing and presentation	20/78	9.91877547948932e-11	9.19139861099344e-09	0	0	7.67110610389088	176.696308233751	PDIA3;HSP90AB1;HSPA5;KLRC4;CD8B2;HLA-B;HLA-C;TNF;TAPBP;CD8B;IFNG;CD8A;CANX;PSME1;KLRD1;KLRC1;CALR;B2M;HSPA1B;HSPA1A
Human immunodeficiency virus 1 infection	33/212	2.30286973395772e-10	1.54631980887401e-08	0	0	4.1379967698377	91.8291617072126	CXCR4;CD3G;FASLG;PIK3R1;CD3E;CD3D;TNF;PPP3CA;GNG2;AP1G2;AKT3;CFL1;MAPK1;PTK2B;RAC1;B2M;SKP1;MAP2K6;PDIA3;JUN;MAP2K2;LIMK1;HLA-B;HLA-C;FOS;RBX1;TAPBP;TNFRSF1A;GNAO1;BCL2;CALR;CALM1;CALM2
Human cytomegalovirus infection	34/225	2.78115073538492e-10	1.54631980887401e-08	0	0	3.99773931297473	87.9622027518561	PTGER4;CCL3L1;ROCK1;PTGER2;CCL4L2;CXCR4;FASLG;PIK3R1;TNF;PPP3CA;GNG2;MYC;CCL5;AKT3;CCL4;CCL3;MAPK1;PTK2B;RAC1;B2M;PRKACB;MAP2K6;PDIA3;MAP2K2;HLA-B;HLA-C;RHOA;TAPBP;TNFRSF1A;GNAO1;GNAS;CALR;CALM1;CALM2
Natural killer cell mediated cytotoxicity	25/131	4.55252377159316e-10	2.1093360141715e-08	0	0	5.26425059792719	113.234920944575	FASLG;PIK3R1;TNF;ICAM1;PPP3CA;KLRK1;KLRC4-KLRK1;MAPK1;PTK2B;FYN;KLRC1;RAC1;MAP2K2;IFNGR1;HLA-B;HLA-C;NCR3;IFNG;LCK;KLRD1;CD48;LCP2;PTPN6;HCST;CD244
Yersinia infection	25/137	1.21739028235449e-09	4.83477854992211e-08	0	0	4.98066524144869	102.235905899437	ROCK1;PIK3R1;TNF;CDC42;AKT3;NLRP3;MAPK1;PTK2B;RAC1;MAP2K6;JUN;MAP2K2;LIMK1;CD8B2;FOS;BAIAP2;IL2;RHOA;CD8B;CD8A;LCK;LCP2;ARHGEF7;SKAP2;ARF6
Human T-cell leukemia virus 1 infection	32/219	2.19356358783483e-09	7.62263346772605e-08	0	0	3.83477517957156	76.4567443781566	CD3G;PIK3R1;CD3E;CD3D;TNF;ICAM1;ANAPC11;PPP3CA;ZFP36;CDC26;MYC;AKT3;MAPK1;BUB3;B2M;PRKACB;EGR1;EGR2;JUN;MAP2K2;TGFB1;HLA-B;HLA-C;FOS;IL2;TGFBR1;TNFRSF1A;LCK;CANX;CALR;TLN1;SLC25A4
Coronavirus disease	33/232	2.47686187834227e-09	7.65075113532389e-08	0	0	3.71818809688252	73.6806320651112	RPL10;RPLP1;RPL36A;PIK3R1;RPL8;TNF;RPS4X;RPS19;RPS18;RPS3;RPL35;RPLP2;RPL13;NLRP3;MAPK1;RPL38;RPS2;RPL39;RPL17;RPS12;JUN;RPL21;RPS7;RPS5;RPL23A;FOS;IL2;TNFRSF1A;RPS29;RPL27A;RPL27;RPS20;RPL22L1
Ribosome	26/158	5.6363570487342e-09	1.56690725954811e-07	0	0	4.39559519994303	83.4900578361353	RPL10;RPLP1;RPL36A;RPL8;RPS4X;RPS19;RPS18;RPS3;RPL35;RPLP2;RPL13;RPL38;RPS2;RPL39;RPL17;RPS12;RPL21;RPS7;RPS5;RPL23A;MRPS6;RPS29;RPL27A;RPL27;RPS20;RPL22L1
Osteoclast differentiation	23/127	6.48959637110551e-09	1.6400979919703e-07	0	0	4.92520491803279	92.8552109235401	JUN;TGFB1;NCF1;IFNGR1;CYBA;PIK3R1;FOS;TNF;TGFBR1;FOSL2;TNFRSF1A;PPP3CA;SOCS1;IFNG;LCK;CAMK4;AKT3;MAPK1;FOSB;LCP2;FYN;RAC1;MAP2K6
Protein processing in endoplasmic reticulum	26/171	3.04816720922498e-08	7.06158736803786e-07	0	0	3.99876818347583	69.2032430063239	PPP1R15A;TRAM1;HSP90AB1;DERL1;HSP90B1;HERPUD1;SEC61G;CAPN2;SEC62;SKP1;PDIA3;BCAP31;HSPA5;SSR4;RAD23A;SVIP;RBX1;DNAJA1;SELENOS;DAD1;CANX;BCL2;STUB1;CALR;HSPA1B;HSPA1A
Fluid shear stress and atherosclerosis	23/139	3.81498646910322e-08	8.15820183392843e-07	0	0	4.41291488330776	75.380280679953	JUN;HSP90AB1;NCF1;DUSP1;MGST3;GSTP1;CYBA;PIK3R1;FOS;TNF;RHOA;ICAM1;HSP90B1;TNFRSF1A;IFNG;GSTA4;AKT3;BCL2;PECAM1;RAC1;CALM1;CALM2;MAP2K6
Lipid and atherosclerosis	29/215	7.50055245491625e-08	1.48939541604766e-06	0	0	3.48177241834043	57.1209279186	HSP90AB1;NCF1;CCL3L1;FASLG;PIK3R1;TNF;ICAM1;HSP90B1;RAP1B;CDC42;PPP3CA;CCL5;AKT3;CCL3;NLRP3;MAPK1;RAC1;MAP2K6;JUN;HSPA5;CYBA;FOS;RHOA;TNFRSF1A;BCL2;CALM1;CALM2;HSPA1B;HSPA1A
Salmonella infection	31/249	1.70867350158469e-07	3.16674155627028e-06	0	0	3.17768993862103	49.5159667803846	CYFIP2;ARF1;RAB5C;HSP90AB1;TNF;MYL12A;MYL12B;HSP90B1;CDC42;TUBA1A;MYC;AKT3;RPS3;NLRP3;MAPK1;RAC1;SKP1;S100A10;MAP2K6;JUN;MAP2K2;ANXA2;VPS33A;DYNLT3;FOS;RHOA;TNFRSF1A;TUBB2A;BCL2;ARF6;RAB7A
Pathogenic Escherichia coli infection	26/197	5.39069167462711e-07	9.36632678466461e-06	0	0	3.38612296507033	48.8733415251674	CYFIP2;ARF1;ROCK1;FASLG;TNF;CDC42;SLC9A3R1;TUBA1A;RPS3;NLRP3;MAPK1;FYN;RAC1;JUN;F2R;FOS;BAIAP2;RHOA;TNFRSF1A;TUBB2A;LPAR5;NCL;MYH9;PTPN6;ARF6;MYO1G
Cellular senescence	22/156	1.292702618551e-06	2.1139489879834e-05	0	0	3.64631229815833	49.4395297734493	MAP2K2;TGFB1;GADD45B;IGFBP3;HLA-B;HLA-C;RRAS2;PIK3R1;ZFP36L2;TGFBR1;ZFP36L1;PPP1CA;RBL2;PPP3CA;MYC;AKT3;CAPN2;MAPK1;CALM1;CALM2;SLC25A4;MAP2K6
Regulation of actin cytoskeleton	26/218	3.72261987584396e-06	5.74937958602568e-05	0	0	3.0124241088915	37.6585634244148	CYFIP2;ROCK1;CXCR4;IQGAP1;PIK3R1;ITGAE;MYL12A;MYL12B;CDC42;TMSB4X;CFL1;MAPK1;ITGB7;RAC1;MAP2K2;F2R;ITGA1;LIMK1;RRAS2;MSN;BAIAP2;RHOA;PPP1CA;LPAR5;MYH9;ARHGEF7
Colorectal cancer	15/86	4.47853343470613e-06	6.55280155183317e-05	0	0	4.66945524656057	57.5100143920961	JUN;MAP2K2;TGFB1;GADD45B;FOS;PIK3R1;RHOA;TGFBR1;MSH3;MYC;AKT3;BCL2;MAPK1;RAC1;APPL1
PD-L1 expression and PD-1 checkpoint pathway in cancer	15/89	6.94152034215851e-06	9.64871327560033e-05	0	0	4.47944754499279	53.2068319711656	JUN;MAP2K2;IFNGR1;CD3G;FOS;PIK3R1;CD3E;CD3D;PPP3CA;IFNG;LCK;AKT3;MAPK1;PTPN6;MAP2K6
Platelet activation	18/124	7.75915157584031e-06	0.000102716387527791	0	0	3.75937355854767	44.2351861264414	VASP;ROCK1;F2R;PIK3R1;MYL12A;RHOA;MYL12B;PPP1CA;RAP1B;APBB1IP;VAMP8;AKT3;GNAS;MAPK1;LCP2;FYN;TLN1;PRKACB
Leukocyte transendothelial migration	17/114	9.56607984437597e-06	0.000120880463488024	0	0	3.877271637497	44.8107413476351	VASP;NCF1;ROCK1;MSN;CXCR4;CYBA;PIK3R1;MYL12A;RHOA;ICAM1;MYL12B;RAP1B;CDC42;PECAM1;PTK2B;RAC1;CD99
Th1 and Th2 cell differentiation	15/92	1.05439996253295e-05	0.000127444865036591	0	0	4.30424563835237	49.3264553662613	JUN;IFNGR1;CD3G;FOS;CD3E;CD3D;RUNX3;IL2;PPP3CA;IFNG;LCK;TBX21;STAT4;MAPK1;IL12RB2
Proteoglycans in cancer	24/205	1.19445435693619e-05	0.000138357629678442	0	0	2.94448582513456	33.3764416939799	CD63;DDX5;MAP2K2;TGFB1;ROCK1;RRAS2;MSN;FASLG;IQGAP1;PIK3R1;TNF;THBS1;RHOA;PPP1CA;CDC42;MYC;AKT3;PDCD4;MAPK1;PTPN6;RAC1;WNT1;PRKACB;EIF4B
