Term Overlap P.value Adjusted.P.value Old.P.value Old.Adjusted.P.value Odds.Ratio Combined.Score Genes Allograft Rejection 40/200 5.10134009894404e-16 2.55067004947202e-14 0 0 5.66397849462366 199.439207703578 GPR65;GCNT1;CD3G;CAPG;FASLG;CD3E;CD3D;TNF;HDAC9;ICAM1;IL18RAP;SOCS1;RPS19;SIT1;CXCR3;CCL5;CCL4;STAT4;NLRP3;B2M;RPL39;TPD52;EIF5A;CD96;TGFB1;IFNGR1;F2R;CRTAM;IL2;TAPBP;CD2;CD8B;IFNG;CD8A;LCK;CD7;KLRD1;DEGS1;LCP2;PTPN6 TNF-alpha Signaling via NF-kB 34/200 1.01977766782442e-11 2.54944416956105e-10 0 0 4.60588260515371 116.569598383381 PTGER4;PPP1R15A;PFKFB3;BCL2A1;TNF;ICAM1;ZFP36;MYC;CCL5;CCL4;SLC16A6;MAP3K8;MCL1;EGR1;JUN;EGR2;GADD45B;DUSP1;GFPT2;FOS;PNRC1;FOSL2;EHD1;NR4A2;NR4A1;KLF6;TUBB2A;NR4A3;ID2;REL;TNFSF9;FOSB;CD69;ATF3 Hypoxia 30/200 3.71358420162044e-09 6.18930700270073e-08 0 0 3.94881588999236 76.6515248446242 PPP1R15A;GPI;PFKFB3;CITED2;CXCR4;ENO2;PRDX5;ZFP36;FAM162A;PGK1;IDS;TPD52;JUN;TPI1;ANXA2;HSPA5;DUSP1;IGFBP3;MIF;FOS;PNRC1;JMJD6;FOSL2;TPST2;KLF6;BCL2;MYH9;S100A4;ALDOA;ATF3 IL-2/STAT5 Signaling 29/199 1.31488313417638e-08 1.64360391772048e-07 0 0 3.81268729189789 69.1885806591927 RNH1;ABCB1;PTGER2;GPR65;ODC1;CAPG;ITGAE;CST7;NT5E;PNP;SOCS1;GLIPR2;MYC;MAP3K8;EOMES;GABARAPL1;PRKCH;GADD45B;CISH;IFNGR1;DHRS3;HOPX;SERPINB6;TWSG1;ARL4A;KLF6;BCL2;CD48;CDC42SE2 Interferon Gamma Response 24/200 7.83533333357699e-06 6.52944444464749e-05 0 0 3.02893530853672 35.6107899947608 IFITM2;AUTS2;HLA-B;LYSMD2;SRI;ICAM1;TAPBP;VAMP8;ARL4A;PNP;KLRK1;SOCS1;CCL5;PSME1;STAT4;TXNIP;SLAMF7;XCL1;ITGB7;LCP2;PTPN6;CD69;B2M;GPR18 Myc Targets V1 24/200 7.83533333357699e-06 6.52944444464749e-05 0 0 3.02893530853672 35.6107899947608 CCT2;XRCC6;SET;HSP90AB1;SSB;EIF1AX;PTGES3;RPS5;GLO1;CNBP;ODC1;PA2G4;HSPE1;MYC;PCBP1;CANX;RPS3;PGK1;AP3S1;PABPC1;RPS2;BUB3;EIF4G2;CCT4 Inflammatory Response 23/200 2.40800651314183e-05 0.000172000465224417 0 0 2.88279813175618 30.6560392365855 PTGER4;IFITM1;PTGER2;ICAM4;EMP3;SRI;SLC4A4;ICAM1;TAPBP;GPR132;KLF6;IL18RAP;SELENOS;LCK;MYC;CCL5;TNFSF9;NLRP3;CD48;NMUR1;LCP2;CD69;CD55 p53 Pathway 22/200 7.05932816257661e-05 0.000441208010161038 0 0 2.73861620342992 26.1772699626364 CYFIP2;PPP1R15A;JUN;TGFB1;F2R;SLC3A2;FOS;BAIAP2;PITPNC1;ZFP36L1;VAMP8;SOCS1;MAPKAPK3;FAM162A;PERP;TXNIP;TNFSF9;STOM;S100A4;ATF3;RPS12;S100A10 