c1

Diagnosis: Colitis

Markers

Showing top 100 markers ordered by p_val_adj ascendingly, then abs(avg_log2FC) descendingly. Use 'Download the entire data' button to download all significant markers by 'p_val_adj < 0.05'.


4.874e-78	0.7561	0.995	0.999	1.635e-73	HLA-B	Colitis
2.796e-40	1.6848	0.55	0.243	9.376e-36	SYTL3	Colitis
2.181e-35	-0.7834	0.761	0.945	7.315e-31	IL32	Colitis
8.329e-35	2.8782	0.218	0.037	2.793e-30	AL157402.2	Colitis
1.969e-33	1.037	0.995	0.999	6.605e-29	FTH1	Colitis
5.041e-31	0.8329	0.944	0.837	1.691e-26	IL7R	Colitis
2.413e-28	1.3644	0.608	0.386	8.093e-24	FKBP5	Colitis
4.52e-27	1.0756	0.712	0.506	1.516e-22	ISG20	Colitis
6.723e-27	0.3937	1	1	2.255e-22	RPL8	Colitis
3.581e-21	3.0168	0.113	0.014	1.201e-16	NPDC1	Colitis
3.075e-20	1.2753	0.574	0.353	0	CREM	Colitis
5.132e-20	1.1695	0.518	0.31	0	PLP2	Colitis
7.244e-19	0.8321	0.608	0.371	0	CD55	Colitis
6.118e-18	-0.4955	0.863	0.94	0	FYB1	Colitis
1.028e-17	2.512	0.126	0.025	0	HLA-DRB1	Colitis
2.743e-17	0.901	0.624	0.427	0	LITAF	Colitis
6.506e-17	0.7175	0.748	0.492	0	KLF2	Colitis
2.281e-16	0.3586	0.995	0.994	0	BTG1	Colitis
0	2.1948	0.104	0.02	0	ZBTB16	Colitis
0	-0.5401	0.718	0.85	0	LAT	Colitis

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Enrichment Analysis


Ribosome	13/158	0	0	13.9177	322.6026	RPS9;RPS6;RPL28;RPL10;RPL14;RPS27;RPS26;RPS29;RPL3;RPL8;RPS19;MRPL23;RPLP0	1	KEGG_2021_Human
Viral myocarditis	8/60	0	0	23.0862	428.0224	HLA-DQB1;ACTB;HLA-A;HLA-B;HLA-DRB1;ITGB2;ITGAL;CD55	2	KEGG_2021_Human
Coronavirus disease	13/232	0	0	9.1803	169.4655	RPL28;RPL10;RPL14;RPS27;RPS26;RPS29;PIK3R1;RPL3;RPL8;RPS19;RPLP0;RPS9;RPS6	3	KEGG_2021_Human
Antigen processing and presentation	7/78	0	0.0001	14.6694	199.5508	HLA-DQB1;B2M;HLA-A;HLA-B;PSME2;PSME1;HLA-DRB1	4	KEGG_2021_Human
Epstein-Barr virus infection	10/202	0	0.0001	7.8798	105.0454	VIM;B2M;HLA-A;HLA-B;PIK3R1;HLA-DRB1;HLA-DQB1;CCND3;TNFAIP3;ITGAL	5	KEGG_2021_Human
Rap1 signaling pathway	10/210	0	0.0001	7.5615	98.1575	ACTB;FYB1;PIK3R1;RASGRP2;LCP2;LAT;EVL;ITGB2;ITGB1;ITGAL	6	KEGG_2021_Human
Human T-cell leukemia virus 1 infection	10/219	0	0.0001	7.2326	91.1721	B2M;HLA-A;HLA-B;PIK3R1;HLA-DRB1;HLA-DQB1;CCND3;LCK;ITGB2;ITGAL	7	KEGG_2021_Human
Natural killer cell mediated cytotoxicity	8/131	0	0.0001	9.7251	120.9853	HLA-A;HLA-B;PIK3R1;LCP2;LAT;LCK;ITGB2;ITGAL	8	KEGG_2021_Human
Yersinia infection	8/137	0	0.0001	9.2699	112.2377	ACTB;FYB1;PIK3R1;PXN;LCP2;LAT;LCK;ITGB1	9	KEGG_2021_Human
Cell adhesion molecules	8/148	0	0.0002	8.5368	98.5027	HLA-A;HLA-B;SELL;HLA-DRB1;HLA-DQB1;ITGB2;ITGB1;ITGAL	10	KEGG_2021_Human
Phagosome	8/152	0	0.0002	8.298	94.1284	ACTB;HLA-A;HLA-B;HLA-DRB1;TUBB;HLA-DQB1;ITGB2;ITGB1	11	KEGG_2021_Human
Leukocyte transendothelial migration	7/114	0	0.0002	9.7162	107.5264	ACTB;PIK3R1;PXN;ITGB2;ITGB1;ITGAL;CXCR4	12	KEGG_2021_Human
Human immunodeficiency virus 1 infection	8/212	0.0001	0.0018	5.8396	52.4344	B2M;HLA-A;HLA-B;PIK3R1;CXCR4;PXN;TNFRSF1B;SAMHD1	13	KEGG_2021_Human
Allograft rejection	4/38	0.0001	0.0018	17.1505	152.0548	HLA-A;HLA-B;HLA-DQB1;HLA-DRB1	14	KEGG_2021_Human
Graft-versus-host disease	4/42	0.0002	0.0025	15.3421	129.967	HLA-A;HLA-B;HLA-DQB1;HLA-DRB1	15	KEGG_2021_Human
Type I diabetes mellitus	4/43	0.0002	0.0026	14.948	125.2496	HLA-A;HLA-B;HLA-DQB1;HLA-DRB1	16	KEGG_2021_Human
Th1 and Th2 cell differentiation	5/92	0.0005	0.005	8.4176	64.4641	HLA-DQB1;LAT;STAT4;LCK;HLA-DRB1	17	KEGG_2021_Human
Autoimmune thyroid disease	4/53	0.0005	0.0052	11.8914	90.0066	HLA-DQB1;HLA-A;HLA-B;HLA-DRB1	18	KEGG_2021_Human
Regulation of actin cytoskeleton	7/218	0.0009	0.0083	4.9012	34.5029	ACTB;PIK3R1;CXCR4;PXN;ITGB2;ITGB1;ITGAL	19	KEGG_2021_Human
Human cytomegalovirus infection	7/225	0.0011	0.0095	4.7422	32.5107	B2M;HLA-A;HLA-B;PIK3R1;PTGER2;CXCR4;PXN	20	KEGG_2021_Human

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Diagnosis: Control

Markers

Showing top 100 markers ordered by p_val_adj ascendingly, then abs(avg_log2FC) descendingly. Use 'Download the entire data' button to download all significant markers by 'p_val_adj < 0.05'.