TGF-beta signaling pathway	15/94	1.37871637679775e-05	0.00015331326109991	0	0	4.19483685277101	46.9476599842424	TGFB1;ROCK1;SMURF2;TNF;THBS1;SMAD5;RHOA;TGFBR1;RBX1;IFNG;MYC;ID2;MAPK1;NBL1;SKP1
Pathways in cancer	45/531	1.97951784617924e-05	0.000211656138937626	0	0	2.07409633190883	22.462612945405	PTGER4;HSP90AB1;ROCK1;GSTP1;MGST3;PTGER2;CXCR4;FASLG;PIK3R1;HSP90B1;CDC42;RASSF1;GNG2;MYC;AKT3;STAT4;MAPK1;RAC1;WNT1;PRKACB;APPL1;IL12RB2;SKP1;JUN;RALBP1;MAP2K2;TGFB1;GADD45B;IFNGR1;TPM3;DAPK2;F2R;FOS;RHOA;IL2;TGFBR1;RBX1;LPAR5;GSTA4;IFNG;MSH3;BCL2;GNAS;CALM1;CALM2
cAMP signaling pathway	24/216	2.85786927966642e-05	0.000294254688795283	0	0	2.77417936694021	29.0258201617166	JUN;MAP2K2;ROCK1;PTGER2;F2R;RRAS2;PIK3R1;FOS;ADRB2;ATP1A1;ATP1B1;RHOA;PPP1CA;RAP1B;FXYD2;CAMK4;AKT3;GNAS;PDE4A;MAPK1;RAC1;CALM1;PRKACB;CALM2
Chemokine signaling pathway	22/192	3.79920777968944e-05	0.000377207058126309	0	0	2.86870313037496	29.1980417087387	NCF1;CCL3L1;ROCK1;CCL4L2;CXCR4;PIK3R1;ARRB2;RHOA;RAP1B;CDC42;GNG2;CCL5;CXCR3;AKT3;CCL4;XCL2;CCL3;XCL1;MAPK1;PTK2B;RAC1;PRKACB
Kaposi sarcoma-associated herpesvirus infection	22/193	4.11439486163824e-05	0.000389861661474567	0	0	2.85177661502685	28.7984770693967	GABARAPL1;JUN;MAP2K2;IFNGR1;HLA-B;HLA-C;PIK3R1;FOS;ICAM1;TNFRSF1A;PPP3CA;ZFP36;GNG2;CLEC2B;UBB;MYC;AKT3;MAPK1;RAC1;CALM1;CALM2;MAP2K6
MAPK signaling pathway	29/294	4.20714023173993e-05	0.000389861661474567	0	0	2.43361516553934	24.5214527794631	FASLG;ARRB2;TNF;RAP1B;CDC42;PPP3CA;MYC;AKT3;MAPK1;MAP3K8;RAC1;PRKACB;MAP2K6;DAXX;JUN;MAP2K2;TGFB1;GADD45B;DUSP1;RRAS2;FOS;DUSP6;TGFBR1;TNFRSF1A;NR4A1;MAPKAPK3;MAP3K13;HSPA1B;HSPA1A
Toll-like receptor signaling pathway	15/104	4.70930298556583e-05	0.000422318138705581	0	0	3.72155165671681	37.0792540148942	JUN;MAP2K2;CCL3L1;CCL4L2;PIK3R1;FOS;TNF;CCL5;AKT3;CCL4;CCL3;MAPK1;MAP3K8;RAC1;MAP2K6
Apoptosis	18/142	5.04571815437987e-05	0.000438346764661751	0	0	3.21061624544669	31.7670747337248	DAXX;JUN;MAP2K2;GADD45B;BCL2A1;CTSW;FASLG;PIK3R1;FOS;TNF;TNFRSF1A;CTSO;TUBA1A;AKT3;CAPN2;BCL2;MAPK1;MCL1
Rap1 signaling pathway	23/210	5.2180567156575e-05	0.00043958174756145	0	0	2.72719758544252	26.8923510661786	VASP;MAP2K2;RGS14;F2R;PIK3R1;THBS1;RHOA;APBB1IP;RAP1B;GNAO1;CDC42;LPAR5;AKT3;GNAS;MAPK1;EVL;LCP2;RAC1;TLN1;CALM1;CALM2;SKAP1;MAP2K6
Neurotrophin signaling pathway	16/119	6.37509288163436e-05	0.000521257594439515	0	0	3.43154832380501	33.1505645625878	JUN;MAP2K2;MATK;FASLG;PIK3R1;RHOA;RAP1B;CDC42;ARHGDIA;CAMK4;AKT3;BCL2;MAPK1;RAC1;CALM1;CALM2
Th17 cell differentiation	15/107	6.58826699888681e-05	0.000523296635911581	0	0	3.5996292746898	34.6559172434645	JUN;TGFB1;HSP90AB1;IFNGR1;CD3G;FOS;CD3E;CD3D;IL2;TGFBR1;PPP3CA;IFNG;LCK;TBX21;MAPK1
Focal adhesion	22/201	7.60631543500469e-05	0.000587376580814251	0	0	2.7231729229965	25.8264265419444	VASP;JUN;ROCK1;ITGA1;PIK3R1;THBS1;MYL12A;RHOA;MYL12B;PPP1CA;RAP1B;CDC42;PARVG;AKT3;ZYX;CAPN2;BCL2;MAPK1;ITGB7;FYN;RAC1;TLN1
Epstein-Barr virus infection	22/202	8.19074136320176e-05	0.000615412459181105	0	0	2.7079012345679	25.481136830281	PDIA3;JUN;GADD45B;HLA-B;HLA-C;CD3G;PIK3R1;CD3E;RUNX3;CD3D;TNF;ICAM1;TAPBP;MYC;AKT3;BCL2;CALR;RAC1;CD58;VIM;B2M;MAP2K6
Shigellosis	25/246	8.63755579204762e-05	0.00063190539741822	0	0	2.50966583816625	23.4824559123149	ARF1;ROCK1;CALCOCO2;PIK3R1;TNF;MYL12A;MYL12B;CDC42;UBB;CCL5;AKT3;CAPN2;NLRP3;MAPK1;RAC1;SKP1;CAST;GABARAPL1;JUN;RHOA;RBX1;TNFRSF1A;BCL2;TLN1;ARF6
Hematopoietic cell lineage	14/99	0.000103871546176216	0.000740417688127897	0	0	3.63345375230046	33.3273297092909	ITGA1;CD8B2;CD3G;CD3E;TNF;CD3D;CD2;CD8B;CD8A;CD7;CD9;MS4A1;IL9R;CD55
Viral protein interaction with cytokine and cytokine receptor	14/100	0.00011599027841435	0.00080613243497973	0	0	3.59101565657927	32.5417988801063	CCL3L1;TNFSF14;CCL4L2;CXCR4;TNF;IL2;TNFRSF1A;IL18RAP;CCL5;CXCR3;CCL4;XCL2;CCL3;XCL1
C-type lectin receptor signaling pathway	14/104	0.000177548565351316	0.00120386588213819	0	0	3.43069396163255	29.6283869170034	EGR2;JUN;RRAS2;PIK3R1;LSP1;TNF;IL2;RHOA;PPP3CA;AKT3;NLRP3;MAPK1;CALM1;CALM2
Sphingolipid signaling pathway	15/119	0.000222156371512844	0.00147046360191835	0	0	3.18227958236659	26.7697465132521	CERS4;MAP2K2;ROCK1;PIK3R1;TNF;RHOA;TNFRSF1A;PPP2R2B;AKT3;BCL2;MAPK1;DEGS1;FYN;RAC1;S1PR5
Adherens junction	11/71	0.000249290925943622	0.00161169482354248	0	0	4.03566204772902	33.4834439509284	CDC42;FER;YES1;MAPK1;FYN;PTPN6;RAC1;IQGAP1;BAIAP2;RHOA;TGFBR1
Malaria	9/50	0.000285443298704259	0.00180348265999509	0	0	4.82572777340677	39.3850187075405	KLRK1;TGFB1;IFNG;KLRB1;KLRC4-KLRK1;PECAM1;TNF;THBS1;ICAM1
Estrogen signaling pathway	16/137	0.000337029079237043	0.00208209075617551	0	0	2.91830564114378	23.3328497435555	JUN;MAP2K2;HSP90AB1;PIK3R1;FOS;HSP90B1;GNAO1;AKT3;BCL2;GNAS;MAPK1;CALM1;PRKACB;CALM2;HSPA1B;HSPA1A
Graft-versus-host disease	8/42	0.000414424305243426	0.00250456427951462	0	0	5.16861842550599	40.2564059633185	IFNG;HLA-B;HLA-C;FASLG;KLRD1;KLRC1;TNF;IL2
Inflammatory bowel disease	10/65	0.00050024826590668	0.00295891527493738	0	0	3.99874174268638	30.3920609373393	JUN;IL18RAP;TGFB1;IFNG;IFNGR1;TBX21;STAT4;TNF;IL2;IL12RB2
Leishmaniasis	11/77	0.000512495608516686	0.00296820373265914	0	0	3.66762894534257	27.7867579577921	EEF1A1;JUN;TGFB1;NCF1;IFNG;IFNGR1;MAPK1;CYBA;PTPN6;FOS;TNF
Fc epsilon RI signaling pathway	10/68	0.000721918880937076	0.00409578467143892	0	0	3.79131368571769	27.4248382551967	MAP2K2;AKT3;ALOX5AP;MAPK1;LCP2;FYN;RAC1;PIK3R1;TNF;MAP2K6
Endocytosis	23/252	0.000757301422889957	0.00417869478913246	0	0	2.22207336653611	15.9672619224779	ARF1;RAB5C;SMURF2;HLA-B;HLA-C;CXCR4;VPS26A;ARRB2;RHOA;TGFBR1;SNX3;EHD1;CDC42;BIN1;DNAJC6;PSD4;MVB12B;VPS35;EPS15;HSPA1B;ARF6;RAB7A;HSPA1A