Apoptosis 19/161 8.45583864948228e-05 0.000469768813860126 0 0 2.96003644243081 27.7594239210084 BCAP31;JUN;ANXA1;GADD45B;ROCK1;IFNGR1;F2R;FASLG;ENO2;TNF;CLU;CD2;DNAJA1;FEZ1;PDCD4;TXNIP;CD69;ATF3;MCL1 PI3K/AKT/mTOR Signaling 14/105 0.000196748179963009 0.000983740899815044 0 0 3.3928157589803 28.9528847941114 ARF1;CXCR4;FASLG;HSP90B1;TNFRSF1A;PPP1CA;LCK;ARHGDIA;CAMK4;CFL1;MAPK1;CALR;RAC1;MAP2K6 TGF-beta Signaling 9/54 0.000518093711908486 0.00235497141776584 0 0 4.39585253456221 33.2561824066208 PPP1R15A;WWTR1;TGFB1;SMURF2;ID2;THBS1;TGFBR1;RHOA;PPP1CA Adipogenesis 19/200 0.00131943909878092 0.00471228249564615 0 0 2.31746706332342 15.3660778945981 COX7B;PHYH;RNF11;PFKFB3;IFNGR1;MGST3;CHCHD10;UQCR11;GHITM;DHRS7;ARL4A;SCP2;REEP5;CMPK1;G3BP2;PDCD4;STOM;ALDOA;MGLL Complement 19/200 0.00131943909878092 0.00471228249564615 0 0 2.31746706332342 15.3660778945981 USP14;HSPA5;LIPA;CLU;DUSP6;EHD1;DOCK10;CTSO;F8;GNG2;LCK;CCL5;FDX1;STX4;LCP2;FYN;CALM1;CD55;HSPA1A mTORC1 Signaling 19/200 0.00131943909878092 0.00471228249564615 0 0 2.31746706332342 15.3660778945981 HSPA9;PPP1R15A;GPI;FKBP2;TPI1;SDF2L1;HSPA5;CXCR4;HSPE1;SYTL2;HSP90B1;SLC9A3R1;PNP;CANX;PGK1;CD9;CALR;ALDOA;SKAP2 Coagulation 14/138 0.00299522972816349 0.00998409909387829 0 0 2.48557171158375 14.442996915094 ANXA1;USP11;HTRA1;CLU;THBS1;DUSP6;CTSO;F8;BMP1;CAPN2;PECAM1;CD9;FYN;RAC1 Unfolded Protein Response 12/113 0.00399002536800157 0.0124688292750049 0 0 2.61276254793109 14.4327897693247 EIF4A2;HSPA9;SPCS3;TUBB2A;HSPA5;IMP3;SRPRA;CALR;YWHAZ;ATF3;HSP90B1;HERPUD1 Apical Junction 17/200 0.00712177688158862 0.0197827135599684 0 0 2.04587622315415 10.1160355276413 VASP;CAP1;MSN;ICAM4;BAIAP2;SORBS3;ICAM1;MYL12B;BMP1;AKT3;ZYX;PECAM1;MYH9;STX4;EVL;CD99;SKAP2 Oxidative Phosphorylation 17/200 0.00712177688158862 0.0197827135599684 0 0 2.04587622315415 10.1160355276413 HSPA9;GPI;COX7B;PHYH;ATP6V0E1;MGST3;COX17;NDUFB2;DLST;UQCR11;ATP1B1;ATP5F1E;COX7A2L;CYB5R3;MPC1;FDX1;SLC25A4 UV Response Up 14/158 0.00980376528890684 0.0257993823392285 0 0 2.13810029612463 9.88868982437824 ABCB1;RAB27A;ARRB2;FOS;ENO2;ICAM1;DNAJA1;NR4A1;BSG;FOSB;MGAT1;ALDOA;SLC25A4;ATF3 IL-6/JAK/STAT3 Signaling 9/87 0.0139210410123429 0.0345228954010844 0 0 2.53168202764977 