9.389e-58	-0.7363	0.879	0.998	3.149e-53	RPS26	Control
5.799e-44	1.7253	0.45	0.155	1.945e-39	HSPA1B	Control
1.574e-37	-0.4683	0.985	0.995	5.278e-33	RPL41	Control
1.898e-34	-0.687	0.74	0.911	6.366e-30	RPL36A	Control
1.915e-32	-0.3988	0.996	0.996	6.424e-28	MT-CO3	Control
4.307e-31	-0.4298	0.987	0.99	1.444e-26	MT-ND3	Control
1.044e-29	-1.2998	0.226	0.474	3.501e-25	PLP2	Control
7.529e-29	-0.3393	0.999	0.997	2.525e-24	MT-CO2	Control
1.499e-28	-0.3124	1	1	5.027e-24	RPL28	Control
2.926e-28	-0.7664	0.417	0.693	9.814e-24	RPS4Y1	Control
6.621e-28	-1.5638	0.192	0.423	2.221e-23	MT2A	Control
2.475e-26	0.4397	0.996	0.991	8.301e-22	MT-ATP8	Control
6.777e-26	-0.3946	0.994	0.997	2.273e-21	MT-ATP6	Control
4.022e-25	-2.0217	0.068	0.248	1.349e-20	KANSL1-AS1	Control
7.505e-25	0.2888	1	0.999	2.517e-20	MALAT1	Control
4.755e-24	-0.6925	0.837	0.928	1.595e-19	TSC22D3	Control
6.095e-24	-0.4126	0.983	0.996	2.044e-19	TMSB10	Control
9.591e-23	-0.2642	1	1	3.217e-18	RPS27	Control
2.935e-22	0.7702	0.669	0.476	9.844e-18	ANXA6	Control
1.48e-21	-0.2565	1	1	4.963e-17	RPS28	Control

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Enrichment Analysis


Ribosome	47/158	1.374e-55	2.185e-53	50.1884	6340.028	RPL22;RPS8;RPS9;RPL24;RPS6;FAU;RPL26;RPL28;RPL29;RPL10;RPL12;RPS4Y1;RPL36AL;RPL15;RPL14;RPS2;RPL18;RPL41;RPS27;RPS26;RPS29;RPS28;RPS21;RPS23;RPS25;RPS24;RPL6;RPL3;RPL31;RPL30;RPL34;RPL8;RPS15;RPS18;RPS19;RPL37;RPL36;RPL39;RPL37A;RPL36A;RPS15A;RPL35A;RPL23A;RPLP0;RPLP1;RPL18A;RPL7A	1	KEGG_2021_Human
Coronavirus disease	49/232	7.378e-50	5.865e-48	32.0071	3620.9853	RPL22;RPL24;RPL26;RPL28;RPL29;RPL10;RPL12;RPS4Y1;RPL36AL;RPL15;RPL14;RPL18;RPL41;RPS27;RPS26;RPS29;RPS28;RPS21;RPS23;RPS25;RPS24;RPL6;RPL3;RPL31;RPL30;RPL34;RPL8;RPS15;RPS18;RPS19;RPL37;RPL36;RPL39;RPS15A;STAT1;RPLP0;RPLP1;RPL18A;RPS8;RPS9;RPS6;FAU;RPS2;NFKBIA;RPL37A;RPL36A;RPL35A;RPL23A;RPL7A	2	KEGG_2021_Human
Viral myocarditis	8/60	0	0	14.8105	226.3297	ACTB;HLA-C;HLA-A;HLA-B;HLA-G;ITGB2;ITGAL;CD55	3	KEGG_2021_Human
Antigen processing and presentation	8/78	0	0.0001	10.9921	145.4303	HSP90AA1;HSPA1A;HSPA1B;HLA-C;HLA-A;HLA-B;HLA-G;HSP90AB1	4	KEGG_2021_Human
Natural killer cell mediated cytotoxicity	8/131	0.0001	0.0026	6.2388	58.7137	HLA-C;HLA-A;HLA-B;HLA-G;LCP2;LCK;ITGB2;ITGAL	5	KEGG_2021_Human
Cell adhesion molecules	8/148	0.0002	0.0051	5.4765	46.8974	HLA-C;HLA-A;HLA-B;HLA-G;SELL;PTPRC;ITGB2;ITGAL	6	KEGG_2021_Human
Phagosome	8/152	0.0002	0.0052	5.3233	44.6149	ACTB;HLA-C;HLA-A;HLA-B;HLA-G;TUBB;ITGB2;TUBA1B	7	KEGG_2021_Human
Endocytosis	10/252	0.0004	0.0077	3.9785	31.2642	HSPA1A;HSPA1B;HLA-C;HLA-A;HLA-B;HLA-G;CAPZA1;SH3KBP1;SMAP2;WIPF1	8	KEGG_2021_Human
Allograft rejection	4/38	0.0007	0.0123	11.1191	80.852	HLA-C;HLA-A;HLA-B;HLA-G	9	KEGG_2021_Human
Th17 cell differentiation	6/107	0.001	0.014	5.6496	38.9916	PRKCQ;HSP90AA1;NFKBIA;STAT1;LCK;HSP90AB1	10	KEGG_2021_Human
Graft-versus-host disease	4/42	0.001	0.014	9.9466	68.5159	HLA-C;HLA-A;HLA-B;HLA-G	11	KEGG_2021_Human
Type I diabetes mellitus	4/43	0.0011	0.014	9.6911	65.8899	HLA-C;HLA-A;HLA-B;HLA-G	12	KEGG_2021_Human
Spliceosome	7/150	0.0011	0.014	4.6679	31.6083	HNRNPK;HSPA1A;HSPA1B;SRSF2;HNRNPU;SNRPD2;FUS	13	KEGG_2021_Human
Epstein-Barr virus infection	8/202	0.0015	0.0169	3.9413	25.6576	HLA-C;HLA-A;HLA-B;HLA-G;STAT1;NFKBIA;TNFAIP3;ITGAL	14	KEGG_2021_Human
Autoimmune thyroid disease	4/53	0.0024	0.0245	7.7094	46.3932	HLA-C;HLA-A;HLA-B;HLA-G	15	KEGG_2021_Human
Human T-cell leukemia virus 1 infection	8/219	0.0025	0.0245	3.6206	21.7427	HLA-C;HLA-A;HLA-B;HLA-G;NFKBIA;LCK;ITGB2;ITGAL	16	KEGG_2021_Human
Legionellosis	4/57	0.0032	0.0297	7.1261	40.9854	NFKBIA;HSPA1A;HSPA1B;ITGB2	17	KEGG_2021_Human
Yersinia infection	6/137	0.0035	0.0311	4.3492	24.5701	ACTB;FYB1;NFKBIA;LCP2;LCK;WIPF1	18	KEGG_2021_Human
Kaposi sarcoma-associated herpesvirus infection	7/193	0.0047	0.0395	3.5809	19.1813	HLA-C;HLA-A;HLA-B;HLA-G;STAT1;UBC;NFKBIA	19	KEGG_2021_Human
T cell receptor signaling pathway	5/104	0.0051	0.0408	4.7805	25.2092	PRKCQ;NFKBIA;PTPRC;LCP2;LCK	20	KEGG_2021_Human