Hepatitis B	17/162	0.000778065977601315	0.00417869478913246	0	0	2.58721732157177	18.5211106562303	EGR2;JUN;MAP2K2;TGFB1;FASLG;PIK3R1;FOS;TNF;YWHAZ;TGFBR1;MYC;AKT3;BCL2;STAT4;MAPK1;PTK2B;MAP2K6
B cell receptor signaling pathway	11/81	0.000793493087705625	0.00417869478913246	0	0	3.45732431540746	24.6820655347922	PPP3CA;IFITM1;JUN;MAP2K2;AKT3;MAPK1;PTPN6;RAC1;FOS;PIK3R1;PIK3AP1
Amphetamine addiction	10/69	0.00081168891587465	0.00417869478913246	0	0	3.72685863976697	26.5217922257874	PPP3CA;JUN;CAMK4;GNAS;FOSB;FOS;CALM1;PRKACB;CALM2;PPP1CA
Renal cell carcinoma	10/69	0.00081168891587465	0.00417869478913246	0	0	3.72685863976697	26.5217922257874	CDC42;RAP1B;JUN;MAP2K2;TGFB1;AKT3;MAPK1;RAC1;PIK3R1;RBX1
Prion disease	24/273	0.000995215871303631	0.00503036385858926	0	0	2.13268548990805	14.7422969776286	EGR1;COX7B;NCF1;NDUFB10;HSPA5;NDUFB2;UQCR11;CYBA;PIK3R1;TNF;ATP5F1E;PPP3CA;COX7A2L;TUBA1A;TUBB2A;CCL5;MAPK1;FYN;NCAM1;RAC1;PRKACB;SLC25A4;HSPA1B;HSPA1A
Tight junction	17/169	0.00124742227863821	0.00609246659497481	0	0	2.4671588127295	16.4970917050818	VASP;JUN;ROCK1;MSN;YBX3;MYL12A;RHOA;MYL12B;RAP2C;CDC42;SLC9A3R1;TUBA1A;PPP2R2B;MYH9;RAC1;PRKACB;TJP3
Toxoplasmosis	13/112	0.00124917480544447	0.00609246659497481	0	0	2.89132061354284	19.3292650336634	TGFB1;IFNGR1;TNF;TNFRSF1A;GNAO1;SOCS1;IFNG;AKT3;BCL2;MAPK1;HSPA1B;MAP2K6;HSPA1A
AGE-RAGE signaling pathway in diabetic complications	12/100	0.0014207244680841	0.00680967934702378	0	0	3.00078822911193	19.6749331398496	CDC42;EGR1;JUN;TGFB1;AKT3;BCL2;MAPK1;PIK3R1;RAC1;TNF;TGFBR1;ICAM1
Dopaminergic synapse	14/132	0.00197977975962729	0.00932845378265063	0	0	2.61278158571793	16.2639635768818	ARRB2;FOS;ARNTL;PPP1CA;GNAO1;PPP3CA;GNG2;CALY;PPP2R2B;AKT3;GNAS;CALM1;PRKACB;CALM2
Phospholipase D signaling pathway	15/148	0.00218574125046004	0.0101272677937982	0	0	2.48460478342027	15.2201926354869	ARF1;DGKD;MAP2K2;F2R;RRAS2;PIK3R1;AGPAT2;RHOA;LPAR5;AKT3;GNAS;MAPK1;PTK2B;FYN;ARF6
Parathyroid hormone synthesis, secretion and action	12/106	0.00234519428771389	0.0106879346226961	0	0	2.80836305497479	17.0057252147285	NR4A2;SLC9A3R1;EGR1;MMP25;BCL2;GNAS;PDE4A;MAPK1;ARRB2;FOS;PRKACB;RHOA
Tuberculosis	17/180	0.00245861302961578	0.0109049650102154	0	0	2.29932943358539	13.8147342945162	HSPA9;RAB5C;TGFB1;IFNGR1;LSP1;TNF;RHOA;TNFRSF1A;PPP3CA;LAMP1;IFNG;AKT3;BCL2;MAPK1;CALM1;CALM2;RAB7A
GnRH signaling pathway	11/93	0.00248251373083477	0.0109049650102154	0	0	2.94951557483242	17.6926208950383	CDC42;EGR1;JUN;MAP2K2;GNAS;MAPK1;PTK2B;CALM1;PRKACB;CALM2;MAP2K6
Long-term potentiation	9/67	0.00251049554192009	0.0109049650102154	0	0	3.40825123152709	20.4061377953175	RAP1B;PPP3CA;MAP2K2;CAMK4;MAPK1;CALM1;PRKACB;CALM2;PPP1CA
Axon guidance	17/182	0.0027602584884706	0.0117458590659989	0	0	2.27121916842847	13.383002118637	ROBO3;SEMA7A;ROCK1;LIMK1;CXCR4;PIK3R1;L1CAM;MYL12A;RHOA;MYL12B;CDC42;PPP3CA;CFL1;MAPK1;FYN;RAC1;EPHA1
Protein export	5/23	0.00278858524588463	0.0117458590659989	0	0	6.08594546381244	35.7988755553315	SPCS3;HSPA5;SEC61G;SRPRA;SEC62
Phagosome	15/152	0.00283217397314477	0.0117514084258843	0	0	2.41155350822226	14.1478867072294	ATP6V0E1;RAB5C;NCF1;HLA-B;HLA-C;CYBA;THBS1;TUBA1A;TUBB2A;LAMP1;SEC61G;CANX;CALR;RAC1;RAB7A
HIF-1 signaling pathway	12/109	0.00296457612238169	0.0121198847356193	0	0	2.72107740897444	15.8394493311835	MAP2K2;PFKFB3;IFNG;IFNGR1;AKT3;PGK1;BCL2;MAPK1;PIK3R1;ENO2;ALDOA;RBX1
Non-alcoholic fatty liver disease	15/155	0.00341417503750862	0.0137405569490015	0	0	2.35950447464369	13.4015592550614	JUN;COX7B;TGFB1;NDUFB10;NDUFB2;FASLG;UQCR11;PIK3R1;FOS;TNF;TNFRSF1A;CDC42;COX7A2L;AKT3;RAC1
Fc gamma R-mediated phagocytosis	11/97	0.00345985246917303	0.0137405569490015	0	0	2.81173800956013	15.9327958988547	VASP;CDC42;NCF1;BIN1;AKT3;CFL1;LIMK1;MAPK1;PIK3R1;RAC1;ARF6
Inflammatory mediator regulation of TRP channels	11/98	0.00374688180072988	0.0146708893042663	0	0	2.77927318096148	15.5273304117353	PTGER4;PRKCH;PTGER2;GNAS;PIK3R1;CALM1;PRKACB;CALM2;ASIC1;MAP2K6;PPP1CA
VEGF signaling pathway	8/59	0.0040461806654353	0.0156227531248752	0	0	3.44267695570748	18.9690876734999	CDC42;PPP3CA;MAP2K2;MAPKAPK3;AKT3;MAPK1;RAC1;PIK3R1
Relaxin signaling pathway	13/129	0.00439342678558865	0.0167311321423787	0	0	2.46538753192848	13.3812502027311	JUN;MAP2K2;TGFB1;PIK3R1;ARRB2;FOS;TGFBR1;GNAO1;GNG2;AKT3;GNAS;MAPK1;PRKACB
FoxO signaling pathway	13/131	0.00500516106460405	0.0188031726481071	0	0	2.42334628060264	12.8371575644399	GABARAPL1;MAP2K2;TGFB1;GADD45B;PRMT1;SETD7;FASLG;PIK3R1;TGFBR1;RBL2;AKT3;MAPK1;SGK3
Cell adhesion molecules	14/148	0.00560885012691293	0.0207761189136549	0	0	2.29887065253109	11.9159880920642	HLA-B;CD8B2;HLA-C;L1CAM;ICAM1;SPN;CD2;CD8B;CD8A;PECAM1;ITGB7;NCAM1;CD58;CD99
Allograft rejection	6/38	0.0058043554852315	0.0207761189136549	0	0	4.10971584385763	21.1615297651405	IFNG;HLA-B;HLA-C;FASLG;TNF;IL2
Primary immunodeficiency	6/38	0.0058043554852315	0.0207761189136549	0	0	4.10971584385763	21.1615297651405	CD8B;CD8A;LCK;CD8B2;CD3E;CD3D
Pancreatic cancer	9/76	0.00590400501503143	0.0207761189136549	0	0	2.94903363367494	15.1348072975115	CDC42;RALBP1;TGFB1;GADD45B;AKT3;MAPK1;RAC1;PIK3R1;TGFBR1
Pertussis	9/76	0.00590400501503143	0.0207761189136549	0	0	2.94903363367494	15.1348072975115	JUN;CFL1;MAPK1;NLRP3;FOS;CALM1;TNF;CALM2;RHOA
Adrenergic signaling in cardiomyocytes	14/150	0.00630425042128659	0.0219072702139709	0	0	2.26482516529207	11.4748073693523	TPM3;ADRB2;ATP1A1;ATP1B1;PPP1CA;PPP2R2B;FXYD2;AKT3;BCL2;GNAS;MAPK1;CALM1;PRKACB;CALM2
cGMP-PKG signaling pathway	15/167	0.00680157886611894	0.0231527491597519	0	0	2.17185401147881	10.8388557320262	VASP;MAP2K2;ROCK1;ADRB2;ATP1A1;ATP1B1;RHOA;PPP1CA;PPP3CA;FXYD2;AKT3;MAPK1;CALM1;CALM2;SLC25A4
Ras signaling pathway	19/232	0.00682922816942321	0.0231527491597519	0	0	1.9659761209057	9.80342567830414	RALBP1;MAP2K2;RAB5C;RRAS2;FASLG;PIK3R1;RHOA;RAP1B;CDC42;RASSF1;GNG2;AKT3;REL;MAPK1;RAC1;CALM1;PRKACB;CALM2;ARF6