10.8213048003481 JUN;SOCS1;TGFB1;IFNGR1;CD9;MAP3K8;TNF;IL9R;TNFRSF1A DNA Repair 13/150 0.0148661924501296 0.0345228954010844 0 0 2.08517504731008 8.77580450641026 BCAP31;ELL;POLR3GL;USP11;COX17;SMAD5;RBX1;APRT;PNP;GUK1;DAD1;TMED2;STX3 Epithelial Mesenchymal Transition 16/200 0.0151900739764771 0.0345228954010844 0 0 1.91274049386457 8.00886076404957 JUN;TGFB1;GADD45B;IGFBP3;HTRA1;CAPG;EMP3;ENO2;THBS1;NT5E;LGALS1;BMP1;ID2;VIM;PPIB;SNTB1 Pperoxisome 10/104 0.0159037006983358 0.0345732623876865 0 0 2.33490392402268 9.66931218211305 PRDX5;ABCD2;ABCB1;SCP2;CNBP;ITGB1BP1;PABPC1;HSD17B11;SLC25A4;DHRS3 Reactive Oxygen Species Pathway 6/49 0.0196159006563867 0.0408664597008057 0 0 3.05663097749179 12.0168842131002 SELENOS;LSP1;GCLM;PRDX6;HMOX2;FTL Fatty Acid Metabolism 13/158 0.0219203045122129 0.0438406090244258 0 0 1.96930076628352 7.52340228040361 GABARAPL1;ODC1;DLST;MIF;ENO2;HSD17B11;PRDX6;LGALS1;PSME1;SERINC1;ALDOA;MGLL;S100A10 Mitotic Spindle 15/199 0.0293715951061761 0.0564838367426464 0 0 1.79111394128922 6.31856141289461 SUN2;RALBP1;ROCK1;MID1IP1;TBCD;CDC42;PCM1;NIN;BIN1;ARHGDIA;ARHGEF3;MYH9;MAPRE1;ARHGEF7;ARF6 Estrogen Response Late 15/200 0.0305214491121758 0.0565212020595849 0 0 1.78133818273029 6.21566891070582 CISH;DYNLT3;LSR;FOS;SLC9A3R1;ZFP36;ID2;PERP;BCL2;PDCD4;BLVRB;CD9;PTPN6;NBL1;TJP3 Myogenesis 14/200 0.0576535649055106 0.0994026981129494 0 0 1.65164031448186 4.71263058983017 EIF4A2;WWTR1;TGFB1;GADD45B;TPM3;DAPK2;IGFBP3;LSP1;SORBS3;CLU;GNAO1;BIN1;MYH9;NCAM1 KRAS Signaling Up 14/200 0.0576535649055106 0.0994026981129494 0 0 1.65164031448186 4.71263058983017 PPP1R15A;SPON1;ABCB1;IGFBP3;GFPT2;LAPTM5;CXCR4;HDAC9;DUSP6;NIN;ID2;PECAM1;ADAM8;LCP1 Protein Secretion 8/96 0.0598439716221463 0.0997399527035772 0 0 1.99131708337692 5.60757793387484 TPD52;CD63;ARF1;GNAS;TMED2;MAPK1;AP3S1;ATP1A1 Androgen Response 8/100 0.0723976345969869 0.116770378382237 0 0 1.90433781958273 4.99999443723304 TPD52;SPCS3;XRCC6;TMEM50A;PTK2B;PA2G4;B2M;MYL12A Glycolysis 13/200 0.102174903840808 0.15481046036486 0 0 1.52361853832442 3.47547930608225 TPI1;HSPA5;CITED2;PGAM1;IGFBP3;CXCR4;MIF;ENO2;NT5E;CHST12;FAM162A;PGK1;ALDOA heme Metabolism 13/200 0.102174903840808 0.15481046036486 0 0 1.52361853832442 3.47547930608225 