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Diagnosis: NoColitis

Markers

Showing top 100 markers ordered by p_val_adj ascendingly, then abs(avg_log2FC) descendingly. Use 'Download the entire data' button to download all significant markers by 'p_val_adj < 0.05'.


3.855e-58	0.9667	0.963	0.777	1.293e-53	RPL36A	NoColitis
4.96e-54	2.4782	0.371	0.079	1.663e-49	KANSL1-AS1	NoColitis
3.998e-49	0.5895	0.998	0.994	1.341e-44	MT-ATP6	NoColitis
7.775e-37	-0.5783	0.989	0.995	2.608e-32	MT-ATP8	NoColitis
9.215e-34	0.4717	0.998	0.987	3.091e-29	RPL41	NoColitis
8.945e-32	-2.9729	0.103	0.369	3e-27	HSPA1B	NoColitis
5.324e-31	0.781	0.795	0.47	1.785e-26	RPS4Y1	NoColitis
5.773e-31	0.5475	0.998	0.921	1.936e-26	RPS26	NoColitis
7.193e-30	1.4621	0.426	0.183	2.412e-25	RNPEPL1	NoColitis
1.193e-26	-0.4833	0.998	0.998	4.002e-22	HLA-B	NoColitis
3.78e-25	2.5076	0.164	0.029	1.268e-20	RAB34	NoColitis
7.022e-24	-0.7387	0.779	0.899	2.355e-19	IL7R	NoColitis
9.143e-24	-0.642	0.86	0.917	3.066e-19	CXCR4	NoColitis
2.587e-22	1.9406	0.242	0.078	8.677e-18	CHI3L2	NoColitis
7.808e-22	0.8346	0.633	0.416	2.619e-17	GZMM	NoColitis
1.183e-19	0.2977	1	1	0	RPS28	NoColitis
3.925e-19	-0.6925	0.876	0.928	0	HSP90AA1	NoColitis
4.399e-19	0.3107	1	1	0	RPL35A	NoColitis
1.381e-18	0.3373	0.996	0.996	0	MT-CO3	NoColitis
0	1.6186	0.185	0.063	0	MRPL23	NoColitis

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Enrichment Analysis


Ribosome	30/158	3.166e-38	3.45e-36	57.1788	4937.1574	RPL22;RPS8;RPL24;RPL26;RPL28;RPS4Y1;RPL36AL;RPL41;RPS27;RPS26;RPS28;RPS21;RPS23;RPS25;RPS24;RPL31;RPL32;RPL34;RPL37;RPL39;RPS10;RPS14;RPS13;MRPL23;RPL37A;RPL36A;RPS15A;RPL35A;RPL23A;RPLP1	1	KEGG_2021_Human
Coronavirus disease	29/232	2.267e-31	1.235e-29	34.2962	2420	RPL22;RPL24;RPL26;RPL28;RPS4Y1;RPL36AL;RPL41;RPS27;RPS26;RPS28;RPS21;RPS23;RPS25;RPS24;RPL31;RPL32;RPL34;RPL37;RPL39;RPS10;RPS14;RPS13;RPS15A;RPLP1;RPS8;RPL37A;RPL36A;RPL35A;RPL23A	2	KEGG_2021_Human
Antigen processing and presentation	6/78	0	0.0002	15.7278	192.8324	HSP90AA1;HSPA1A;HSPA1B;HLA-C;HLA-B;HSP90AB1	3	KEGG_2021_Human
Protein processing in endoplasmic reticulum	6/171	0.0004	0.0105	6.8308	53.6857	HSPA1A;HSPA1B;PPP1R15A;HSP90AA1;DNAJB1;HSP90AB1	4	KEGG_2021_Human
Estrogen signaling pathway	5/137	0.001	0.0219	7.0601	48.7359	HSPA1A;FKBP5;HSPA1B;HSP90AA1;HSP90AB1	5	KEGG_2021_Human
IL-17 signaling pathway	4/94	0.0019	0.0339	8.2239	51.6732	HSP90AA1;JUND;FOSB;HSP90AB1	6	KEGG_2021_Human
Spliceosome	4/150	0.0098	0.1526	5.0552	23.3834	HSPA1A;HSPA1B;SRSF2;SNRPD2	7	KEGG_2021_Human
Endocytosis	5/252	0.0133	0.1712	3.7511	16.2104	HSPA1A;HSPA1B;HLA-C;HLA-B;CXCR4	8	KEGG_2021_Human
Prostate cancer	3/97	0.0168	0.1712	5.8496	23.8958	HSP90AA1;HSP90AB1;GSTP1	9	KEGG_2021_Human
Prion disease	5/273	0.0182	0.1712	3.4534	13.8441	HSPA1A;HSPA1B;ATP5F1E;NDUFA11;TUBA1B	10	KEGG_2021_Human
Allograft rejection	2/38	0.0188	0.1712	10.1188	40.188	HLA-C;HLA-B	11	KEGG_2021_Human
Primary immunodeficiency	2/38	0.0188	0.1712	10.1188	40.188	PTPRC;IL7R	11	KEGG_2021_Human
Graft-versus-host disease	2/42	0.0227	0.1851	9.105	34.4465	HLA-C;HLA-B	13	KEGG_2021_Human
Type I diabetes mellitus	2/43	0.0238	0.1851	8.8825	33.2133	HLA-C;HLA-B	14	KEGG_2021_Human
Human immunodeficiency virus 1 infection	4/212	0.0305	0.2173	3.5372	12.3399	HLA-C;HLA-B;GNG10;CXCR4	15	KEGG_2021_Human
Lipid and atherosclerosis	4/215	0.0319	0.2173	3.4864	12.0087	HSPA1A;HSPA1B;HSP90AA1;HSP90AB1	16	KEGG_2021_Human
Autoimmune thyroid disease	2/53	0.035	0.2173	7.1373	23.9255	HLA-C;HLA-B	17	KEGG_2021_Human
Human cytomegalovirus infection	4/225	0.0368	0.2173	3.3269	10.9881	HLA-C;HLA-B;GNG10;CXCR4	18	KEGG_2021_Human
Oxidative phosphorylation	3/133	0.0379	0.2173	4.222	13.8131	ATP5F1E;ATP5MG;NDUFA11	19	KEGG_2021_Human
Legionellosis	2/57	0.04	0.2173	6.6168	21.3034	HSPA1A;HSPA1B	20	KEGG_2021_Human