Rheumatoid arthritis	10/93	0.00754086980209678	0.0252573711443723	0	0	2.6458776281597	12.9315092716204	JUN;ATP6V0E1;TGFB1;IFNG;CCL3L1;CCL5;CCL3;FOS;TNF;ICAM1
Oxytocin signaling pathway	14/154	0.00790142688410264	0.0261499604021492	0	0	2.19965237543453	10.6478834682943	JUN;MAP2K2;ROCK1;FOS;RHOA;PPP1CA;GNAO1;PPP3CA;CAMK4;GNAS;MAPK1;CALM1;PRKACB;CALM2
Measles	13/139	0.00816745723322302	0.0265588839684621	0	0	2.26852770429159	10.9061684617379	JUN;MSN;CD3G;FASLG;PIK3R1;FOS;CD3E;CD3D;IL2;AKT3;BCL2;HSPA1B;HSPA1A
Diabetic cardiomyopathy	17/203	0.00821605763053144	0.0265588839684621	0	0	2.01255938984746	9.66363556394613	COX7B;TGFB1;NCF1;NDUFB10;GFPT2;NDUFB2;UQCR11;CYBA;PIK3R1;ATP5F1E;TGFBR1;PPP1CA;COX7A2L;MPC1;AKT3;RAC1;SLC25A4
Bladder cancer	6/41	0.00846186398010146	0.0267317975735023	0	0	3.7568640314909	17.9284531874271	RASSF1;MAP2K2;MYC;DAPK2;MAPK1;THBS1
Ferroptosis	6/41	0.00846186398010146	0.0267317975735023	0	0	3.7568640314909	17.9284531874271	PCBP1;PCBP2;ACSL6;SLC3A2;GCLM;FTL
Chemical carcinogenesis	19/239	0.00925718930799073	0.0289157149170947	0	0	1.90271773680865	8.90919954103101	JUN;MAP2K2;HSP90AB1;MGST3;GSTP1;PTGES3;PIK3R1;FOS;ADRB2;ARRB2;HSP90B1;GSTA4;MYC;AKT3;BCL2;GNAS;MAPK1;WNT1;PRKACB
Regulation of lipolysis in adipocytes	7/55	0.00987750725062014	0.03051052239636	0	0	3.1974377394636	14.7641530997235	AKT3;GNAS;ADRB2;PIK3R1;PRKACB;MGLL;PNPLA2
TNF signaling pathway	11/112	0.0101336836735973	0.0309578468270336	0	0	2.39226670934992	10.9850265052857	JUN;CCL5;AKT3;MAPK1;MAP3K8;PIK3R1;FOS;TNF;ICAM1;MAP2K6;TNFRSF1A
Renin secretion	8/69	0.0104176677141937	0.0314794741798463	0	0	2.87679450659322	13.130415355106	PTGER4;PPP3CA;PTGER2;GNAS;ADRB2;CALM1;PRKACB;CALM2
Lysosome	12/128	0.0105993653432262	0.0315202165295146	0	0	2.27311142116803	10.3357493283488	CD63;CTSO;GNPTAB;LAMP1;AP1G2;NEU1;LAPTM5;IDS;CTSW;AP3S1;AGA;LIPA
Type I diabetes mellitus	6/43	0.0106579149416344	0.0315202165295146	0	0	3.55341794147764	16.1376787080374	IFNG;HLA-B;HLA-C;FASLG;TNF;IL2
Cytokine-cytokine receptor interaction	22/295	0.0110126499134996	0.0322264913258198	0	0	1.77666388192704	8.01046340994387	TGFB1;TNFSF14;CCL3L1;IFNGR1;CCL4L2;CXCR4;FASLG;TNF;IL2;TGFBR1;TNFRSF1A;IL18RAP;IFNG;CXCR3;CCL5;CCL4;XCL2;CCL3;TNFSF9;XCL1;IL9R;IL12RB2
Oocyte meiosis	12/129	0.0112358727862128	0.0325372149434079	0	0	2.25356454720617	10.1154482888495	PPP3CA;SLK;CDC26;MAPK1;CALM1;PRKACB;CALM2;YWHAZ;SKP1;RBX1;ANAPC11;PPP1CA
JAK-STAT signaling pathway	14/162	0.0120484796968055	0.0345306943887829	0	0	2.07987535623689	9.19058815199661	CISH;IFNGR1;PIK3R1;IL2;SOCS1;IFNG;MYC;AKT3;BCL2;STAT4;PTPN6;IL9R;MCL1;IL12RB2
PI3K-Akt signaling pathway	25/354	0.0134270892375592	0.0380890898779741	0	0	1.6761919031922	7.22519339763809	HSP90AB1;FASLG;PIK3R1;THBS1;HSP90B1;GNG2;MYC;AKT3;MAPK1;ITGB7;RAC1;EIF4B;MCL1;MAP2K2;F2R;ITGA1;YWHAZ;IL2;RBL2;NR4A1;LPAR5;PPP2R2B;BCL2;SGK3;PIK3AP1
Viral myocarditis	7/60	0.0155903869116709	0.0437790662772172	0	0	2.89503361526784	12.0465266296415	HLA-B;HLA-C;FYN;RAC1;CD55;EIF4G2;ICAM1
NF-kappa B signaling pathway	10/104	0.0159037006983358	0.0442122879413735	0	0	2.33490392402268	9.66931218211305	GADD45B;TNFSF14;BCL2A1;LCK;CCL4L2;CCL4;BCL2;TNF;ICAM1;TNFRSF1A
Proximal tubule bicarbonate reclamation	4/23	0.0167103299866921	0.0451857860923124	0	0	4.60698137095316	18.8505155404034	FXYD2;ATP1A1;ATP1B1;SLC4A4
Glioma	8/75	0.0167414962860006	0.0451857860923124	0	0	2.61834670147536	10.7086840977	MAP2K2;GADD45B;CAMK4;AKT3;MAPK1;PIK3R1;CALM1;CALM2
Thyroid hormone synthesis	8/75	0.0167414962860006	0.0451857860923124	0	0	2.61834670147536	10.7086840977	HSPA5;FXYD2;CANX;GNAS;ATP1A1;ATP1B1;PRKACB;HSP90B1
Apelin signaling pathway	12/137	0.0174429311402081	0.045746555254508	0	0	2.10844855491329	8.53673037468282	EGR1;GABARAPL1;MAP2K2;GNG2;CAMK4;AKT3;RRAS2;MAPK1;CALM1;PRKACB;CALM2;TGFBR1
Autophagy	12/137	0.0174429311402081	0.045746555254508	0	0	2.10844855491329	8.53673037468282	VAMP8;GABARAPL1;MAP2K2;LAMP1;DAPK2;AKT3;BCL2;RRAS2;MAPK1;PIK3R1;PRKACB;RAB7A
Insulin signaling pathway	12/137	0.0174429311402081	0.045746555254508	0	0	2.10844855491329	8.53673037468282	MAP2K2;SOCS1;PRKAR1A;AKT3;FLOT1;FLOT2;MAPK1;PIK3R1;CALM1;PRKACB;CALM2;PPP1CA
Chronic myeloid leukemia	8/76	0.0180164970934007	0.0468092167473401	0	0	2.57970622080823	10.3613060293722	MAP2K2;TGFB1;GADD45B;MYC;AKT3;MAPK1;PIK3R1;TGFBR1
Influenza A	14/172	0.0194101908588085	0.0499632690624885	0	0	1.94721093623949	7.67582187567829	MAP2K2;CALCOCO2;IFNGR1;FASLG;PIK3R1;TNF;ICAM1;TNFRSF1A;IFNG;CCL5;AKT3;NLRP3;MAPK1;SLC25A4
Vibrio cholerae infection	6/50	0.0214907332607817	0.0546815055275494	0	0	2.98700553178165	11.4704998516181	ARF1;ATP6V0E1;KDELR1;SEC61G;GNAS;PRKACB
Aldosterone-regulated sodium reabsorption	5/37	0.02183326299841	0.0546815055275494	0	0	3.42083572247706	13.0823726816207	FXYD2;MAPK1;ATP1A1;PIK3R1;ATP1B1
Thyroid cancer	5/37	0.02183326299841	0.0546815055275494	0	0	3.42083572247706	13.0823726816207	MAP2K2;GADD45B;TPM3;MYC;MAPK1
Cholinergic synapse	10/113	0.0267431521359363	0.066380324051699	0	0	2.12987536533745	7.71329429345132	GNAO1;GNG2;CAMK4;AKT3;BCL2;MAPK1;FYN;PIK3R1;FOS;PRKACB
Acute myeloid leukemia	7/67	0.0270535149472668	0.0665564350030103	0	0	2.55634099616858	9.22823337099097	MAP2K2;BCL2A1;MYC;AKT3;MAPK1;PIK3R1;DUSP6
Aldosterone synthesis and secretion	9/98	0.0280582012144247	0.0684226310316672	0	0	2.21749598715891	7.92416494560482	NR4A2;NR4A1;CAMK4;GNAS;ATP1A1;ATP1B1;CALM1;PRKACB;CALM2
Mitophagy	7/68	0.0290601878232939	0.0702498453467452	0	0	2.51430186546071	8.89657091669336	GABARAPL1;JUN;UBB;CALCOCO2;CITED2;RRAS2;RAB7A
Gastric cancer	12/149	0.031153265263904	0.0746604115807354	0	0	1.92255179106367	6.66901727874874	MAP2K2;ABCB1;TGFB1;GADD45B;MYC;REG4;AKT3;BCL2;MAPK1;PIK3R1;WNT1;TGFBR1