CAST;MGST3;SLC10A3;ACSL6;ICAM4;RAD23A;NUDT4;ARL2BP;BSG;BLVRB;YPEL5;GCLM;TMEM9B Estrogen Response Early 12/200 0.169569698754035 0.249367204050051 0 0 1.39724511130242 2.47939920258455 SLC9A3R1;CISH;MYC;DYNLT3;BCL2;BLVRB;FOS;NBL1;RETREG1;MYBL1;DHRS3;TJP3 UV Response Dn 9/144 0.181806342801119 0.259723346858741 0 0 1.45837173579109 2.48625139873937 ANXA2;CITED2;DUSP1;MYC;AKT3;GCNT1;FYN;SRI;MGLL Bile Acid Metabolism 7/112 0.220921504301082 0.306835422640392 0 0 1.45731800766284 2.20047415558881 PHYH;PRDX5;ABCD2;SCP2;LCK;GCLM;HSD17B11 Myc Targets V2 4/58 0.249284353243845 0.332216430939106 0 0 1.61800517585168 2.24766977414108 MYC;NDUFAF4;PA2G4;HSPE1 Interferon Alpha Response 6/97 0.252484487513721 0.332216430939106 0 0 1.44070854518616 1.98299911901856 IFITM1;IFITM2;PSME1;HLA-C;TXNIP;B2M Apical Surface 3/44 0.303706798734652 0.389367690685452 0 0 1.5975330691522 1.90376821028805 SCUBE1;CD160;FLOT2 Xenobiotic Metabolism 10/200 0.381422627565968 0.47677828445746 0 0 1.14933527590603 1.10778365641712 CYFIP2;GABARAPL1;DHRS7;ABCD2;SERTAD1;DDAH2;ID2;PTGES3;BLVRB;TNFRSF1A Cholesterol Homeostasis 4/74 0.40874155545867 0.49104447366142 0 0 1.24712812960236 1.11577088786161 CD9;CLU;ATF3;PNRC1 Notch Signaling 2/32 0.412477357875593 0.49104447366142 0 0 1.45470476190476 1.28824866348612 SKP1;RBX1 Hedgehog Signaling 2/36 0.472509785426533 0.549429983054109 0 0 1.28329411764706 0.96208152216016 MYH9;L1CAM Wnt-beta Catenin Signaling 2/42 0.555217414328489 0.630928879918737 0 0 1.09045714285714 0.641620080615467 MYC;WNT1 Angiogenesis 1/36 0.801248094650066 0.890275660722295 0 0 0.622570123939987 0.137951982218005 S100A4 Pancreas Beta Cells 1/40 0.83393946144433 0.906455936352533 0 0 0.558599695585997 0.101438614240066 AKT3 G2-M Checkpoint 6/200 0.876478063226844 0.912997982527962 0 0 0.672138908944571 0.0886172152212496 TGFB1;MYC;NCL;ODC1;BUB3;MNAT1 E2F Targets 6/200 0.876478063226844 0.912997982527962 0 0 0.672138908944571 0.0886172152212496 XRCC6;MYC;PA2G4;LYAR;DCK;ASF1A Spermatogenesis 3/135 0.939002716518985 0.95816603726427 0 0 0.493837112544206 0.0310805803199559 ARL4A;CAMK4;IL12RB2 KRAS Signaling Dn 4/200 0.977701919940317 0.977701919940317 0 0 0.442457395329266 0.00997760927374999 NR4A2;IFNG;CLSTN3;SLC16A7