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Diagnosis (Overlaps)

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c2

Diagnosis: Colitis

Markers

Showing top 100 markers ordered by p_val_adj ascendingly, then abs(avg_log2FC) descendingly. Use 'Download the entire data' button to download all significant markers by 'p_val_adj < 0.05'.


2.62e-54	3.0666	0.32	0.044	8.786e-50	AL157402.2	Colitis
3.338e-43	1.9577	0.605	0.267	1.119e-38	FKBP5	Colitis
3.198e-40	0.567	1	1	1.073e-35	HLA-B	Colitis
1.552e-37	-0.6141	1	1	5.203e-33	ACTB	Colitis
1.104e-34	-0.6454	0.959	0.996	3.703e-30	IL32	Colitis
9.82e-33	1.1389	0.815	0.574	3.294e-28	ISG20	Colitis
4.153e-30	0.7999	0.966	0.806	1.393e-25	CXCR4	Colitis
2.222e-29	0.6284	1	0.981	7.451e-25	SRGN	Colitis
5.778e-28	-0.727	0.991	1	1.938e-23	FOS	Colitis
9.822e-27	0.6403	0.994	0.993	3.294e-22	BTG1	Colitis
4.622e-24	0.6194	0.994	0.987	1.55e-19	ZFP36L2	Colitis
9.833e-24	-1.9645	0.197	0.497	3.298e-19	LGALS1	Colitis
6.206e-21	4.3559	0.063	0.001	2.082e-16	IGKV3D-20	Colitis
2.279e-20	1.764	0.464	0.23	7.644e-16	KLF2	Colitis
3.094e-20	1.1323	0.592	0.352	0	SMAP2	Colitis
4.952e-20	0.4682	0.991	0.987	0	IL7R	Colitis
2.618e-19	-1.0858	0.636	0.78	0	CCL5	Colitis
4.484e-18	1.1006	0.552	0.319	0	STAT1	Colitis
6.54e-18	3.4072	0.088	0.009	0	NPDC1	Colitis
2.058e-17	2.7791	0.116	0.019	0	SELL	Colitis

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Enrichment Analysis


Yersinia infection	13/137	0	12.6707	280.0482	CD4;TNF;ACTB;FYB1;ARPC5;PXN;ACTG1;ACTR3;NFKBIA;LCP2;LAT;FOS;LCK	1	KEGG_2021_Human
Regulation of actin cytoskeleton	15/218	0	9.0051	187.0314	PFN1;CYFIP2;MYL12B;ACTB;MYL12A;TMSB4X;CXCR4;PPP1CA;ARPC5;PXN;ACTG1;ITGA1;ACTR3;ITGAE;ITGB2	2	KEGG_2021_Human
Th17 cell differentiation	11/107	0	13.7	270.4508	CD4;HLA-DRB1;HSP90AA1;NFKBIA;IRF4;LAT;CD3G;CD3E;STAT1;FOS;LCK	3	KEGG_2021_Human
T cell receptor signaling pathway	10/104	0	12.6442	220.0956	CD4;TNF;NFKBIA;LCP2;LAT;CD3G;CD3E;FOS;LCK;CD40LG	4	KEGG_2021_Human
Salmonella infection	14/249	0	7.2037	121.7008	PFN1;CYFIP2;MYL12B;ACTB;MYL12A;RIPK2;FOS;TNF;ARPC5;ACTG1;ACTR3;HSP90AA1;NFKBIA;GAPDH	5	KEGG_2021_Human
Viral myocarditis	8/60	0	18.1062	303.2913	ACTB;HLA-C;HLA-B;CD40LG;HLA-DRB1;ITGB2;ACTG1;CD55	6	KEGG_2021_Human
Human T-cell leukemia virus 1 infection	13/219	0	7.5953	124.5871	CD4;EGR1;HLA-C;HLA-B;HLA-DRB1;CD3G;CD3E;FOS;TNF;CCND3;NFKBIA;LCK;ITGB2	7	KEGG_2021_Human
Th1 and Th2 cell differentiation	9/92	0	12.8179	204.2961	NFKBIA;CD4;LAT;CD3G;CD3E;STAT1;FOS;LCK;HLA-DRB1	8	KEGG_2021_Human
Hematopoietic cell lineage	9/99	0	11.8168	180.8153	CD2;CD4;TNF;HLA-DRB1;IL7R;ITGA1;CD3G;CD3E;CD55	9	KEGG_2021_Human
Epstein-Barr virus infection	12/202	0	7.5612	115.2443	VIM;HLA-C;HLA-B;HLA-DRB1;CD3G;CD3E;STAT1;TNF;CCND3;TAPBP;NFKBIA;TNFAIP3	10	KEGG_2021_Human
Allograft rejection	6/38	0	21.8294	303.1248	GZMB;HLA-C;HLA-B;CD40LG;HLA-DRB1;TNF	11	KEGG_2021_Human
PD-L1 expression and PD-1 checkpoint pathway in cancer	8/89	0	11.6067	158.4246	NFKBIA;CD4;LAT;CD3G;CD3E;STAT1;FOS;LCK	12	KEGG_2021_Human
Pathogenic Escherichia coli infection	11/197	0	7.0387	94.7538	CYFIP2;ACTB;FOS;TNF;ARPC5;ACTG1;ACTR3;NFKBIA;TMBIM6;MYO1B;GAPDH	13	KEGG_2021_Human
Shigellosis	12/246	0	6.1257	80.5551	PFN1;MYL12B;ACTB;MYL12A;RIPK2;TNF;ARPC5;PXN;ACTG1;ACTR3;NFKBIA;CCL5	14	KEGG_2021_Human
Natural killer cell mediated cytotoxicity	9/131	0	8.7032	112.5134	TNF;HLA-C;HLA-B;LCP2;LAT;GZMB;LCK;CD48;ITGB2	15	KEGG_2021_Human
Human immunodeficiency virus 1 infection	11/212	0	6.5085	82.9684	CD4;HLA-C;HLA-B;CD3G;CD3E;FOS;CXCR4;TNF;PXN;TAPBP;NFKBIA	16	KEGG_2021_Human
Antigen processing and presentation	7/78	0.0001	11.5235	139.2237	HSP90AA1;TAPBP;CD4;TNF;HLA-C;HLA-B;HLA-DRB1	17	KEGG_2021_Human
Cytokine-cytokine receptor interaction	12/295	0.0001	5.0524	57.0752	CD4;IL16;CD27;IL32;CD40LG;CXCR4;CXCR3;TNF;IL7R;TNFRSF4;TNFRSF18;CCL5	18	KEGG_2021_Human
Rap1 signaling pathway	10/210	0.0002	5.9108	64.7308	PFN1;SKAP1;ACTB;FYB1;APBB1IP;ACTG1;LCP2;LAT;EVL;ITGB2	19	KEGG_2021_Human
Primary immunodeficiency	5/38	0.0002	17.5359	189.9309	LCK;CD4;CD40LG;IL7R;CD3E	20	KEGG_2021_Human