Vascular smooth muscle contraction	11/133	0.0322039693569136	0.0765188331728374	0	0	1.97829667209329	6.79676574787908	MAP2K2;PRKCH;ROCK1;GNAS;MYH9;MAPK1;CALM1;PRKACB;CALM2;RHOA;PPP1CA
Prolactin signaling pathway	7/70	0.0333696258629222	0.0786165761855287	0	0	2.43422733077905	8.27663873755354	MAP2K2;SOCS1;CISH;AKT3;MAPK1;FOS;PIK3R1
Amoebiasis	9/102	0.0350797555726304	0.0810888098585677	0	0	2.12167385164263	7.10788551034655	RAB5C;TGFB1;IFNG;GNAS;PIK3R1;TNF;PRKACB;SERPINB6;RAB7A
Human papillomavirus infection	22/331	0.0352550180208002	0.0810888098585677	0	0	1.56667612937414	5.24076258811145	PTGER4;BCAP31;ATP6V0E1;MAP2K2;ITGA1;HLA-B;HLA-C;FASLG;PIK3R1;TNF;THBS1;TNFRSF1A;RBL2;CDC42;SLC9A3R1;PPP2R2B;AKT3;GNAS;MAPK1;ITGB7;WNT1;PRKACB
Pyrimidine metabolism	6/56	0.0352940503341248	0.0810888098585677	0	0	2.62773823191734	8.7872640563944	NT5E;PNP;NME7;NME2;CMPK1;DCK
Growth hormone synthesis, secretion and action	10/119	0.0364056000215934	0.0829570230000242	0	0	2.01199961905971	6.66582046881663	MAP2K2;SOCS1;IGFBP3;AKT3;GNAS;MAPK1;PIK3R1;FOS;PRKACB;MAP2K6
Glutathione metabolism	6/57	0.0380416245067952	0.0852868678458797	0	0	2.57607888161005	8.42139336193547	GSTA4;GSTP1;MGST3;ODC1;GCLM;PRDX6
Legionellosis	6/57	0.0380416245067952	0.0852868678458797	0	0	2.57607888161005	8.42139336193547	EEF1A1;ARF1;RAB1B;TNF;HSPA1B;HSPA1A
Thyroid hormone signaling pathway	10/121	0.0401039019577273	0.0891910779539855	0	0	1.97553955339422	6.35389160203358	MAP2K2;THRA;MYC;FXYD2;AKT3;MAPK1;PIK3R1;ATP1A1;ATP1B1;PRKACB
Endometrial cancer	6/58	0.0409218518168622	0.0902878952784738	0	0	2.5264064293915	8.07462506443822	MAP2K2;GADD45B;MYC;AKT3;MAPK1;PIK3R1
Vasopressin-regulated water reabsorption	5/44	0.042440673916399	0.0929016326673931	0	0	2.80581039755352	8.86537345255629	RAB5C;ARHGDIA;GNAS;STX4;PRKACB
Circadian rhythm	4/31	0.0451469621499155	0.0980535584193478	0	0	3.24059225319248	10.038811304085	CRY1;ARNTL;SKP1;RBX1
Cell cycle	10/124	0.0461218077214711	0.0993942833067361	0	0	1.92324814342662	5.91681403937049	RBL2;TGFB1;GADD45B;CDC26;MYC;BUB3;YWHAZ;SKP1;RBX1;ANAPC11
Necroptosis	12/159	0.0474386857679985	0.101445804950028	0	0	1.79082222484369	5.4589942397603	HSP90AB1;IFNG;IFNGR1;CAPN2;BCL2;STAT4;NLRP3;FASLG;TNF;SLC25A4;FTL;TNFRSF1A
Parkinson disease	17/249	0.0479347844363661	0.101724199032899	0	0	1.60959803528468	4.88982016345819	DAXX;COX7B;NDUFB10;HSPA5;DUSP1;NDUFB2;UQCR11;ATP5F1E;COX7A2L;TUBA1A;TUBB2A;UBB;GNAS;CALM1;PRKACB;CALM2;SLC25A4
Salivary secretion	8/93	0.0513929595263096	0.108236687487228	0	0	2.06192377986868	6.12031369306791	FXYD2;GNAS;ADRB2;ATP1A1;ATP1B1;CALM1;PRKACB;CALM2
Carbohydrate digestion and absorption	5/47	0.0539385871570049	0.112276778871259	0	0	2.60498580166011	7.60632188954721	FXYD2;AKT3;ATP1A1;PIK3R1;ATP1B1
IL-17 signaling pathway	8/94	0.0541190229091679	0.112276778871259	0	0	2.03784087563893	5.94350460487062	JUN;HSP90AB1;IFNG;MAPK1;FOSB;FOS;TNF;HSP90B1
NOD-like receptor signaling pathway	13/181	0.0557557736134381	0.114815593070636	0	0	1.69763420414462	4.90068681073174	GABARAPL1;JUN;HSP90AB1;CYBA;TNF;RHOA;PSTPIP1;NLRP6;CCL5;BCL2;TXNIP;NLRP3;MAPK1
Circadian entrainment	8/97	0.0628438759106355	0.127522609512092	0	0	1.96883929610427	5.44797873744158	GNAO1;GNG2;GNAS;MAPK1;FOS;CALM1;PRKACB;CALM2
Prostate cancer	8/97	0.0628438759106355	0.127522609512092	0	0	1.96883929610427	5.44797873744158	MAP2K2;HSP90AB1;GSTP1;AKT3;BCL2;MAPK1;PIK3R1;HSP90B1
Viral carcinogenesis	14/203	0.0636135037156723	0.128148942267804	0	0	1.62516630187546	4.47721860141878	EGR2;JUN;HLA-B;HLA-C;PIK3R1;YWHAZ;HDAC9;RHOA;RBL2;CDC42;REL;MAPK1;RAC1;PRKACB
Choline metabolism in cancer	8/98	0.0659359378869638	0.130929933804114	0	0	1.94686101521545	5.29365458596591	JUN;DGKD;MAP2K2;AKT3;MAPK1;PIK3R1;RAC1;FOS
mRNA surveillance pathway	8/98	0.0659359378869638	0.130929933804114	0	0	1.94686101521545	5.29365458596591	RBM8A;PPP2R2B;MAGOH;PAPOLA;SAP18;PABPC1;SRRM1;PPP1CA
Hepatocellular carcinoma	12/168	0.0664101980909303	0.130936418931054	0	0	1.68670520231214	4.57418367894455	MAP2K2;TGFB1;GADD45B;GSTA4;MYC;MGST3;GSTP1;AKT3;MAPK1;PIK3R1;WNT1;TGFBR1
Pathways of neurodegeneration	28/475	0.0697444817405125	0.136542013548327	0	0	1.37792850122397	3.66930919795668	COX7B;HIP1;NDUFB10;NDUFB2;DERL1;FASLG;UQCR11;TNF;PPP3CA;TUBA1A;UBB;CAPN2;MAPK1;RAC1;WNT1;MAP2K6;DAXX;GABARAPL1;MAP2K2;HSPA5;ATP5F1E;TNFRSF1A;COX7A2L;TUBB2A;BCL2;CALM1;SLC25A4;CALM2
Mucin type O-glycan biosynthesis	4/36	0.0713652087987838	0.138737958364069	0	0	2.73353379152348	7.21637831887861	GALNT11;GALNT6;GCNT1;ST3GAL1
Progesterone-mediated oocyte maturation	8/100	0.0723976345969869	0.139767655680294	0	0	1.90433781958273	4.99999443723304	STK10;HSP90AB1;CDC26;AKT3;MAPK1;PIK3R1;PRKACB;ANAPC11
Glycolysis / Gluconeogenesis	6/67	0.0729766859131511	0.139913921957628	0	0	2.15264158400934	5.63478745939011	GPI;TPI1;PGAM1;PGK1;ENO2;ALDOA
Melanogenesis	8/101	0.0757676043747474	0.144269822028629	0	0	1.88376207976045	4.86026526947031	GNAO1;MAP2K2;GNAS;MAPK1;WNT1;CALM1;PRKACB;CALM2
African trypanosomiasis	4/37	0.077369085851126	0.146317046711653	0	0	2.65056058870492	6.78322980298146	IFNG;FASLG;TNF;ICAM1
Pancreatic secretion	8/102	0.0792304019192198	0.148824673875291	0	0	1.86362412163651	4.7250236362048	RAP1B;FXYD2;GNAS;RAC1;ATP1A1;ATP1B1;SLC4A4;RHOA
Endocrine and other factor-regulated calcium reabsorption	5/53	0.0818160316886476	0.152650045700967	0	0	2.27864583333333	5.70409325427648	FXYD2;GNAS;ATP1A1;ATP1B1;PRKACB
Hepatitis C	11/157	0.0849854748020328	0.157506413299767	0	0	1.65100920623873	4.07019159176203	MAP2K2;IFNG;PPP2R2B;MYC;AKT3;MAPK1;FASLG;PIK3R1;TNF;YWHAZ;TNFRSF1A