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Diagnosis: Control

Markers

Showing top 100 markers ordered by p_val_adj ascendingly, then abs(avg_log2FC) descendingly. Use 'Download the entire data' button to download all significant markers by 'p_val_adj < 0.05'.


6.259e-72	-0.9793	0.983	0.994	2.099e-67	ZFP36L2	Control
1.133e-70	-1.5899	0.695	0.883	3.798e-66	NFKBIA	Control
3.606e-48	0.5976	0.994	0.996	1.21e-43	MT-ATP8	Control
1.854e-46	0.4964	1	1	6.217e-42	ACTB	Control
1.254e-42	0.5393	0.995	0.984	4.205e-38	IL32	Control
7.613e-41	-1.1484	0.396	0.683	2.553e-36	PLP2	Control
1.165e-39	-1.9102	0.185	0.463	3.907e-35	MT2A	Control
1.046e-36	-0.6105	0.995	0.99	3.509e-32	BTG1	Control
1.727e-31	-0.5118	0.973	0.995	5.791e-27	SRGN	Control
2.55e-31	0.7521	0.681	0.397	8.553e-27	HSPA1B	Control
3.34e-31	0.3944	0.991	0.985	1.12e-26	ITM2B	Control
1.151e-30	0.4909	0.983	0.966	3.861e-26	CORO1A	Control
1.187e-30	-0.4792	0.95	1	3.981e-26	RPS26	Control
6.31e-29	0.4866	1	0.997	2.116e-24	FOS	Control
4.515e-28	-0.7741	0.791	0.875	1.514e-23	CXCR4	Control
9.308e-28	0.6991	0.776	0.59	3.122e-23	ANXA6	Control
3.659e-27	-0.3906	0.997	0.998	1.227e-22	MT-ND3	Control
3.463e-24	0.6143	0.759	0.525	1.161e-19	NR4A1	Control
4.341e-24	0.6453	0.786	0.607	1.456e-19	EIF5A	Control
5.403e-24	0.3642	1	0.997	1.812e-19	PFN1	Control