Central carbon metabolism in cancer	6/70	0.0861363678886295	0.158582187238669	0	0	2.05141360505166	5.02970421936529	MAP2K2;MYC;PGAM1;AKT3;MAPK1;PIK3R1
Cardiac muscle contraction	7/87	0.0872039245535153	0.15949138832814	0	0	1.91524425287356	4.67224973666895	COX7B;COX7A2L;TPM3;FXYD2;UQCR11;ATP1A1;ATP1B1
Non-small cell lung cancer	6/72	0.0955860668915174	0.173679258796352	0	0	1.98904080993633	4.66972722701001	RASSF1;MAP2K2;GADD45B;AKT3;MAPK1;PIK3R1
Glucagon signaling pathway	8/107	0.0979321866461424	0.176010701751048	0	0	1.76903674256954	4.11032151332916	PPP3CA;PRMT1;PGAM1;AKT3;GNAS;CALM1;PRKACB;CALM2
Hedgehog signaling pathway	5/56	0.0981354632065193	0.176010701751048	0	0	2.1442705522576	4.97772354879482	SMURF2;KIF3A;BCL2;ARRB2;PRKACB
Bile secretion	7/90	0.100002651319027	0.177973802249532	0	0	1.84572773854037	4.24989624100667	ABCB1;FXYD2;GNAS;ATP1A1;ATP1B1;SLC4A4;PRKACB
p53 signaling pathway	6/73	0.100510384723656	0.177973802249532	0	0	1.95925081823946	4.50136744265644	GADD45B;IGFBP3;PERP;SHISA5;BCL2;THBS1
Hippo signaling pathway	11/163	0.103599535293076	0.182282726654905	0	0	1.5853363923666	3.59431023540693	WWTR1;MOB1A;RASSF1;TGFB1;PPP2R2B;MYC;ID2;WNT1;YWHAZ;TGFBR1;PPP1CA
Gastric acid secretion	6/76	0.116062568067594	0.202927005803717	0	0	1.8749876988683	4.03802198308181	GNAS;ATP1A1;ATP1B1;CALM1;PRKACB;CALM2
Mineral absorption	5/60	0.122221391853674	0.212359668345758	0	0	1.98790658882402	4.17842298573086	FXYD2;ATP1A1;ATP1B1;HMOX2;FTL
Dilated cardiomyopathy	7/96	0.128476346669689	0.221841145181203	0	0	1.72075422962676	3.53100568551005	TGFB1;TPM3;ITGA1;GNAS;ITGB7;TNF;PRKACB
Alzheimer disease	21/369	0.135038915967383	0.231733448388472	0	0	1.32356791814373	2.65003746201802	COX7B;MAP2K2;NDUFB10;NDUFB2;UQCR11;PIK3R1;TNF;ATP5F1E;RTN4;TNFRSF1A;PPP3CA;COX7A2L;TUBA1A;TUBB2A;AKT3;CAPN2;MAPK1;CALM1;WNT1;CALM2;SLC25A4
mTOR signaling pathway	10/154	0.139751685810007	0.238334246938609	0	0	1.52016852492631	2.99152155624502	MAP2K2;AKT3;MAPK1;SLC3A2;PIK3R1;WNT1;TNF;RHOA;EIF4B;TNFRSF1A
Type II diabetes mellitus	4/46	0.141673109158661	0.238334246938609	0	0	2.08160148366334	4.06793415266031	SOCS1;MAPK1;PIK3R1;TNF
Cytosolic DNA-sensing pathway	5/63	0.141912645305288	0.238334246938609	0	0	1.88478725086998	3.68012925499266	POLR3GL;CCL4L2;CCL5;CCL4;POLR2L
Thermogenesis	14/232	0.142314694215141	0.238334246938609	0	0	1.40681641808498	2.74289039307852	COX7B;NDUFB10;COX17;ACSL6;NDUFB2;UQCR11;ATP5F1E;COX7A2L;NDUFAF4;GNAS;PRKACB;MGLL;PNPLA2;COX20
GnRH secretion	5/64	0.148765159707763	0.247644996399749	0	0	1.85274451873737	3.53019407110583	MAP2K2;AKT3;MAPK1;ARRB2;PIK3R1
Intestinal immune network for IgA production	4/48	0.158170844242949	0.261735087497261	0	0	1.98677496615641	3.66377106061516	TGFB1;CXCR4;ITGB7;IL2
Longevity regulating pathway	7/102	0.160551057872651	0.264101740169213	0	0	1.61156684815487	2.94778665351342	CAMK4;AKT3;PIK3R1;PRKACB;HSPA1B;APPL1;HSPA1A
Cocaine addiction	4/49	0.166673909195783	0.272560863273104	0	0	1.94252259131984	3.48044883636221	JUN;GNAS;FOSB;PRKACB
ErbB signaling pathway	6/85	0.169236785609814	0.27513348771654	0	0	1.66059672426572	2.94997775569004	JUN;MAP2K2;MYC;AKT3;MAPK1;PIK3R1
Fructose and mannose metabolism	3/33	0.174718085682207	0.280760854448864	0	0	2.18455377574371	3.81113219679843	PFKFB3;TPI1;ALDOA
SNARE interactions in vesicular transport	3/33	0.174718085682207	0.280760854448864	0	0	2.18455377574371	3.81113219679843	VAMP8;STX4;STX3
Amyotrophic lateral sclerosis	20/364	0.178315833522073	0.284895412178944	0	0	1.27398171012998	2.19659793374374	DAXX;GABARAPL1;COX7B;NDUFB10;HSPA5;DERL1;NDUFB2;ANXA11;CHCHD10;UQCR11;TNF;ATP5F1E;TNFRSF1A;PPP3CA;COX7A2L;TUBA1A;TUBB2A;BCL2;RAC1;MAP2K6
Other glycan degradation	2/18	0.185534952789226	0.294735525002313	0	0	2.72957142857143	4.59799579883877	NEU1;AGA
Gap junction	6/88	0.18889775964722	0.298372597624587	0	0	1.59959116238694	2.66579763519742	TUBA1A;MAP2K2;TUBB2A;GNAS;MAPK1;PRKACB
Epithelial cell signaling in Helicobacter pylori infection	5/70	0.192595409573656	0.301220595251152	0	0	1.68119266055046	2.76919937840011	CDC42;JUN;ATP6V0E1;CCL5;RAC1
Alcoholism	11/186	0.194675345792097	0.301220595251152	0	0	1.37530847904982	2.25058505364678	GNAO1;GNG2;CAMK4;GNAS;MAPK1;FOSB;CALM1;PRKACB;CALM2;HDAC9;PPP1CA
RNA transport	11/186	0.194675345792097	0.301220595251152	0	0	1.37530847904982	2.25058505364678	CYFIP2;EIF4A2;EEF1A1;RBM8A;EIF1AX;MAGOH;SAP18;PABPC1;EIF4G2;EIF4B;SRRM1
Insulin resistance	7/108	0.195841599801499	0.301220595251152	0	0	1.51535222487766	2.47070468755586	GFPT2;AKT3;PIK3R1;SLC27A3;TNF;TNFRSF1A;PPP1CA
Nicotinate and nicotinamide metabolism	3/35	0.197078139956662	0.301220595251152	0	0	2.04780463386728	3.32595209285728	NT5E;PNP;NMRK1
Breast cancer	9/147	0.197201972430611	0.301220595251152	0	0	1.42644259667401	2.31586783383088	JUN;MAP2K2;GADD45B;MYC;AKT3;MAPK1;PIK3R1;FOS;WNT1
Autoimmune thyroid disease	4/53	0.202182278491699	0.307140291916352	0	0	1.78357528578442	2.85119780350744	HLA-B;HLA-C;FASLG;IL2
Purine metabolism	8/129	0.205739969117586	0.310846257688527	0	0	1.44571988321334	2.28588870716186	NT5E;PNP;GUK1;NME7;NME2;PDE4A;DCK;APRT
Melanoma	5/72	0.208122659380323	0.312746482744485	0	0	1.63083664247569	2.55980631036126	MAP2K2;GADD45B;AKT3;MAPK1;PIK3R1
Morphine addiction	6/91	0.209388097768951	0.312956404192304	0	0	1.54289187546431	2.41241300328752	GNAO1;GNG2;GNAS;PDE4A;ARRB2;PRKACB
Oxidative phosphorylation	8/133	0.229134798067557	0.340638897661929	0	0	1.39916225546605	2.06158836472436	COX7A2L;COX7B;ATP6V0E1;NDUFB10;COX17;NDUFB2;UQCR11;ATP5F1E
Various types of N-glycan biosynthesis	3/39	0.243580034508237	0.360187497836648	0	0	1.81988939740656	2.57024746099057	DAD1;MGAT4A;MGAT1
Long-term depression	4/60	0.268749183411943	0.395303031685292	0	0	1.56005563737523	2.04987681751564	GNAO1;MAP2K2;GNAS;MAPK1
Ubiquitin mediated proteolysis	8/140	0.272141680185722	0.398186247850687	0	0	1.32447606095477	1.72371614519003	SOCS1;UBB;SMURF2;CDC26;STUB1;SKP1;RBX1;ANAPC11
Glycerolipid metabolism	4/61	0.278581647143532	0.405474858146083	0	0	1.53260585599164	1.95873786436384	DGKD;AGPAT2;MGLL;PNPLA2
Peroxisome	5/82	0.290771167556068	0.419498324156278	0	0	1.41829500774455	1.75190449716703	ABCD2;PHYH;PRDX5;SCP2;ACSL6
Signaling pathways regulating pluripotency of stem cells	8/143	0.29123444806533	0.419498324156278	0	0	1.29483868218045	1.59734753521842	MAP2K2;MYC;ID2;AKT3;MAPK1;PIK3R1;WNT1;SMAD5
Lysine degradation	4/63	0.298406005042165	0.427612728874855	0	0	1.48049779641602	1.79036640969286	COLGALT2;SETD7;SMYD2;DLST
Riboflavin metabolism	1/8	0.301477099975569	0.429798122016452	0	0	3.1174168297456	3.73797362508468	BLVRB
Wnt signaling pathway	9/166	0.305285876233386	0.433007518331028	0	0	1.25256097918929	1.48617192161799	PPP3CA;JUN;MYC;RAC1;WNT1;PRKACB;RHOA;SKP1;RBX1
Insulin secretion	5/86	0.32538437297549	0.459171856280133	0	0	1.34797259032733	1.51343367730792	FXYD2;GNAS;ATP1A1;ATP1B1;PRKACB
Biosynthesis of unsaturated fatty acids	2/27	0.333057442350793	0.467200229058957	0	0	1.74610285714286	1.91973585664181	SCP2;SCD5
Transcriptional misregulation in cancer	10/192	0.334434696340764	0.467200229058957	0	0	1.20036249794035	1.31477342432567	DDX5;NR4A3;GADD45B;BCL2A1;MYC;IGFBP3;ID2;REL;ITGB7;DUSP6
Drug metabolism	6/108	0.336566920496064	0.467828019489529	0	0	1.28459512392787	1.3988704933957	GSTA4;NME7;MGST3;GSTP1;CMPK1;NME2
Nucleotide excision repair	3/47	0.340150221365761	0.468127532374661	0	0	1.48837632619097	1.6050173000232	RAD23A;MNAT1;RBX1
Other types of O-glycan biosynthesis	3/47	0.340150221365761	0.468127532374661	0	0	1.48837632619097	1.6050173000232	GALNT11;GALNT6;COLGALT2
Phototransduction	2/28	0.349249849773302	0.478283045502354	0	0	1.67885714285714	1.76610350564397	CALM1;CALM2
Amino sugar and nucleotide sugar metabolism	3/48	0.352282177584654	0.480070810630067	0	0	1.45522501906941	1.51826941774859	GPI;CYB5R3;GFPT2
Adipocytokine signaling pathway	4/69	0.358599204177287	0.486295506152613	0	0	1.34341351660939	1.37773764740785	AKT3;ACSL6;TNF;TNFRSF1A
Hypertrophic cardiomyopathy	5/90	0.360396803633243	0.486360735000201	0	0	1.28426875337291	1.31065999109581	TGFB1;TPM3;ITGA1;ITGB7;TNF
Sphingolipid metabolism	3/49	0.364387062116323	0.48937006409825	0	0	1.42351507312705	1.43709344083264	CERS4;NEU1;DEGS1
Serotonergic synapse	6/113	0.375897305961611	0.50034359404959	0	0	1.22424541562497	1.1978498217867	GNAO1;GNG2;DUSP1;GNAS;MAPK1;PRKACB
N-Glycan biosynthesis	3/50	0.376454200308965	0.50034359404959	0	0	1.39315448658649	1.36105465394216	DAD1;MGAT4A;MGAT1
Small cell lung cancer	5/92	0.377957391188539	0.50034359404959	0	0	1.25461351892861	1.22070609739557	GADD45B;MYC;AKT3;BCL2;PIK3R1
Pentose phosphate pathway	2/30	0.381207561681671	0.502254512547415	0	0	1.55877551020408	1.50330067080971	GPI;ALDOA
Glutamatergic synapse	6/114	0.383787781621186	0.503268883446649	0	0	1.21284602627886	1.16150083400923	GNAO1;PPP3CA;GNG2;GNAS;MAPK1;PRKACB
RNA polymerase	2/31	0.396936401759372	0.518067228587349	0	0	1.50494581280788	1.39053864051348	POLR3GL;POLR2L
Glycosaminoglycan biosynthesis	3/53	0.412330382399152	0.535644141621328	0	0	1.30935926773455	1.16000111689933	CHST12;DSE;ST3GAL1
Bacterial invasion of epithelial cells	4/77	0.438467088649032	0.566948142532237	0	0	1.19568799133832	0.985809505212135	CDC42;RAC1;PIK3R1;RHOA
Non-homologous end-joining	1/13	0.441836869720105	0.568660415658283	0	0	1.81801750380518	1.48498312755578	XRCC6
Neutrophil extracellular trap formation	9/189	0.448582324006297	0.574681502644012	0	0	1.0911866359447	0.874764017868912	MAP2K2;NCF1;AKT3;MAPK1;CYBA;PIK3R1;RAC1;SLC25A4;HDAC9
Starch and sucrose metabolism	2/36	0.472509785426533	0.598786248926062	0	0	1.28329411764706	0.96208152216016	GPI;GYG1
Protein digestion and absorption	5/103	0.473458571160668	0.598786248926062	0	0	1.11314594645198	0.832289055677154	COL18A1;FXYD2;SLC3A2;ATP1A1;ATP1B1
Retrograde endocannabinoid signaling	7/148	0.47385962145228	0.598786248926062	0	0	1.08318252221407	0.808968539222508	GNAO1;GNG2;NDUFB10;NDUFB2;MAPK1;PRKACB;MGLL
Calcium signaling pathway	11/240	0.484037275664692	0.608879468935676	0	0	1.04800467944774	0.760425236022098	PPP3CA;CAMK4;F2R;GNAS;CXCR4;PTK2B;ADRB2;CALM1;PRKACB;CALM2;SLC25A4
Spliceosome	7/150	0.487986634699284	0.611082362371175	0	0	1.06792058516196	0.766198057645232	DDX5;RBM8A;PCBP1;MAGOH;WBP11;HSPA1B;HSPA1A
MicroRNAs in cancer	14/310	0.493834267240452	0.61563195647016	0	0	1.03182643825749	0.728010621995192	ABCB1;MAP2K2;ROCK1;PIK3R1;THBS1;RHOA;RASSF1;SOCS1;MYC;BCL2;PDCD4;MAPK1;VIM;MCL1
Complement and coagulation cascades	4/85	0.515215502518878	0.63941923973325	0	0	1.07714281673808	0.71432881723518	F8;F2R;CLU;CD55
Cushing syndrome	7/155	0.522780884865651	0.645924826634004	0	0	1.03157036346692	0.669069173257141	RAP1B;NR4A1;MAP2K2;GNAS;MAPK1;WNT1;PRKACB
Phenylalanine metabolism	1/17	0.533547274451297	0.653419129063703	0	0	1.36322773972603	0.856390026982747	MIF
Primary bile acid biosynthesis	1/17	0.533547274451297	0.653419129063703	0	0	1.36322773972603	0.856390026982747	SCP2
Cortisol synthesis and secretion	3/65	0.547235283748104	0.667243021412162	0	0	1.05527053960286	0.636197740051883	NR4A1;GNAS;PRKACB
GABAergic synapse	4/89	0.551728386199418	0.669639842967974	0	0	1.02623812411563	0.610303204662973	GNAO1;GABARAPL1;GNG2;PRKACB
Fatty acid biosynthesis	1/18	0.554018575117389	0.669639842967974	0	0	1.28297072253559	0.75766742271905	ACSL6
Porphyrin and chlorophyll metabolism	2/43	0.568077564939707	0.683660446117916	0	0	1.06380487804878	0.601578798594762	BLVRB;HMOX2
Glycosaminoglycan degradation	1/19	0.573592424312559	0.68732195671936	0	0	1.21163115169964	0.673468451587262	IDS