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Enrichment Analysis


Salmonella infection	24/249	0	8.7827	274.9736	PFN1;CYFIP2;AHNAK;MYL12B;ACTB;MYL12A;ANXA2;TUBB;PTPRC;FOS;TUBA1B;TNF;HSP90B1;M6PR;ARPC5;ARPC3;ARPC2;ACTG1;ACTR3;ACTR2;NFKBIA;CDC42;GAPDH;HSP90AB1	1	KEGG_2021_Human
Regulation of actin cytoskeleton	21/218	0	8.6798	238.7993	PFN1;CYFIP2;MYL12B;ACTB;MYL12A;CXCR4;RAC2;PPP1CA;PPP1CC;CFL1;ARPC5;ARPC3;ARPC2;ACTG1;ACTR3;ACTR2;ITGA4;MSN;CDC42;ITGB2;ITGB7	2	KEGG_2021_Human
Ribosome	18/158	0	10.3698	275.7577	RPL23;RPS7;RPSA;RPL28;RPL12;RPS5;RPL41;RPS27;RPS26;RPS29;RPS28;RPL5;RPL6;RPL7;RPL8;MRPL32;RPL36A;RPS4X	3	KEGG_2021_Human
Coronavirus disease	21/232	0	8.0981	213.0218	RPL23;RPL28;RPL12;RPL41;RPS27;RPS26;RPS29;RPS28;RPL5;RPL6;RPL7;RPL8;STAT1;FOS;RPS7;RPSA;TNF;RPS5;NFKBIA;RPL36A;RPS4X	4	KEGG_2021_Human
Pathogenic Escherichia coli infection	19/197	0	8.628	215.8854	CYFIP2;ACTB;TUBB;FOS;TUBA1B;PTPN6;TNF;ARPC5;ARPC3;ARPC2;NCL;ACTG1;ACTR3;ACTR2;NFKBIA;TMBIM6;CDC42;GAPDH;MYO1G	5	KEGG_2021_Human
Yersinia infection	14/137	0	9.0393	176.4548	TNF;ACTB;ARPC5;ARPC3;ARPC2;ACTG1;ACTR3;ACTR2;ITGA4;NFKBIA;LCP2;FOS;CDC42;RAC2	6	KEGG_2021_Human
Leukocyte transendothelial migration	12/114	0	9.2781	160.0592	MYL12B;ACTB;MYL12A;ACTG1;RASSF5;ITGA4;MSN;RAP1A;CDC42;ITGB2;CXCR4;RAC2	7	KEGG_2021_Human
Tight junction	14/169	0	7.1614	120.4471	MYL6;MYL12B;ACTB;ARPC5;MYL12A;ARPC3;ARPC2;ACTG1;ACTR3;ACTR2;MSN;RAP1A;CDC42;TUBA1B	8	KEGG_2021_Human
Shigellosis	16/246	0	5.5394	86.6445	PFN1;MYL12B;ACTB;MYL12A;TNF;ARPC5;ARPC3;ARPC2;ACTG1;UBC;UBB;ACTR3;ACTR2;NFKBIA;CDC42;CCL5	9	KEGG_2021_Human
Antigen processing and presentation	9/78	0	10.1812	142.9876	HSPA8;TAPBP;HSPA1A;HSPA1B;TNF;PDIA3;HLA-C;KIR3DL2;HSP90AB1	10	KEGG_2021_Human
Endocytosis	15/252	0	5.0175	68.3454	HSPA1A;HSPA1B;HLA-C;CXCR4;CAPZA1;ACAP1;ARPC5;ARPC3;ARPC2;ACTR3;ACTR2;HSPA8;CAPZB;CDC42;SMAP2	11	KEGG_2021_Human
Measles	11/139	0	6.7413	87.911	HSPA1A;HSPA1B;HSPA8;MSN;NFKBIA;CDK6;TNFAIP3;CD3G;CD3E;STAT1;FOS	12	KEGG_2021_Human
Rap1 signaling pathway	13/210	0.0001	5.1999	64.4981	PFN1;SKAP1;CALM1;ACTB;RASSF5;APBB1IP;RAP1A;RAC2;ACTG1;LCP2;CDC42;EVL;ITGB2	13	KEGG_2021_Human
Fc gamma R-mediated phagocytosis	9/97	0.0001	7.9752	97.3055	CFL1;ARPC5;ARPC3;ARPC2;ACTR3;ACTR2;PTPRC;CDC42;RAC2	14	KEGG_2021_Human
Bacterial invasion of epithelial cells	8/77	0.0001	9.0141	106.6074	ACTR3;ACTR2;ACTB;ARPC5;CDC42;ARPC3;ARPC2;ACTG1	15	KEGG_2021_Human
T cell receptor signaling pathway	9/104	0.0001	7.385	85.8621	PTPN6;TNF;NFKBIA;PTPRC;LCP2;CD3G;CD3E;FOS;CDC42	16	KEGG_2021_Human
Human immunodeficiency virus 1 infection	12/212	0.0003	4.7082	50.1528	CALM1;HLA-C;CD3G;CD3E;FOS;CXCR4;RAC2;TNF;CFL1;PDIA3;TAPBP;NFKBIA	17	KEGG_2021_Human
Glycolysis / Gluconeogenesis	7/67	0.0003	9.0389	95.2444	TPI1;ALDOA;LDHA;PGAM1;PKM;GAPDH;ENO1	18	KEGG_2021_Human
Lipid and atherosclerosis	12/215	0.0003	4.6379	48.7609	HSPA1A;CALM1;HSPA1B;RAP1A;FOS;TNF;HSP90B1;HSPA8;NFKBIA;CDC42;HSP90AB1;CCL5	19	KEGG_2021_Human
Platelet activation	9/124	0.0004	6.0944	62.2301	PPP1CA;MYL12B;PPP1CC;ACTB;MYL12A;ACTG1;APBB1IP;LCP2;RAP1A	20	KEGG_2021_Human

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Diagnosis: NoColitis

Markers

Showing top 100 markers ordered by p_val_adj ascendingly, then abs(avg_log2FC) descendingly. Use 'Download the entire data' button to download all significant markers by 'p_val_adj < 0.05'.


1.587e-47	-1.6867	0.305	0.652	5.321e-43	HSPA1B	NoColitis
1.497e-45	0.7144	0.969	0.852	5.019e-41	RPL36A	NoColitis
6.637e-42	1.0124	0.884	0.744	2.226e-37	NFKBIA	NoColitis
5.408e-41	-0.6015	0.994	0.996	1.814e-36	MT-ATP8	NoColitis
1.673e-38	1.2607	0.554	0.255	5.61e-34	RNPEPL1	NoColitis
1.582e-33	2.1346	0.286	0.076	5.305e-29	KANSL1-AS1	NoColitis
1.256e-32	0.3901	0.998	0.994	4.212e-28	RPL41	NoColitis
4.665e-27	0.5516	0.994	0.986	1.564e-22	ZFP36L2	NoColitis
5.116e-26	0.4228	1	0.963	1.716e-21	RPS26	NoColitis
1.007e-25	0.356	0.998	0.997	3.376e-21	MT-ATP6	NoColitis
1.094e-25	-0.7308	0.952	0.979	3.668e-21	HSP90AA1	NoColitis
3.563e-25	2.7997	0.152	0.023	1.195e-20	RAB34	NoColitis
8.127e-25	0.7923	0.698	0.465	2.726e-20	PLP2	NoColitis
3.366e-24	0.4024	0.997	0.997	1.129e-19	MT-ND3	NoColitis
2.245e-23	-0.8281	0.863	0.925	7.528e-19	DNAJB1	NoColitis
2.553e-23	-0.3494	0.998	1	8.563e-19	RPS5	NoColitis
3.277e-20	-0.7475	0.853	0.904	0	LTB	NoColitis
3.874e-20	1.0463	0.467	0.257	0	MT2A	NoColitis
3.191e-19	1.9107	0.166	0.043	0	C20orf204	NoColitis
4.045e-19	-0.4333	0.979	0.996	0	HSPA8	NoColitis