Steroid biosynthesis	1/20	0.592308122712916	0.701487055201148	0	0	1.14780100937275	0.601135873608389	LIPA
ABC transporters	2/45	0.592983661770755	0.701487055201148	0	0	1.01421926910299	0.530019257731278	ABCD2;ABCB1
Basal transcription factors	2/45	0.592983661770755	0.701487055201148	0	0	1.01421926910299	0.530019257731278	TAF7;MNAT1
Proteasome	2/46	0.605028255331551	0.712702775348183	0	0	0.991116883116883	0.498016529385843	IFNG;PSME1
AMPK signaling pathway	5/120	0.609533095833606	0.712758420638364	0	0	0.947746310331073	0.469193213797794	PFKFB3;PPP2R2B;AKT3;SCD5;PIK3R1
Pantothenate and CoA biosynthesis	1/21	0.610203252201189	0.712758420638364	0	0	1.09035388127854	0.538594667233033	VNN2
Phosphatidylinositol signaling system	4/97	0.620096293682951	0.721283554995232	0	0	0.937565433741024	0.448044238831602	DGKD;PIK3R1;CALM1;CALM2
PPAR signaling pathway	3/74	0.635583515232109	0.736217571810526	0	0	0.921068746575563	0.417439206519277	SCP2;SCD5;ACSL6
Mismatch repair	1/23	0.643673982365368	0.739427136766827	0	0	0.99112702366127	0.436653815261345	MSH3
Renin-angiotensin system	1/23	0.643673982365368	0.739427136766827	0	0	0.99112702366127	0.436653815261345	ATP6AP2
Arginine and proline metabolism	2/50	0.650493339402924	0.741135853909889	0	0	0.908333333333333	0.39060533341929	ODC1;AZIN2
Cysteine and methionine metabolism	2/50	0.650493339402924	0.741135853909889	0	0	0.908333333333333	0.39060533341929	MAT2B;GCLM
Metabolism of xenobiotics by cytochrome P450	3/76	0.653498168985489	0.741520371338636	0	0	0.895739945456255	0.38106169956493	GSTA4;GSTP1;MGST3
Ovarian steroidogenesis	2/51	0.66118801892734	0.747196216511384	0	0	0.889749271137026	0.368104428919308	GNAS;PRKACB
RNA degradation	3/79	0.679170152415729	0.764410131058999	0	0	0.86024629651933	0.332815175616783	HSPA9;PABPC1;ENO2
Collecting duct acid secretion	1/27	0.702248296736924	0.787197687471229	0	0	0.838470319634703	0.296372626863527	ATP6V0E1
Citrate cycle (TCA cycle)	1/30	0.739775090534426	0.825933635215142	0	0	0.751613919067863	0.226543252864485	DLST
ECM-receptor interaction	3/88	0.747630130765932	0.831364705411717	0	0	0.768797953964194	0.223602502319267	ITGA1;ITGB7;THBS1
Asthma	1/31	0.75120303130014	0.832009731878243	0	0	0.726522070015221	0.207842936717466	TNF
Herpes simplex virus 1 infection	19/498	0.765809920228585	0.844822054855344	0	0	0.861925826435221	0.229980157403413	PDIA3;DAXX;TNFSF14;IFNGR1;HLA-B;HLA-C;FASLG;PIK3R1;TNF;TNFRSF1A;PPP1CA;TAPBP;IFNG;CCL5;AKT3;BCL2;ZNF699;CALR;B2M
Basal cell carcinoma	2/63	0.769799284201602	0.845866407146425	0	0	0.714266978922717	0.186870432625282	GADD45B;WNT1
Huntington disease	11/306	0.79045528114875	0.86514396913131	0	0	0.810694014952832	0.190631612333288	COX7A2L;COX7B;HIP1;TUBA1A;TUBB2A;NDUFB10;NDUFB2;UQCR11;SLC25A4;ATP5F1E;POLR2L
Tyrosine metabolism	1/36	0.801248094650066	0.873517530638111	0	0	0.622570123939987	0.137951982218005	MIF
Glycerophospholipid metabolism	3/98	0.809434437500475	0.87616406790805	0	0	0.687510538359629	0.145353134606089	DGKD;LPCAT4;AGPAT2
Alanine, aspartate and glutamate metabolism	1/37	0.809979012418593	0.87616406790805	0	0	0.605244799594115	0.127553490824551	GFPT2
Glycine, serine and threonine metabolism	1/40	0.83393946144433	0.898585931323736	0	0	0.558599695585997	0.101438614240066	PGAM1
Tryptophan metabolism	1/42	0.848211776535564	0.909397834580246	0	0	0.531295244459294	0.0874644466196092	DLST
Fat digestion and absorption	1/43	0.854881622521785	0.909397834580246	0	0	0.518618177864753	0.081315322834115	AGPAT2
Fatty acid degradation	1/43	0.854881622521785	0.909397834580246	0	0	0.518618177864753	0.081315322834115	ACSL6
Arrhythmogenic right ventricular cardiomyopathy	2/77	0.857058390863397	0.909397834580246	0	0	0.580510476190476	0.0895432931905673	ITGA1;ITGB7
Synaptic vesicle cycle	2/78	0.861960627818192	0.911121880355351	0	0	0.572842105263158	0.0850932227779563	ATP6V0E1;STX3
Glycosphingolipid biosynthesis	1/45	0.867355842725449	0.913351985900284	0	0	0.494992735574927	0.0704404146977444	ST3GAL1
Pyruvate metabolism	1/47	0.878758893371564	0.921867820216207	0	0	0.473421679571173	0.0611872502539735	GLO1
Ether lipid metabolism	1/49	0.889182660250043	0.92929616371997	0	0	0.453648211567732	0.0532821607888787	LPCAT4
Cholesterol metabolism	1/50	0.894053854853156	0.930887534266582	0	0	0.444366787811015	0.0497643100884916	LIPA
Arachidonic acid metabolism	1/61	0.935394069764744	0.970296833561936	0	0	0.362690258751903	0.0242231297745662	PTGES3
Systemic lupus erythematosus	3/135	0.939002716518985	0.97041916428356	0	0	0.493837112544206	0.0310805803199559	SSB;IFNG;TNF
Retinol metabolism	1/68	0.95284669062813	0.974430499088879	0	0	0.324677979963198	0.0156823550536584	DHRS3
Spinocerebellar ataxia	3/143	0.953086115506805	0.974430499088879	0	0	0.465421706440013	0.0223635208432649	AKT3;PIK3R1;SLC25A4
Ribosome biogenesis in eukaryotes	2/108	0.953460736137436	0.974430499088879	0	0	0.410070080862534	0.0195427235647262	IMP3;EFL1
RIG-I-like receptor signaling pathway	1/70	0.956904770688	0.974430499088879	0	0	0.315233935543644	0.0138864963910469	TNF
Inositol phosphate metabolism	1/73	0.962347173009665	0.976294088964815	0	0	0.30205162354135	0.0115927433400778	TPI1
Neuroactive ligand-receptor interaction	9/341	0.965758541242173	0.976294088964815	0	0	0.586860113264116	0.0204470475046896	PTGER4;THRA;GPR35;PTGER2;F2R;NMUR1;ADRB2;S1PR5;PTGDR
Taste transduction	1/86	0.9790284625787	0.986122871727821	0	0	0.255680902497985	0.00541904519024514	PRKACB
Staphylococcus aureus infection	1/95	0.98601767344457	0.989577304034623	0	0	0.231091518507724	0.00325399970773406	ICAM1
Olfactory transduction	4/440	0.999992220147496	0.999992220147496	0	0	0.196380718181532	1.527818965214e-06	ARRB2;CALM1;PRKACB;CALM2