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Enrichment Analysis


Ribosome	25/158	1.35e-26	2.215e-24	30.8929	1840.189	RPL23;RPS7;RPSA;RPL11;RPL13;RPL12;RPS5;RPL41;RPS27;RPS26;RPS29;RPS28;RPS21;RPL5;RPL6;RPL4;RPL34;RPL7;RPL37;RPL39;RPL13A;RPL37A;RPL36A;RPS4X;RPL18A	1	KEGG_2021_Human
Coronavirus disease	26/232	1.224e-23	1.004e-21	20.8401	1099.4593	RPL23;RPL11;RPL13;RPL12;RPL41;RPS27;RPS26;RPS29;RPS28;RPS21;RPL5;RPL6;RPL4;RPL34;RPL7;RPL37;RPL39;RPL18A;RPS7;RPSA;RPS5;RPL13A;NFKBIA;RPL37A;RPL36A;RPS4X	2	KEGG_2021_Human
Antigen processing and presentation	8/78	0	0	16.5047	266.6885	HSP90AA1;HSPA8;HSPA1A;HSPA1B;KIR3DL2;HLA-B;PSME2;HSP90AB1	3	KEGG_2021_Human
Salmonella infection	8/249	0.0005	0.0175	4.7525	36.3718	S100A10;PTPRC;TUBA1B;ARPC3;HSP90AA1;NFKBIA;CDC42;HSP90AB1	4	KEGG_2021_Human
Measles	6/139	0.0005	0.0175	6.4008	48.2403	HSPA1A;HSPA1B;HSPA8;MSN;NFKBIA;RACK1	5	KEGG_2021_Human
Legionellosis	4/57	0.0008	0.0203	10.5992	75.8907	HSPA8;NFKBIA;HSPA1A;HSPA1B	6	KEGG_2021_Human
Prion disease	8/273	0.0009	0.0203	4.3168	30.4419	HSPA1A;HSPA1B;ATP5F1E;NDUFA11;ATP5F1B;TUBA1B;HSPA8;SLC25A6	7	KEGG_2021_Human
Lipid and atherosclerosis	7/215	0.001	0.0204	4.7913	33.1304	HSPA1A;HSPA1B;HSP90AA1;HSPA8;NFKBIA;CDC42;HSP90AB1	8	KEGG_2021_Human
Toxoplasmosis	5/112	0.0013	0.0228	6.5915	43.5707	HSPA1A;HSPA1B;HSPA8;NFKBIA;SOCS1	9	KEGG_2021_Human
MAPK signaling pathway	8/294	0.0014	0.0228	3.9955	26.284	HSPA1A;HSPA1B;JUND;CDC25B;RASGRP2;NR4A1;HSPA8;CDC42	10	KEGG_2021_Human
Protein processing in endoplasmic reticulum	6/171	0.0016	0.0233	5.1511	33.2828	HSPA1A;HSPA1B;HSP90AA1;HSPA8;DNAJB1;HSP90AB1	11	KEGG_2021_Human
Endocytosis	7/252	0.0025	0.0336	4.06	24.3981	HSPA1A;HSPA1B;HLA-B;CAPZA1;ARPC3;HSPA8;CDC42	12	KEGG_2021_Human
Estrogen signaling pathway	5/137	0.0032	0.041	5.3363	30.5767	HSPA1A;HSPA1B;HSP90AA1;HSPA8;HSP90AB1	13	KEGG_2021_Human
Viral carcinogenesis	6/203	0.0037	0.0431	4.3073	24.1463	HNRNPK;SP100;HLA-B;NFKBIA;YWHAZ;CDC42	14	KEGG_2021_Human
Pyruvate metabolism	3/47	0.0048	0.05	9.5123	50.801	MDH2;LDHB;LDHA	15	KEGG_2021_Human
IL-17 signaling pathway	4/94	0.0049	0.05	6.2301	33.1593	HSP90AA1;NFKBIA;JUND;HSP90AB1	16	KEGG_2021_Human
Cysteine and methionine metabolism	3/50	0.0057	0.055	8.9038	46.0036	LDHB;LDHA;MDH2	17	KEGG_2021_Human
Progesterone-mediated oocyte maturation	4/100	0.0061	0.0553	5.8389	29.8036	CDC25B;HSP90AA1;PDE3B;HSP90AB1	18	KEGG_2021_Human
HIF-1 signaling pathway	4/109	0.0082	0.0707	5.336	25.6361	ENO1;LDHB;LDHA;TIMP1	19	KEGG_2021_Human
Parkinson disease	6/249	0.0097	0.0796	3.4838	16.1485	ATP5F1E;NDUFA11;ATP5F1B;TUBA1B;UBB;SLC25A6	20	KEGG_2021_Human

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Diagnosis (Overlaps)

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# Generated by pipen_runinfo v0.9.3
# Lang: R
R version 4.3.3 (2024-02-29)
Platform: x86_64-conda-linux-gnu (64-bit)
Running under: Debian GNU/Linux 12 (bookworm)

Matrix products: default
BLAS/LAPACK: /opt/conda/lib/libopenblasp-r0.3.30.so;  LAPACK version 3.12.0

locale:
 [1] LC_CTYPE=C.UTF-8       LC_NUMERIC=C           LC_TIME=C.UTF-8       
 [4] LC_COLLATE=C.UTF-8     LC_MONETARY=C.UTF-8    LC_MESSAGES=C.UTF-8   
 [7] LC_PAPER=C.UTF-8       LC_NAME=C              LC_ADDRESS=C          
[10] LC_TELEPHONE=C         LC_MEASUREMENT=C.UTF-8 LC_IDENTIFICATION=C   

time zone: Etc/UTC
tzcode source: system (glibc)

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
 [1] biopipen.utils_0.3.2 plotthis_0.8.2       ggplot2_3.5.2       
 [4] tidyr_1.3.1          tidyseurat_0.8.0     ttservice_0.5.3     
 [7] Seurat_5.3.0         SeuratObject_5.2.0   sp_2.2-0            
[10] dplyr_1.1.4          rlang_1.1.6         

loaded via a namespace (and not attached):
  [1] cubature_2.0.4.6            RcppAnnoy_0.0.22           
  [3] splines_4.3.3               later_1.4.4                
  [5] bitops_1.0-9                tibble_3.3.0               
  [7] polyclip_1.10-7             enrichit_0.0.4             
  [9] fastDummies_1.7.5           lifecycle_1.0.4            
 [11] doParallel_1.0.17           globals_0.18.0             
 [13] lattice_0.22-7              MASS_7.3-60.0.1            
 [15] magrittr_2.0.3              limma_3.58.1               
 [17] plotly_4.11.0               httpuv_1.6.16              
 [19] sctransform_0.4.2           spam_2.11-1                
 [21] spatstat.sparse_3.1-0       reticulate_1.43.0          
 [23] cowplot_1.2.0               pbapply_1.7-4              
 [25] RColorBrewer_1.1-3          abind_1.4-5                
 [27] zlibbioc_1.48.0             Rtsne_0.17                 
 [29] GenomicRanges_1.54.1        presto_1.0.0               
 [31] purrr_1.1.0                 ggraph_2.2.1               
 [33] BiocGenerics_0.48.1         RCurl_1.98-1.17            
 [35] tweenr_2.0.3                evmix_2.12                 
 [37] circlize_0.4.16             GenomeInfoDbData_1.2.11    
 [39] IRanges_2.36.0              S4Vectors_0.40.2           
 [41] ggrepel_0.9.6               irlba_2.3.5.1              
 [43] listenv_0.9.1               spatstat.utils_3.1-5       
 [45] iNEXT_3.0.2                 MatrixModels_0.5-4         
 [47] goftest_1.2-3               RSpectra_0.16-2            
 [49] scRepertoire_2.2.1          spatstat.random_3.4-1      
 [51] fitdistrplus_1.2-4          parallelly_1.45.1          
 [53] codetools_0.2-20            DelayedArray_0.28.0        
 [55] xml2_1.4.0                  ggforce_0.5.0              
 [57] tidyselect_1.2.1            shape_1.4.6.1              
 [59] farver_2.1.2                viridis_0.6.5              
 [61] matrixStats_1.1.0           stats4_4.3.3               
 [63] spatstat.explore_3.5-2      jsonlite_2.0.0             
 [65] GetoptLong_1.0.5            ellipsis_0.3.2             
 [67] tidygraph_1.3.0             progressr_0.15.1           
 [69] iterators_1.0.14            ggridges_0.5.7             
 [71] ggalluvial_0.12.5           survival_3.8-3             
 [73] systemfonts_1.2.3           foreach_1.5.2              
 [75] tools_4.3.3                 ggnewscale_0.5.2           
 [77] ragg_1.5.0                  stringdist_0.9.15          
 [79] ica_1.0-3                   ggVennDiagram_1.5.4        
 [81] Rcpp_1.1.0                  glue_1.8.0                 
 [83] gridExtra_2.3               SparseArray_1.2.2          
 [85] qs2_0.1.5                   qvalue_2.34.0              
 [87] MatrixGenerics_1.14.0       GenomeInfoDb_1.38.1        
 [89] withr_3.0.2                 fastmap_1.2.0              
 [91] fansi_1.0.6                 SparseM_1.84-2             
 [93] digest_0.6.37               R6_2.6.1                   
 [95] mime_0.13                   textshaping_0.4.0          
 [97] colorspace_2.1-1            Cairo_1.6-2                
 [99] scattermore_1.2             tensor_1.5.1               
[101] dichromat_2.0-0.1           spatstat.data_3.1-8        
[103] generics_0.1.4              data.table_1.17.8          
[105] graphlayouts_1.2.2          httr_1.4.7                 
[107] htmlwidgets_1.6.4           S4Arrays_1.2.0             
[109] uwot_0.2.3                  pkgconfig_2.0.3            
[111] gtable_0.3.6                ComplexHeatmap_2.18.0      
[113] lmtest_0.9-40               SingleCellExperiment_1.24.0
[115] XVector_0.42.0              htmltools_0.5.8.1          
[117] dotCall64_1.2               clue_0.3-66                
[119] gglogger_0.1.6              scales_1.4.0               
[121] Biobase_2.62.0              png_0.1-8                  
[123] spatstat.univar_3.1-4       ggdendro_0.2.0             
[125] rjson_0.2.23                reshape2_1.4.4             
[127] nlme_3.1-168                cachem_1.1.0               
[129] zoo_1.8-14                  GlobalOptions_0.1.2        
[131] stringr_1.5.2               KernSmooth_2.23-26         
[133] parallel_4.3.3              miniUI_0.1.2               
[135] pillar_1.11.0               grid_4.3.3                 
[137] logger_0.4.0                vctrs_0.6.5                
[139] RANN_2.6.2                  VGAM_1.1-13                
[141] promises_1.3.3              stringfish_0.17.0          
[143] xtable_1.8-4                cluster_2.1.8.1            
[145] truncdist_1.0-2             cli_3.6.5                  
[147] compiler_4.3.3              crayon_1.5.3               
[149] future.apply_1.20.0         labeling_0.4.3             
[151] plyr_1.8.9                  forcats_1.0.0              
[153] stringi_1.8.7               viridisLite_0.4.2          
[155] deldir_2.0-4                scplotter_0.6.2            
[157] assertthat_0.2.1            gsl_2.1-8                  
[159] lazyeval_0.2.2              spatstat.geom_3.5-0        
[161] quantreg_6.1                Matrix_1.6-5               
[163] RcppHNSW_0.6.0              patchwork_1.3.2            
[165] future_1.67.0               statmod_1.5.0              
[167] shiny_1.11.1                SummarizedExperiment_1.32.0
[169] evd_2.3-7.1                 ROCR_1.0-11                
[171] gridtext_0.1.5              memoise_2.0.1              
[173] igraph_2.1.4                RcppParallel_5.1.9         
[175] bracer_1.2.1

# Generated by pipen-runinfo v0.9.3

Command: stdbuf -oL Rscript /mnt/disks/.cwd/.pipen/Immunopipe/MarkersFinder/0/job.script
Voluntary context switches: 2690
Involuntary context switches: 273
Percentage of CPU this job got: 96%
Major page faults: 0
Minor page faults: 1180172
Maximum resident set size (kB): 4028880
Elapsed real time (s): 47.40
System (kernel) time (s): 1.80
User time (s): 44.14
Exit status: 0